甜蜜素的段塞流结晶研究
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摘要
段塞流是通过在液体管道内引入气体,使气、液两相在管道中连续交替流动,将其应用于结晶过程中可制备形状完整、尺寸分布窄的高质量晶体。以甜蜜素为研究对象,运用段塞流结晶方式考察气/液速比、管径对段塞稳定性的影响。在此基础上,以晶体尺寸及尺寸分布为指标,优化确定合适的气/液速比和管径。与间歇结晶过程的对比结果表明,段塞流结晶方式可有效改善晶体破碎现象。
Slug flow is defined as the gas and liquid phases flow alternately in the pipeline by drawing gas into liquid pipeline.High quality of crystals with the complete shape and narrow size distribution can be prepared by using slug flow in the crystallization process.Through using slug flow crystallization in the crystallization of sodium cyclamate,the influences of flow rate ratio of gas/liquid and tube diameter on the stability of slugs are evaluated,which is therefore used to optimize and determine the suitable flow rate ratio of gas/liquid and tube diameter by using crystal size and size distribution as indexes. By comparing with the batch crystallization,the slug-flow crystallization can effectively reduce crystal fragmentation.
Slug flow is defined as the gas and liquid phases flow alternately in the pipeline by drawing gas into liquid pipeline.High quality of crystals with the complete shape and narrow size distribution can be prepared by using slug flow in the crystallization process.Through using slug flow crystallization in the crystallization of sodium cyclamate,the influences of flow rate ratio of gas/liquid and tube diameter on the stability of slugs are evaluated,which is therefore used to optimize and determine the suitable flow rate ratio of gas/liquid and tube diameter by using crystal size and size distribution as indexes. By comparing with the batch crystallization,the slug-flow crystallization can effectively reduce crystal fragmentation.
引文
[1]朱丽娜,祝莹,方群.基于微流控技术的蛋白质结晶及其筛选方法的研究进展[J].高等学校化学学报,2014,35(1):1-11.
[2]Paglianti A,Giona M,Soldati A.Characterization of subregimes in two-phase slug flow[J].International Journal of Multiphase Flow,1996,22(4):783-796.
[3]Mishima K,Hibiki T.Some characteristics of air-water two-phase flow in small diameter vertical tubes[J].International Journal of Multiphase Flow,1996,22(4):703-712.
[4]Tripletta K A,Ghiaasiaana S M,Abdel-khalika S I,et al.Gas-liquid two-phase flow in microchannels partⅠ:Two-phase flow patterns[J].International Journal of Multiphase Flow,1999,25(3):377-394.
[5]Gerdts C J,Tereshko V,Yadav M K,et al.Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization[J].Angewandte Chemie,2006,118(48):8336-8340.
[6]邓楠楠,汪伟,巨晓洁,等.微流控技术操控微尺度液滴及其聚并的研究进展[J].中国科学:化学,2015,45(1):7-15.
[7]戴莉.微通道内的气液两相流动与传质研究[D].天津:天津大学,2010:2.
[8]Suwankamnerd P,Wongwises S.An experimental study of two-phase air-water flow and heat transfer characteristics of segmented flow in a microchannel[J].Experimental Thermal and Fluid Science,2015,62:29-39.
[9]Jiang M,Papageorgiou C D,Waetzig J,et al.Indirect ultrasonication in continuous slug-flow crystallization[J].Crystal Growth and Design,2015,15(5):2486-2492.
[10]Neugebauer P,Khinast J G.Continuous crystallization of proteins in a tubular plug-flow crystallizer[J].Crystal Growth and Design,2015,15(3):1089-1095.
[11]Eder R J P,Radl S,Schmitt E,et al.Continuously seeded,continuously operated tubular crystallizer for the production of active pharmaceutical ingredients[J].Crystal Growth and Design,2010,10(5):2247-2257.
[12]Eder R J P,Schrank S,Besenhard M O,et al.Continuous sonocrystallization of acetylsalicylic acid(ASA):Control of crystal size[J].Crystal Growth and Design,2012,12(10):4733-4738.
[13]Qian D,Lawal A.Numerical study on gas and liquid slugs for Taylor flow in a T-junction microchannel[J].Chemical Engineering Science,2006,61(23):7609-7625.
[14]Niu H,Pan L,Su H,et al.Flow pattern,pressure drop,and mass transfer in a gas-liquid concurrent two-phase flow microchannel reactor[J].Industrial and Engineering Chemistry Research,2009,48(3):1621-1628.
[15]Jiang M,Zhu Z,Jimenez E,et al.Continuous-flow tubular crystallization in slugs spontaneously induced by hydrodynamics[J].Crystal Growth and Design,2014,14(2):851-860.
[16]Talimi V,Muzychka Y S,Kocabiyik S.A review on numerical studies of slug flow hydrodynamics and heat transfer in microtubes and microchannels[J].International Journal of Multiphase Flow,2012,39:88-104.
[17]Yu L,Pan Y,Wang C,et al.A two-phase segmented microfluidic technique for one-step continuous versatile preparation of zeolites[J].Chemical Engineering Journal,2013,219(3):78-85.
[18]Kashid M N,Gerlach I,Goetz S,et al.Internal circulation within the liquid slugs of a liquid-liquid slug-flow capillary microreactor[J].Industrial and Engineering Chemistry Research,2005,44:5003-5010.
[19]Suwankamnerd P,Wongwises S.An experimental study of two-phase air-water flow and heat transfer characteristics of segmented flow in a microchannel[J].Experimental Thermal and Fluid Science,2015,62:29-39.
[20]Fukano T,Kariyasaki A,Ide H.Fundamental data on the gas-liquid two-phase flow[C].ASME 3rd International Conference on Microchannels and Minichannels.Ontario,Canada:Nanotechnology Institute,2005:37-47.
[21]Taylor G I.Deposition of a viscous fluid on the wall of a tube[J].Journal of Fluid Mechanics,1961,10(2):161-165.
[22]Tsaoulidis D,Angeli P.Effect of channel size on mass transfer during liquid-liquid plug flow in small scale extractors[J].Chemical Engineering Journal,2015,262:785-793.
[2]Paglianti A,Giona M,Soldati A.Characterization of subregimes in two-phase slug flow[J].International Journal of Multiphase Flow,1996,22(4):783-796.
[3]Mishima K,Hibiki T.Some characteristics of air-water two-phase flow in small diameter vertical tubes[J].International Journal of Multiphase Flow,1996,22(4):703-712.
[4]Tripletta K A,Ghiaasiaana S M,Abdel-khalika S I,et al.Gas-liquid two-phase flow in microchannels partⅠ:Two-phase flow patterns[J].International Journal of Multiphase Flow,1999,25(3):377-394.
[5]Gerdts C J,Tereshko V,Yadav M K,et al.Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization[J].Angewandte Chemie,2006,118(48):8336-8340.
[6]邓楠楠,汪伟,巨晓洁,等.微流控技术操控微尺度液滴及其聚并的研究进展[J].中国科学:化学,2015,45(1):7-15.
[7]戴莉.微通道内的气液两相流动与传质研究[D].天津:天津大学,2010:2.
[8]Suwankamnerd P,Wongwises S.An experimental study of two-phase air-water flow and heat transfer characteristics of segmented flow in a microchannel[J].Experimental Thermal and Fluid Science,2015,62:29-39.
[9]Jiang M,Papageorgiou C D,Waetzig J,et al.Indirect ultrasonication in continuous slug-flow crystallization[J].Crystal Growth and Design,2015,15(5):2486-2492.
[10]Neugebauer P,Khinast J G.Continuous crystallization of proteins in a tubular plug-flow crystallizer[J].Crystal Growth and Design,2015,15(3):1089-1095.
[11]Eder R J P,Radl S,Schmitt E,et al.Continuously seeded,continuously operated tubular crystallizer for the production of active pharmaceutical ingredients[J].Crystal Growth and Design,2010,10(5):2247-2257.
[12]Eder R J P,Schrank S,Besenhard M O,et al.Continuous sonocrystallization of acetylsalicylic acid(ASA):Control of crystal size[J].Crystal Growth and Design,2012,12(10):4733-4738.
[13]Qian D,Lawal A.Numerical study on gas and liquid slugs for Taylor flow in a T-junction microchannel[J].Chemical Engineering Science,2006,61(23):7609-7625.
[14]Niu H,Pan L,Su H,et al.Flow pattern,pressure drop,and mass transfer in a gas-liquid concurrent two-phase flow microchannel reactor[J].Industrial and Engineering Chemistry Research,2009,48(3):1621-1628.
[15]Jiang M,Zhu Z,Jimenez E,et al.Continuous-flow tubular crystallization in slugs spontaneously induced by hydrodynamics[J].Crystal Growth and Design,2014,14(2):851-860.
[16]Talimi V,Muzychka Y S,Kocabiyik S.A review on numerical studies of slug flow hydrodynamics and heat transfer in microtubes and microchannels[J].International Journal of Multiphase Flow,2012,39:88-104.
[17]Yu L,Pan Y,Wang C,et al.A two-phase segmented microfluidic technique for one-step continuous versatile preparation of zeolites[J].Chemical Engineering Journal,2013,219(3):78-85.
[18]Kashid M N,Gerlach I,Goetz S,et al.Internal circulation within the liquid slugs of a liquid-liquid slug-flow capillary microreactor[J].Industrial and Engineering Chemistry Research,2005,44:5003-5010.
[19]Suwankamnerd P,Wongwises S.An experimental study of two-phase air-water flow and heat transfer characteristics of segmented flow in a microchannel[J].Experimental Thermal and Fluid Science,2015,62:29-39.
[20]Fukano T,Kariyasaki A,Ide H.Fundamental data on the gas-liquid two-phase flow[C].ASME 3rd International Conference on Microchannels and Minichannels.Ontario,Canada:Nanotechnology Institute,2005:37-47.
[21]Taylor G I.Deposition of a viscous fluid on the wall of a tube[J].Journal of Fluid Mechanics,1961,10(2):161-165.
[22]Tsaoulidis D,Angeli P.Effect of channel size on mass transfer during liquid-liquid plug flow in small scale extractors[J].Chemical Engineering Journal,2015,262:785-793.
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