益生菌在预防和治疗器官疾病中的功能活性研究进展
|
摘要
益生菌是当前大健康市场的关注热点。本文对2类主要的益生菌,即乳杆菌和双歧杆菌,在皮肤、口腔、呼吸道、肝胃、肠道和女性生殖道等器官疾病方面的预防和治疗功能活性进行总结,包括动物实验活性、临床实验活性及相关的作用机制。本文将为益生菌的进一步科学研究以及产品开发提供重要的理论支持。
Nowadays, probiotics are a hot concern in the health market. In this paper, the functional activities of the two main probiotics, Lactobacillus and Bifidobacterium, in the prevention and treatment of skin, oral, respiratory, liver,gastrointestinal and female genital tract diseases are summarized including the activities in animal experiment and clinical trials and the related mechanisms. This review will provide important theoretical support for further scientific research and product development of probiotics.
Nowadays, probiotics are a hot concern in the health market. In this paper, the functional activities of the two main probiotics, Lactobacillus and Bifidobacterium, in the prevention and treatment of skin, oral, respiratory, liver,gastrointestinal and female genital tract diseases are summarized including the activities in animal experiment and clinical trials and the related mechanisms. This review will provide important theoretical support for further scientific research and product development of probiotics.
引文
[1]PYO S S,MI C Y,HEE K W,et al.A double blind,placebo-controlled,randomized clinical trial that breast milk derived Lactobacillus gasseri BNR17 mitigated diarrhea dominant irritable bowel syndrome[J].Journal of Clinical Biochemistry and Nutrition,2018,62(2):179-186.DOI:10.3 164/j cbn.17/73.
[2]PRESTON K,KRUMIAN R,HATTNER J,et al.Lactobacillus acidophilus CL 1285,Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms:a double-blind,randomised,placebo-controlled study[J].Beneficial Microbes,2018,9(5):697-706.DOI:10.3920/BM2017.0105.
[3]SATISH KUMAR C S,KONDAL REDDY K,BOOBALAN G,et al.Immunomodulatory effects of Bifidobacterium bifidum 231 on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats[J].Research in Veterinary Science,2017,110:40-46.DOI:10.1016/j.rvsc.2016.10.010.
[4]WANG Yuanyuan,GUO Yilin,CHEN Hui,et al.Potential of Lactobacillus plantarum ZDY20 1 3 and Bifidobacterium bifidum WBIN03 in relieving colitis by gut microbiota,immune,and antioxidative stress[J].Canadian Journal of Microbiology,2018,64(5):327-337.DOI:10.1139/cjm-2017-0716.
[5]HUGHES K R,HARNISCH L C,ALCON-GINER C,et al.Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD8 8-dependent manner[J].Open Biology,201 8,7:1-12.DOI:10.1098/rsob.16015510.6084/m9.figshare.c.3655565.
[6]PARK J S,CHOI J W,JHUN J,et al.Lactobacillus acidophilus improves intestinal inflammation in an acute colitis mouse model by regulation of Th 17 and Treg cell balance and fibrosis development[J].Journal of Medicinal Food,2018,21(3):215-224.DOI:10.1089/jmf.2017.3990.
[7]YOKOTA Y,SHIKANO A,KUDA T,et al.Lactobacillus plantarum AN1 cells increase Caecal L.reuteri in an ICR mouse model of dextran sodium sulphate-induced inflammatory bowel disease[J].International Immunopharmacology,2018,56:119-127.DOI:10.1016/j.intimp.2018.01.020.
[8]SANTIAGO-LOPEZ L,HERNANDEZ-MENDOZAA,MATA-HARO V,et al.Effect of milk fermented with Lactobacillus fermentum on the inflammatory response in mice[J].Nutrients,201 8,10(8):1039-105 1.DOI:10.3390/nu10081039.
[9]TAIBI A,SINGH N,CHEN J,et al.Time-and strain-specific downregulation of Intestinal EPAS 1 via miR-148a by Bifidobacterium bifidum[J].Molecular Nutrition and Food Research,2017,61(5):1600596.DOI:10.1002/mnfr.201600596.
[10]GUO S,GILLINGHAM T,GUO Y,et al.Secretions of Bifidobacterium infantis and Lactobacillus acidophilus protect intestinal epithelial barrier function[J].Journal of Pediatric Gastroenterology and Nutrition,2017,64(3):404-412.DOI:10.1097/MPG.0000000000001310.
[11]KARIMI S,JONSSON H,LUNDH T,et al.Lactobacillus reuteri strains protect epithelial barrier integrity of IPEC-J2 monolayers from the detrimental effect of enterotoxigenic Escherichia coli[J].Physiological Reports,2018,6(2):e13514.DOI:10.14814/phy2.13514.
[12]KIM K,LEE G,THANH H D,et al.Exopolysaccharide from Lactobacillus plantarum LRCC5310 offers protection against rotavirus-induced diarrhea and regulates inflammatory response[J].Journal of Dairy Science,2018,101(7):5702-5712.DOI:10.3168/jds.2017-14151.
[13]BARBA-VIDAL E,CASTILLEJOS L,ROLL V F B,et al.The probiotic combination of Bifidobacterium longum subsp.infantis CECT 72 10 and Bifidobacterium animalis subsp.lactis BPL6 reduces pathogen loads and improves gut health of weaned piglets orally challenged with Salmonella typhimurium[J].Frontiers in Microbiology,2017,8:1570.DOI:10.3389/fmicb.2017.01570.
[14]CHATTERJEE M, PUSHKARAN A C, VASUDEVAN A K,et al.Understanding the adhesion mechanism of a mucin binding domain from Lactobacillus fermentum and its role in enteropathogen exclusion[J].International Journal of Biological Macromolecules,2018,110:598-607.DOI:10.1016/j.ijbiomac.2017.10.107.
[15]郝薇,范或,闫雪,等·唾液乳杆菌Ls04对小鼠肠道菌群及黏膜SIgA质量浓度的影响[J].中国乳品工业,2018,46(2):18-28.
[16]MAKIOKA Y,TSUKAHARA T,IJICHI T,et al.Oral supplementation of Bifidobacterium longum strain BR-108 alters cecal microbiota by stimulating gut immune system in mice irrespectively of viability[J].Bioscience,Biotechnology,and Biochemistry,201 8,82(7):1180-11 87.DOI:10.1080/09168451.2018.1451738.
[17]KOSCIK R J E,REID G,KIM S O,et al.Effect of Lactobacillus rhamnosus GR-1 supernatant on cytokine and chemokine output from human amnion cells treated with lipoteichoic acid and lipopolysaccharide[J].Reproductive Sciences,2018,25(2):239-245.DOI:10.1177/1933719117711259.
[18]CIANCI A,CICINELLI E,DE LEO V,et al.Observational prospective study on Lactobacillus plantarum P 17630 in the prevention of vaginal infections,during and after systemic antibiotic therapy or in women with recurrent vaginal or genitourinary infections[J].Journal of Obstetrics and Gynaecology,2018,38(5):693-696.DOI:10.1080/01443615.2017.1399992.
[19]PALMA E,RECINE N,DOMENICI L,et al.Long-term Lactobacillus rhamnosus BMX 54 application to restore a balanced vaginal ecosystem:a promising solution against HPV-infection[J].BMC Infectious Diseases,2018,1 8(1):13-20.DOI:10.11 86/s12879-017-2938-z.
[20]LE O M V P,TAVARES T A A,GON ALVES E SILVA C R,et al.Lactobacillus rhamnosus intake can prevent the development of Candidiasis[J].Clinical Oral Investigations,2018,22(7):2511-2518.DOI:10.1007/s00784-018-2347-8
[21]KANG C H,HAN S H,KIM Y,et al.In vitro probiotic properties of Lactobacillus salivarius MG242 isolated from human vagina[J].Probiotics Antimicrob Proteins,2018,10(2):343-349.DOI:10.1007/S12602-017-9323-5.
[22]DE BARROS P P,SCORZONI L,RIBEIRO F C,et al.Lactobacillus paracasei 28.4 reduces in vitro hyphae formation of Candida albicans and prevents the filamentation in an experimental model of Caenorhabditis elegans[J].Microbial Pathogenesis,2018,117:80-87.DOI:10.1016/j.micpath.201 8.02.019.
[23]KANG C H,KIM Y,HAN S H,et al.In vitro probiotic properties of vaginal Lactobacillus fermentum MG90 1 and Lactobacillus plantarum MG989 against Candida albicans[J].European Journal of Obstetrics,Gynecology,and Reproductive Biology,2018,228:232-237.DOI:10.1016/j.ejogrb.201 8.07.005.
[24]WANG Shuai,WANG Qiangyi,YANG Ence,et al.Antimicrobial compounds produced by vaginal Lactobacillus crispatus are able to strongly inhibit Candida albicans growth,hyphal formation and regulate virulence-related gene expressions[J].Frontiers in Microbiology,2017,8:564.DOI:10.3389/fmicb.2017.00564.
[25]PAROLIN C,FRISCO G,FOSCHI C,et al.Lactobacillus crispatus BC5 interferes with chlamydia trachomatis infectivity through integrin modulation in cervical cells[J].Frontiers in Microbiology,2018,9:2630-2639.DOI:10.3389/fmicb.2018.02630.
[26]PHUKAN N,BROOKS A E S,SIMOES-BARBOSA A A.Cell surface aggregation-promoting factor from Lactobacillus gasseri contributes to inhibition of trichomonas vaginalis adhesion to human vagina:ectocervical cells[J].Infection and Immunity,2018,86(8):1-14.DOI:10.1128/IAI.00907-17.
[27]KIM J,YUN J M,KIM M K,et al.Lactobacillus gasseri BNR17supplementation reduces the visceral fat accumulation and waist circumference in obese adults:a randomized,double-blind,placebocontrolled trial[J].Journal of Medicinal Food,2018,21(5):454-461.DOI:10.1089/jmf.2017.3937.
[28]PARK S S,LEE Y J, SONG S,et al.Lactobacillus acidophilus NS1attenuates diet-induced obesity and fatty liver[J].The Journal of Endocrinology,201 8,237(2):87-100.DOI:10.1530/JOE-17-0592.
[29]JENA P K,SHENG L,NAGAR N,et al.Synbiotics Bifidobacterium infantis and milk oligosaccharides are effective in reversing cancerprone nonalcoholic steatohepatitis using western diet-fed FXR knockout mouse models[J].The Journal of Nutritional Biochemistry,2018,57:246-254.DOI:10.1016/j.j nutbio.2018.04.007.
[30]KWON E K,KANG G-D,KIM W-K,et al.Lactobacillus plantarum LC27 and Bifidobacterium longum LC67 simultaneously alleviate ethanol-induced gastritis and hepatic injury in mice[J].Journal of Functional Foods,2017,38:389-398.DOI:10.1016/j.jff.2017.09.036.
[31]GARCIA-CASTILLO V,ZELAYA H,ILABACA A,et al.Lactobacillus fermentum UCO-979C beneficially modulates the innate immune response triggered by Helicobacter pylori infection in vitro[J].Beneficial Microbes,2018,9(5):829-841.DOI:10.3920/BM2018.0019.
[32]AIBA Y,ISHIKAWA H, TOKUNAGA M,et al.Anti-Helicobacter pylori activity of non-living,heat-killed form of lactobacilli includingLactobacillus johnsonii No.1088[J].FEMS Microbiology Letters,2017,364(11):1-5.DOI:10.1093/femsle/fnx102.
[33]DEL GIUDICE M M,INDOLFI C,CAPASSO M,et al.Bifidobacterium mixture(B.longum BB536,B.infantis M-63,B.breve M-16V)treatment in children with seasonal allergic rhinitis and intermittent asthma[J].Italian Journal of Pediatrics,2017,43(1):25-31.DOI:10.1186/s 13052-017-0340-5.
[34]HSIEH M H,JAN R L,WU L S,et al.Lactobacillus gasseri attenuates allergic airway inflammation through PPARgamma activation in dendritic cells[J].Journal of Molecular Medicine,2018,96(1):39-51.DOI:10.1007/s00109-017-1598-1.
[35]FONSECA W,LUCEY K,JANG S,et al.Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation[J].Mucosal Immunology,2017,10(6):1569-1580.DOI:10.103 8/mi.2017.13.
[36]PARK S,KIM J I,BAE J Y,et al.Effects of heat-killed Lactobacillu:plantarum against influenza viruses in mice[J].Journal of Microbiology,2018,56(2):145-149.DOI:10.1007/s 12275-018-74 11-1.
[37]SANUDO A I,LUQUE R,DIAZ-ROPERO M P,et al.In vitro and in vivo anti-microbial activity evaluation of inactivated cells of Lactobacillus salivarius CECT 5713 against Streptococcus mutans[J].Archives of Oral Biology,2017,84:58-63.DOI:10.1016/j.archoralbio.2017.09.014.
[38]ALANZI A,HONKALA S,HONKALA E,et al.Effect of Lactobacillus rhamnosus and Bifidobacterium lactis on gingival health,dental plaque,and periodontopathogens in adolescents:a randomised placebo-controlled clinical trial[J].Beneficial Microbes,2018,9(4):593-602.DOI:10.3920/bm2017.0139.
[39]PAHUMUNTO N,PIWAT S,CHANKANKA O,et al.Reducing Mutans streptococci and caries development by Lactobacillus paracasei SD1 in preschool children:a randomized placebo-controlled trial[J].Acta Odontologica Scandinavica,2018,76(5):331-337.DOI:10.1080/00016357.2018.1453083.
[40]LIU T H,TSAI T Y,PAN T M.The anti-periodontitis effects of ethanol extract prepared using Lactobacillus paracasei subsp.paracasei NTU 101[J].Nutrients,2018,10(4):472-485.DOI:10.3390/nu10040472.
[41]HOLOWACZ S,BLONDEAU C,GUINOBERT I,et al.Lactobacillus salivarius LA307 and Lactobacillus rhamnosus LA305 attenuate skin inflammation in mice[J].Beneficial Microbes,2018,9(2):299-309.DOI:10.3920/BM2017.0084.
[42]BLANCHET-RETHORE S,BOURDES V,MERCENIER A,et al.Effect of a lotion containing the heat-treated probiotic strain Lactobacillus johnsonii NCC 533 on Staphylococcus aureus colonization in atopic dermatitis[J].Clinical,Cosmetic and Investigational Dermatology,2017,10:249-257.DOI:10.2147/CCID.S135529.
[43]ROSIGNOLI C,DE MENONVILLE S T,ORFILA D,et al.A topical treatment containing heat-treated Lactobacillus johnsonii NCC 533 reduces Staphylococcus aureus adhesion and induces antimicrobial peptide expression in an in vitro reconstructed human epidermis model[J].Experimental Dermatology,2018,27(4):358-365.DOI:10.1111/exd.13504.
[2]PRESTON K,KRUMIAN R,HATTNER J,et al.Lactobacillus acidophilus CL 1285,Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms:a double-blind,randomised,placebo-controlled study[J].Beneficial Microbes,2018,9(5):697-706.DOI:10.3920/BM2017.0105.
[3]SATISH KUMAR C S,KONDAL REDDY K,BOOBALAN G,et al.Immunomodulatory effects of Bifidobacterium bifidum 231 on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats[J].Research in Veterinary Science,2017,110:40-46.DOI:10.1016/j.rvsc.2016.10.010.
[4]WANG Yuanyuan,GUO Yilin,CHEN Hui,et al.Potential of Lactobacillus plantarum ZDY20 1 3 and Bifidobacterium bifidum WBIN03 in relieving colitis by gut microbiota,immune,and antioxidative stress[J].Canadian Journal of Microbiology,2018,64(5):327-337.DOI:10.1139/cjm-2017-0716.
[5]HUGHES K R,HARNISCH L C,ALCON-GINER C,et al.Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD8 8-dependent manner[J].Open Biology,201 8,7:1-12.DOI:10.1098/rsob.16015510.6084/m9.figshare.c.3655565.
[6]PARK J S,CHOI J W,JHUN J,et al.Lactobacillus acidophilus improves intestinal inflammation in an acute colitis mouse model by regulation of Th 17 and Treg cell balance and fibrosis development[J].Journal of Medicinal Food,2018,21(3):215-224.DOI:10.1089/jmf.2017.3990.
[7]YOKOTA Y,SHIKANO A,KUDA T,et al.Lactobacillus plantarum AN1 cells increase Caecal L.reuteri in an ICR mouse model of dextran sodium sulphate-induced inflammatory bowel disease[J].International Immunopharmacology,2018,56:119-127.DOI:10.1016/j.intimp.2018.01.020.
[8]SANTIAGO-LOPEZ L,HERNANDEZ-MENDOZAA,MATA-HARO V,et al.Effect of milk fermented with Lactobacillus fermentum on the inflammatory response in mice[J].Nutrients,201 8,10(8):1039-105 1.DOI:10.3390/nu10081039.
[9]TAIBI A,SINGH N,CHEN J,et al.Time-and strain-specific downregulation of Intestinal EPAS 1 via miR-148a by Bifidobacterium bifidum[J].Molecular Nutrition and Food Research,2017,61(5):1600596.DOI:10.1002/mnfr.201600596.
[10]GUO S,GILLINGHAM T,GUO Y,et al.Secretions of Bifidobacterium infantis and Lactobacillus acidophilus protect intestinal epithelial barrier function[J].Journal of Pediatric Gastroenterology and Nutrition,2017,64(3):404-412.DOI:10.1097/MPG.0000000000001310.
[11]KARIMI S,JONSSON H,LUNDH T,et al.Lactobacillus reuteri strains protect epithelial barrier integrity of IPEC-J2 monolayers from the detrimental effect of enterotoxigenic Escherichia coli[J].Physiological Reports,2018,6(2):e13514.DOI:10.14814/phy2.13514.
[12]KIM K,LEE G,THANH H D,et al.Exopolysaccharide from Lactobacillus plantarum LRCC5310 offers protection against rotavirus-induced diarrhea and regulates inflammatory response[J].Journal of Dairy Science,2018,101(7):5702-5712.DOI:10.3168/jds.2017-14151.
[13]BARBA-VIDAL E,CASTILLEJOS L,ROLL V F B,et al.The probiotic combination of Bifidobacterium longum subsp.infantis CECT 72 10 and Bifidobacterium animalis subsp.lactis BPL6 reduces pathogen loads and improves gut health of weaned piglets orally challenged with Salmonella typhimurium[J].Frontiers in Microbiology,2017,8:1570.DOI:10.3389/fmicb.2017.01570.
[14]CHATTERJEE M, PUSHKARAN A C, VASUDEVAN A K,et al.Understanding the adhesion mechanism of a mucin binding domain from Lactobacillus fermentum and its role in enteropathogen exclusion[J].International Journal of Biological Macromolecules,2018,110:598-607.DOI:10.1016/j.ijbiomac.2017.10.107.
[15]郝薇,范或,闫雪,等·唾液乳杆菌Ls04对小鼠肠道菌群及黏膜SIgA质量浓度的影响[J].中国乳品工业,2018,46(2):18-28.
[16]MAKIOKA Y,TSUKAHARA T,IJICHI T,et al.Oral supplementation of Bifidobacterium longum strain BR-108 alters cecal microbiota by stimulating gut immune system in mice irrespectively of viability[J].Bioscience,Biotechnology,and Biochemistry,201 8,82(7):1180-11 87.DOI:10.1080/09168451.2018.1451738.
[17]KOSCIK R J E,REID G,KIM S O,et al.Effect of Lactobacillus rhamnosus GR-1 supernatant on cytokine and chemokine output from human amnion cells treated with lipoteichoic acid and lipopolysaccharide[J].Reproductive Sciences,2018,25(2):239-245.DOI:10.1177/1933719117711259.
[18]CIANCI A,CICINELLI E,DE LEO V,et al.Observational prospective study on Lactobacillus plantarum P 17630 in the prevention of vaginal infections,during and after systemic antibiotic therapy or in women with recurrent vaginal or genitourinary infections[J].Journal of Obstetrics and Gynaecology,2018,38(5):693-696.DOI:10.1080/01443615.2017.1399992.
[19]PALMA E,RECINE N,DOMENICI L,et al.Long-term Lactobacillus rhamnosus BMX 54 application to restore a balanced vaginal ecosystem:a promising solution against HPV-infection[J].BMC Infectious Diseases,2018,1 8(1):13-20.DOI:10.11 86/s12879-017-2938-z.
[20]LE O M V P,TAVARES T A A,GON ALVES E SILVA C R,et al.Lactobacillus rhamnosus intake can prevent the development of Candidiasis[J].Clinical Oral Investigations,2018,22(7):2511-2518.DOI:10.1007/s00784-018-2347-8
[21]KANG C H,HAN S H,KIM Y,et al.In vitro probiotic properties of Lactobacillus salivarius MG242 isolated from human vagina[J].Probiotics Antimicrob Proteins,2018,10(2):343-349.DOI:10.1007/S12602-017-9323-5.
[22]DE BARROS P P,SCORZONI L,RIBEIRO F C,et al.Lactobacillus paracasei 28.4 reduces in vitro hyphae formation of Candida albicans and prevents the filamentation in an experimental model of Caenorhabditis elegans[J].Microbial Pathogenesis,2018,117:80-87.DOI:10.1016/j.micpath.201 8.02.019.
[23]KANG C H,KIM Y,HAN S H,et al.In vitro probiotic properties of vaginal Lactobacillus fermentum MG90 1 and Lactobacillus plantarum MG989 against Candida albicans[J].European Journal of Obstetrics,Gynecology,and Reproductive Biology,2018,228:232-237.DOI:10.1016/j.ejogrb.201 8.07.005.
[24]WANG Shuai,WANG Qiangyi,YANG Ence,et al.Antimicrobial compounds produced by vaginal Lactobacillus crispatus are able to strongly inhibit Candida albicans growth,hyphal formation and regulate virulence-related gene expressions[J].Frontiers in Microbiology,2017,8:564.DOI:10.3389/fmicb.2017.00564.
[25]PAROLIN C,FRISCO G,FOSCHI C,et al.Lactobacillus crispatus BC5 interferes with chlamydia trachomatis infectivity through integrin modulation in cervical cells[J].Frontiers in Microbiology,2018,9:2630-2639.DOI:10.3389/fmicb.2018.02630.
[26]PHUKAN N,BROOKS A E S,SIMOES-BARBOSA A A.Cell surface aggregation-promoting factor from Lactobacillus gasseri contributes to inhibition of trichomonas vaginalis adhesion to human vagina:ectocervical cells[J].Infection and Immunity,2018,86(8):1-14.DOI:10.1128/IAI.00907-17.
[27]KIM J,YUN J M,KIM M K,et al.Lactobacillus gasseri BNR17supplementation reduces the visceral fat accumulation and waist circumference in obese adults:a randomized,double-blind,placebocontrolled trial[J].Journal of Medicinal Food,2018,21(5):454-461.DOI:10.1089/jmf.2017.3937.
[28]PARK S S,LEE Y J, SONG S,et al.Lactobacillus acidophilus NS1attenuates diet-induced obesity and fatty liver[J].The Journal of Endocrinology,201 8,237(2):87-100.DOI:10.1530/JOE-17-0592.
[29]JENA P K,SHENG L,NAGAR N,et al.Synbiotics Bifidobacterium infantis and milk oligosaccharides are effective in reversing cancerprone nonalcoholic steatohepatitis using western diet-fed FXR knockout mouse models[J].The Journal of Nutritional Biochemistry,2018,57:246-254.DOI:10.1016/j.j nutbio.2018.04.007.
[30]KWON E K,KANG G-D,KIM W-K,et al.Lactobacillus plantarum LC27 and Bifidobacterium longum LC67 simultaneously alleviate ethanol-induced gastritis and hepatic injury in mice[J].Journal of Functional Foods,2017,38:389-398.DOI:10.1016/j.jff.2017.09.036.
[31]GARCIA-CASTILLO V,ZELAYA H,ILABACA A,et al.Lactobacillus fermentum UCO-979C beneficially modulates the innate immune response triggered by Helicobacter pylori infection in vitro[J].Beneficial Microbes,2018,9(5):829-841.DOI:10.3920/BM2018.0019.
[32]AIBA Y,ISHIKAWA H, TOKUNAGA M,et al.Anti-Helicobacter pylori activity of non-living,heat-killed form of lactobacilli includingLactobacillus johnsonii No.1088[J].FEMS Microbiology Letters,2017,364(11):1-5.DOI:10.1093/femsle/fnx102.
[33]DEL GIUDICE M M,INDOLFI C,CAPASSO M,et al.Bifidobacterium mixture(B.longum BB536,B.infantis M-63,B.breve M-16V)treatment in children with seasonal allergic rhinitis and intermittent asthma[J].Italian Journal of Pediatrics,2017,43(1):25-31.DOI:10.1186/s 13052-017-0340-5.
[34]HSIEH M H,JAN R L,WU L S,et al.Lactobacillus gasseri attenuates allergic airway inflammation through PPARgamma activation in dendritic cells[J].Journal of Molecular Medicine,2018,96(1):39-51.DOI:10.1007/s00109-017-1598-1.
[35]FONSECA W,LUCEY K,JANG S,et al.Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation[J].Mucosal Immunology,2017,10(6):1569-1580.DOI:10.103 8/mi.2017.13.
[36]PARK S,KIM J I,BAE J Y,et al.Effects of heat-killed Lactobacillu:plantarum against influenza viruses in mice[J].Journal of Microbiology,2018,56(2):145-149.DOI:10.1007/s 12275-018-74 11-1.
[37]SANUDO A I,LUQUE R,DIAZ-ROPERO M P,et al.In vitro and in vivo anti-microbial activity evaluation of inactivated cells of Lactobacillus salivarius CECT 5713 against Streptococcus mutans[J].Archives of Oral Biology,2017,84:58-63.DOI:10.1016/j.archoralbio.2017.09.014.
[38]ALANZI A,HONKALA S,HONKALA E,et al.Effect of Lactobacillus rhamnosus and Bifidobacterium lactis on gingival health,dental plaque,and periodontopathogens in adolescents:a randomised placebo-controlled clinical trial[J].Beneficial Microbes,2018,9(4):593-602.DOI:10.3920/bm2017.0139.
[39]PAHUMUNTO N,PIWAT S,CHANKANKA O,et al.Reducing Mutans streptococci and caries development by Lactobacillus paracasei SD1 in preschool children:a randomized placebo-controlled trial[J].Acta Odontologica Scandinavica,2018,76(5):331-337.DOI:10.1080/00016357.2018.1453083.
[40]LIU T H,TSAI T Y,PAN T M.The anti-periodontitis effects of ethanol extract prepared using Lactobacillus paracasei subsp.paracasei NTU 101[J].Nutrients,2018,10(4):472-485.DOI:10.3390/nu10040472.
[41]HOLOWACZ S,BLONDEAU C,GUINOBERT I,et al.Lactobacillus salivarius LA307 and Lactobacillus rhamnosus LA305 attenuate skin inflammation in mice[J].Beneficial Microbes,2018,9(2):299-309.DOI:10.3920/BM2017.0084.
[42]BLANCHET-RETHORE S,BOURDES V,MERCENIER A,et al.Effect of a lotion containing the heat-treated probiotic strain Lactobacillus johnsonii NCC 533 on Staphylococcus aureus colonization in atopic dermatitis[J].Clinical,Cosmetic and Investigational Dermatology,2017,10:249-257.DOI:10.2147/CCID.S135529.
[43]ROSIGNOLI C,DE MENONVILLE S T,ORFILA D,et al.A topical treatment containing heat-treated Lactobacillus johnsonii NCC 533 reduces Staphylococcus aureus adhesion and induces antimicrobial peptide expression in an in vitro reconstructed human epidermis model[J].Experimental Dermatology,2018,27(4):358-365.DOI:10.1111/exd.13504.