旋覆代赭汤加减治疗妇科恶性肿瘤化疗期呕吐的临床研究
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摘要
目的:观察旋覆代赭汤加减治疗妇科恶性肿瘤化疗期呕吐的疗效。方法:将90例妇科恶性肿瘤化疗期患者分为治疗组、对照组、联合治疗组,每组30例。治疗组患者用旋覆代赭汤加减治疗,对照组患者用盐酸昂丹司琼注射液静脉推注治疗,联合治疗组患者用盐酸昂丹司琼注射液静脉推注+旋覆代赭汤加减联合治疗。治疗前、治疗后观察患者呕吐评分及生存质量(KPS、QLQ-C30)评分,比较3组患者治疗后临床疗效及安全性。结果:3组患者治疗后呕吐评分均低于治疗前(P<0.05);联合治疗组患者呕吐评分低于治疗组和对照组。治疗组患者在第1天至第3天评分降幅高于对照组,差异有统计学意义(P<0.01);联合治疗组患者第3天呕吐评分降幅高于治疗组,差异有统计学意义(P<0.05)。3组患者治疗后KPS评分、QLQ-C30评分均高于治疗前(P<0.05);治疗后3组比较,差异有统计学意义(P<0.05)。治疗组患者治疗后KPS评分和QLQ-C30评分高于对照组(P<0.01);治疗组患者治疗后KPS评分和QLQ-C30评分增幅高于对照组,差异有统计学意义(P<0.01);联合治疗组患者治疗后KPS评分、QLQ-C30评分增幅高于治疗组,差异有统计学意义(P<0.05)。联合治疗组的临床疗效(96.43%)优于治疗组(89.66%)和对照组(75.00%),差异有统计学意义(P<0.05)。结论:旋覆代赭汤加减治疗妇科恶性肿瘤化疗期呕吐,能显著缓解呕吐,提高患者生存质量。
Objective: To observe the effect of Xuanfu Daizhe decoction in the treatment of vomiting during chemotherapy of gynecological malignant tumors. Methods: A total of 90 patients with gynecological malignant tumors during chemotherapy were divided into the treatment group, the control group and the combination group,with 30 cases in each group. The patients in the treatment group were treated with Xuanfu Daizhe decoction,the patients in the control group were treated with intravenous injection of ondansetron hydrochloride injection,and the patients in the combination group were treated with intravenous injection of ondansetron hydrochloride +Xuanfu Daizhe decoction. The vomiting score and quality of life(KPS, QLQ-C30) scores were observed before and after treatment, and the clinical efficacy and safety of the three groups were compared. Results: After treatment, the vomiting scores of the three groups were lower than those before treatment(P<0.05), and the vomiting scores of the combination group were lower than those of the treatment group and the control group. The scores of the patients in the treatment group decreased more than those in the control group from the first day to the third day(P<0.01). On the third day, the vomiting scores of the combination group were higher than those of the treatment group, the difference was statistically significant(P<0.05). After treatment, the KPS scores and QLQC30 scores of the three groups were higher than those before treatment(P<0.05); There was significant difference among the three groups after treatment(P <0.05). The KPS scores and QLQ-C30 scores in the treatment group were higher than those in the control group after treatment. The KPS scores and QLQ-C30 scores in the treatment group were higher than those in the control group(P<0.01), and the KPS scores and QLQ-C30 scores in the combination group were higher than those in the treatment group(P<0.05). The combination group showed better clinical efficacy(96.43%) than the treatment group(89.66%) and control group(75.00%). Conclusion: Xuanfu Daizhe decoction can significantly relieve vomiting and improve the quality of life of patients with gynecological malignant tumors during chemotherapy.
Objective: To observe the effect of Xuanfu Daizhe decoction in the treatment of vomiting during chemotherapy of gynecological malignant tumors. Methods: A total of 90 patients with gynecological malignant tumors during chemotherapy were divided into the treatment group, the control group and the combination group,with 30 cases in each group. The patients in the treatment group were treated with Xuanfu Daizhe decoction,the patients in the control group were treated with intravenous injection of ondansetron hydrochloride injection,and the patients in the combination group were treated with intravenous injection of ondansetron hydrochloride +Xuanfu Daizhe decoction. The vomiting score and quality of life(KPS, QLQ-C30) scores were observed before and after treatment, and the clinical efficacy and safety of the three groups were compared. Results: After treatment, the vomiting scores of the three groups were lower than those before treatment(P<0.05), and the vomiting scores of the combination group were lower than those of the treatment group and the control group. The scores of the patients in the treatment group decreased more than those in the control group from the first day to the third day(P<0.01). On the third day, the vomiting scores of the combination group were higher than those of the treatment group, the difference was statistically significant(P<0.05). After treatment, the KPS scores and QLQC30 scores of the three groups were higher than those before treatment(P<0.05); There was significant difference among the three groups after treatment(P <0.05). The KPS scores and QLQ-C30 scores in the treatment group were higher than those in the control group after treatment. The KPS scores and QLQ-C30 scores in the treatment group were higher than those in the control group(P<0.01), and the KPS scores and QLQ-C30 scores in the combination group were higher than those in the treatment group(P<0.05). The combination group showed better clinical efficacy(96.43%) than the treatment group(89.66%) and control group(75.00%). Conclusion: Xuanfu Daizhe decoction can significantly relieve vomiting and improve the quality of life of patients with gynecological malignant tumors during chemotherapy.
引文
[1]刘荣华.护理风险管理在妇科恶性肿瘤病人紫杉醇化疗护理中的应用[J].全科护理,2016,14(35):3679-3681.
[2]孙建衡,蔡树模,高永良,等.妇科肿瘤学[M].北京:北京大学医学出版社,2011:371-800.
[3]中华人民共和国卫生部医政司.中国常见恶性肿瘤诊治规范[M].北京:北京医科大学、中国协和医科大学联合出版社,1991.
[4]周琼.香砂六君子汤加味治疗化疗后迟发性恶心呕吐的临床观察[J].现代诊断与治疗,2016,27(13):2395-236.
[5]林兰娟,曾勇梅,李水云.黄芪扶正汤对卵巢癌术后化疗患者免疫功能的影响[J].陕西中医,2017,38(2):217-219.
[6]刘洋,许新华.常见妇科恶性肿瘤的化学治疗研究进展[J].山东医药,2014,54(18):101-103.
[7]佟玉涛,李庆芬,李丽艳,等.甘麦大枣汤治疗妇科恶性肿瘤放化疗后白细胞减少症临床研究[J].中医学报,2015,30(5):624-625.
[8]应瑜,邹雪平.香砂六君子丸对妇科肿瘤患者化疗后消化道症状及IgM、IgA和IgG的影响[J].中国生化药物杂,2016,36(8):94-97.
[9]周冬爱,易俊,马进安.奥氮平防治化疗相关性呕吐的研究进展[J].临床肿瘤学杂志,2015,20(6):559-563.
[10]毛咏旻,王一红,谢腾,等.中西医防治顺铂引起化疗后恶心呕吐反应的研究进展[J].中华全科医学,2017,15(2):321-324.
[11]谭光根,刘洋博.肿瘤化学疗法止吐治疗新进展[J].河北医科大学学报,2016,37(3):365-368.
[12]史国军,山广志,王海荣,等.旋覆代赭汤加味防治肿瘤化疗后恶心呕吐随机对照试验的Meta分析[J].中华肿瘤防治杂志,2011,18(23):1881-1884.
[13]万姜维.旋覆代赭汤治疗肿瘤化疗所致呕吐反应体悟[J].中医临床研究,2013,5(2):81-83.
[14]宋庆.旋覆代赭汤加减防治恶性肿瘤患者化疗所致呕吐疗效观察[J].山西中医,2016,32(10):46-48.
[15]李小峰.旋覆代赭汤加减防治恶性肿瘤患者化疗所致呕吐39例[J].河南中医,2015,35(10):2529-2530.
[16]苏小丁.旋覆代赭汤治疗化疗后呕吐36例[J].国医论坛,2007,22(6):6.
[2]孙建衡,蔡树模,高永良,等.妇科肿瘤学[M].北京:北京大学医学出版社,2011:371-800.
[3]中华人民共和国卫生部医政司.中国常见恶性肿瘤诊治规范[M].北京:北京医科大学、中国协和医科大学联合出版社,1991.
[4]周琼.香砂六君子汤加味治疗化疗后迟发性恶心呕吐的临床观察[J].现代诊断与治疗,2016,27(13):2395-236.
[5]林兰娟,曾勇梅,李水云.黄芪扶正汤对卵巢癌术后化疗患者免疫功能的影响[J].陕西中医,2017,38(2):217-219.
[6]刘洋,许新华.常见妇科恶性肿瘤的化学治疗研究进展[J].山东医药,2014,54(18):101-103.
[7]佟玉涛,李庆芬,李丽艳,等.甘麦大枣汤治疗妇科恶性肿瘤放化疗后白细胞减少症临床研究[J].中医学报,2015,30(5):624-625.
[8]应瑜,邹雪平.香砂六君子丸对妇科肿瘤患者化疗后消化道症状及IgM、IgA和IgG的影响[J].中国生化药物杂,2016,36(8):94-97.
[9]周冬爱,易俊,马进安.奥氮平防治化疗相关性呕吐的研究进展[J].临床肿瘤学杂志,2015,20(6):559-563.
[10]毛咏旻,王一红,谢腾,等.中西医防治顺铂引起化疗后恶心呕吐反应的研究进展[J].中华全科医学,2017,15(2):321-324.
[11]谭光根,刘洋博.肿瘤化学疗法止吐治疗新进展[J].河北医科大学学报,2016,37(3):365-368.
[12]史国军,山广志,王海荣,等.旋覆代赭汤加味防治肿瘤化疗后恶心呕吐随机对照试验的Meta分析[J].中华肿瘤防治杂志,2011,18(23):1881-1884.
[13]万姜维.旋覆代赭汤治疗肿瘤化疗所致呕吐反应体悟[J].中医临床研究,2013,5(2):81-83.
[14]宋庆.旋覆代赭汤加减防治恶性肿瘤患者化疗所致呕吐疗效观察[J].山西中医,2016,32(10):46-48.
[15]李小峰.旋覆代赭汤加减防治恶性肿瘤患者化疗所致呕吐39例[J].河南中医,2015,35(10):2529-2530.
[16]苏小丁.旋覆代赭汤治疗化疗后呕吐36例[J].国医论坛,2007,22(6):6.
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