中西医结合治疗新生儿脓疱疮临床疗效的Meta分析

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英文篇名：Clinical Effect of Combined Chinese and Western Medicine on Neonatal Pustular:A Meta-analysis 作者：颜群芳 ; 董晓斐 英文作者：YAN Qunfang;DONG Xiaofei;Hunan University of Chinese Medicine;The First Affiliated Hospital of Hunan University of Chinese Medicine; 关键词：新生儿脓疱疮 ; 中西医结合 ; Meta分析 英文关键词：neonatal pustules;;integrative medicine;;Meta-analysis 中文刊名：HNZX 英文刊名：Journal of Hunan University of Chinese Medicine 机构：湖南中医药大学;湖南中医药大学第一附属医院; 出版日期：2017-11-25 出版单位：湖南中医药大学学报 年：2017 期：v.37;No.242 基金：湖南省教育厅科学研究项目(15A145) 语种：中文; 页：HNZX201711019 页数：5 CN：11 ISSN：43-1472/R 分类号：82-86

摘要

目的通过对相关文献进行Meta分析,系统评价中西医结合治疗新生儿脓疱疮的临床疗效。方法检索PubMed、Medline、中国期刊全文数据库、维普期刊数据库、中国知网和万方数据库,检索中西医结合治疗新生儿脓疱疮的随机对照研究(RCT),由两名评价者独立提取资料并进行方法学质量评估,数据分析采用RevMan 5.3软件进行统计分析。结果共纳入16个RCT,Meta分析结果显示,中西医结合治疗新生儿脓疱疮总有效率Meta分析结果为:[OR=5.59(95%CI∶3.81,8.20),P<0.01],提示中西医结合治疗新生儿脓疱疮总有效率优于单纯西医治疗;中西医结合治疗新生儿脓疱疮显效率Meta分析结果为:[OR=3.57(95%CI∶2.41,5.29),P<0.01],提示中西医结合治疗新生儿脓疱疮显效率高于单纯西医治疗;脓疱症状消失时间Meta分析结果显示:[MD=-1.64(95%CI∶-1.88,-1.40),P<0.01],提示中西医结合治疗新生儿脓疱疮较单纯西医治疗的脓疱消失所需时间更短。结论中西医结合治疗新生儿脓疱疮的临床疗效较单纯西医治疗临床疗效更好,且痊愈所需时间更少,临床值得推广。
        Objective Using Meta-analysis to evaluate the clinical effect on integrative medicine in treating neonatal pustules.Methods Randomized controlled studies(RCT) of integrative medicine in the treatment of neonatal pustules were retrieved via Pub Med,Medline,China Journal Full-text database,VIP Journal database,CNKI and WANFANG database.The relevant literatures were extracted and assessed independently by two evaluators.Software Rev Man 5.3 was using for statistical analysis.Results A total of 16 RCT were adopted for Meta-analysis.The result of Meta-analysis showed that the total effect of integrative medicine in treating neonatal pustules was [OR=5.59(95% CI: 3.81,8.20),P<0.01],which suggested that the clinical effect on integrative medicine in treating neonatal pustule was better than that of western medicine.The efficiency of integrative medicine in treating neonatal pustule was [OR=3.57(95% CI: 2.41,5.29),P<0.01],which suggested that the clinical effect on integrative medicine in treating neonatal pustules was better than that of Western medicine.The Meta-analysis result of pustule disappeared time was [MD =-1.64(95% CI:-1.88,-1.40),P <0.01],which suggested that the pustule disappeared time of integrative medicine in the treatment of neonatal pustules was shorter than that of western medicine.Conclusion The clinical effect of integrative medicine on the treatment of neonatal pustules is better than that of Western medicine.It takes less time to heal and is worth promoting.

引文

[1]邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].第4版.北京:人民卫生出版社,2015:251.
    [2]郭江,李玲.百多邦与紫草油治疗新生儿红斑合并脓疱疮的疗效观察[J].四川医学,2007,28(4):436-437.
    [3]李桂贤.苦瓜煮水洗浴加百多邦外涂治疗新生儿脓疱疮的观察和护理[J].北方药学,2015,12(10):196.
    [4]高茂玲,黄友荣,胡安伟.小儿解毒方治疗新生儿脓疱疮的临床研究[J].中国妇幼保健,2004,9(5):55-56.
    [5]李爱华,李艾玲.新生儿毒性红斑并发脓疱疮与单纯性脓疱疮用莫匹罗星软膏与紫草油联合治疗的疗效观察[J].临床和实验医学杂志,2010,9(5):342-343.
    [6]林晓燕,徐佳君.中药颗粒剂外洗治疗新生儿脓疱疹疗效观察[J].中医临床研究,2016,8(11):118-119.
    [7]罗香花.中药外洗治疗新生儿脓疱疮[J].当代医学,2012,18(12):58-59.
    [8]吴玲玲.复方黄柏液湿敷治疗新生儿脓疱疮效果观察[J].临床合理用药杂志,2013,6(5):50.
    [9]金春梅.洁尔阴洗液治疗新生儿脓疱病疗效观察[J].河北中医,2007,29(1):57.
    [10]李红姗,蒙晶,郑诗华.康复新液联合莫匹罗星治疗新生儿脓疱疮临床观察及护理[J].海南医学,2012,23(17):141-142.
    [11]徐芳.日舒安洗剂与氯锌搽剂治疗新生儿脓疱疮的效果观察[J].中国临床护理,2011,3(3):243-244.
    [12]李婷婷,李媚,廖尧生.三黄炉甘石混合液治疗新生儿脓疱疮的效果观察[J].南方护理学报,2009,16(1):63-64.
    [13]杨国平,李海华,张华,等.银甘洗方对热毒蕴结型新生儿脓疱病的疗效、白细胞计数、C-反应蛋白及降钙素原水平的影响研究[J].河北中医药学报,2015,30(1):61-64.
    [14]黄俊勇,张晓春.中西医结合治疗新生儿脓疱疮疗效观察[J].四川中医,2003,21(11):73-74.
    [15]宋文英.中西医结合治疗新生儿脓疱疹临床观察[J].中国生化药物杂志,2006,27(4):245.
    [16]苏丽华.青柏洁肤洗液治疗新生儿脓疱疮的临床观察[J].国际医药卫生导报,2008,14(8):103-104.
    [17]张方霞,崔西美,杨乐娥.中药泡浴+碘伏消毒液原液治疗新生儿脓疱疮疗效观察与心得体会[J].中国医学创新研究,2008,5(9):188.
    [18]韩新民.中医儿科学[M].北京:高等教育出版社,2014:20.
    [19]江苏新医学院.中药大辞典(下册)[M].上海:上海科技山版社,1986:2017-2036.
    [20]王君棪,王爱华,邸春阳.新生儿感染性疾病的病原菌分布及药敏分析[J].山东医药,2013,53(24):75-77.