六价铬化合物的肝脏毒性及其作用机制研究进展
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摘要
六价铬化合物普遍存在于环境中,并被广泛应用于多种工业生产中,由此引发的铬污染及健康问题已经引起了人们的重视。作为体内代谢及解毒的重要场所,肝脏是Cr(Ⅵ)毒性作用的靶器官之一。本文对Cr(Ⅵ)化合物在环境中的污染来源与污染状况、机体内吸收、分布与代谢及对肝脏的毒性损害及其作用机制的研究现状加以综述。
Hexavalent chromium compounds, the ubiquitous environmental pollutants that are widely used in a variety of industrial processes, have attracted peoples attention because of the serious pollution and the consequent health problems. As an important place for metabolism and detoxification in the body, the liver is one of the target organs for the toxicity of Cr(Ⅵ). This paper reviews the research progress of pollution sources and status of Cr(Ⅵ)compounds in the environment, their absorption, distribution and metabolism in the body, and the toxicity damage to the liver as well as the related mechanisms.
Hexavalent chromium compounds, the ubiquitous environmental pollutants that are widely used in a variety of industrial processes, have attracted peoples attention because of the serious pollution and the consequent health problems. As an important place for metabolism and detoxification in the body, the liver is one of the target organs for the toxicity of Cr(Ⅵ). This paper reviews the research progress of pollution sources and status of Cr(Ⅵ)compounds in the environment, their absorption, distribution and metabolism in the body, and the toxicity damage to the liver as well as the related mechanisms.
引文
[1]Yang Q,Li Z,Lu X,et al.A review of soil heavy metal pollution from industrial and agricultural regions in China:Pollution and risk assessment[J].Science of the Total Environment,2018,642:690-700
[2]Panchal S K,Wanyonyi S,Brown L.Selenium,vanadium,and chromium as micronutrients to improve metabolic syndrome[J].Current Hypertension Reports,2017,19(3):10
[3]Xiao F,Feng X,Zeng M,et al.Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes[J].Molecular and Cellular Biochemistry,2012,371(1-2):65-76
[4]仪民,仪慧兰,吴丽华.铬在小鼠体内的蓄积效应与毒性[J].生态毒理学报,2017,12(6):259-265Yi M,Yi H L,Wu L H.Accumulation and toxicity of hexavalent chromium in mice[J].Asian Journal of Ecotoxicology,2017,12(6):259-265(in Chinese)
[5]Proctor D M,Suh M,Campleman S L,et al.Assessment of the mode of action for hexavalent chromium-induced lung cancer following inhalation exposures[J].Toxicology,2014,325(6):160-179
[6]Yoshinaga M,Ninomiya H,Al Hossain M M A,et al.Acomprehensive study including monitoring,assessment of health effects and development of a remediation method for chromium pollution[J].Chemosphere,2018,201:667-675
[7]Keane M,Siert A,Stone S,et al.Profiling stainless steel welding processes to reduce fume emissions,hexavalent chromium emissions and operating costs in the workplace[J].Journal Occupational Environmental Hyginen,2016,13(1):1-8
[8]Remy L L,Byers V,Clay T.Reproductive outcomes after non-occupational exposure to hexavalent chromium,Willits California,1983-2014[J].Environmental Health,2017,16(1):18
[9]Eleftheriou E P,Adamakis I S,Melissa P.Effects of hexavalent chromium on microtubule organization,ER distribution and callose deposition in root tip cells of Allium cepa[J].Protoplasma,2012,249:401-416
[10]徐衍忠,秦绪娜,刘祥红,等.铬污染及其生态效应[J].环境科学与技术,2002,25(增刊):8-10Xu Y Z,Qin X N,Liu X H,et al.The study of chromium pollution and ecological effects[J].Environmental Science and Technology,2002,25(S1):8-10(in Chinese)
[11]Lee P K,Yu S,Chang H J,et al.Lead chromate detected as a source of atmospheric Pb and Cr(Ⅵ)pollution[J].Scientific Reports,2016,6:36088
[12]Vimercati L,Gatti M F,Gagliardi T,et al.Environmental exposure to arsenic and chromium in an industrial area[J].Environmental Science&Pollution Research,2017,24(12):11528-11535
[13]中华人民共和国卫生部,中国国家标准化管理委员会.GB5749-2006生活饮用水卫生标准[S].北京:中国标准出版社,2006
[14]中华人民共和国生态环境部.《2017中国生态环境状况公报》[J].环境经济,2018(11):10-11
[15]彭湘莲,刘宗敏,刘云.湘江长沙段水中铅、镉、铬含量对淡水鱼的影响[J].食品与机械,2013,29(5):68-70,216Peng X L,Liu Z M,Liu Y.Effects of lead,cadmium,and chromium contents in Xiangjiang River on freshwater fish[J].Food&Machinery,2013,29(5):68-70,216(in Chinese)
[16]谢文平,陈昆慈,朱新平,等.珠江三角洲河网区水体及鱼体内重金属含量分析与评价[J].农业环境科学学报,2010,29(10):1917-1923Xie W P,Chen K C,Zhu X P,et al.Evaluation on heavy metal contents in water and fishes collected from the waterway in the Pearl River Delta,South China[J].Journal of Agro-Environment Science,2010,29(10):1917-1923(in Chinese)
[17]曹泉,王兴润.铬渣污染场地污染状况研究与修复技术分析[J].环境工程学报,2009,8(3):1493-1497Cao Q,Wang X R.Study on pollution characteristics of contaminated sites with chrome and discussion on common remediation technologies[J].Chinese Journal of Environmental Engineering,2009,8(3):1493-1497(in Chinese)
[18]金宁.药用胶囊铬超标[J].晚霞,2012,10:29
[19]Hong S,Brocato J,Costa M.Oral chromium exposure and toxicity[J].Current Environmental Health Reports,2015,2(3):295-303
[20]Salhen K A.Assessment of oxidative stress,haematological,kidney and liver function parameters of libyan cement factory workers[J].Journal of American Science,2014,10(5):58-65
[21]Kirman C R,Aylward L L,Suh M,et al.Physiologically based pharmacokinetic model for humans orally exposed to chromium[J].Chemico-Biological Interactions,2013,204(1):13-27
[22]王道贤.镁铬质作业工人肝肿大的调查[J].职业卫生与病伤,2000,15(3):188
[23]冯文艇,王薇,周金鹏,等.深圳市某化工厂铬酸盐暴露对工人的健康的影响[J].职业与健康,2015,31(16):2186-2190Feng W T,Wang W,Zhou J P,et al.Effect of chromate exposure on health of workers in a chemical plant of Shenzhen City[J].Occupation and Health,2015,31(16):2186-2190(in Chinese)
[24]童振,张春玲.职业性接铬者肝脏毒性损害的研究[J].安全、健康和环境,2003,3(3):21
[25]李丹,柳晓琳.六价铬污染地下水和重铬酸钾染毒对小鼠肝脏和血糖的影响及维生素C的干预作用[J].环境与健康杂志,2012,29(8):714-717Li D,Liu X L.The effect of the hexavalent chromiumpolluted groundwater and potassium dichromate exposure on the blood glucose and livers of the mice as well as the antagonistic action of vitamin C[J].Journal of Environment and Health,2012,29(8):714-717(in Chinese)
[26]Das Neves R P,Santos T M,Pereira M de L,et al.Comparative histological studies on liver of mice exposed to Cr(Ⅵ)and Cr(Ⅴ)compounds[J].Human&Experimental Toxicology,2002,21(7):365-369
[27]考庆君,吴坤,邓晶,等.三价铬和六价铬对大鼠长期慢性毒性的比较[J].癌变·畸变·突变,2007,19(6):474-478Kao Q J,Wu K,Deng J,et al.The chronic toxic effects of trivalent chromium and hexavalent chromium on rats[J].Carcinogenesis,Teratogenesis&Mutagenesis,2007,19(6):474-478(in Chinese)
[28]付婧,刘燕群,熊旭,等.重铬酸钾对昆明小鼠肝肾毒性的影响[J].现代医药卫生,2015,31(21):3230-3234Fu J,Liu Y Q,Xiong X,et al.Toxic effect of potassium bichromate on liver and kidney in Kunming mice[J].Journal of Modern Medicine&Health,2015,31(21):3230-3234(in Chinese)
[29]Velma V,Tchounwou P B.Chromium induced biochemical,genotoxic and histopathologic effects in liver and kidney of Goldfish,Carassius auratus[J].Mutation ResearchGenetic Toxicology and Environmental Mutagenesis,2010,698(1-2):43-51
[30]王心如,邱清徐,徐锡坤,等.铬铁生产工人的职业危害调查与早期生物学监测[J].卫生研究,1996,25(6):321-324Wang X R,Qiu Q X,Xu X K,et al.Investigation on occupational hazards among ferrochromium-producing workers and early biological monitoring[J].Journal of Hygiene Research,1996,25(6):321-324(in Chinese)
[31]王彦,徐波,耿盈.156名铬作业人员职业健康状况调查[J].中国现代药物应用,2014,8(13):251-252
[32]刘瑛,李溥,黎从飞,等.职业接触铬盐导致血清酶活力的变化[J].工业卫生与职业病,2010,36(6):337-340Liu Y,Li P,Li C F,et al.Study on serum enzyme activity changes in workers occupationally exposed to chromate[J].Industrial Health and Occupational Diseases,2010,36(6):337-340(in Chinese)
[33]García-Ni1o W R,Zatarain-Barrón Z L,Hernández-Pando R,et al.Oxidative stress markers and histological analysis in diverse organs from rats treated with a hepatotoxic dose of Cr(Ⅵ):Effect of curcumin[J].Biological Trace Element Research,2015,167(1):130-145
[34]Najafi M,Roustazadeh A,Moshtaghie A A,et al.Liver aspartate transaminase isoenzymes as biomarkers of chronic exposure to chromium(Ⅵ)[J].Arh Hig Rada Toksikol,2013,64(4):547-552
[35]Liu Y,Ding J,Lu X,et al.Study on the DNA-protein crosslinks induced by chromium(Ⅵ)in SPC-A1[J].IOPConference Series-Earth and Environmental Science,2018,108:042096
[36]Cupo D Y,Wetterhahn K E.Binding of chromium to chromatin and DNA from liver and kidney of rats treated with sodium dichromate and chromium(Ⅲ)chloride in vivo[J].Cancer Research,1985,45(3):1146-1151
[37]Elshazly M O,Ashraf M,Morgan B,et al.The mitigative effect of Raphanus sativus oil on chromium-induced genoand hepatotoxicity in male rats[J].Journal of Advanced Research,2016,7(3):413-421
[38]Bagchi D,Hassoun E A,Bagchi M,et al.Oxidative stress induced by chronic administration of sodium dichromate[Cr(Ⅵ)]to rats[J].Comparative Biochemistry and Physiology C-Pharmacology Toxicology&Endocrinology,1995,110(3):281-287
[39]Marouani N,Tebourbi O,Mokni M,et al.Hexavalent chromium-induced apoptosis in rat uterus:Involvement of oxidative stress[J].Archives of Environmental&Occupational Health,2015,70(4):189-195
[40]Chen H,Guo Z,Zhou Y,et al.Accumulation,depuration dynamics and effects of dissolved hexavalent chromium in juvenile Japanese medaka(Oryzias latipes)[J].Ecotoxicology and Environmental Safety,2018,148:254-260
[41]Chen L,Zhang J,Zhu Y,et al.Interaction of chromium(Ⅲ)or chromium(Ⅵ)with catalase and its effect on the structure and function of catalase:An in vitro study[J].Food Chemistry,2017,244:378
[42]Liu K J,Shi X L.In vivo reduction of chromium(Ⅵ)and its related free radical generation[J].Molecular and Cellular Biochemistry,2001,222(1-2):41-47
[43]Susa N,Ueno S,Furukawa Y,et al.Induction of lipid peroxidation in mice by hexavalent chromium and its relation to the toxicity[J].Nippon Juigaku Zasshi,1989,51(6):1103-1110
[44]Huang Y L,Chen C Y,Shell J Y,et al.Lipid peroxidation in workers exposed to hexavalent chromium[J].Journal of Toxicology and Environmental Health-Part A,1999,56(5):235-247
[45]张西旗,李奇,林荔军,等.慢性微量铬暴露对小鼠肝细胞氧化应激的影响[J].南方医科大学学报,2012,32(7):1031-1036Zhang X Q,Li Q,Lin L J,et al.Chronic exposure to trace chromium induces oxidative stress in mouse liver cells[J].Journal of Southern Medical University,2012,32(7):1031-1036(in Chinese)
[46]Michael S M,Christine E B,William E D,et al.Temporal changes in rat liver gene expression after acute cadmium and chromium exposure[J].PLOS ONE,2015,10(5):1-27
[47]Anita K P,Constance B,Diahanna H,et al.Potassium dichromate induced cytotoxicity,genotoxicity and oxidative stress in human liver carcinoma(HepG2)cells[J].International Journal of Environmental Research and Public Health,2009,6(2):643-653
[48]Bo爧gelmez I,S9ylemezogˇlu T,Güvendik G.The protective and antidotal effects of taurine on hexavalent chromium-induced oxidative stress in mice liver tissue[J].Biological Trace Element Research,2008,125(1):46-58
[49]Ipek Bo爧gelmez I,Güvendik G.N-acetyl-L-cysteine protects liver and kidney against chromium(Ⅵ)-induced oxidative stress in mice[J].Biological Trace Element Research,2017,178(1):44-53
[50]Marouani N,Tebourbi O,Hallègue D,et al.Mechanisms of chromium hexavalent-induced apoptosis in testis rats[J].Toxicology&Industrial Health,2015,33(2):97
[51]王晓峰,傅文宇,朱欣,等.六价铬对大鼠肝细胞体外的毒作用[J].癌变·畸变·突变,2005,17(6):343Wang X F,Fu W Y,Zhu X,et al.Cytotoxicity of hexavalent chromium to rat hepatocytes in vitro[J].Carcinogenesis,Teratogenesis and Mutagenesis,2005,17(6):343(in Chinese)
[52]Green D R,Reed J C.Mitochondria and apoptosis[J].Science,1998,281(5381):1309-1312
[53]Shadel G S,Horvath T L.Mitochondrial ROS signaling in organismal homeostasis[J].Cell,2015,163(3):560-569
[54]Zhong X,Zhong C.Mitochondrial biogenesis in response to chromium(Ⅵ)toxicity in human livercells[J].International Journal of Molecular Sciences,2017,18(9):1877
[55]Hayashi Y,Kondo T,Zhao Q L,et al.Signal transduction of p53 independent apoptotic pathway induced by hexavalent chromium in U937 cells[J].Toxicology and Applied Pharmacology,2004,197(2):96-106
[56]王晓峰,徐立红.Cr(Ⅵ)染毒对小鼠肝脏细胞凋亡以及凋亡相关蛋白的影响[J].环境科学学报,2008,28(3):540-543Wang X F,Xu L H.Exposure to Cr(Ⅵ)leads to increased apoptosis and concomitant changes of apoptosis-related proteins in mice liver[J].Acta Scientiae Circumstantiae,2008,28(3):540-543(in Chinese)
[57]张洪霞,钟才高,徐顺清,等.Cr(Ⅵ)诱导肝细胞凋亡与氧化损伤、p53和半胱氨酸天冬氨酸蛋白酶3表达的关系[J].中国药理学与毒理学杂志,2006,20(2):144-151Zhang H X,Zhong C G,Xu S Q,et al.Relationships of hexavalent chromium(Ⅵ)-induced apoptosis,oxidative damage and expressions of p53 and caspase 3 in L-02hepatocytes[J].Chinese Journal of Pharmacology and Toxicology,2006,20(2):144-151(in Chinese)
[58]Zeng M,Xiao F,Zhong X,et al.Reactive oxygen species play a central role in hexavalent chromium-induced apoptosis in Hep3B cells without the functional roles of p53and caspase-3[J].Cellular Physiology and Biochemistry,2013,32(2):279-290
[59]肖经纬,钟才高,李斌.六价铬诱导L-02肝细胞凋亡与线粒体功能损伤的关系研究[J].卫生研究,2006,35(4):416-418Xiao J W,Zhong C G,Li B,et al.Study of L-02 hepatocyte apoptosis induced by hexavalent chromium associated with mitochondria function damage[J].Journal of Hygiene Research,2006,35(4):416-418(in Chinese)
[60]Xie Y,Zhong C,Zeng M,et al.Effect of hexavalent chromium on electron leakage of respiratory chain in mitochondria isolated from rat liver[J].Cellular Physiology and Biochemistry,2013,31(2-3):473-485
[61]Yang Y,Zen M,Hu G H,et al.Cr(Ⅵ)induces the decrease of ATP level and the increase of apoptosis rate mediated by ROS or VDAC1 in L-02 hepatocytes[J].Environmental Toxicology and Pharmacology,2012,34(2):579-587
[62]周晓昕,张玉静,肖芳,等.六价铬诱导的肝细胞线粒体依赖性凋亡中VDAC1的作用[J].生态毒理学报,2017,12(6):91-98Zhou X X,Zhang Y J,Xiao F,et al.The effect of VDAC1 on Cr(Ⅵ)-induced mitochondria-dependent apoptosis in L02 hepatocytes[J].Asian Journal of Ecotoxicology,2017,12(6):91-98(in Chinese)
[63]Zhang Y,Xiao F,Liu X,et al.Cr(Ⅵ)induces cytotoxicity in vitro through activation of ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction via the PI3K/Akt signaling pathway[J].Toxicology in Vitro,2017,41:232-244
[64]朱武晖,王曼.线粒体损伤拮抗剂在Cr(Ⅵ)所致肝细胞凋亡中的保护作用[J].中国现代药物应用,2017,11(15):193-194Zhu W H,Wang M.Protective effects of mitochondrial damage antagonists on hepatocellular apoptosis induced by Cr(Ⅵ)[J].Chinese Journal of Modern Drug Application,2017,11(15):193-194(in Chinese)
[65]Bagur R,Hajnóczky G.Intracellular Ca2+,sensing:Its role in calcium homeostasis and signaling[J].Molecular Cell,2017,66(6):780-788
[66]Yi X,Zhang Y,Zhong C,et al.The role of STIM1 in the Cr(Ⅵ)-induced[Ca2+]increase and cell injury in L-02hepatocytes[J].Metallomics,2016,8(12):1273-1282
[67]Yi X,Xiao F,Zhong X,et al.A Ca2+chelator ameliorates chromium(Ⅵ)-induced hepatocyte L-02 injury via downregulation of voltage-dependent anion channel 1(VDAC1)expression[J].Environmental Toxicology and Pharmacology,2017,49:27-33
[68]Zhong X,Yi X,da Silveira E,et al.Co Q10 deficiency may indicate mitochondrial dysfunction in Cr(Ⅵ)toxicity[J].International Journal of Molecular Science,2017,18(4):1-20
[2]Panchal S K,Wanyonyi S,Brown L.Selenium,vanadium,and chromium as micronutrients to improve metabolic syndrome[J].Current Hypertension Reports,2017,19(3):10
[3]Xiao F,Feng X,Zeng M,et al.Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes[J].Molecular and Cellular Biochemistry,2012,371(1-2):65-76
[4]仪民,仪慧兰,吴丽华.铬在小鼠体内的蓄积效应与毒性[J].生态毒理学报,2017,12(6):259-265Yi M,Yi H L,Wu L H.Accumulation and toxicity of hexavalent chromium in mice[J].Asian Journal of Ecotoxicology,2017,12(6):259-265(in Chinese)
[5]Proctor D M,Suh M,Campleman S L,et al.Assessment of the mode of action for hexavalent chromium-induced lung cancer following inhalation exposures[J].Toxicology,2014,325(6):160-179
[6]Yoshinaga M,Ninomiya H,Al Hossain M M A,et al.Acomprehensive study including monitoring,assessment of health effects and development of a remediation method for chromium pollution[J].Chemosphere,2018,201:667-675
[7]Keane M,Siert A,Stone S,et al.Profiling stainless steel welding processes to reduce fume emissions,hexavalent chromium emissions and operating costs in the workplace[J].Journal Occupational Environmental Hyginen,2016,13(1):1-8
[8]Remy L L,Byers V,Clay T.Reproductive outcomes after non-occupational exposure to hexavalent chromium,Willits California,1983-2014[J].Environmental Health,2017,16(1):18
[9]Eleftheriou E P,Adamakis I S,Melissa P.Effects of hexavalent chromium on microtubule organization,ER distribution and callose deposition in root tip cells of Allium cepa[J].Protoplasma,2012,249:401-416
[10]徐衍忠,秦绪娜,刘祥红,等.铬污染及其生态效应[J].环境科学与技术,2002,25(增刊):8-10Xu Y Z,Qin X N,Liu X H,et al.The study of chromium pollution and ecological effects[J].Environmental Science and Technology,2002,25(S1):8-10(in Chinese)
[11]Lee P K,Yu S,Chang H J,et al.Lead chromate detected as a source of atmospheric Pb and Cr(Ⅵ)pollution[J].Scientific Reports,2016,6:36088
[12]Vimercati L,Gatti M F,Gagliardi T,et al.Environmental exposure to arsenic and chromium in an industrial area[J].Environmental Science&Pollution Research,2017,24(12):11528-11535
[13]中华人民共和国卫生部,中国国家标准化管理委员会.GB5749-2006生活饮用水卫生标准[S].北京:中国标准出版社,2006
[14]中华人民共和国生态环境部.《2017中国生态环境状况公报》[J].环境经济,2018(11):10-11
[15]彭湘莲,刘宗敏,刘云.湘江长沙段水中铅、镉、铬含量对淡水鱼的影响[J].食品与机械,2013,29(5):68-70,216Peng X L,Liu Z M,Liu Y.Effects of lead,cadmium,and chromium contents in Xiangjiang River on freshwater fish[J].Food&Machinery,2013,29(5):68-70,216(in Chinese)
[16]谢文平,陈昆慈,朱新平,等.珠江三角洲河网区水体及鱼体内重金属含量分析与评价[J].农业环境科学学报,2010,29(10):1917-1923Xie W P,Chen K C,Zhu X P,et al.Evaluation on heavy metal contents in water and fishes collected from the waterway in the Pearl River Delta,South China[J].Journal of Agro-Environment Science,2010,29(10):1917-1923(in Chinese)
[17]曹泉,王兴润.铬渣污染场地污染状况研究与修复技术分析[J].环境工程学报,2009,8(3):1493-1497Cao Q,Wang X R.Study on pollution characteristics of contaminated sites with chrome and discussion on common remediation technologies[J].Chinese Journal of Environmental Engineering,2009,8(3):1493-1497(in Chinese)
[18]金宁.药用胶囊铬超标[J].晚霞,2012,10:29
[19]Hong S,Brocato J,Costa M.Oral chromium exposure and toxicity[J].Current Environmental Health Reports,2015,2(3):295-303
[20]Salhen K A.Assessment of oxidative stress,haematological,kidney and liver function parameters of libyan cement factory workers[J].Journal of American Science,2014,10(5):58-65
[21]Kirman C R,Aylward L L,Suh M,et al.Physiologically based pharmacokinetic model for humans orally exposed to chromium[J].Chemico-Biological Interactions,2013,204(1):13-27
[22]王道贤.镁铬质作业工人肝肿大的调查[J].职业卫生与病伤,2000,15(3):188
[23]冯文艇,王薇,周金鹏,等.深圳市某化工厂铬酸盐暴露对工人的健康的影响[J].职业与健康,2015,31(16):2186-2190Feng W T,Wang W,Zhou J P,et al.Effect of chromate exposure on health of workers in a chemical plant of Shenzhen City[J].Occupation and Health,2015,31(16):2186-2190(in Chinese)
[24]童振,张春玲.职业性接铬者肝脏毒性损害的研究[J].安全、健康和环境,2003,3(3):21
[25]李丹,柳晓琳.六价铬污染地下水和重铬酸钾染毒对小鼠肝脏和血糖的影响及维生素C的干预作用[J].环境与健康杂志,2012,29(8):714-717Li D,Liu X L.The effect of the hexavalent chromiumpolluted groundwater and potassium dichromate exposure on the blood glucose and livers of the mice as well as the antagonistic action of vitamin C[J].Journal of Environment and Health,2012,29(8):714-717(in Chinese)
[26]Das Neves R P,Santos T M,Pereira M de L,et al.Comparative histological studies on liver of mice exposed to Cr(Ⅵ)and Cr(Ⅴ)compounds[J].Human&Experimental Toxicology,2002,21(7):365-369
[27]考庆君,吴坤,邓晶,等.三价铬和六价铬对大鼠长期慢性毒性的比较[J].癌变·畸变·突变,2007,19(6):474-478Kao Q J,Wu K,Deng J,et al.The chronic toxic effects of trivalent chromium and hexavalent chromium on rats[J].Carcinogenesis,Teratogenesis&Mutagenesis,2007,19(6):474-478(in Chinese)
[28]付婧,刘燕群,熊旭,等.重铬酸钾对昆明小鼠肝肾毒性的影响[J].现代医药卫生,2015,31(21):3230-3234Fu J,Liu Y Q,Xiong X,et al.Toxic effect of potassium bichromate on liver and kidney in Kunming mice[J].Journal of Modern Medicine&Health,2015,31(21):3230-3234(in Chinese)
[29]Velma V,Tchounwou P B.Chromium induced biochemical,genotoxic and histopathologic effects in liver and kidney of Goldfish,Carassius auratus[J].Mutation ResearchGenetic Toxicology and Environmental Mutagenesis,2010,698(1-2):43-51
[30]王心如,邱清徐,徐锡坤,等.铬铁生产工人的职业危害调查与早期生物学监测[J].卫生研究,1996,25(6):321-324Wang X R,Qiu Q X,Xu X K,et al.Investigation on occupational hazards among ferrochromium-producing workers and early biological monitoring[J].Journal of Hygiene Research,1996,25(6):321-324(in Chinese)
[31]王彦,徐波,耿盈.156名铬作业人员职业健康状况调查[J].中国现代药物应用,2014,8(13):251-252
[32]刘瑛,李溥,黎从飞,等.职业接触铬盐导致血清酶活力的变化[J].工业卫生与职业病,2010,36(6):337-340Liu Y,Li P,Li C F,et al.Study on serum enzyme activity changes in workers occupationally exposed to chromate[J].Industrial Health and Occupational Diseases,2010,36(6):337-340(in Chinese)
[33]García-Ni1o W R,Zatarain-Barrón Z L,Hernández-Pando R,et al.Oxidative stress markers and histological analysis in diverse organs from rats treated with a hepatotoxic dose of Cr(Ⅵ):Effect of curcumin[J].Biological Trace Element Research,2015,167(1):130-145
[34]Najafi M,Roustazadeh A,Moshtaghie A A,et al.Liver aspartate transaminase isoenzymes as biomarkers of chronic exposure to chromium(Ⅵ)[J].Arh Hig Rada Toksikol,2013,64(4):547-552
[35]Liu Y,Ding J,Lu X,et al.Study on the DNA-protein crosslinks induced by chromium(Ⅵ)in SPC-A1[J].IOPConference Series-Earth and Environmental Science,2018,108:042096
[36]Cupo D Y,Wetterhahn K E.Binding of chromium to chromatin and DNA from liver and kidney of rats treated with sodium dichromate and chromium(Ⅲ)chloride in vivo[J].Cancer Research,1985,45(3):1146-1151
[37]Elshazly M O,Ashraf M,Morgan B,et al.The mitigative effect of Raphanus sativus oil on chromium-induced genoand hepatotoxicity in male rats[J].Journal of Advanced Research,2016,7(3):413-421
[38]Bagchi D,Hassoun E A,Bagchi M,et al.Oxidative stress induced by chronic administration of sodium dichromate[Cr(Ⅵ)]to rats[J].Comparative Biochemistry and Physiology C-Pharmacology Toxicology&Endocrinology,1995,110(3):281-287
[39]Marouani N,Tebourbi O,Mokni M,et al.Hexavalent chromium-induced apoptosis in rat uterus:Involvement of oxidative stress[J].Archives of Environmental&Occupational Health,2015,70(4):189-195
[40]Chen H,Guo Z,Zhou Y,et al.Accumulation,depuration dynamics and effects of dissolved hexavalent chromium in juvenile Japanese medaka(Oryzias latipes)[J].Ecotoxicology and Environmental Safety,2018,148:254-260
[41]Chen L,Zhang J,Zhu Y,et al.Interaction of chromium(Ⅲ)or chromium(Ⅵ)with catalase and its effect on the structure and function of catalase:An in vitro study[J].Food Chemistry,2017,244:378
[42]Liu K J,Shi X L.In vivo reduction of chromium(Ⅵ)and its related free radical generation[J].Molecular and Cellular Biochemistry,2001,222(1-2):41-47
[43]Susa N,Ueno S,Furukawa Y,et al.Induction of lipid peroxidation in mice by hexavalent chromium and its relation to the toxicity[J].Nippon Juigaku Zasshi,1989,51(6):1103-1110
[44]Huang Y L,Chen C Y,Shell J Y,et al.Lipid peroxidation in workers exposed to hexavalent chromium[J].Journal of Toxicology and Environmental Health-Part A,1999,56(5):235-247
[45]张西旗,李奇,林荔军,等.慢性微量铬暴露对小鼠肝细胞氧化应激的影响[J].南方医科大学学报,2012,32(7):1031-1036Zhang X Q,Li Q,Lin L J,et al.Chronic exposure to trace chromium induces oxidative stress in mouse liver cells[J].Journal of Southern Medical University,2012,32(7):1031-1036(in Chinese)
[46]Michael S M,Christine E B,William E D,et al.Temporal changes in rat liver gene expression after acute cadmium and chromium exposure[J].PLOS ONE,2015,10(5):1-27
[47]Anita K P,Constance B,Diahanna H,et al.Potassium dichromate induced cytotoxicity,genotoxicity and oxidative stress in human liver carcinoma(HepG2)cells[J].International Journal of Environmental Research and Public Health,2009,6(2):643-653
[48]Bo爧gelmez I,S9ylemezogˇlu T,Güvendik G.The protective and antidotal effects of taurine on hexavalent chromium-induced oxidative stress in mice liver tissue[J].Biological Trace Element Research,2008,125(1):46-58
[49]Ipek Bo爧gelmez I,Güvendik G.N-acetyl-L-cysteine protects liver and kidney against chromium(Ⅵ)-induced oxidative stress in mice[J].Biological Trace Element Research,2017,178(1):44-53
[50]Marouani N,Tebourbi O,Hallègue D,et al.Mechanisms of chromium hexavalent-induced apoptosis in testis rats[J].Toxicology&Industrial Health,2015,33(2):97
[51]王晓峰,傅文宇,朱欣,等.六价铬对大鼠肝细胞体外的毒作用[J].癌变·畸变·突变,2005,17(6):343Wang X F,Fu W Y,Zhu X,et al.Cytotoxicity of hexavalent chromium to rat hepatocytes in vitro[J].Carcinogenesis,Teratogenesis and Mutagenesis,2005,17(6):343(in Chinese)
[52]Green D R,Reed J C.Mitochondria and apoptosis[J].Science,1998,281(5381):1309-1312
[53]Shadel G S,Horvath T L.Mitochondrial ROS signaling in organismal homeostasis[J].Cell,2015,163(3):560-569
[54]Zhong X,Zhong C.Mitochondrial biogenesis in response to chromium(Ⅵ)toxicity in human livercells[J].International Journal of Molecular Sciences,2017,18(9):1877
[55]Hayashi Y,Kondo T,Zhao Q L,et al.Signal transduction of p53 independent apoptotic pathway induced by hexavalent chromium in U937 cells[J].Toxicology and Applied Pharmacology,2004,197(2):96-106
[56]王晓峰,徐立红.Cr(Ⅵ)染毒对小鼠肝脏细胞凋亡以及凋亡相关蛋白的影响[J].环境科学学报,2008,28(3):540-543Wang X F,Xu L H.Exposure to Cr(Ⅵ)leads to increased apoptosis and concomitant changes of apoptosis-related proteins in mice liver[J].Acta Scientiae Circumstantiae,2008,28(3):540-543(in Chinese)
[57]张洪霞,钟才高,徐顺清,等.Cr(Ⅵ)诱导肝细胞凋亡与氧化损伤、p53和半胱氨酸天冬氨酸蛋白酶3表达的关系[J].中国药理学与毒理学杂志,2006,20(2):144-151Zhang H X,Zhong C G,Xu S Q,et al.Relationships of hexavalent chromium(Ⅵ)-induced apoptosis,oxidative damage and expressions of p53 and caspase 3 in L-02hepatocytes[J].Chinese Journal of Pharmacology and Toxicology,2006,20(2):144-151(in Chinese)
[58]Zeng M,Xiao F,Zhong X,et al.Reactive oxygen species play a central role in hexavalent chromium-induced apoptosis in Hep3B cells without the functional roles of p53and caspase-3[J].Cellular Physiology and Biochemistry,2013,32(2):279-290
[59]肖经纬,钟才高,李斌.六价铬诱导L-02肝细胞凋亡与线粒体功能损伤的关系研究[J].卫生研究,2006,35(4):416-418Xiao J W,Zhong C G,Li B,et al.Study of L-02 hepatocyte apoptosis induced by hexavalent chromium associated with mitochondria function damage[J].Journal of Hygiene Research,2006,35(4):416-418(in Chinese)
[60]Xie Y,Zhong C,Zeng M,et al.Effect of hexavalent chromium on electron leakage of respiratory chain in mitochondria isolated from rat liver[J].Cellular Physiology and Biochemistry,2013,31(2-3):473-485
[61]Yang Y,Zen M,Hu G H,et al.Cr(Ⅵ)induces the decrease of ATP level and the increase of apoptosis rate mediated by ROS or VDAC1 in L-02 hepatocytes[J].Environmental Toxicology and Pharmacology,2012,34(2):579-587
[62]周晓昕,张玉静,肖芳,等.六价铬诱导的肝细胞线粒体依赖性凋亡中VDAC1的作用[J].生态毒理学报,2017,12(6):91-98Zhou X X,Zhang Y J,Xiao F,et al.The effect of VDAC1 on Cr(Ⅵ)-induced mitochondria-dependent apoptosis in L02 hepatocytes[J].Asian Journal of Ecotoxicology,2017,12(6):91-98(in Chinese)
[63]Zhang Y,Xiao F,Liu X,et al.Cr(Ⅵ)induces cytotoxicity in vitro through activation of ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction via the PI3K/Akt signaling pathway[J].Toxicology in Vitro,2017,41:232-244
[64]朱武晖,王曼.线粒体损伤拮抗剂在Cr(Ⅵ)所致肝细胞凋亡中的保护作用[J].中国现代药物应用,2017,11(15):193-194Zhu W H,Wang M.Protective effects of mitochondrial damage antagonists on hepatocellular apoptosis induced by Cr(Ⅵ)[J].Chinese Journal of Modern Drug Application,2017,11(15):193-194(in Chinese)
[65]Bagur R,Hajnóczky G.Intracellular Ca2+,sensing:Its role in calcium homeostasis and signaling[J].Molecular Cell,2017,66(6):780-788
[66]Yi X,Zhang Y,Zhong C,et al.The role of STIM1 in the Cr(Ⅵ)-induced[Ca2+]increase and cell injury in L-02hepatocytes[J].Metallomics,2016,8(12):1273-1282
[67]Yi X,Xiao F,Zhong X,et al.A Ca2+chelator ameliorates chromium(Ⅵ)-induced hepatocyte L-02 injury via downregulation of voltage-dependent anion channel 1(VDAC1)expression[J].Environmental Toxicology and Pharmacology,2017,49:27-33
[68]Zhong X,Yi X,da Silveira E,et al.Co Q10 deficiency may indicate mitochondrial dysfunction in Cr(Ⅵ)toxicity[J].International Journal of Molecular Science,2017,18(4):1-20
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