肺部疾病的T淋巴细胞亚群特点与免疫干预进展
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摘要
呼吸系统疾病的发生、发展多与机体的免疫功能减低有关,免疫功能越低,发病率越高、病情越重、预后越差。淋巴细胞作为机体重要的免疫效应细胞群,其水平能反映患者的免疫状态,而T淋巴细胞是机体关键的免疫应答参与者,其亚群分布及功能与患者病情息息相关。近年来在诸多肺部疾病中发现了新的淋巴细胞亚群特性及活性因子,在诊断、评估及治疗方面存在一定的参考意义。近年来根据T淋巴细胞亚群在不同疾病中分化机制及作用的研究成果,从细胞及分子水平上进行免疫干预,并取得一定成效。本文就多种肺部疾病发生、发展过程中T淋巴细胞亚群的特点及其免疫干预进展进行综述。
The happening of respiratory system disease, development is concerned with the decrease of immune function. The worse immune function is, the higher incidence of diseases, the more severe the illness and the poorer prognosis. As an important immune effector cell population in the body, lymphocytes could reflect the immune status of patients, whose subsets became the key immune response participants in the body, related to the patient's condition closely. In recent years, new lymphocyte subsets members and active factors had been found in many lung diseases. In recent years, according to the research results on the mechanism and function of T lymphocyte subsets in different diseases, immune intervention has been carried out at the cellular and molecular level, and some results have been achieved. This article reviews the characteristics of T lymphocyte subsets and the progress of immune intervention in the occurrence and development of various pulmonary diseases.
The happening of respiratory system disease, development is concerned with the decrease of immune function. The worse immune function is, the higher incidence of diseases, the more severe the illness and the poorer prognosis. As an important immune effector cell population in the body, lymphocytes could reflect the immune status of patients, whose subsets became the key immune response participants in the body, related to the patient's condition closely. In recent years, new lymphocyte subsets members and active factors had been found in many lung diseases. In recent years, according to the research results on the mechanism and function of T lymphocyte subsets in different diseases, immune intervention has been carried out at the cellular and molecular level, and some results have been achieved. This article reviews the characteristics of T lymphocyte subsets and the progress of immune intervention in the occurrence and development of various pulmonary diseases.
引文
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[13]Felipe Grabarz,Cristhiane Favero Aguiar,Matheus CorreaCosta,et al.Protective role of NKT cells and macrophage M2-driven phenotype in bleomycin-induced pulmonary fibrosis[J].Inflammopharmacology,2018,26(2):491-504.
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[15]赵丽珂,周荣伟,穆冰瑶,等.艾拉莫德对博来霉素诱导的肺间质纤维化小鼠模型的影响[J].中华风湿学杂志,2017,21(6):370-374.
[16]张邦禹,赵兰,徐瑛.阿奇霉素和支扩养阴颗粒联合给药对大鼠支气管扩张模型的影响及机制[J].中国抗生素杂志,2018,43(1):103-108.
[17]王碧瑛.胸腺肽α1对支气管扩张症患者急性发作期细胞免疫的影响[J].临床合理用药杂志,2016,9(2):22-23.
[18]范荣梅,朱建勇.小剂量阿奇霉素联合胸腺肽对支气管扩张稳定期的临床疗效观察[J].中华肺部疾病杂志(电子版),2017,10(5):583-584.
[19]贾民勇,王少芳,宋璐,等.外周血T淋巴细胞亚群检测在不同呼吸科疾病中的运用效果比较及其临床价值评价[J].临床肺科杂志,2018,23(4):732-735.
[2]Sun JL,Liu T,Yan Y,et al.The role of Th1/Th2 cytokines played in regulation of specific CD4+Th1 cell conversion and activation during inflammatory reaction of chronic obstructive pulmonary disease[J].Scandinavian Journal of Immunology,2018,88(1):e12674.
[3]Ju JY.An Increased Proportion of Apoptosis in CD4?TLymphocytes Isolated from the Peripheral Blood in Patients with Stable Chronic Obstructive Pulmonary Disease[J].Tuberc Respir Dis,2018,81(2):132-137.
[4]陈欣,曹洁,陈宝元.慢性阻塞性肺疾病患者肺组织中白细胞介素17的表达及其临床意义[J].中华医学杂志,2016,96(26):2086-2090.
[5]Li JL,Chen TS,Yuan CC,et al.Regulatory T cell activity in immunosuppresive mice model of pseudomonas aeruginosa pneumonia[J].Journal of Huazhong University of Science and Technology(Medical Science),2017,37(4):505-509.
[6]Shindo Y,Fuchs AG,Davis CG,et al.Interleukin 7immunotherapy improves host immunity and survival in a twohitmodel of Pseudomonas aeruginosa pneumonia[J].Journal of Leukocyte Biology,2017,101(2):543-554.
[7]Okuma Y,Hosomi Y,Nakahara Y,et al.High plasma levels of soluble programmed cell death ligand 1 are prognostic for reduced survival in advanced lung cancer[J].Lung Cancer,2017,104:1-6.
[8]刘洪千,林宗斌.香菇多糖联合顺铂治疗肺癌胸腔积液的疗效及对凋亡分子、血管新生指标表达的影响[J].临床和实验医学杂志,2018,17(2):141-144.
[9]何娅,潘洪秋,范琳.免疫辅助治疗初治肺结核的研究[J].中国防痨杂志,2017,39(2):134-139.
[10]廖春信,方毅敏,詹晓霞,等.肺结核患者外周血CD4+CD8+T细胞的检测及临床意义[J].中华微生物学和免疫学杂志,2014,34(10):781-786.
[11]袁琳洁,陈诗皓,安高,等.IL-33诱导的小鼠过敏原非依赖性哮喘样模型肺组织免疫细胞及亚群的改变[J].首都医科大学学报,2016,37(5):561-567.
[12]Kaustav Chakraborty,Soumya Chatterjee,Arindam Bhattacharyya.Impact of Treg on other T cell subsets in progression of fibrosis in experimental lung fibrosis[J].Tissue and Cell,2018,53:87-92.
[13]Felipe Grabarz,Cristhiane Favero Aguiar,Matheus CorreaCosta,et al.Protective role of NKT cells and macrophage M2-driven phenotype in bleomycin-induced pulmonary fibrosis[J].Inflammopharmacology,2018,26(2):491-504.
[14]刘培培,姜悦垚,侯松萍.淋巴细胞免疫分型对间质性肺病变的临床分析[J].中国实验诊断学,2015,19(12):2066-2068.
[15]赵丽珂,周荣伟,穆冰瑶,等.艾拉莫德对博来霉素诱导的肺间质纤维化小鼠模型的影响[J].中华风湿学杂志,2017,21(6):370-374.
[16]张邦禹,赵兰,徐瑛.阿奇霉素和支扩养阴颗粒联合给药对大鼠支气管扩张模型的影响及机制[J].中国抗生素杂志,2018,43(1):103-108.
[17]王碧瑛.胸腺肽α1对支气管扩张症患者急性发作期细胞免疫的影响[J].临床合理用药杂志,2016,9(2):22-23.
[18]范荣梅,朱建勇.小剂量阿奇霉素联合胸腺肽对支气管扩张稳定期的临床疗效观察[J].中华肺部疾病杂志(电子版),2017,10(5):583-584.
[19]贾民勇,王少芳,宋璐,等.外周血T淋巴细胞亚群检测在不同呼吸科疾病中的运用效果比较及其临床价值评价[J].临床肺科杂志,2018,23(4):732-735.