《本草纲目》中有毒中药的药物警戒思想:草部
|
摘要
目的通过对《本草纲目》草部有毒中药梳理及研究,总结"识毒-用毒-防毒-解毒"的药物警戒思想,以期为草部有毒中药临床安全合理用药提供重要保障。方法基于Excel 2016提取《本草纲目》(金陵版点校本)草部中药的毒性、性味、炮制、适应证、配伍等情况,应用统计学方法进行分析。结果草部中有毒中药共74种,占草部总数的16.8%。用药部位包括根、茎、叶、花等,共84种,其中大毒药物11种,有毒药物42种,小毒药物29种,微毒药物2种。草部有毒中药入药多为炮制品,并注重配伍减毒。结论《本草纲目》中草部有毒中药药物警戒思想丰富,经验宝贵,值得认真研究挖掘和继承。
Objective Through the combing and research of toxic Chinese medicines of grass classification in the Compendium of Materia Medica,the paper summarizethe pharmacovigilance thought of "cognition,application,prevention and rescue of drug toxicity ",in order to provide important guarantee for the clinical safety and rational use of toxic traditional Chinese medicine. Methods Based on Excel 2016,the toxicity,property and flavor,processing methods,indications,compatibility of Chinese herbal medicines in the Compendium of Materia Medica( Jinling Edition) were applied to analyze with statistical methods. Results There were 74 kinds of toxic Chinese medicines in the grass classification,accounting for 16.8%of the total number of Chinese herbal medicines in the grass classification. A total of 84 drug-containing parts consisted of roots stems,leaves,flowers including 11 major poisonous drugs,42 toxic drugs,29 small posionous drugs and 2 micro-toxic drug. It has been found that the toxic Chinese medicines of grass classification are mostly processed ones,and they focus on compatibility and attenuation. Conclusion The pharmacovigilance thought and experience of toxic Chinese medicine are effective and valuable,and they are worth exploring and inheriting by us.
Objective Through the combing and research of toxic Chinese medicines of grass classification in the Compendium of Materia Medica,the paper summarizethe pharmacovigilance thought of "cognition,application,prevention and rescue of drug toxicity ",in order to provide important guarantee for the clinical safety and rational use of toxic traditional Chinese medicine. Methods Based on Excel 2016,the toxicity,property and flavor,processing methods,indications,compatibility of Chinese herbal medicines in the Compendium of Materia Medica( Jinling Edition) were applied to analyze with statistical methods. Results There were 74 kinds of toxic Chinese medicines in the grass classification,accounting for 16.8%of the total number of Chinese herbal medicines in the grass classification. A total of 84 drug-containing parts consisted of roots stems,leaves,flowers including 11 major poisonous drugs,42 toxic drugs,29 small posionous drugs and 2 micro-toxic drug. It has been found that the toxic Chinese medicines of grass classification are mostly processed ones,and they focus on compatibility and attenuation. Conclusion The pharmacovigilance thought and experience of toxic Chinese medicine are effective and valuable,and they are worth exploring and inheriting by us.
引文
[1]戴卫波,梅全喜.《本草纲目》对中药安全合理应用的贡献[J].时珍国医国药,2017,28(4):963-965.
[2]骆和生,魏炜佳.五味与毒性关系的探讨[J].中国中药杂志,1989,35(12):49-51,60.
[3]石琳,董春茹,张冰.《本草纲目》草部药物药性与禁忌反恶解毒相关性研究[J].世界中医药,2017,12(5):1166-1170.
[4]刘红杰,李天昊,詹莎,等.四性、五味和归经对中药肝毒性预测价值的研究[J].中药新药与临床药理,2015,26(5):708-713.
[5]白云飞,林志健,张冰,等.祛风湿类中药饮片安全问题分析与用药警戒思考[J].中华中医药杂志,2016,31(10):4117-4123.
[6]张卫,张瑞贤,李健.中药药味理论的传承与创新及中药药味的标定原则与方法研究——《本草纲目》药味及药味理论考[J].中国中药杂志,2015,40(24):4928-4931.
[7]邓先瑜,芮正祥.《本草纲目》药物气味探析[J].基层中药杂志,1996,10(3):43-45.
[8]张冰,林志健,张晓朦.基于“识毒-用毒-防毒-解毒”实践的中药药物警戒思想[J].中国中药杂志,2017,42(10):2017-2020.
[9]石琳,张冰.基于《本草纲目》的中毒解救思想研究[J].成都中医药大学学报,2017,40(2):104-108.
[10]王佐德,朱昌柏.《本草纲目》服药食忌初探[J].时珍国药研究,1995,6(4):4-5.
[2]骆和生,魏炜佳.五味与毒性关系的探讨[J].中国中药杂志,1989,35(12):49-51,60.
[3]石琳,董春茹,张冰.《本草纲目》草部药物药性与禁忌反恶解毒相关性研究[J].世界中医药,2017,12(5):1166-1170.
[4]刘红杰,李天昊,詹莎,等.四性、五味和归经对中药肝毒性预测价值的研究[J].中药新药与临床药理,2015,26(5):708-713.
[5]白云飞,林志健,张冰,等.祛风湿类中药饮片安全问题分析与用药警戒思考[J].中华中医药杂志,2016,31(10):4117-4123.
[6]张卫,张瑞贤,李健.中药药味理论的传承与创新及中药药味的标定原则与方法研究——《本草纲目》药味及药味理论考[J].中国中药杂志,2015,40(24):4928-4931.
[7]邓先瑜,芮正祥.《本草纲目》药物气味探析[J].基层中药杂志,1996,10(3):43-45.
[8]张冰,林志健,张晓朦.基于“识毒-用毒-防毒-解毒”实践的中药药物警戒思想[J].中国中药杂志,2017,42(10):2017-2020.
[9]石琳,张冰.基于《本草纲目》的中毒解救思想研究[J].成都中医药大学学报,2017,40(2):104-108.
[10]王佐德,朱昌柏.《本草纲目》服药食忌初探[J].时珍国药研究,1995,6(4):4-5.