舒肝解郁胶囊应用于轻中度抑郁症治疗的效果研究
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摘要
目的:探讨轻中度抑郁症患者采取舒肝解郁胶囊治疗的效果。方法:将医院2014年10月—2016年10月收治的轻中度抑郁症患者90例作为研究,按照随机数表法实施分组,纳入研究对象临床资料完整,愿意配合本研究,每组有45例患者。对照组患者接受舍曲林治疗,研究组患者接受舒肝解郁胶囊治疗,两组患者均顺利完成疗程,对两组患者临床效果、不良反应,以及治疗前后汉密尔顿焦虑量表(HAMA)与汉密尔顿抑郁量表(HAMD)进行观察与记录,并实施统计学分析。结果:两组患者治疗后均取得比较良好的效果,组间总有效率比较差异无统计学意义(P>0.05);两组患者均有不同程度不良反应发生,研究组发生率显著低于对照组(P<0.05);两组患者在治疗前HAMA与HAMD比较并无差异(P>0.05),治疗后两组患者均有明显下降(P<0.05),且研究组治疗后明显低于对照组(P<0.05)。结论:轻中度抑郁症患者采取舒肝解郁胶囊治疗,除了临床效果比较理想,而且可以更好地改善患者的焦虑、抑郁症状,同时不良反应少,安全性高,值得推广应用。
Objective:To investigate the effect of Shugan Jieyu Capsule in treating patients with depression. Methods:In our hospital,90 cases with mild to moderate depression in October 2014-October 2016 as the objects,according to the random number table method,were divided into two groups,45 patients in each group. The control group received sertraline treatment and the study group received Shuganjieyu Capsule. Two groups successfully completed the course of treatment. The two groups' clinical effect and adverse reactions before and after treatment,and Hamilton Anxiety Scale( HAMA) and Hamilton Depression Scale( HAMD) were observed and recorded. Results:Two groups achieved relatively good results. Between the groups there was no significant difference( P > 0. 05). Two groups had different degrees of adverse reactions. The incidence rate of study group was significantly lower than that of the control group( P < 0. 05). The difference between the two groups' HAMA before treatment was not signficant( P > 0. 05). The two groups' after treatment were significantly decreased( P < 0. 05) and the study group's after treatment was significantly lower than that of the control group( P < 0. 05). Conclusion:Shugan Jieyu Capsule can better improve the symptoms of anxiety and depression of patients,and reduce adverse reaction,with high safety,worthy of popularization and application.
Objective:To investigate the effect of Shugan Jieyu Capsule in treating patients with depression. Methods:In our hospital,90 cases with mild to moderate depression in October 2014-October 2016 as the objects,according to the random number table method,were divided into two groups,45 patients in each group. The control group received sertraline treatment and the study group received Shuganjieyu Capsule. Two groups successfully completed the course of treatment. The two groups' clinical effect and adverse reactions before and after treatment,and Hamilton Anxiety Scale( HAMA) and Hamilton Depression Scale( HAMD) were observed and recorded. Results:Two groups achieved relatively good results. Between the groups there was no significant difference( P > 0. 05). Two groups had different degrees of adverse reactions. The incidence rate of study group was significantly lower than that of the control group( P < 0. 05). The difference between the two groups' HAMA before treatment was not signficant( P > 0. 05). The two groups' after treatment were significantly decreased( P < 0. 05) and the study group's after treatment was significantly lower than that of the control group( P < 0. 05). Conclusion:Shugan Jieyu Capsule can better improve the symptoms of anxiety and depression of patients,and reduce adverse reaction,with high safety,worthy of popularization and application.
引文
[1]叶庆红,陈志斌,唐锴,等.舒肝解郁胶囊与黛力新治疗脑卒中后抑郁的对照研究[J].实用医学杂志,2012,28(5):807-808.
[2]傅锦华,刘勇,王清勇,等.舒肝解郁胶囊对抑郁模型大鼠海马神经元凋亡及脑组织caspase-3蛋白表达的影响[J].中南大学学报(医学版),2012,37(12):1198-1204.
[3]钟华,陈莉.黛力新联合舒肝解郁胶囊治疗卒中后抑郁的疗效研究[J].重庆医学,2016,45(25):3496-3497,3500.
[4]齐文耀,汤义平,陈倩倩,等.舒肝解郁胶囊对抑郁症患者糖脂代谢与睡眠及体质量的影响[J].中国生化药物杂志,2017,37(2):84-86.
[5]谢芳.舒肝解郁胶囊治疗冠心病合并抑郁症的疗效观察[J].中西医结合心脑血管病杂志,2014,12(2):164-165.
[6]叶庆红,陈志斌,唐锴,等.舒肝解郁胶囊与西酞普兰治疗产后抑郁症的对比[J].广东医学,2012,33(8):1179-1180.
[7]邱堂威,刘学文,朱怀轩,等.舒肝解郁胶囊与舍曲林治疗抑郁症的对照研究[J].湖南中医药大学学报,2011,31(8):60-61.
[8]李清伟,姚军,吴文源,等.舒肝解郁胶囊剂量加倍治疗中度抑郁症的随机、双盲、平行对照、多中心临床研究[J].中国神经精神疾病杂志,2016,42(10):580-585.
[9]李春芳.舒肝解郁胶囊与氟西汀胶囊治疗血管性抑郁症对照研究[J].精神医学杂志,2014,27(6):462-463.
[10]肖迎光,柯春兰.舒肝解郁胶囊联合舍曲林治疗老年抑郁症的临床疗效观察[J].中医药学报,2014,21(2):118-120.
[11]赵金凤,刘丽宁,韵国萍,等.舒肝解郁胶囊与圣·约翰草提取物片治疗脑卒中后轻、中度抑郁症的对照研究[J].河北医药,2013,35(16):2523-2524.
[12]陈峰,张伟,王朋,等.舒肝解郁胶囊治疗轻中度抑郁症的效果及安全性研究[J].解放军医药杂志,2012,24(12):7-9.
[13]李春芳,武建斌.舒肝解郁胶囊治疗血管性抑郁症的观察[J].陕西中医,2015,11(8):982-983.
[14]陈远岭,刘家洪,范银莹,等.舒肝解郁胶囊治疗伴焦虑症状抑郁症患者的对照研究[J].临床精神医学杂志,2014,18(2):117.
[15]肖刚,陆德青,姜宝顺,等.舒肝解郁胶囊与西酞普兰治疗女性首发轻、中度抑郁症患者的对照研究[J].中国健康心理学杂志,2014,12(7):977-978.
[16]郑昌爱,卢俊杰.舒肝解郁胶囊与西酞普兰治疗抑郁伴发焦虑患者的疗效观察[J].浙江临床医学,2016,18(6):1090-1091.
[17]卢继萍.舒肝解郁胶囊合舍曲林片治疗老年期抑郁症的疗效观察[J].浙江中医药大学学报,2012,36(6):648-650.
[18]王树锋.舒肝解郁胶囊治疗伴躯体化症状抑郁症的临床分析[J].陕西中医,2015,19(3):294-295.
[19]傅锦华,刘勇.舒肝解郁胶囊对抑郁模型大鼠脑内5-HT、DA及其代谢产物水平的影响[J].湖南中医药大学学报,2016,36(6):47-51.
[20]喻良,黄雨兰,黄斌,等.舒肝解郁胶囊与舍曲林治疗癫痫合并轻中度抑郁症的对照研究[J].实用医院临床杂志,2015,16(4):18-20.
[2]傅锦华,刘勇,王清勇,等.舒肝解郁胶囊对抑郁模型大鼠海马神经元凋亡及脑组织caspase-3蛋白表达的影响[J].中南大学学报(医学版),2012,37(12):1198-1204.
[3]钟华,陈莉.黛力新联合舒肝解郁胶囊治疗卒中后抑郁的疗效研究[J].重庆医学,2016,45(25):3496-3497,3500.
[4]齐文耀,汤义平,陈倩倩,等.舒肝解郁胶囊对抑郁症患者糖脂代谢与睡眠及体质量的影响[J].中国生化药物杂志,2017,37(2):84-86.
[5]谢芳.舒肝解郁胶囊治疗冠心病合并抑郁症的疗效观察[J].中西医结合心脑血管病杂志,2014,12(2):164-165.
[6]叶庆红,陈志斌,唐锴,等.舒肝解郁胶囊与西酞普兰治疗产后抑郁症的对比[J].广东医学,2012,33(8):1179-1180.
[7]邱堂威,刘学文,朱怀轩,等.舒肝解郁胶囊与舍曲林治疗抑郁症的对照研究[J].湖南中医药大学学报,2011,31(8):60-61.
[8]李清伟,姚军,吴文源,等.舒肝解郁胶囊剂量加倍治疗中度抑郁症的随机、双盲、平行对照、多中心临床研究[J].中国神经精神疾病杂志,2016,42(10):580-585.
[9]李春芳.舒肝解郁胶囊与氟西汀胶囊治疗血管性抑郁症对照研究[J].精神医学杂志,2014,27(6):462-463.
[10]肖迎光,柯春兰.舒肝解郁胶囊联合舍曲林治疗老年抑郁症的临床疗效观察[J].中医药学报,2014,21(2):118-120.
[11]赵金凤,刘丽宁,韵国萍,等.舒肝解郁胶囊与圣·约翰草提取物片治疗脑卒中后轻、中度抑郁症的对照研究[J].河北医药,2013,35(16):2523-2524.
[12]陈峰,张伟,王朋,等.舒肝解郁胶囊治疗轻中度抑郁症的效果及安全性研究[J].解放军医药杂志,2012,24(12):7-9.
[13]李春芳,武建斌.舒肝解郁胶囊治疗血管性抑郁症的观察[J].陕西中医,2015,11(8):982-983.
[14]陈远岭,刘家洪,范银莹,等.舒肝解郁胶囊治疗伴焦虑症状抑郁症患者的对照研究[J].临床精神医学杂志,2014,18(2):117.
[15]肖刚,陆德青,姜宝顺,等.舒肝解郁胶囊与西酞普兰治疗女性首发轻、中度抑郁症患者的对照研究[J].中国健康心理学杂志,2014,12(7):977-978.
[16]郑昌爱,卢俊杰.舒肝解郁胶囊与西酞普兰治疗抑郁伴发焦虑患者的疗效观察[J].浙江临床医学,2016,18(6):1090-1091.
[17]卢继萍.舒肝解郁胶囊合舍曲林片治疗老年期抑郁症的疗效观察[J].浙江中医药大学学报,2012,36(6):648-650.
[18]王树锋.舒肝解郁胶囊治疗伴躯体化症状抑郁症的临床分析[J].陕西中医,2015,19(3):294-295.
[19]傅锦华,刘勇.舒肝解郁胶囊对抑郁模型大鼠脑内5-HT、DA及其代谢产物水平的影响[J].湖南中医药大学学报,2016,36(6):47-51.
[20]喻良,黄雨兰,黄斌,等.舒肝解郁胶囊与舍曲林治疗癫痫合并轻中度抑郁症的对照研究[J].实用医院临床杂志,2015,16(4):18-20.