药物性急性肾损伤的研究进展
|
摘要
药物性肾损伤是临床实践中的严重问题,会导致患者住院时间延长、总治疗费用和死亡率增加。可能导致肾损伤的临床常用药物主要包括抗癌药物、抗菌/抗病毒药物、非甾体抗炎药、造影剂及其他药物如环孢素等。药物引起肾毒性的危险因素除患者年龄、性别以及疾病等自身因素外,药物本身的肾脏毒性、药物过量和长期使用、药物间相互作用和药物相关的不良反应也是重要的风险因素。了解药物性肾损伤的发病机制及危险因素,及时采取预防和处理措施,对于减少肾损伤发生具有重要意义。
Drug-induced kidney injury is a serious problem in clinical practice, which will lead to prolonged hospital stay and increased total treatment costs and mortality. There are many clinical drugs that may cause kidney damage including anticancer drugs, antibacterial/antiviral drugs, non-steroidal anti-inflammatory drugs, contrast agents and other drugs such as cyclosporine. The risk factors of drug-induced nephrotoxicity include not only the age, sex and disease of patients themselves, but also the drug nephrotoxicity, drug overdose and long-term use, drug interactions and drug-related adverse reactions. It is important to understand the pathogenesis and risk factors of drug-induced kidney injury and take preventive and treatment measures to reduce the occurrence of kidney injury.
Drug-induced kidney injury is a serious problem in clinical practice, which will lead to prolonged hospital stay and increased total treatment costs and mortality. There are many clinical drugs that may cause kidney damage including anticancer drugs, antibacterial/antiviral drugs, non-steroidal anti-inflammatory drugs, contrast agents and other drugs such as cyclosporine. The risk factors of drug-induced nephrotoxicity include not only the age, sex and disease of patients themselves, but also the drug nephrotoxicity, drug overdose and long-term use, drug interactions and drug-related adverse reactions. It is important to understand the pathogenesis and risk factors of drug-induced kidney injury and take preventive and treatment measures to reduce the occurrence of kidney injury.
引文
[1]BENTLEY ML,CORWIN HL,DASTA J.Drug-induced acute kidney injury in the critically ill adult:recognition and prevention strategies[J].Crit Care Med,2010,38(6 Suppl):S169-S174.
[2]AWDISHU L.Drug-induced kidney disease in the ICU:mechanisms,susceptibility,diagnosis and management strategies[J].Curr Opin Crit Care,2017,23(6):484-490.
[3]TILLYARD A,KEAYS R,SONI N.The diagnosis of acute renal failure in intensive care:mongrel or pedigree?[J].Anaesthesia,2005,60(9):903-914.
[4]HOSOHATA K.Role of oxidative stress in drug-induced kidney injury[J].Int J Mol Sci,2016,17(11):E1826.
[5]BARRANTES F,HORWEDEL TA.Drug use and nephrotoxicity in the intensive care unit:are we under-dosing antimicrobials in patients with acute kidney injury with the need of extended dialysis?[J].Kidney Int,2012,82(8):935-936.
[6]PAUEKSAKON P,FOGO AB.Drug-induced nephropathies[J].Histopathology,2017,70(1):94-108.
[7]ASHRAF T,MAJONI W.Acute interstitial nephritis associated with sofosbuvir and daclatasvir[J].ACG Case Rep J,2017,4:e84.
[8]BLANK ML,PARKIN L,PAUL C,et al.A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use[J].Kidney Int,2014,86(4):837-844.
[9]KODA R,WATANABE H,TSUCHIDA M,et al.Immune checkpoint inhibitor(nivolumab)-associated kidney injury and the importance of recognizing concomitant medications known to cause acute tubulointerstitial nephritis:a case report[J].BMCNephrol,2018,19(1):48.
[10]PETAZELLA MA,IZZEDINE H.New drug toxicities in the onco-nephrology world[J].Kidney Int,2015,87(5):909-917.
[11]VARRIER M,OSTERMANN M.Novel risk factors for acute kidney injury[J].Curr Opin Nephrol Hypertens,2014,23(6):560-569.
[12]KHAN S,LOI V,ROSNER MH.Drug-induced kidney injury in the elderly[J].Drugs Aging,2017,34(10):729-741.
[13]KANE-GILL SL,GOLDSTEIN SL.Drug-induced acute kidney injury:a focus on risk assessment for prevention[J].Crit Care Clin,2015,31(4):675-684.
[14]OZKOK A,EDELSTEIN CL.Pathophysiology of cisplatininduced acute kidney injury[J].Biomed Res Int,2014,2014:967826.
[15]FAUGHT LN,GREFF MJE,RIEDER MJ,et al.Drug-induced acute kidney injury in children[J].Br J Clin Pharmacol,2015,80(4):901-909.
[16]左乔竹,覃文新.CTLA-4和PD-1信号通路在实体瘤治疗中的研究进展[J].生命科学,2017,29(8):713-721.
[17]JHAVERI KD,SAKHIYA V,FISHBANE S.Nephrotoxicity of the BRAF inhibitors vemurafenib and dabrafenib[J].JAMAOncol,2015,1(8):1133-1134.
[18]ROSNER MH,PERAZELLA MA.Acute kidney injury in patients with cancer[J].N Engl J Med,2017,376(18):1770-1781.
[19]MCWILLIAM SJ,ANTOINE DJ,SMYTH RL,et al.Aminoglycosideinduced nephrotoxicity in children[J].Pediatr Nephrol,2017,32(11):2015-2025.
[20]RAO S,ABZUG MJ,CAROSONE-LINK P,et al.Intravenous acyclovir and renal dysfunction in children:a matched case control study[J].J Pediatr,2015,166(6):1462-1468.
[21]STEINBERG I,KIMBERLIN DW.Acyclovir dosing and acute kidney injury:deviations and direction[J].J Pediatr,2015,166(6):1341-1344.
[22]RICHELSEN RKB,JENSEN SB,NIELSEN H.Incidence and predictors of intravenous acyclovir-induced nephrotoxicity[J].Eur J Clin Microbiol Infect Dis,2018,37(10):1965-1971.
[23]BLUMENTHAL KG,LAI KH,HUANG M,et al.Adverse and hypersensitivity reactions to prescription nonsteroidal antiinflammatory agents in a large health care system[J].J Allergy Clin Immunol Pract,2017,5(3):737-743.
[24]CHENG W,ZHAO F,TANG CY,et al.Comparison of iohexol and iodixanol induced nephrotoxicity,mitochondrial damage and mitophagy in a new contrast-induced acute kidney injury rat model[J].Arch Toxicol,2018,92(7):2245-2257.
[25]JANUS N,LAUNAY-VACHER V,DERAY G.Non-iodinated contrast media nephrotoxicity[J].Nephrol Ther,2018,14(6):484-490.
[26]MA Z,CAO X,GUO X,et al.Establishment and validation of an in vitro screening method for traditional Chinese medicineinduced nephrotoxicity[J].Evid Based Complement Alternat Med,2018,2018:2461915.
[27]王京丽,周超凡.中草药及其制剂的肾毒性概述[J].中国中医基础医学杂志,2016,22(3):437-439.
[28]KANE-GILL SL,GOLDSTEIN SL.Drug-induced acute kidney injury:a focus on risk assessment for prevention[J].Crit Care Clin,2015,31(4):675-684.
[29]HANNA MH,ASKENAZI DJ,SELEWSKI DT.Drug-induced acute kidney injury in neonates[J].Curr Opin Pediatr,2016,28(2):180-187.
[30]梅和坤,王冬,白楠,等.两性霉素B肾毒性文献计量分析[J].中国新药与临床杂志,2014,33(12):924-928.
[31]JOYCE EL,KANE-GILL SL,FUHRMAN DY,et al.Drugassociated acute kidney injury:who's at risk?[J].Pediatr Nephrol,2017,32(1):59-69.
[32]CHEN H,BUSSE LW.Novel therapies for acute kidney injury[J].Kidney Int Rep,2017,2(5):785-799.
[2]AWDISHU L.Drug-induced kidney disease in the ICU:mechanisms,susceptibility,diagnosis and management strategies[J].Curr Opin Crit Care,2017,23(6):484-490.
[3]TILLYARD A,KEAYS R,SONI N.The diagnosis of acute renal failure in intensive care:mongrel or pedigree?[J].Anaesthesia,2005,60(9):903-914.
[4]HOSOHATA K.Role of oxidative stress in drug-induced kidney injury[J].Int J Mol Sci,2016,17(11):E1826.
[5]BARRANTES F,HORWEDEL TA.Drug use and nephrotoxicity in the intensive care unit:are we under-dosing antimicrobials in patients with acute kidney injury with the need of extended dialysis?[J].Kidney Int,2012,82(8):935-936.
[6]PAUEKSAKON P,FOGO AB.Drug-induced nephropathies[J].Histopathology,2017,70(1):94-108.
[7]ASHRAF T,MAJONI W.Acute interstitial nephritis associated with sofosbuvir and daclatasvir[J].ACG Case Rep J,2017,4:e84.
[8]BLANK ML,PARKIN L,PAUL C,et al.A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use[J].Kidney Int,2014,86(4):837-844.
[9]KODA R,WATANABE H,TSUCHIDA M,et al.Immune checkpoint inhibitor(nivolumab)-associated kidney injury and the importance of recognizing concomitant medications known to cause acute tubulointerstitial nephritis:a case report[J].BMCNephrol,2018,19(1):48.
[10]PETAZELLA MA,IZZEDINE H.New drug toxicities in the onco-nephrology world[J].Kidney Int,2015,87(5):909-917.
[11]VARRIER M,OSTERMANN M.Novel risk factors for acute kidney injury[J].Curr Opin Nephrol Hypertens,2014,23(6):560-569.
[12]KHAN S,LOI V,ROSNER MH.Drug-induced kidney injury in the elderly[J].Drugs Aging,2017,34(10):729-741.
[13]KANE-GILL SL,GOLDSTEIN SL.Drug-induced acute kidney injury:a focus on risk assessment for prevention[J].Crit Care Clin,2015,31(4):675-684.
[14]OZKOK A,EDELSTEIN CL.Pathophysiology of cisplatininduced acute kidney injury[J].Biomed Res Int,2014,2014:967826.
[15]FAUGHT LN,GREFF MJE,RIEDER MJ,et al.Drug-induced acute kidney injury in children[J].Br J Clin Pharmacol,2015,80(4):901-909.
[16]左乔竹,覃文新.CTLA-4和PD-1信号通路在实体瘤治疗中的研究进展[J].生命科学,2017,29(8):713-721.
[17]JHAVERI KD,SAKHIYA V,FISHBANE S.Nephrotoxicity of the BRAF inhibitors vemurafenib and dabrafenib[J].JAMAOncol,2015,1(8):1133-1134.
[18]ROSNER MH,PERAZELLA MA.Acute kidney injury in patients with cancer[J].N Engl J Med,2017,376(18):1770-1781.
[19]MCWILLIAM SJ,ANTOINE DJ,SMYTH RL,et al.Aminoglycosideinduced nephrotoxicity in children[J].Pediatr Nephrol,2017,32(11):2015-2025.
[20]RAO S,ABZUG MJ,CAROSONE-LINK P,et al.Intravenous acyclovir and renal dysfunction in children:a matched case control study[J].J Pediatr,2015,166(6):1462-1468.
[21]STEINBERG I,KIMBERLIN DW.Acyclovir dosing and acute kidney injury:deviations and direction[J].J Pediatr,2015,166(6):1341-1344.
[22]RICHELSEN RKB,JENSEN SB,NIELSEN H.Incidence and predictors of intravenous acyclovir-induced nephrotoxicity[J].Eur J Clin Microbiol Infect Dis,2018,37(10):1965-1971.
[23]BLUMENTHAL KG,LAI KH,HUANG M,et al.Adverse and hypersensitivity reactions to prescription nonsteroidal antiinflammatory agents in a large health care system[J].J Allergy Clin Immunol Pract,2017,5(3):737-743.
[24]CHENG W,ZHAO F,TANG CY,et al.Comparison of iohexol and iodixanol induced nephrotoxicity,mitochondrial damage and mitophagy in a new contrast-induced acute kidney injury rat model[J].Arch Toxicol,2018,92(7):2245-2257.
[25]JANUS N,LAUNAY-VACHER V,DERAY G.Non-iodinated contrast media nephrotoxicity[J].Nephrol Ther,2018,14(6):484-490.
[26]MA Z,CAO X,GUO X,et al.Establishment and validation of an in vitro screening method for traditional Chinese medicineinduced nephrotoxicity[J].Evid Based Complement Alternat Med,2018,2018:2461915.
[27]王京丽,周超凡.中草药及其制剂的肾毒性概述[J].中国中医基础医学杂志,2016,22(3):437-439.
[28]KANE-GILL SL,GOLDSTEIN SL.Drug-induced acute kidney injury:a focus on risk assessment for prevention[J].Crit Care Clin,2015,31(4):675-684.
[29]HANNA MH,ASKENAZI DJ,SELEWSKI DT.Drug-induced acute kidney injury in neonates[J].Curr Opin Pediatr,2016,28(2):180-187.
[30]梅和坤,王冬,白楠,等.两性霉素B肾毒性文献计量分析[J].中国新药与临床杂志,2014,33(12):924-928.
[31]JOYCE EL,KANE-GILL SL,FUHRMAN DY,et al.Drugassociated acute kidney injury:who's at risk?[J].Pediatr Nephrol,2017,32(1):59-69.
[32]CHEN H,BUSSE LW.Novel therapies for acute kidney injury[J].Kidney Int Rep,2017,2(5):785-799.