异亮氨酸对鱼类非特异性免疫功能影响的研究进展
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摘要
异亮氨酸是鱼类的必需氨基酸,能增强鳃和肠道的物理屏障功能以及吞噬细胞的吞噬和杀菌能力,提高非特异性免疫因子的活性,促进抗炎因子表达,抑制促炎因子表达,发挥抗炎作用,进而增强非特异性免疫功能。本文就异亮氨酸对鱼类非特异性免疫功能的影响做一简要综述。
Isoleucine is an essential amino acid for fish,which can through enhancing the physical barrier function of gill and intestine,phagocytosis and bactericidal activity of phagocytes,increasing non-specific immune factor activities,promoting the expression of anti-inflammatory factors,inhibiting the expression of pro-inflammatory factors and playing an anti-inflammatory role to strengthen non-specific immune function. This article mainly aimed to reviewthe effects of isoleucine on non-specific immune function of fish.[Chinese Journal of Animal Nutrition,2019,31(7):3023-3030]
Isoleucine is an essential amino acid for fish,which can through enhancing the physical barrier function of gill and intestine,phagocytosis and bactericidal activity of phagocytes,increasing non-specific immune factor activities,promoting the expression of anti-inflammatory factors,inhibiting the expression of pro-inflammatory factors and playing an anti-inflammatory role to strengthen non-specific immune function. This article mainly aimed to reviewthe effects of isoleucine on non-specific immune function of fish.[Chinese Journal of Animal Nutrition,2019,31(7):3023-3030]
引文
[1] ZHU L Y,NIE L,ZHU G,et al.Advances in research of fish immune-relevant genes:a comparative overviewof innate and adaptive immunity in teleosts[J].Developmental&Comparative Immunology,2013,39(1/2):39-62.
[2] AZEREDO R,SERRA C R,OLIVA-TELES A,et al.Amino acids as modulators of the European seabass,Dicentrarchus labrax,innate immune response:an in vitro approach[J]. Scientific Reports,2017,7(1):18009.
[3] ZHAO J,FENG L,LIU Y,et al.Effect of dietary isoleucine on the immunity,antioxidant status,tight junctions and microflora in the intestine of juvenile Jian carp(Cyprinus carpio var. Jian)[J]. Fish&Shellfish Immunology,2014,41(2):663-673.
[4]黄忠,周传鹏,林黑着,等.饲料异亮氨酸水平对卵形鲳鲹消化酶活性和免疫指标的影响[J].南方水产科学,2017,13(1):50-57.
[5] ZHAO J,LIU Y,JIANG J,et al.Effects of dietary isoleucine on the immune response,antioxidant status and gene expression in the head kidney of juvenile Jian carp(Cyprinus carpio var. Jian)[J]. Fish&Shellfish Immunology,2013,35(2):572-580.
[6] FENG L,GAN L,JIANG W D,et al. Gill structural integrity changes in fish deficient or excessive in dietary isoleucine:towards the modulation of tight junction protein,inflammation,apoptosis and antioxidant defense via NF-κB,TOR and Nrf2 signaling pathways[J]. Fish&Shellfish Immunology,2017,63:127-138.
[7]王莉苹,姜志强,孙梦蕾,等.饲料中亮氨酸和异亮氨酸交互作用对牙鲆消化酶及免疫相关酶活力的影响[J].大连海洋大学学报,2017,32(3):287-293.
[8] RAHIMNEJAD S,LEE K J.Isoleucine effects on nonspecific immune response of juvenile olive flounder(Paralichthys olivaceus)[J].Fish&Shellfish Immunology,2013,34(6):1731-1732.
[9] ZHAO J,WU P,JIANG W D,et al. Preventive and reparative effects of isoleucine against copper-induced oxidative damage in primary fish enterocytes[J]. Fish Physiology and Biochemistry,2017,43(4):1021-1032.
[10]孙玉轩.吉富罗非鱼亮氨酸和异亮氨酸需求量的研究[D].硕士学位论文.重庆:西南大学,2014.
[11]王旭,周婧,薛晓强,等.牙鲆饲料中异亮氨酸与缬氨酸的交互作用对消化酶和部分免疫酶的影响[J].饲料工业,2018,39(20):23-28.
[12] XU J,WU P,JIANG W D,et al.Optimal dietary protein level improved growth,disease resistance,intestinal immune and physical barrier function of young grass carp(Ctenopharyngodon idella)[J]. Fish&Shellfish Immunology,2016,55:64-87.
[13] GAN L,JIANG W D,WU P,et al.Flesh quality loss in response to dietary isoleucine deficiency and excess in fish:a link to impaired Nrf2-dependent antioxidant defense in muscle[J]. PLoS One,2014,9(12):e115129.
[14] HUANG H M,OU H C,CHEN H L,et al.Protective effect ofα-keto-β-methyl-N-valeric acid on BV-2 microglia under hypoxia or oxidative stress[J].Annals of the NewYork Academy of Sciences,2005,1042(1):272-278.
[15] HUANG H M,ZHANG H,OU H C,et al.α-keto-β-methyl-N-valeric acid diminishes reactive oxygen species and alters endoplasmic reticulum Ca2+stores[J].Free Radical Biology and Medicine,2004,37(11):1779-1789.
[16] REISMAN S A,YEAGER R L,YAMAMOTO M,et al. Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species[J]. Toxicological Sciences,2009,108(1):35-47.
[17] SHAY K P,MICHELS A J,LI W G,et al.Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response[J]. Biochimica et Biophysica Acta:Molecular Cell Research,2012,1823(6):1102-1109.
[18] NIKLASSON L. Intestinal mucosal immunology of salmonids response to stress and infection and crosstalk with the physical barrier[D]. Ph. D. Thesis.Geoteborg:University of Gothenburg,2013.
[19] GU Y T,XUE Y X,WANG Y F,et al.Role of ROS/RhoA/PI3K/PKB signaling in NS1619-mediated blood-tumor barrier permeability increase[J]. Journal of Molecular Neuroscience,2012,48(1):302-312.
[20] GONZLEZ-MARISCAL L,TAPIA R,CHAMORRO D.Crosstalk of tight junction components with signaling pathways[J]. Biochimica et Biophysica Acta:Biomembranes,2008,1778(3):729-756.
[21] ZHAO J,LIU Y,JIANG J,et al.Effects of dietary isoleucine on growth,the digestion and absorption capacity and gene expression in hepatopancreas and intestine of juvenile Jian carp(Cyprinus carpio var. Jian)[J].Aquaculture,2012,368/369:117-128.
[22] DONG X Y,AZZAMMMM,ZOU X T.Effects of dietary L-isoleucine on laying performance and immunomodulation of laying hens[J]. Poultry Science,2016,95(10):2297-2305.
[23] GONZLEZ-MARISCAL L,DAZ-CORNGUEZ M,QUIRS M.Regulation of tight junctions for therapeutic advantages[M]//MARTIN T A,JIANG W G.Tight Junctions in cancer metastasis. Dordrecht:Springer,2013:197-246.
[24] ZHANG K,YAO H P,WANG MH. Activation of RON differentially regulates claudin expression and localization:role of claudin-1 in RON-mediated epithelial cell motility[J]. Carcinogenesis,2008,29(3):552-559.
[25] WU H L,GAO X,JIANG Z D,et al. Attenuated expression of the tight junction proteins is involved in clopidogrel-induced gastric injury through p38 MAPK activation[J].Toxicology,2013,304:41-48.
[26] KARCZEWSKI J,TROOST F J,KONINGS I,et al.Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier[J]. American Journal of Physiology:Gastrointestinal and Liver Physiology,2010,298(6):G851-G859.
[27] GMEZ G D,BALCZAR J L.A reviewon the interactions between gut microbiota and innate immunity of fish[J].FEMS Immunology&Medical Microbiology,2008,52(2):145-154.
[28] PETRO T M,BHATTACHARJEE J K.Effect of dietary essential amino acid limitations upon native levels of murine serum immunoglobulins,transferrin,and complement[J]. Infection and Immunity,1980,27(2):513-518.
[29] SUAREZCARMONA M,HUBERT P,DELVENNE P,et al.Defensins:“Simple”antimicrobial peptides or broad-spectrum molecules?[J]. Cytokine&Growth Factor Reviews,2015,26(3):361.
[30] FEHLBAUMP,RAO M,ZASLOFF M,et al. An essential amino acid induces epithelialβ-defensin expression[J]. Proceedings of the National Academy of Sciences of the United States of America,2000,97(23):12723-12728.
[31] MAO X B,QI S,YU B,et al. Zn2+and L-isoleucine induce the expressions of porcineβ-defensins in IPECJ2 cells[J].Molecular Biology Reports,2013,40(2):1547-1552.
[32]任曼,吕照勇,史凯,等.异亮氨酸对大鼠空肠形态和抗菌肽表达的影响[J].安徽科技学院学报,2016,30(4):6-10.
[33] RIVAS-SANTIAGO C E,RIVAS-SANTIAGO B,LEN D A,et al. Induction ofβ-defensins by L-isoleucine as novel immunotherapy in experimental murine tuberculosis[J]. Clinical&Experimental Immunology,2011,164(1):80-89.
[34] REN M,ZHANG S H,LIU X T,et al. Different lipopolysaccharide branched-chain amino acids modulate porcine intestinal endogenousβ-defensin expression through the Sirt1/ERK/90RSK pathway[J].Journal of Agricultural and Food Chemistry,2016,64(17):3371-3379.
[35] CHEN K,JIANG W D,WU P,et al.Effect of dietary phosphorus deficiency on the growth,immune function and structural integrity of head kidney,spleen and skin in young grass carp(Ctenopharyngodon idella)[J].Fish&Shellfish Immunology,2017,63:103-126.
[36] SECOMBES C J,WANG T,HONG S,et al.Cytokines and innate immunity of fish[J].Developmental&Comparative Immunology,2001,25(8/9):713-723.
[37] WEICHHART T,COSTANTINO G,POGLITSCH M,et al. The TSC-mTOR signaling pathway regulates the innate inflammatory response[J]. Immunity,2008,29(4):565-577.
[38] RYU J M,LEE MY,YUN S P,et al. High glucose regulates cyclin D1/E of human mesenchymal stem cells through TG F-β1expression via Ca2+/PKC/MAPKs and PI3K/Akt/mTOR signal pathways[J].Journal of Cellular Physiology,2010,224(1):59-70.
[39] CHEEKATLA S S,AGGARWAL A,NAIK S.mTOR signaling pathway regulates the IL-12/IL-10 axis in Leishmania donovani infection[J].Medical Microbiology and Immunology,2012,201(1):37-46.
[40] BROQUET A H,HIRATA Y,MCALLISTER C S,et al.RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium[J]. Journal of Immunology,2011,186(3):1618-1626.
[41] AKIRA S,TAKEDA K. Toll-like receptor signalling[J].Nature Reviews Immunology,2004,4(7):499-511.
[42] MAO X B,GU C S,REN M,et al. L-isoleucine administration alleviates rotavirus infection and immune response in the weaned piglet model[J]. Frontiers in Immunology,2018,9:1654.
[2] AZEREDO R,SERRA C R,OLIVA-TELES A,et al.Amino acids as modulators of the European seabass,Dicentrarchus labrax,innate immune response:an in vitro approach[J]. Scientific Reports,2017,7(1):18009.
[3] ZHAO J,FENG L,LIU Y,et al.Effect of dietary isoleucine on the immunity,antioxidant status,tight junctions and microflora in the intestine of juvenile Jian carp(Cyprinus carpio var. Jian)[J]. Fish&Shellfish Immunology,2014,41(2):663-673.
[4]黄忠,周传鹏,林黑着,等.饲料异亮氨酸水平对卵形鲳鲹消化酶活性和免疫指标的影响[J].南方水产科学,2017,13(1):50-57.
[5] ZHAO J,LIU Y,JIANG J,et al.Effects of dietary isoleucine on the immune response,antioxidant status and gene expression in the head kidney of juvenile Jian carp(Cyprinus carpio var. Jian)[J]. Fish&Shellfish Immunology,2013,35(2):572-580.
[6] FENG L,GAN L,JIANG W D,et al. Gill structural integrity changes in fish deficient or excessive in dietary isoleucine:towards the modulation of tight junction protein,inflammation,apoptosis and antioxidant defense via NF-κB,TOR and Nrf2 signaling pathways[J]. Fish&Shellfish Immunology,2017,63:127-138.
[7]王莉苹,姜志强,孙梦蕾,等.饲料中亮氨酸和异亮氨酸交互作用对牙鲆消化酶及免疫相关酶活力的影响[J].大连海洋大学学报,2017,32(3):287-293.
[8] RAHIMNEJAD S,LEE K J.Isoleucine effects on nonspecific immune response of juvenile olive flounder(Paralichthys olivaceus)[J].Fish&Shellfish Immunology,2013,34(6):1731-1732.
[9] ZHAO J,WU P,JIANG W D,et al. Preventive and reparative effects of isoleucine against copper-induced oxidative damage in primary fish enterocytes[J]. Fish Physiology and Biochemistry,2017,43(4):1021-1032.
[10]孙玉轩.吉富罗非鱼亮氨酸和异亮氨酸需求量的研究[D].硕士学位论文.重庆:西南大学,2014.
[11]王旭,周婧,薛晓强,等.牙鲆饲料中异亮氨酸与缬氨酸的交互作用对消化酶和部分免疫酶的影响[J].饲料工业,2018,39(20):23-28.
[12] XU J,WU P,JIANG W D,et al.Optimal dietary protein level improved growth,disease resistance,intestinal immune and physical barrier function of young grass carp(Ctenopharyngodon idella)[J]. Fish&Shellfish Immunology,2016,55:64-87.
[13] GAN L,JIANG W D,WU P,et al.Flesh quality loss in response to dietary isoleucine deficiency and excess in fish:a link to impaired Nrf2-dependent antioxidant defense in muscle[J]. PLoS One,2014,9(12):e115129.
[14] HUANG H M,OU H C,CHEN H L,et al.Protective effect ofα-keto-β-methyl-N-valeric acid on BV-2 microglia under hypoxia or oxidative stress[J].Annals of the NewYork Academy of Sciences,2005,1042(1):272-278.
[15] HUANG H M,ZHANG H,OU H C,et al.α-keto-β-methyl-N-valeric acid diminishes reactive oxygen species and alters endoplasmic reticulum Ca2+stores[J].Free Radical Biology and Medicine,2004,37(11):1779-1789.
[16] REISMAN S A,YEAGER R L,YAMAMOTO M,et al. Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species[J]. Toxicological Sciences,2009,108(1):35-47.
[17] SHAY K P,MICHELS A J,LI W G,et al.Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response[J]. Biochimica et Biophysica Acta:Molecular Cell Research,2012,1823(6):1102-1109.
[18] NIKLASSON L. Intestinal mucosal immunology of salmonids response to stress and infection and crosstalk with the physical barrier[D]. Ph. D. Thesis.Geoteborg:University of Gothenburg,2013.
[19] GU Y T,XUE Y X,WANG Y F,et al.Role of ROS/RhoA/PI3K/PKB signaling in NS1619-mediated blood-tumor barrier permeability increase[J]. Journal of Molecular Neuroscience,2012,48(1):302-312.
[20] GONZLEZ-MARISCAL L,TAPIA R,CHAMORRO D.Crosstalk of tight junction components with signaling pathways[J]. Biochimica et Biophysica Acta:Biomembranes,2008,1778(3):729-756.
[21] ZHAO J,LIU Y,JIANG J,et al.Effects of dietary isoleucine on growth,the digestion and absorption capacity and gene expression in hepatopancreas and intestine of juvenile Jian carp(Cyprinus carpio var. Jian)[J].Aquaculture,2012,368/369:117-128.
[22] DONG X Y,AZZAMMMM,ZOU X T.Effects of dietary L-isoleucine on laying performance and immunomodulation of laying hens[J]. Poultry Science,2016,95(10):2297-2305.
[23] GONZLEZ-MARISCAL L,DAZ-CORNGUEZ M,QUIRS M.Regulation of tight junctions for therapeutic advantages[M]//MARTIN T A,JIANG W G.Tight Junctions in cancer metastasis. Dordrecht:Springer,2013:197-246.
[24] ZHANG K,YAO H P,WANG MH. Activation of RON differentially regulates claudin expression and localization:role of claudin-1 in RON-mediated epithelial cell motility[J]. Carcinogenesis,2008,29(3):552-559.
[25] WU H L,GAO X,JIANG Z D,et al. Attenuated expression of the tight junction proteins is involved in clopidogrel-induced gastric injury through p38 MAPK activation[J].Toxicology,2013,304:41-48.
[26] KARCZEWSKI J,TROOST F J,KONINGS I,et al.Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier[J]. American Journal of Physiology:Gastrointestinal and Liver Physiology,2010,298(6):G851-G859.
[27] GMEZ G D,BALCZAR J L.A reviewon the interactions between gut microbiota and innate immunity of fish[J].FEMS Immunology&Medical Microbiology,2008,52(2):145-154.
[28] PETRO T M,BHATTACHARJEE J K.Effect of dietary essential amino acid limitations upon native levels of murine serum immunoglobulins,transferrin,and complement[J]. Infection and Immunity,1980,27(2):513-518.
[29] SUAREZCARMONA M,HUBERT P,DELVENNE P,et al.Defensins:“Simple”antimicrobial peptides or broad-spectrum molecules?[J]. Cytokine&Growth Factor Reviews,2015,26(3):361.
[30] FEHLBAUMP,RAO M,ZASLOFF M,et al. An essential amino acid induces epithelialβ-defensin expression[J]. Proceedings of the National Academy of Sciences of the United States of America,2000,97(23):12723-12728.
[31] MAO X B,QI S,YU B,et al. Zn2+and L-isoleucine induce the expressions of porcineβ-defensins in IPECJ2 cells[J].Molecular Biology Reports,2013,40(2):1547-1552.
[32]任曼,吕照勇,史凯,等.异亮氨酸对大鼠空肠形态和抗菌肽表达的影响[J].安徽科技学院学报,2016,30(4):6-10.
[33] RIVAS-SANTIAGO C E,RIVAS-SANTIAGO B,LEN D A,et al. Induction ofβ-defensins by L-isoleucine as novel immunotherapy in experimental murine tuberculosis[J]. Clinical&Experimental Immunology,2011,164(1):80-89.
[34] REN M,ZHANG S H,LIU X T,et al. Different lipopolysaccharide branched-chain amino acids modulate porcine intestinal endogenousβ-defensin expression through the Sirt1/ERK/90RSK pathway[J].Journal of Agricultural and Food Chemistry,2016,64(17):3371-3379.
[35] CHEN K,JIANG W D,WU P,et al.Effect of dietary phosphorus deficiency on the growth,immune function and structural integrity of head kidney,spleen and skin in young grass carp(Ctenopharyngodon idella)[J].Fish&Shellfish Immunology,2017,63:103-126.
[36] SECOMBES C J,WANG T,HONG S,et al.Cytokines and innate immunity of fish[J].Developmental&Comparative Immunology,2001,25(8/9):713-723.
[37] WEICHHART T,COSTANTINO G,POGLITSCH M,et al. The TSC-mTOR signaling pathway regulates the innate inflammatory response[J]. Immunity,2008,29(4):565-577.
[38] RYU J M,LEE MY,YUN S P,et al. High glucose regulates cyclin D1/E of human mesenchymal stem cells through TG F-β1expression via Ca2+/PKC/MAPKs and PI3K/Akt/mTOR signal pathways[J].Journal of Cellular Physiology,2010,224(1):59-70.
[39] CHEEKATLA S S,AGGARWAL A,NAIK S.mTOR signaling pathway regulates the IL-12/IL-10 axis in Leishmania donovani infection[J].Medical Microbiology and Immunology,2012,201(1):37-46.
[40] BROQUET A H,HIRATA Y,MCALLISTER C S,et al.RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium[J]. Journal of Immunology,2011,186(3):1618-1626.
[41] AKIRA S,TAKEDA K. Toll-like receptor signalling[J].Nature Reviews Immunology,2004,4(7):499-511.
[42] MAO X B,GU C S,REN M,et al. L-isoleucine administration alleviates rotavirus infection and immune response in the weaned piglet model[J]. Frontiers in Immunology,2018,9:1654.
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