茵陈的药理作用研究进展
|
摘要
茵陈Artemisiae Scopariae Herba主要化学成分包括香豆素类、黄酮类、有机酸类、挥发油类等。除传统的清热利湿,利胆退黄作用外,茵陈还具有解热、镇痛、抗炎、抗病毒、抗肿瘤、降血压、调血脂、抗骨质疏松、神经保护、调节代谢、预防阿尔茨海默病等多种功效,其药理作用多样,机制复杂。综述茵陈的药理作用及其机制,为茵陈及其制剂的研发和临床应用提供参考。
The main chemical components of Artemisiae Scopariae Herba(ASH) include coumarins, flavonoids, organic acids,essential oils, and so on. Except for the traditional actions of clearing and draining dampness-heat, and disinhibiting gallbladder and anti-icteric, ASH has multiple pharmacological activities, such as antipyretic, analgesic, anti-inflammatory, antiviral, antitumor,hypotensive, hypolipidemic, anti-osteoporotic, neuroprotective, metabolic regulation effects, as well as prevention of Alzheimer's disease, whose mechanism of actions are complex. This article reviews pharmacological actions and the corresponding mechanism of ASH, which can provide reference for the research, development and clinical application of ASH and its preparations.
The main chemical components of Artemisiae Scopariae Herba(ASH) include coumarins, flavonoids, organic acids,essential oils, and so on. Except for the traditional actions of clearing and draining dampness-heat, and disinhibiting gallbladder and anti-icteric, ASH has multiple pharmacological activities, such as antipyretic, analgesic, anti-inflammatory, antiviral, antitumor,hypotensive, hypolipidemic, anti-osteoporotic, neuroprotective, metabolic regulation effects, as well as prevention of Alzheimer's disease, whose mechanism of actions are complex. This article reviews pharmacological actions and the corresponding mechanism of ASH, which can provide reference for the research, development and clinical application of ASH and its preparations.
引文
[1]中国药典[S].一部.2015.
[2]Feng H,Wang F,Wang C.C-kit expression in the gallbladder of guinea pig with chronic calculous cholecystitis and the effect of Artemisia capillaris Thunb.on interstitial cells of Cajal[J].Iran J Basic Med Sci,2016,19(7):720-725.
[3]UlicnáO,Greksák M,VancováO,et al.Hepatoprotective effect of rooibos tea(Aspalathus linearis)on CCl4-induced liver damage in rats[J].Physiol Res,2003,52(4):461-466.
[4]魏克伦,杨于嘉,刘义.新生儿黄疸[M].北京:人民卫生出版社,2011.
[5]张启伟,章育中.滨蒿中利胆成分的含量测定[J].药学学报,1986,21(12):922-927.
[6]湖南医药工业研究所,中医研究院中药研究所.茵陈蒿利胆有效成分的研究[J].药学学报,1985,12(6):22.
[7]林霄.茵陈蒿的药理作用研究[J].长春中医药大学学报,2008,24(6):663-666.
[8]董岩,王新芳,崔长军,等.茵陈蒿的化学成分和药理作用研究进展[J].时珍国医国药,2008,19(4):874-878.
[9]唐凯.经方合用治慢性乙型肝炎高胆红素血40例[J].国医论坛,2002,17(1):6-8.
[10]Han J M,Kim H G,Choi M K,et al.Artemisia capillaris extract protects against bile duct ligation-induced liver fibrosis in rats[J].Exp Toxicol Pathol,2013,65(6):837-844.
[11]Choi M K,Han J M,Kim H G,et al.Aqueous extract of Artemisia capillaris exerts hepatoprotective action inalcohol-pyrazole-fed rat model[J].J Ethnopharmacol,2013,147(3):662-670.
[12]Zhou Y,Ruan Z,Zhou L,et al.Chlorogenic acid ameliorates endotoxin-induced liver injury by promoting mitochondrial oxidative phosphorylation[J].Biochem Biophys Res Commun,2015,496(4):1083-1089.
[13]Shi H,Dong L,Bai Y,et al.Chlorogenic acid against carbon tetrachloride-induced liver fibrosis in rats[J].Eur J Pharmacol,2009,623(1/3):119-124.
[14]Shi H,Dong L,Jiang J,et al.Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway[J].Toxicology,2013,doi:10.1016/j.tox.2012.10.025.
[15]Ali N,Rashid S,Nafees S,et al.Protective effect of chlorogenic acid against methotrexate induced oxidative stress,inflammation and apoptosis in rat liver:An experimental approach[J].Chem Biol Interact,2017,doi:10.1016/j.cbi.2017.05.002.
[16]Gao Q H,Zhao X,Yin L,et al.The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivo[J].Rev Bras Farmacogn,2016,26(3):369-374.
[17]Lee H I,Seo K O,Yun K W,et al.Comparative study of the hepatoprotective efficacy of Artemisia iwayomogi and Artemisia capillaris on ethanol-administered mice[J].Food Sci,2011,76(9):209-211.
[18]王喜军,孙文军,孙晖,等.四氯化碳诱导大鼠肝损伤模型的代谢组学及茵陈蒿汤的干预作用研究[J].世界科学技术-中医药现代化,2006,8(6):101-105.
[19]张姣姣,张婷,吴灿,等.茵陈色原酮对小鼠急性乙醇性肝损伤的保护作用研究[J].抗感染药学,2011,8(4):257-261.
[20]Kang J W,Kim D W,Choi J S,et al.Scoparone attenuates D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure through inhibition of toll-like receptor 4signaling in mice[J].Food Chem Toxicol,2013,doi:10.1016/j.fct.2013.03.016.
[21]Liu X,Zhao X.Scoparone attenuates hepatic stellate cell activation through inhibiting TGF-β/Smad signaling pathway[J].Biomed Pharmacother,2017,doi:10.1016/j.biopha.2017.06.006.
[22]Habib M,Waheed I.Evaluation of anti-nociceptive,anti-inflammatory and antipyretic activities of Artemisia scoparia hydromethanolic extract[J].J Ethnopharmacol,2013,145(1):18-24.
[23]谢田,牛孝亮,刘占滨,等.茵陈的药理作用及临床应用进展[J].黑龙江中医药,2004(4):50-52.
[24]Khan S,Shehzad O,Chun J,et al.Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model[J].JEthnopharmacol,2014,152(3):478-486.
[25]Ha H,Lee H,Seo C S,et al.Artemisia capillaris inhibits atopic dermatitis-like skin lesions in Dermatophagoides farinae-sensitized Nc/Nga mice[J].BMC Compl Altern Med,2014,doi:10.1186/1472-6882-14-100.
[26]Ryu K J,Yoou M S,Seo Y,et al.Therapeutic effects of Artemisia scoparia Waldst.et Kitaib in a murine model of atopic dermatitis[J].Clin Exp Dermatol,2018,43(7):798-805.
[27]Ohkawara T,Takeda H,Nishihira J.Protective effect of chlorogenic acid on the inflammatory damage of pancreas and lung in mice with L-arginine-induced pancreatitis[J].Life Sci,2017,doi:10.1016/j.lfs.2017.09.015.
[28]Wang X,Huang H,Ma X,et al.Anti-inflammatory effects and mechanism of the total flavonoids from Artemisia scoparia Waldst.et Kit.in vitro and in vivo[J].Biomed Pharmacother,2018,doi:10.1016/j.biopha.2018.05.054.
[29]Niu N,Li B,Hu Y,et al.Protective effects of scoparone against lipopolysaccharide-induced acute lung injury[J].Int Immunopharmacol,2014,23(1):127-133.
[30]Kim J,Lim J,Kang B Y,et al.Capillarisin augments anti-oxidative and anti-inflammatory responses by activating Nrf2/HO-1 signaling[J].Neurochem Int,2017,doi:10.1016/j.neuint.2017.01.018.
[31]Khan S,Choi R J,Shehzad O,et al.Molecular mechanism of capillarisin-mediated inhibition of MyD88/TIRAP inflammatory signaling in in vitro and in vivo experimental models[J].J Ethnopharmacol,2013,145(2):626-637.
[32]Yoon M,Kim M Y.The anti-angiogenic herbal composition Ob-X from Morus alba,Melissa officinalis,and Artemisia capillaris regulates obesity in genetically obese ob/ob mice[J].Pharm Biol,2011,49(6):614-619.
[33]魏建华,刘学敏.茵陈的现代药理研究[J].中西医结合与祖国医学,2009,13(22):743-746.
[34]Zhang T,Chen D.Anticomplementary principles of a Chinese multiherb remedy for the treatment and prevention of SARS[J].J Ethnopharmacol,2008,117(2):351-361.
[35]Yen M H,Huang C I,Lee M S,et al.Artemisia capillaris inhibited enterovirus 71-induced cell injury by preventing viral internalization[J].Kaohsiung J Med Sci,2018,34(3):150-159.
[36]Zhao Y,Geng C A,Ma Y B,et al.UFLC/MS-IT-TOFguided isolation of anti-HBV active chlorogenic acid analogues from Artemisia capillaris as a traditional Chinese herb for the treatment of hepatitis[J].JEthnopharmacol,2014,doi:10.1016/j.jep.2014.08.043.
[37]Wang G F,Shi L P,Ren Y D,et al.Anti-hepatitis B virus activity of chlorogenic acid,quinic acid and caffeic acid in vivo and in vitro[J].Antiviral Res,2009,83(2):186-190.
[38]Zhao Y,Geng C A,Sun C L,et al.Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillari[J].Fitoterapia,2014,95:187-193.
[39]Geng C A,Yang T H,Huang X Y,et al.Anti-hepatitis Bvirus effects of the traditional Chinese herb Artemisia capillaris and its active enynes[J].J Ethnopharmacol,2018,doi:10.1016/j.jep.2018.06.005.
[40]Yan H,Wang H,Ma L,et al.Cirsimaritin inhibits influenza A virus replication by downregulating the NF-κB signal transduction pathway[J].Virol J,2018,doi:10.1186/s12985-018-0995-6.
[41]蒋洁云,徐强,王蓉,等.茵陈抗肿瘤活性成分的研究[J].中国药科大学学报,1992,23(5):283-286.
[42]张慧,崔戈,李阳,等.茵陈色原酮对结肠癌细胞增殖迁移的作用及其机制研究[J].南京医科大学学报:自然科学版,2017,37(2):203-206.
[43]Lee J H,Chiang S Y,Nam D,et al.Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases[J].Cancer Lett,2014,345(1):140-148.
[44]Lee S O,Jeong Y J,Kim M,et al.Suppression of PMA-induced tumor cell invasion by capillarisin via the inhibition of NF-κB-dependent MMP-9 expression[J].Biochem Biophys Res Commun,2008,366(4):1019-1024.
[45]Yan H,Jung K H,Kim J,et al.Artemisia capillaris extract AC68 induces apoptosis of hepatocellular carcinoma by blocking the PI3K/AKT pathway[J].Biomed Pharmacother,2018,doi:10.1016/j.biopha.2017.12.043.
[46]Masuda Y,Asada K,Satoh R,et al.Capillin,a major constituent of Artemisia capillaris Thunb.flower essential oil,induces apoptosis through the mitochondrial pathway in human leukemia HL-60 cells[J].Phytomedicine,2015,22(5):545-552.
[47]Feng G,Wang X,You C,et al.Antiproliferative potential of Artemisia capillaris polysaccharide against human nasopharyngeal carcinoma cells[J].Carbohydr Polym,2013,92(2):1040-1045.
[48]Cho J Y,Park K H,Hwang D Y,et al.Antihypertensive effects of Artemisia scoparia Waldst in spontaneously hypertensive rats and identification of angiotensin Iconverting enzyme inhibitors[J].Molecules,2015,20(11):19789-19804.
[49]Noh J R,Kim Y H,Hwang J H,et al.Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor c in 3T3-L1preadipocytes[J].Food Chem,2013,141(2):723-730.
[50]张宏宇,陈沫,熊文激.红花黄色素抗血栓和降血脂作用的实验研究[J].中国实验诊断学,2010,14(7):1028-1031.
[51]张瑱,贺兴冬,季申,等.对羟基苯乙酮降血脂作用的研究[J].世界临床药物,2010,31(10):599-602.
[52]Promyo K,Cho J Y,Park K H,et al.Artemisia scoparia attenuates amyloidβaccumulation and tau hyperphosphorylation in spontaneously hypertensive rats[J].Food Sci Biotechnol,2017,26(3):775-782.
[53]McCarty M F.A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk[J].Med Hypotheses,2005,64(4):848-853.
[54]Bassoli B K,Cassolla P,Borba-Murad G R,et al.Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test:Effects on hepatic glucose release and glycaemia[J].Cell Biochem Funct,2008,26(3):320-328.
[55]Wang Y,Wang M,Chen B,et al.Scoparone attenuates high glucose-induced extracellular matrix accumulation in rat mesangial cells[J].Eur J Pharmacol,2017,doi:10.1016/j.ejphar.2017.09.039.
[56]Ong K W,Hsu A,Tan B K.Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation:A contributor to the beneficial effects of coffee on diabetes[J].PLoS One,2012,7(3):1-11.
[57]Ong K W,Hsu A,Tan B K.Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation[J].Biochem Pharmacol,2013,85(9):1341-1351.
[58]Cho A S,Jeon S M,Kim M J,et al.Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice[J].Food Chem Toxicol,2010,48(3):937-943.
[59]Boudreau A,Richard A J,Burrell J A,et al.An ethanolic extract of Artemisia scoparia inhibits lipolysis in vivo and has antilipolytic effects on murine adipocytes in vitro[J].Am J Physiol Endocrinol Metab,2018,315(5):1053-1061.
[60]Yahagi T,Yakura N,Matsuzaki K,et al.Inhibitory effect of chemical constituents from Artemisia scoparia Waldst.et Kit.on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells[J].J Nat Med,2014,68(2):414-420.
[61]An J,Hao D,Zhang Q,et al.Natural products for treatment of bone erosive diseases:The effects and mechanisms on inhibiting osteoclastogenesis and bone resorption[J].Int Immunopharmacol,2016,doi:10.1016/j.intimp.2016.04.024.
[62]Lee S H,Lee J Y,Kwon Y I,et al.Anti-osteoclastic activity of Artemisia capillaris Thunb.extract depends upon attenuation of osteoclast differentiation and bone resorption-associated acidification due to chlorogenic acid,hyperoside,and scoparone[J].Int J Mol Sci,2017,18(2):322-335.
[63]Lee S H,Jang H D.Scoparone attenuates RANKL-induced osteoclastic differentiation through controlling reactive oxygen species production and scavenging[J].Exp Cell Res,2015,331(2):267-277.
[64]Kwon H,Jung J W,Lee Y C,et al.Neuroprotective effect of the ethanol extract of Artemisia capillaris on transient forebrain ischemia in mice via nicotinic cholinergic receptor[J].Chin J Nat Med,2018,16(6):428-435.
[65]Xia J,Li C Y,Wang H,et al.Therapeutic effects of scoparone on pilocarpine(Pilo)-induced seizures in mice[J].Biomed Pharmacother,2018,97:1501-1513.
[66]Fu B,Su Y,Ma X,et al.Scoparone attenuates angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts[J].J Pharmacol Sci,2018,137(2):110-115.
[67]Kim M,Chun J,Jung H A,et al.Capillarisin attenuates exercise-induced muscle damage through MAPK and NF-κB signaling[J].Phytomedicine,2017,doi:10.1016/j.phymed.2017.04.007.
[68]Khan M A,Khan H,Tariq S A,et al.In vitro attenuation of thermal-induced protein denaturation by aerial parts of Artemisia scoparia[J].Evid-Based Compl Alt,2015,20(1):9-12.
[2]Feng H,Wang F,Wang C.C-kit expression in the gallbladder of guinea pig with chronic calculous cholecystitis and the effect of Artemisia capillaris Thunb.on interstitial cells of Cajal[J].Iran J Basic Med Sci,2016,19(7):720-725.
[3]UlicnáO,Greksák M,VancováO,et al.Hepatoprotective effect of rooibos tea(Aspalathus linearis)on CCl4-induced liver damage in rats[J].Physiol Res,2003,52(4):461-466.
[4]魏克伦,杨于嘉,刘义.新生儿黄疸[M].北京:人民卫生出版社,2011.
[5]张启伟,章育中.滨蒿中利胆成分的含量测定[J].药学学报,1986,21(12):922-927.
[6]湖南医药工业研究所,中医研究院中药研究所.茵陈蒿利胆有效成分的研究[J].药学学报,1985,12(6):22.
[7]林霄.茵陈蒿的药理作用研究[J].长春中医药大学学报,2008,24(6):663-666.
[8]董岩,王新芳,崔长军,等.茵陈蒿的化学成分和药理作用研究进展[J].时珍国医国药,2008,19(4):874-878.
[9]唐凯.经方合用治慢性乙型肝炎高胆红素血40例[J].国医论坛,2002,17(1):6-8.
[10]Han J M,Kim H G,Choi M K,et al.Artemisia capillaris extract protects against bile duct ligation-induced liver fibrosis in rats[J].Exp Toxicol Pathol,2013,65(6):837-844.
[11]Choi M K,Han J M,Kim H G,et al.Aqueous extract of Artemisia capillaris exerts hepatoprotective action inalcohol-pyrazole-fed rat model[J].J Ethnopharmacol,2013,147(3):662-670.
[12]Zhou Y,Ruan Z,Zhou L,et al.Chlorogenic acid ameliorates endotoxin-induced liver injury by promoting mitochondrial oxidative phosphorylation[J].Biochem Biophys Res Commun,2015,496(4):1083-1089.
[13]Shi H,Dong L,Bai Y,et al.Chlorogenic acid against carbon tetrachloride-induced liver fibrosis in rats[J].Eur J Pharmacol,2009,623(1/3):119-124.
[14]Shi H,Dong L,Jiang J,et al.Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway[J].Toxicology,2013,doi:10.1016/j.tox.2012.10.025.
[15]Ali N,Rashid S,Nafees S,et al.Protective effect of chlorogenic acid against methotrexate induced oxidative stress,inflammation and apoptosis in rat liver:An experimental approach[J].Chem Biol Interact,2017,doi:10.1016/j.cbi.2017.05.002.
[16]Gao Q H,Zhao X,Yin L,et al.The essential oil of Artemisia capillaris protects against CCl4-induced liver injury in vivo[J].Rev Bras Farmacogn,2016,26(3):369-374.
[17]Lee H I,Seo K O,Yun K W,et al.Comparative study of the hepatoprotective efficacy of Artemisia iwayomogi and Artemisia capillaris on ethanol-administered mice[J].Food Sci,2011,76(9):209-211.
[18]王喜军,孙文军,孙晖,等.四氯化碳诱导大鼠肝损伤模型的代谢组学及茵陈蒿汤的干预作用研究[J].世界科学技术-中医药现代化,2006,8(6):101-105.
[19]张姣姣,张婷,吴灿,等.茵陈色原酮对小鼠急性乙醇性肝损伤的保护作用研究[J].抗感染药学,2011,8(4):257-261.
[20]Kang J W,Kim D W,Choi J S,et al.Scoparone attenuates D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure through inhibition of toll-like receptor 4signaling in mice[J].Food Chem Toxicol,2013,doi:10.1016/j.fct.2013.03.016.
[21]Liu X,Zhao X.Scoparone attenuates hepatic stellate cell activation through inhibiting TGF-β/Smad signaling pathway[J].Biomed Pharmacother,2017,doi:10.1016/j.biopha.2017.06.006.
[22]Habib M,Waheed I.Evaluation of anti-nociceptive,anti-inflammatory and antipyretic activities of Artemisia scoparia hydromethanolic extract[J].J Ethnopharmacol,2013,145(1):18-24.
[23]谢田,牛孝亮,刘占滨,等.茵陈的药理作用及临床应用进展[J].黑龙江中医药,2004(4):50-52.
[24]Khan S,Shehzad O,Chun J,et al.Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model[J].JEthnopharmacol,2014,152(3):478-486.
[25]Ha H,Lee H,Seo C S,et al.Artemisia capillaris inhibits atopic dermatitis-like skin lesions in Dermatophagoides farinae-sensitized Nc/Nga mice[J].BMC Compl Altern Med,2014,doi:10.1186/1472-6882-14-100.
[26]Ryu K J,Yoou M S,Seo Y,et al.Therapeutic effects of Artemisia scoparia Waldst.et Kitaib in a murine model of atopic dermatitis[J].Clin Exp Dermatol,2018,43(7):798-805.
[27]Ohkawara T,Takeda H,Nishihira J.Protective effect of chlorogenic acid on the inflammatory damage of pancreas and lung in mice with L-arginine-induced pancreatitis[J].Life Sci,2017,doi:10.1016/j.lfs.2017.09.015.
[28]Wang X,Huang H,Ma X,et al.Anti-inflammatory effects and mechanism of the total flavonoids from Artemisia scoparia Waldst.et Kit.in vitro and in vivo[J].Biomed Pharmacother,2018,doi:10.1016/j.biopha.2018.05.054.
[29]Niu N,Li B,Hu Y,et al.Protective effects of scoparone against lipopolysaccharide-induced acute lung injury[J].Int Immunopharmacol,2014,23(1):127-133.
[30]Kim J,Lim J,Kang B Y,et al.Capillarisin augments anti-oxidative and anti-inflammatory responses by activating Nrf2/HO-1 signaling[J].Neurochem Int,2017,doi:10.1016/j.neuint.2017.01.018.
[31]Khan S,Choi R J,Shehzad O,et al.Molecular mechanism of capillarisin-mediated inhibition of MyD88/TIRAP inflammatory signaling in in vitro and in vivo experimental models[J].J Ethnopharmacol,2013,145(2):626-637.
[32]Yoon M,Kim M Y.The anti-angiogenic herbal composition Ob-X from Morus alba,Melissa officinalis,and Artemisia capillaris regulates obesity in genetically obese ob/ob mice[J].Pharm Biol,2011,49(6):614-619.
[33]魏建华,刘学敏.茵陈的现代药理研究[J].中西医结合与祖国医学,2009,13(22):743-746.
[34]Zhang T,Chen D.Anticomplementary principles of a Chinese multiherb remedy for the treatment and prevention of SARS[J].J Ethnopharmacol,2008,117(2):351-361.
[35]Yen M H,Huang C I,Lee M S,et al.Artemisia capillaris inhibited enterovirus 71-induced cell injury by preventing viral internalization[J].Kaohsiung J Med Sci,2018,34(3):150-159.
[36]Zhao Y,Geng C A,Ma Y B,et al.UFLC/MS-IT-TOFguided isolation of anti-HBV active chlorogenic acid analogues from Artemisia capillaris as a traditional Chinese herb for the treatment of hepatitis[J].JEthnopharmacol,2014,doi:10.1016/j.jep.2014.08.043.
[37]Wang G F,Shi L P,Ren Y D,et al.Anti-hepatitis B virus activity of chlorogenic acid,quinic acid and caffeic acid in vivo and in vitro[J].Antiviral Res,2009,83(2):186-190.
[38]Zhao Y,Geng C A,Sun C L,et al.Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillari[J].Fitoterapia,2014,95:187-193.
[39]Geng C A,Yang T H,Huang X Y,et al.Anti-hepatitis Bvirus effects of the traditional Chinese herb Artemisia capillaris and its active enynes[J].J Ethnopharmacol,2018,doi:10.1016/j.jep.2018.06.005.
[40]Yan H,Wang H,Ma L,et al.Cirsimaritin inhibits influenza A virus replication by downregulating the NF-κB signal transduction pathway[J].Virol J,2018,doi:10.1186/s12985-018-0995-6.
[41]蒋洁云,徐强,王蓉,等.茵陈抗肿瘤活性成分的研究[J].中国药科大学学报,1992,23(5):283-286.
[42]张慧,崔戈,李阳,等.茵陈色原酮对结肠癌细胞增殖迁移的作用及其机制研究[J].南京医科大学学报:自然科学版,2017,37(2):203-206.
[43]Lee J H,Chiang S Y,Nam D,et al.Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases[J].Cancer Lett,2014,345(1):140-148.
[44]Lee S O,Jeong Y J,Kim M,et al.Suppression of PMA-induced tumor cell invasion by capillarisin via the inhibition of NF-κB-dependent MMP-9 expression[J].Biochem Biophys Res Commun,2008,366(4):1019-1024.
[45]Yan H,Jung K H,Kim J,et al.Artemisia capillaris extract AC68 induces apoptosis of hepatocellular carcinoma by blocking the PI3K/AKT pathway[J].Biomed Pharmacother,2018,doi:10.1016/j.biopha.2017.12.043.
[46]Masuda Y,Asada K,Satoh R,et al.Capillin,a major constituent of Artemisia capillaris Thunb.flower essential oil,induces apoptosis through the mitochondrial pathway in human leukemia HL-60 cells[J].Phytomedicine,2015,22(5):545-552.
[47]Feng G,Wang X,You C,et al.Antiproliferative potential of Artemisia capillaris polysaccharide against human nasopharyngeal carcinoma cells[J].Carbohydr Polym,2013,92(2):1040-1045.
[48]Cho J Y,Park K H,Hwang D Y,et al.Antihypertensive effects of Artemisia scoparia Waldst in spontaneously hypertensive rats and identification of angiotensin Iconverting enzyme inhibitors[J].Molecules,2015,20(11):19789-19804.
[49]Noh J R,Kim Y H,Hwang J H,et al.Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor c in 3T3-L1preadipocytes[J].Food Chem,2013,141(2):723-730.
[50]张宏宇,陈沫,熊文激.红花黄色素抗血栓和降血脂作用的实验研究[J].中国实验诊断学,2010,14(7):1028-1031.
[51]张瑱,贺兴冬,季申,等.对羟基苯乙酮降血脂作用的研究[J].世界临床药物,2010,31(10):599-602.
[52]Promyo K,Cho J Y,Park K H,et al.Artemisia scoparia attenuates amyloidβaccumulation and tau hyperphosphorylation in spontaneously hypertensive rats[J].Food Sci Biotechnol,2017,26(3):775-782.
[53]McCarty M F.A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk[J].Med Hypotheses,2005,64(4):848-853.
[54]Bassoli B K,Cassolla P,Borba-Murad G R,et al.Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test:Effects on hepatic glucose release and glycaemia[J].Cell Biochem Funct,2008,26(3):320-328.
[55]Wang Y,Wang M,Chen B,et al.Scoparone attenuates high glucose-induced extracellular matrix accumulation in rat mesangial cells[J].Eur J Pharmacol,2017,doi:10.1016/j.ejphar.2017.09.039.
[56]Ong K W,Hsu A,Tan B K.Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation:A contributor to the beneficial effects of coffee on diabetes[J].PLoS One,2012,7(3):1-11.
[57]Ong K W,Hsu A,Tan B K.Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation[J].Biochem Pharmacol,2013,85(9):1341-1351.
[58]Cho A S,Jeon S M,Kim M J,et al.Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice[J].Food Chem Toxicol,2010,48(3):937-943.
[59]Boudreau A,Richard A J,Burrell J A,et al.An ethanolic extract of Artemisia scoparia inhibits lipolysis in vivo and has antilipolytic effects on murine adipocytes in vitro[J].Am J Physiol Endocrinol Metab,2018,315(5):1053-1061.
[60]Yahagi T,Yakura N,Matsuzaki K,et al.Inhibitory effect of chemical constituents from Artemisia scoparia Waldst.et Kit.on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells[J].J Nat Med,2014,68(2):414-420.
[61]An J,Hao D,Zhang Q,et al.Natural products for treatment of bone erosive diseases:The effects and mechanisms on inhibiting osteoclastogenesis and bone resorption[J].Int Immunopharmacol,2016,doi:10.1016/j.intimp.2016.04.024.
[62]Lee S H,Lee J Y,Kwon Y I,et al.Anti-osteoclastic activity of Artemisia capillaris Thunb.extract depends upon attenuation of osteoclast differentiation and bone resorption-associated acidification due to chlorogenic acid,hyperoside,and scoparone[J].Int J Mol Sci,2017,18(2):322-335.
[63]Lee S H,Jang H D.Scoparone attenuates RANKL-induced osteoclastic differentiation through controlling reactive oxygen species production and scavenging[J].Exp Cell Res,2015,331(2):267-277.
[64]Kwon H,Jung J W,Lee Y C,et al.Neuroprotective effect of the ethanol extract of Artemisia capillaris on transient forebrain ischemia in mice via nicotinic cholinergic receptor[J].Chin J Nat Med,2018,16(6):428-435.
[65]Xia J,Li C Y,Wang H,et al.Therapeutic effects of scoparone on pilocarpine(Pilo)-induced seizures in mice[J].Biomed Pharmacother,2018,97:1501-1513.
[66]Fu B,Su Y,Ma X,et al.Scoparone attenuates angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts[J].J Pharmacol Sci,2018,137(2):110-115.
[67]Kim M,Chun J,Jung H A,et al.Capillarisin attenuates exercise-induced muscle damage through MAPK and NF-κB signaling[J].Phytomedicine,2017,doi:10.1016/j.phymed.2017.04.007.
[68]Khan M A,Khan H,Tariq S A,et al.In vitro attenuation of thermal-induced protein denaturation by aerial parts of Artemisia scoparia[J].Evid-Based Compl Alt,2015,20(1):9-12.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |