细虫草资源研究现状及开发利用进展
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摘要
细虫草(Ophiocordyceps gracilis)是一种虫生真菌,为传统的哈萨克民族药,一直以来被作为冬虫夏草的替代品使用,具有重要的食用和药用价值。本文从分布、生境、形态特征、系统发育分类、生物活性成分、药理作用、人工培养菌丝体及寄主昆虫等方面对细虫草的研究进展进行总结,并对其研究前景进行了展望,为今后细虫草的研究和开发利用提供参考。
Ophiocordyceps gracilis,an entomophagous fungus,is a traditional Kazakh medicine with important edible and medicinal values.It has been used as a substitute for Ophiocordyceps sinensis.The recent research progresses of O.gracilis were reviewed in this paper,including distribution,habitat,morphological characteristics,phylogenetic classification,bioactive compounds,pharmacological effects,mycelium culture and host insect.The future prospects in the research approaches of O.gracilis are also discussed,which provide references for further exploitation and application of O.gracilis.
Ophiocordyceps gracilis,an entomophagous fungus,is a traditional Kazakh medicine with important edible and medicinal values.It has been used as a substitute for Ophiocordyceps sinensis.The recent research progresses of O.gracilis were reviewed in this paper,including distribution,habitat,morphological characteristics,phylogenetic classification,bioactive compounds,pharmacological effects,mycelium culture and host insect.The future prospects in the research approaches of O.gracilis are also discussed,which provide references for further exploitation and application of O.gracilis.
引文
[1]SHIMITSU D.Cordyceps green book 51[M].Japan:New Science Company,1978.
[2]刘飞,伍晓丽,尹定华,等.冬虫夏草寄主昆虫的种类和分布研究概况[J].重庆中草药研究,2006(1):47-50.
[3]SUNG GH,HYWEL-JONES NL,SUNG JM,et al.Phylogenetic classification of Cordyceps and the clavicipitaceous fungi[J].Studies in Mycology,2007,57(1):5-59.
[4]邹志文,刘昕,张古忍.中国蝠蛾属(鳞翅目,蝙蝠蛾科)现行分类系统的修订[J].湖南科技大学学报(自然科学版),2010,25(1):114-120.
[5]梁宗琦,刘爱英,樊美珍,等.西北地区的几种虫草[J].菌物系统,1995,14(3):237-240.
[6]赵恒,刘平义,屈新兰,等.阿尔泰山虫草的分布及生境调查[J].新疆农业科学,1993,30(1):22-23.
[7]何苏琴,王三喜,罗进仓,等.甘肃省一新记录虫草——细蛇形虫草[J].草原与草坪,2011,31(4):15-17.
[8]LI CR,FAN MZ,HUANG B,et al.The genus Cordyceps and its allies from Anhui[J].Mycosystema,2002,21(2):167-171.
[9]邓叔群.中国的真菌[M].北京:科学出版社,1963.
[10]梁佩琼,陆大京.中国虫草属真菌已知种类资源[J].食用菌,1988,10(2):1-4.
[11]ZANG M,KINJO N.Notes on the alpine Cordyceps of China and nearby nations[J].Mycotaxon,1998,66:215-230.
[12]GORBUNOVA IA,KRYUKOV VY,ZIBZEEV EG.First records of the entomopathogenic fungus Ophiocordyceps gracilis(Ascomycota,Hypocreales)from Siberia[J].Euroasian Entomlogical Journal,2011,10(1):17-22.
[13]MEDEL R,MORALES O,DEL MORAL RC,et al.New ascomycete records from Guatemala[J].Mycotaxon,2013,124(1):73-85.
[14]RUBIO-BUSTOS SY,GUZMAN-DAVALOS L,NAVARRETE-HEREDIA JL.Especies entomopatógenas de Cordyceps(Fungi,Ascomycotina)en Mexico[J].Boletin del Instituto de Botánica,1999,7:135-157.
[15]KLINGEN I,SALINAS SH,MEADOW R.Checklist of naturally occurring pathogens of insects and mites in Norway[J].Norwegian Journal of Entomology,2002,49:23-28.
[16]SAMSON RA,BRADY BL.Paraisaria,a new genus for Isaria dubia,the anamorph of Cordyceps gracilis[J].Transactions of the British Mycological Society,1983,81(2):285-290.
[17]宋斌,林群英,李泰辉,等.中国虫草属已知种类及其分布[J].菌物研究,2006,4(4):10-26.
[18]SHRESTHA B,SUNG JM.Notes on Cordyceps species collected from the central region of Nepal[J].Mycobiology,2005,33(4):235-239.
[19]赵恒.阿勒泰地区的虫草[J].新疆农业科学,1987,24(1):29-29.
[20]新疆卫生厅.新疆维吾尔自治区药品标准[M].乌鲁木齐:新疆维吾尔自治区卫生局,1987:21.
[21]邱翠嫦,戴斌,王少珩.新疆虫草的生药鉴定及氨基酸分析[J].中药材,1991,14(12):20-23.
[22]赵恒,屈新兰,刘平义,等.新疆黑槌虫草的形态及发生特点[J].中国食用菌,1999,18(2):20-22.
[23]常玮,龙涛,冯怀蓉.新疆虫草的生物学特性[J].新疆农业科学,2002,39(4):227-227.
[24]常玮,张慧涛,杨新平.新疆虫草理化性质的研究[J].新疆农业科学,2004,41(8):24-25.
[25]索菲娅,苏俊,姜彦成,等.新疆虫草与冬虫夏草中腺苷和虫草素的HPLC法测定比较[J].中国民族医药杂志,2008,14(3):65-67.
[26]索菲娅,苏俊,姜彦成,等.新疆虫草与冬虫夏草中甘露醇、多糖和氨基酸的含量比较研究[J].新疆农业科学,2008,45(3):517-521.
[27]索菲娅,郭瑞,虞泓,等.新疆细虫草核苷类成分分析[J].食用菌学报,2013,20(4):55-60.
[28]索菲娅,黄罗冬,李萍,等.新疆细虫草抑菌及抗氧化作用的初步研究[J].食用菌学报,2014,21(1):51-54.
[29]巴哈尔古丽,严萍.哈萨克民间用药新疆虫草和冬虫夏草的生药学研究[J].中国药品标准,2009,10(3):182-184.
[30]王岩,陶常诚,李琪,等.阿尔泰蝠蛾(鳞翅目:蝠蛾科)活蛹性别的无损鉴别方法[J].环境昆虫学报,2018,40(1):30-35.
[31]MAINS EB.North American entomogenous species of Cordyceps[J].Mycologia,1958,50:169-222.
[32]YOSIO K.Miscellaneous notes on the genus Cordyceps and its allies(13)[J].Journal of Japanese Botany,1980,55(3):86-87.
[33]KOBAYASHI Y,SHIMIZU D.Iconography of vegetable wasps and plant worms[M].Japan:Hoikusha Publ Co Ltd.,1983.
[34]QUANDT CA,KEPLER RM,GAMS W,et al.Phylogenetic-based nomenclatural proposals for Ophiocordycipitaceae(Hypocreales)with new combinations in Tolypocladium[J].IMA Fungus,2014,5(1):121-134.
[35]索菲娅,黄罗冬,虞泓,等.新疆细虫草菌核的膨大弯颈霉菌株SFYT002核苷类成分分析[J].药物分析杂志,2014,34(8):1407-1411.
[36]WU DT,CHEONG KL,WANG LY,et al.Characterization and discrimination of polysaccharides from different species of Cordyceps using saccharide mapping based on PACE and HPTLC[J].Carbohydrate Polymers,2014,103:100-109.
[37]SHARMA SK,GAUTAM N,ATRI NS.Optimization,composition,and antioxidant activities of exo-and intracellular polysaccharides in submerged culture of Cordyceps gracilis(Grev.)Durieu Mont[J].Evidence-Based Complementray and Alternative Medicine,2015(10):462864.
[38]马赞,索菲娅,王傲立,等.不同居群的新疆虫草发酵液体外抗氧化活性的研究[J].中国生化药物杂志,2012,33(6):792-794.
[39]SHARMA SK.Development of cosmeceutical formulation from myceliai extract of Cordyceps gracilis[J].EPRA International Journal of Multidisciplinary Research,2016,2(12):82-86.
[40]叶星,索菲娅,卢帅,等.新疆细虫草提取物对胃癌AGS细胞增殖的影响[J].食用菌学报,2015,22(2):51-54.
[41]吴念江,管继萍,平学如,等.新疆阿尔泰人工虫草菌丝体及培养液对实验性肝损伤的保护作用[J].中国医院药学杂志,1998,18(11):488-490.
[42]常玮.新疆黑槌虫草发酵工艺及药效学[D].天津:天津大学,2009.
[43]丘雪红,曹莉,韩日畴.冬虫夏草的研究进展、现存问题与研究展望[J].环境昆虫学报,2016,38(1):1-23.
[44]吴瑶,陈丽华,金晨,等.发酵虫草菌粉类产品质量标准研究进展[J].中国实验方剂学杂志,2017,23(20):220-227.
[45]常玮,杨新平,冯蕾,等.新疆虫草速生菌株选育[J].新疆农业科学,2002,39(1):40-41.
[46]高有华,郭庆元,孔军.新疆虫草菌适宜培养温度研究[J].农村科技,2012(6):60-60.
[47]潘巍,艾米旦木·玛依提,唐晖.新疆虫草人工发酵菌丝体食品安全性研究[J].安徽农业科学,2009,37(14):6438-6440.
[48]赵恒,黄吉海.阿尔泰蝠蛾生殖规律的观察[J].新疆农业科学,1998,35(4):181-183.
[49]MORTIMER PE,KARUNARATHNA SC,LI Q,et al.Prized edible Asian mushrooms:ecology,conservation and sustain ability[J].Fungal Diversity,2012,56(1):31-47.
[50]FINIMUNDY TC,DILLON AJP,HENRIQUES JAP,et al.A review on general nutritional compounds and pharmacological properties of the Lentinula edodes mushroom[J].Food and Nutrition Sciences,2014,5(5):1095-1105.
[51]梁宗琦.我国虫草属真菌研究开发的现状及思考[J].食用菌学报,2001,8(2):53-62.
[52]董彩虹,李文佳,李增智,等.我国虫草产业发展现状、问题及展望——虫草产业发展金湖宣言[J].菌物学报,2016,35(1):1-15.
[2]刘飞,伍晓丽,尹定华,等.冬虫夏草寄主昆虫的种类和分布研究概况[J].重庆中草药研究,2006(1):47-50.
[3]SUNG GH,HYWEL-JONES NL,SUNG JM,et al.Phylogenetic classification of Cordyceps and the clavicipitaceous fungi[J].Studies in Mycology,2007,57(1):5-59.
[4]邹志文,刘昕,张古忍.中国蝠蛾属(鳞翅目,蝙蝠蛾科)现行分类系统的修订[J].湖南科技大学学报(自然科学版),2010,25(1):114-120.
[5]梁宗琦,刘爱英,樊美珍,等.西北地区的几种虫草[J].菌物系统,1995,14(3):237-240.
[6]赵恒,刘平义,屈新兰,等.阿尔泰山虫草的分布及生境调查[J].新疆农业科学,1993,30(1):22-23.
[7]何苏琴,王三喜,罗进仓,等.甘肃省一新记录虫草——细蛇形虫草[J].草原与草坪,2011,31(4):15-17.
[8]LI CR,FAN MZ,HUANG B,et al.The genus Cordyceps and its allies from Anhui[J].Mycosystema,2002,21(2):167-171.
[9]邓叔群.中国的真菌[M].北京:科学出版社,1963.
[10]梁佩琼,陆大京.中国虫草属真菌已知种类资源[J].食用菌,1988,10(2):1-4.
[11]ZANG M,KINJO N.Notes on the alpine Cordyceps of China and nearby nations[J].Mycotaxon,1998,66:215-230.
[12]GORBUNOVA IA,KRYUKOV VY,ZIBZEEV EG.First records of the entomopathogenic fungus Ophiocordyceps gracilis(Ascomycota,Hypocreales)from Siberia[J].Euroasian Entomlogical Journal,2011,10(1):17-22.
[13]MEDEL R,MORALES O,DEL MORAL RC,et al.New ascomycete records from Guatemala[J].Mycotaxon,2013,124(1):73-85.
[14]RUBIO-BUSTOS SY,GUZMAN-DAVALOS L,NAVARRETE-HEREDIA JL.Especies entomopatógenas de Cordyceps(Fungi,Ascomycotina)en Mexico[J].Boletin del Instituto de Botánica,1999,7:135-157.
[15]KLINGEN I,SALINAS SH,MEADOW R.Checklist of naturally occurring pathogens of insects and mites in Norway[J].Norwegian Journal of Entomology,2002,49:23-28.
[16]SAMSON RA,BRADY BL.Paraisaria,a new genus for Isaria dubia,the anamorph of Cordyceps gracilis[J].Transactions of the British Mycological Society,1983,81(2):285-290.
[17]宋斌,林群英,李泰辉,等.中国虫草属已知种类及其分布[J].菌物研究,2006,4(4):10-26.
[18]SHRESTHA B,SUNG JM.Notes on Cordyceps species collected from the central region of Nepal[J].Mycobiology,2005,33(4):235-239.
[19]赵恒.阿勒泰地区的虫草[J].新疆农业科学,1987,24(1):29-29.
[20]新疆卫生厅.新疆维吾尔自治区药品标准[M].乌鲁木齐:新疆维吾尔自治区卫生局,1987:21.
[21]邱翠嫦,戴斌,王少珩.新疆虫草的生药鉴定及氨基酸分析[J].中药材,1991,14(12):20-23.
[22]赵恒,屈新兰,刘平义,等.新疆黑槌虫草的形态及发生特点[J].中国食用菌,1999,18(2):20-22.
[23]常玮,龙涛,冯怀蓉.新疆虫草的生物学特性[J].新疆农业科学,2002,39(4):227-227.
[24]常玮,张慧涛,杨新平.新疆虫草理化性质的研究[J].新疆农业科学,2004,41(8):24-25.
[25]索菲娅,苏俊,姜彦成,等.新疆虫草与冬虫夏草中腺苷和虫草素的HPLC法测定比较[J].中国民族医药杂志,2008,14(3):65-67.
[26]索菲娅,苏俊,姜彦成,等.新疆虫草与冬虫夏草中甘露醇、多糖和氨基酸的含量比较研究[J].新疆农业科学,2008,45(3):517-521.
[27]索菲娅,郭瑞,虞泓,等.新疆细虫草核苷类成分分析[J].食用菌学报,2013,20(4):55-60.
[28]索菲娅,黄罗冬,李萍,等.新疆细虫草抑菌及抗氧化作用的初步研究[J].食用菌学报,2014,21(1):51-54.
[29]巴哈尔古丽,严萍.哈萨克民间用药新疆虫草和冬虫夏草的生药学研究[J].中国药品标准,2009,10(3):182-184.
[30]王岩,陶常诚,李琪,等.阿尔泰蝠蛾(鳞翅目:蝠蛾科)活蛹性别的无损鉴别方法[J].环境昆虫学报,2018,40(1):30-35.
[31]MAINS EB.North American entomogenous species of Cordyceps[J].Mycologia,1958,50:169-222.
[32]YOSIO K.Miscellaneous notes on the genus Cordyceps and its allies(13)[J].Journal of Japanese Botany,1980,55(3):86-87.
[33]KOBAYASHI Y,SHIMIZU D.Iconography of vegetable wasps and plant worms[M].Japan:Hoikusha Publ Co Ltd.,1983.
[34]QUANDT CA,KEPLER RM,GAMS W,et al.Phylogenetic-based nomenclatural proposals for Ophiocordycipitaceae(Hypocreales)with new combinations in Tolypocladium[J].IMA Fungus,2014,5(1):121-134.
[35]索菲娅,黄罗冬,虞泓,等.新疆细虫草菌核的膨大弯颈霉菌株SFYT002核苷类成分分析[J].药物分析杂志,2014,34(8):1407-1411.
[36]WU DT,CHEONG KL,WANG LY,et al.Characterization and discrimination of polysaccharides from different species of Cordyceps using saccharide mapping based on PACE and HPTLC[J].Carbohydrate Polymers,2014,103:100-109.
[37]SHARMA SK,GAUTAM N,ATRI NS.Optimization,composition,and antioxidant activities of exo-and intracellular polysaccharides in submerged culture of Cordyceps gracilis(Grev.)Durieu Mont[J].Evidence-Based Complementray and Alternative Medicine,2015(10):462864.
[38]马赞,索菲娅,王傲立,等.不同居群的新疆虫草发酵液体外抗氧化活性的研究[J].中国生化药物杂志,2012,33(6):792-794.
[39]SHARMA SK.Development of cosmeceutical formulation from myceliai extract of Cordyceps gracilis[J].EPRA International Journal of Multidisciplinary Research,2016,2(12):82-86.
[40]叶星,索菲娅,卢帅,等.新疆细虫草提取物对胃癌AGS细胞增殖的影响[J].食用菌学报,2015,22(2):51-54.
[41]吴念江,管继萍,平学如,等.新疆阿尔泰人工虫草菌丝体及培养液对实验性肝损伤的保护作用[J].中国医院药学杂志,1998,18(11):488-490.
[42]常玮.新疆黑槌虫草发酵工艺及药效学[D].天津:天津大学,2009.
[43]丘雪红,曹莉,韩日畴.冬虫夏草的研究进展、现存问题与研究展望[J].环境昆虫学报,2016,38(1):1-23.
[44]吴瑶,陈丽华,金晨,等.发酵虫草菌粉类产品质量标准研究进展[J].中国实验方剂学杂志,2017,23(20):220-227.
[45]常玮,杨新平,冯蕾,等.新疆虫草速生菌株选育[J].新疆农业科学,2002,39(1):40-41.
[46]高有华,郭庆元,孔军.新疆虫草菌适宜培养温度研究[J].农村科技,2012(6):60-60.
[47]潘巍,艾米旦木·玛依提,唐晖.新疆虫草人工发酵菌丝体食品安全性研究[J].安徽农业科学,2009,37(14):6438-6440.
[48]赵恒,黄吉海.阿尔泰蝠蛾生殖规律的观察[J].新疆农业科学,1998,35(4):181-183.
[49]MORTIMER PE,KARUNARATHNA SC,LI Q,et al.Prized edible Asian mushrooms:ecology,conservation and sustain ability[J].Fungal Diversity,2012,56(1):31-47.
[50]FINIMUNDY TC,DILLON AJP,HENRIQUES JAP,et al.A review on general nutritional compounds and pharmacological properties of the Lentinula edodes mushroom[J].Food and Nutrition Sciences,2014,5(5):1095-1105.
[51]梁宗琦.我国虫草属真菌研究开发的现状及思考[J].食用菌学报,2001,8(2):53-62.
[52]董彩虹,李文佳,李增智,等.我国虫草产业发展现状、问题及展望——虫草产业发展金湖宣言[J].菌物学报,2016,35(1):1-15.