乳腺癌伴发抑郁症研究进展
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摘要
[目的]总结目前临床对于乳腺癌伴发抑郁症的研究进展。[方法]收集近5年国内外关于乳腺癌、抑郁症及其二者相关性的文献,分析乳腺癌伴发抑郁症的流行病学、相关因素、中西医的病机及对应治疗方法,并对未来发展趋势进行展望。[结果]共收集41篇相关文献,综合各学者观点认为乳腺癌伴发抑郁症的比例越来越高,发病与患者的性别、年龄、治疗方法、家庭关系和社会因素有关。西医通过药物、电痉挛、心理疗法治疗,中医通过中药、针灸、音乐和情志疗法治疗。[结论]目前临床对于乳腺癌伴发抑郁症的研究日益深入,并有良好发展趋势。
[Objective]To summarize the research progress of breast cancer with depression. [Methods]Collecting the literatures on breast cancer, depression and their correlation in recent 5 years, analyzing the epidemiology of breast cancer associated with depression, related factors, pathogenesis of Chinese and western medicine and corresponding treatment methods, and discussing the future trend of development. [Result]The number of total collection related papers is 41. Scholars agree that the rate of breast cancer with depression is increasing because of the patient's gender, age, treatment, family relations and social factors. Western medicine treats with drugs, electroshock therapy, and psychological therapy, Chinese medicine treats with Chinese medicine,acupuncture, music and emotional therapy. [Conclusion]The current clinical research on breast cancer with depression is increasingly in-depth,and has a good trend of development.
[Objective]To summarize the research progress of breast cancer with depression. [Methods]Collecting the literatures on breast cancer, depression and their correlation in recent 5 years, analyzing the epidemiology of breast cancer associated with depression, related factors, pathogenesis of Chinese and western medicine and corresponding treatment methods, and discussing the future trend of development. [Result]The number of total collection related papers is 41. Scholars agree that the rate of breast cancer with depression is increasing because of the patient's gender, age, treatment, family relations and social factors. Western medicine treats with drugs, electroshock therapy, and psychological therapy, Chinese medicine treats with Chinese medicine,acupuncture, music and emotional therapy. [Conclusion]The current clinical research on breast cancer with depression is increasingly in-depth,and has a good trend of development.
引文
[1]孔军辉.医学心理学[M].2版.北京:人民卫生出版社,2012:90.
[2]IARC.Latest global cancer data:Cancer burden rises to18.1 million new cases and 9.5 million cancer deaths in2018[R].France:International Agency for Research on Cancer,2018.
[3]齐元富,李慧杰,孙海燕.肿瘤相关性抑郁及其相关因素分析[J].中国肿瘤,2013,22(2):98-101.
[4]张永晖,陈玉英,巢冬花,等.癌症患者抑郁现状调查分析及护理干预[J].齐鲁护理杂志,2011,17(35):53-54.
[5]高秀飞,刘胜,陈维珺.乳腺癌术后抑郁障碍的调查及心理干预[D].北京:中华中医药学会-第十一届全国中医及中西医结合乳腺病学术会议论文集,2009:52.
[6]张玉人,李杰,黎磊.乳腺癌发生发展过程的抑郁障碍特征观察及分析[J].中国中西医结合杂志,2013,33(4):459-461.
[7]李玲艳,朱熊兆,王榆萍,等.女性乳腺癌患者情绪抑制对其抑郁症状的影响[J].中国临床心理学杂志,2015,23(5):915-918.
[8]金艾香,章小飞,沈利凤.乳腺癌患者手术前后生存质量与焦虑抑郁状况调查研究[J].中国现代医生,2017,55(25):114-117.
[9]杜锦锦.癌症患者抑郁状态的相关因素和护理措施[J].实用临床护理学杂志,2017,40(2):186.
[10]李玲,施军平,邵喜音.术后乳腺癌患者焦虑、抑郁及生活质量分析[J].中国肿瘤,2014,23(7):580-584.
[11]Maraste R,Brandt L,Olsson H,et al.Anxiety and depression in breast cancer patients at start of adjuvant radiotherapy:Relations to age and type of surgery[J].Acta Oncologica,2009,31(6):641-643.
[12]童兆莹.乳腺癌患者抑郁相关因素分析[J].临床护理杂志,2017,16(1):11-14.
[13]李虹,叶浩生,赵守盈.乳腺癌术后应对方式及焦虑抑郁情绪调查[J].中国心理卫生杂志,2009,23(3):173-174.
[14]姜永红,朱盼盼,穆少锋,等.乳腺癌根治术后疾病不确定感、抑郁和焦虑情绪与25-(OH)维生素D水平的关系[J].国际精神病学杂志,2017,44(3):509-511.
[15]李佳莹,王立平,李沙沙,等.化疗期乳腺癌患者情绪状态及其影响因素的调查研究[J].现代生物医学进展,2014,15(14):2943-2946.
[16]DC Allred,SK Mohsin,SA Fuqua.Histological and biological evolution of human premalignant breast disease[J].Endocrine Related Cancer,2001,8(1):47-61.
[17]周立芝,陈长香,马杰,等.疾病症状与配偶在意程度对女性乳腺癌患者术后抑郁的影响[J].中华现代护理杂志,2016,22(28):4051-4053.
[18]E Andrzejczak,K Markockamaczka,A Lewandowski.Partner relationship after mastectomy in women not offered breast reconstruction[J].Psycho-Oncology,2013,22(7):1653-1657.
[19]郭静.农民工家庭乳腺癌患者术后焦虑、抑郁状况及影响因素研究[J].国际护理学杂志,2010,29(12):1779-1781.
[20]李予春,李秀坤,于德志,等.不同地区女性乳腺癌患者术后抑郁发生情况及危险因素分析[J].新乡医学院学报,2017,34(4):282-285.
[21]Dubovsky SL,Thomas M.Beyond specificity:effects of serotonin and serotonergic treatments on psychobiological dysfunction[J].Journal of Psychosomatic Research,1995,39(4):429-444.
[22]Vrshek-Schallhorn S,Doane LD,Mineka S,et al.The cortisol awakening response predicts major depression:predictive stability over a 4-year follow-up and effect of depression history[J].Psychological Medicine,2012,43(3):1-11.
[23]Howren MB,Lamkin DM,Suls J.Associations of depression with C-reactive protein,IL-1,and IL-6:a metaanalysis[J].Psychosomatic Medicine,2009,71(2):171-186.
[24]刘新发,韩亚光.抑郁与癌症研究进展[J].广东医学,2006,27(8):1266-1268.
[25]Anglin RE,Samaan Z,Walter SD,et al.Vitamin D deficiency and depression in adults:systematic review and meta-analysis[J].British Journal of Psychiatry,2013,202(2):100-107.
[26]余听鸿.外证医案汇编[M].上海:上海科学技术出版社,1961:148.
[27]陈实功.外科正宗[M].天津:天津科学技术出版社,1993:160.
[28]杨婧,张婕,王笑民,等.乳腺癌患者伴发抑郁焦虑中医证型的研究[J].北京中医药,2009,28(3):219-220.
[29]李德辉,范焕芳,孙春霞.乳腺癌中医证型与TNM分期相关性的Meta分析[J].中国老年学杂志,2017,37(15):3769-3771.
[30]武瑞仙,梁晨,裴晓华,等.乳腺癌中医证型与生物学指标相关性研究[J].中医学报,2017,32(8)
[31]Montegomery S A,Nielsen R Z,Poulsen L H,et al.Arandomised,double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine[J].Human Psychopharmacol,2014,29(5):470-482.
[32]Blum S I,Tourkodimitris S,Ruth A.Evaluation of functional health and well-being in patients receiving levomilnacipran ER for the treatment of major depressive disorder[J].Affect Disorder,2015,170:230-236.
[33]陶建英,付锐,张盼攀.WL-HA-2脑波治疗仪缓解乳腺癌术后患者焦虑抑郁的研究[J].荆楚理工学院学报,2017,32(4):38-40.
[34]孙凤环.综合护理干预对抑郁症患者院外康复的影响[J].齐鲁护理杂志,2018,24(7):94-96.
[35]熊静悦,曾南,张崇燕,等.逍遥散抗抑郁作用研究[J].中药药理临床,2007,23(1):3-5.
[36]贾飞,赵星星,张冬颖.甘麦大枣汤合逍遥散加味治疗乳腺癌伴抑郁症的临床疗效研究[J].世界最新医学信息文摘,2015,79(6):175-176.
[37]陶飞宝,何钦,叶旭,等.开郁解毒法对乳腺癌术后伴发抑郁状态患者IGF-1的影响[J].新中医,2017,49(10):127-129.
[38]于明薇,李道睿,杨国旺,等.针刺治疗康复期乳腺癌患者癌因性疲乏的随机对照研究[J].中国医药导报,2017,14(19):89-93.
[39]肖彬,刘展华.针刺配合耳穴压贴治疗乳腺癌抑郁症疗效观察[J].中国针灸,2014,34(10):956-960.
[40]杨巾夏,章琼,顾佳佳.中医五行音乐干预对乳腺癌化疗患者抑郁状态的影响[J].中华现代护理杂志,2013,19(36):4461-4463.
[41]李阳,黄立中,龚辉,等.中医情志疗法对三阴性乳腺癌患者术后恢复期的生存质量的影响[J].湖南中医药大学学报,2015,35(10):54-62.
[2]IARC.Latest global cancer data:Cancer burden rises to18.1 million new cases and 9.5 million cancer deaths in2018[R].France:International Agency for Research on Cancer,2018.
[3]齐元富,李慧杰,孙海燕.肿瘤相关性抑郁及其相关因素分析[J].中国肿瘤,2013,22(2):98-101.
[4]张永晖,陈玉英,巢冬花,等.癌症患者抑郁现状调查分析及护理干预[J].齐鲁护理杂志,2011,17(35):53-54.
[5]高秀飞,刘胜,陈维珺.乳腺癌术后抑郁障碍的调查及心理干预[D].北京:中华中医药学会-第十一届全国中医及中西医结合乳腺病学术会议论文集,2009:52.
[6]张玉人,李杰,黎磊.乳腺癌发生发展过程的抑郁障碍特征观察及分析[J].中国中西医结合杂志,2013,33(4):459-461.
[7]李玲艳,朱熊兆,王榆萍,等.女性乳腺癌患者情绪抑制对其抑郁症状的影响[J].中国临床心理学杂志,2015,23(5):915-918.
[8]金艾香,章小飞,沈利凤.乳腺癌患者手术前后生存质量与焦虑抑郁状况调查研究[J].中国现代医生,2017,55(25):114-117.
[9]杜锦锦.癌症患者抑郁状态的相关因素和护理措施[J].实用临床护理学杂志,2017,40(2):186.
[10]李玲,施军平,邵喜音.术后乳腺癌患者焦虑、抑郁及生活质量分析[J].中国肿瘤,2014,23(7):580-584.
[11]Maraste R,Brandt L,Olsson H,et al.Anxiety and depression in breast cancer patients at start of adjuvant radiotherapy:Relations to age and type of surgery[J].Acta Oncologica,2009,31(6):641-643.
[12]童兆莹.乳腺癌患者抑郁相关因素分析[J].临床护理杂志,2017,16(1):11-14.
[13]李虹,叶浩生,赵守盈.乳腺癌术后应对方式及焦虑抑郁情绪调查[J].中国心理卫生杂志,2009,23(3):173-174.
[14]姜永红,朱盼盼,穆少锋,等.乳腺癌根治术后疾病不确定感、抑郁和焦虑情绪与25-(OH)维生素D水平的关系[J].国际精神病学杂志,2017,44(3):509-511.
[15]李佳莹,王立平,李沙沙,等.化疗期乳腺癌患者情绪状态及其影响因素的调查研究[J].现代生物医学进展,2014,15(14):2943-2946.
[16]DC Allred,SK Mohsin,SA Fuqua.Histological and biological evolution of human premalignant breast disease[J].Endocrine Related Cancer,2001,8(1):47-61.
[17]周立芝,陈长香,马杰,等.疾病症状与配偶在意程度对女性乳腺癌患者术后抑郁的影响[J].中华现代护理杂志,2016,22(28):4051-4053.
[18]E Andrzejczak,K Markockamaczka,A Lewandowski.Partner relationship after mastectomy in women not offered breast reconstruction[J].Psycho-Oncology,2013,22(7):1653-1657.
[19]郭静.农民工家庭乳腺癌患者术后焦虑、抑郁状况及影响因素研究[J].国际护理学杂志,2010,29(12):1779-1781.
[20]李予春,李秀坤,于德志,等.不同地区女性乳腺癌患者术后抑郁发生情况及危险因素分析[J].新乡医学院学报,2017,34(4):282-285.
[21]Dubovsky SL,Thomas M.Beyond specificity:effects of serotonin and serotonergic treatments on psychobiological dysfunction[J].Journal of Psychosomatic Research,1995,39(4):429-444.
[22]Vrshek-Schallhorn S,Doane LD,Mineka S,et al.The cortisol awakening response predicts major depression:predictive stability over a 4-year follow-up and effect of depression history[J].Psychological Medicine,2012,43(3):1-11.
[23]Howren MB,Lamkin DM,Suls J.Associations of depression with C-reactive protein,IL-1,and IL-6:a metaanalysis[J].Psychosomatic Medicine,2009,71(2):171-186.
[24]刘新发,韩亚光.抑郁与癌症研究进展[J].广东医学,2006,27(8):1266-1268.
[25]Anglin RE,Samaan Z,Walter SD,et al.Vitamin D deficiency and depression in adults:systematic review and meta-analysis[J].British Journal of Psychiatry,2013,202(2):100-107.
[26]余听鸿.外证医案汇编[M].上海:上海科学技术出版社,1961:148.
[27]陈实功.外科正宗[M].天津:天津科学技术出版社,1993:160.
[28]杨婧,张婕,王笑民,等.乳腺癌患者伴发抑郁焦虑中医证型的研究[J].北京中医药,2009,28(3):219-220.
[29]李德辉,范焕芳,孙春霞.乳腺癌中医证型与TNM分期相关性的Meta分析[J].中国老年学杂志,2017,37(15):3769-3771.
[30]武瑞仙,梁晨,裴晓华,等.乳腺癌中医证型与生物学指标相关性研究[J].中医学报,2017,32(8)
[31]Montegomery S A,Nielsen R Z,Poulsen L H,et al.Arandomised,double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine[J].Human Psychopharmacol,2014,29(5):470-482.
[32]Blum S I,Tourkodimitris S,Ruth A.Evaluation of functional health and well-being in patients receiving levomilnacipran ER for the treatment of major depressive disorder[J].Affect Disorder,2015,170:230-236.
[33]陶建英,付锐,张盼攀.WL-HA-2脑波治疗仪缓解乳腺癌术后患者焦虑抑郁的研究[J].荆楚理工学院学报,2017,32(4):38-40.
[34]孙凤环.综合护理干预对抑郁症患者院外康复的影响[J].齐鲁护理杂志,2018,24(7):94-96.
[35]熊静悦,曾南,张崇燕,等.逍遥散抗抑郁作用研究[J].中药药理临床,2007,23(1):3-5.
[36]贾飞,赵星星,张冬颖.甘麦大枣汤合逍遥散加味治疗乳腺癌伴抑郁症的临床疗效研究[J].世界最新医学信息文摘,2015,79(6):175-176.
[37]陶飞宝,何钦,叶旭,等.开郁解毒法对乳腺癌术后伴发抑郁状态患者IGF-1的影响[J].新中医,2017,49(10):127-129.
[38]于明薇,李道睿,杨国旺,等.针刺治疗康复期乳腺癌患者癌因性疲乏的随机对照研究[J].中国医药导报,2017,14(19):89-93.
[39]肖彬,刘展华.针刺配合耳穴压贴治疗乳腺癌抑郁症疗效观察[J].中国针灸,2014,34(10):956-960.
[40]杨巾夏,章琼,顾佳佳.中医五行音乐干预对乳腺癌化疗患者抑郁状态的影响[J].中华现代护理杂志,2013,19(36):4461-4463.
[41]李阳,黄立中,龚辉,等.中医情志疗法对三阴性乳腺癌患者术后恢复期的生存质量的影响[J].湖南中医药大学学报,2015,35(10):54-62.
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