抗生素-重金属复合污染对土壤中细菌耐药的影响
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摘要
目前复合污染环境下耐药细菌在数量、种类以及抗性强度上都显著增大,多重耐药菌株也高频率检出,甚至出现了能够抵抗绝大多数抗生素的"超级细菌",因此抗生素-重金属复合污染对环境中细菌耐药的影响更需高度重视。就我国土壤环境中抗生素-重金属复合污染的现状,对抗生素与重金属复合污染的对土壤微生物耐药效应研究进展进行了综述,并对该领域需要进一步研究的问题进行展望,对于消除环境中的微生物耐药性具有重要意义。
At present, the number, type and intensity of resistance of drug-resistant bacteria are significantly increased with the appearing of compound pollution. The multi-drug resistant strains are also detected at a high frequency, even "super-bacteria" that can resist most antibiotics emerged in the environment. Therefore, more attention should be paid to the effects of combined pollution of antibiotics and heavy metals on soil environment.Microbial resistance was reviewed based on the research on combined pollution of antibiotics and heavy metals in soil environment in China. The further research on the effects of antibiotic and heavy metals contamination was prospected,which would show important significance for eliminating bacterial resistance in the environment.
At present, the number, type and intensity of resistance of drug-resistant bacteria are significantly increased with the appearing of compound pollution. The multi-drug resistant strains are also detected at a high frequency, even "super-bacteria" that can resist most antibiotics emerged in the environment. Therefore, more attention should be paid to the effects of combined pollution of antibiotics and heavy metals on soil environment.Microbial resistance was reviewed based on the research on combined pollution of antibiotics and heavy metals in soil environment in China. The further research on the effects of antibiotic and heavy metals contamination was prospected,which would show important significance for eliminating bacterial resistance in the environment.
引文
[1] JI X, SHEN Q, LIU F, et al. Antibiotic resistance gene abundances associated with antibiotics and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai; China[J]. Journal of Hazardous Materials, 2012, 235-236.
[2] HE L Y, YING G G, LIU Y S, et al. Discharge of swine wastes risks water quality and food safety:Antibiotics and antibiotic resistance genes from swine sources to the receiving environments.[J].Environment International, 2016, s 92–93:210-219.
[3] FERNANDEZ CALVINO D, BAATH E. Co-selection for antibiotic tolerance in Cu-polluted soil is detected at higher Cuconcentrations than increased Cu-tolerance[J]. Soil Biology&Biochemistry, 2013, 57(3):953-956.
[4] XU Y, XU J, MAO D, et al. Effect of the selective pressure of sublethal level of heavy metals on the fate and distribution of ARGs in the catchment scale[J]. Environmental Pollution, 2016, 220(Pt B):900-908.
[5] MU Q, LI J, SUN Y, et al. Occurrence of sulfonamide-, tetracycline-,plasmid-mediated quinolone-and macrolide-resistance genes in livestock feedlots in Northern China[J].Environmental Science&Pollution Research, 2015, 22(9):6932-6940.
[6]张兰河,王佳佳,哈雪姣,等.北京地区菜田土壤抗生素抗性基因的分布特征[J].环境科学, 2016, 37(11):4395-4401.
[7] PAN M, CHU L M. Occurrence of antibiotics and antibiotic resistance genes in soils from wastewater irrigation areas in the Pearl River Delta region, southern China[J]. Science of the Total Environment,2017, 624:145-152.
[8] KNAPP C W, Mccluskey S M, Singh B K, et al. Antibiotic resistance gene abundances correlate with metal and geochemical conditions in Scottish soils[J]. Plos One, 2011, 6(11):1119-1119.
[9] KNAPP C W, Callan A C, Aitken B, et al. Relationship between antibiotic resistance genes and metals in residential soil samples from Western Australia[J]. Environmental Science and Pollution Research,2017, 24(3):2484-2494.
[10] GUO T, LOU C, ZHAI W, et al. Increased occurrence of heavy metals, antibiotics and resistance genes in surface soil after longterm application of manure[J]. Science of The Total Environment,2018, 635:995-1003.
[11] KONG W D, ZHU Y G, FU B J, et al. The veterinary antibiotic oxytetracycline and Cu influence functional diversity of the soil microbial community.[J]. Environmental Pollution, 2006, 143(1):0-137.
[12] HAMSCHER G, PAWELZICK H T, HOPER H, et al. Different behavior of tetracyclines and sulfonamides in sandy soils after repeated fertilization with liquid manure.[J]. Environmental Toxicology&Chemistry, 2005, 24(4):861-868.
[13] HOU J, WAN W, MAO D, et al. Occurrence and distribution of sulfonamides, tetracyclines, quinolones, macrolides, and nitrofurans in livestock manure and amended soils of Northern China[J].Environmental Science&Pollution Research International, 2015, 22(6):4545-4554.
[14]何良英.典型畜禽养殖环境中抗生素耐药基因的污染特征与扩散机理研究[D].中国科学院大学, 2016.
[15]邵云,郝真真,王文斐,等.土壤重金属污染现状及修复技术研究进展[J].北方园艺, 2016(17):193-196.
[16]陆安祥,孙江,王纪华,等.北京农田土壤重金属年际变化及其特征分析[J].中国农业科学, 2011, 44(18):3778-3789.
[17]王瑾,韩剑众.饲料中重金属和抗生素对土壤和蔬菜的影响[J].生态与农村环境学报, 2008, 24(4):90-93.
[18] WANG Y J, JIA D A, SUN R J, et al. Adsorption and Cosorption of Tetracycline and Copper(II)on Montmorillonite as Affected by Solution p H[J]. Environmental Science&Technology, 2008, 42(9):3254-3259.
[19]周启星,程云,张倩茹,等.复合污染生态毒理效应的定量关系分析[J].中国科学, 2003, 33(6):566-573.
[20] UDIKOVICKOLIC N, WICHMANN F, BRODERICK N A, et al.Bloom of resident antibiotic-resistant bacteria in soil following manure fertilization.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(42):15202-15207.
[21] YANG Q, WANG R, REN S, et al. Practical survey on antibioticresistant bacterial communities in livestock manure and manureamended soil[J]. Journal of Environmental Science&Health.part.b Pesticides Food Contaminants&Agricultural Wastes, 2016, 51(1):14-23.
[22] AKINBOWALE O L, PENG H, M. D. BARTON. Diversity of tetracycline resistance genes in bacteria from aquaculture sources in Australia[J]. Journal of Applied Microbiology, 2007, 103(5):2016-2025.
[23] TAN L, LI L, Ashbolt N, et al. Arctic antibiotic resistance gene contamination, a result of anthropogenic activities and natural origin[J]. Science of the Total Environment, 2018, 621:1176-1184.
[24] ALLEN H K, MOE L A, RODBUMRER J, et al. Functional metagenomics reveals diverse|[beta]|-lactamases in a remote Alaskan soil[J]. Isme Journal, 2009, 3(2):243-251.
[25] LIAO M, XIE X M. Effect of heavy metals on substrate utilization pattern, biomass, and activity of microbial communities in a reclaimed mining wasteland of red soil area.[J]. Ecotoxicology&Environmental Safety, 2007, 66(2):217-223.
[26]闫雷,毕世欣,赵启慧,等.土霉素及镉污染对土壤呼吸及酶活性的影响[J].水土保持通报, 2014, 34(6):101-108.
[27]刘爱菊,刘敏,李梦红,等. Cu、抗生素协同污染对土壤微生物活性的影响[J].生态环境学报, 2013,(11):1825-1829.
[28]魏子艳.土霉素、恩诺沙星、磺胺二甲嘧啶与铜单一及复合污染对土壤微生物的影响[D].山东农业大学, 2014.
[29] IGLESIA R D L, VALENZUELAHERDIA D, PAVISSICH J P, et al.Novel polymerase chain reaction primers for the specific detection of bacterial copper P-type ATPases gene sequences in environmental isolates and metagenomic DNA.[J]. Letters in Applied Microbiology,2010, 50(6):552-562.
[30] ZHANG F, ZHAO X, LI Q, et al. Bacterial community structure and abundances of antibiotic resistance genes in heavy metals contaminated agricultural soil.[J]. Environmental Science&Pollution Research International, 2018(1):1-9.
[31] SEILER C, BERENDONK T U. Heavy metal driven co-selection of antibiotic resistance in soil and water bodies impacted by agriculture and aquaculture[J]. Frontiers in Microbiology, 2012, 3(69):399-409.
[32] GRAHAM D W, OLIVARESRIEUMONT S, KNAPP C W, et al.Antibiotic Resistance Gene Abundances Associated with Waste Discharges to the Almendares River near Havana, Cuba[J].Environmental Science&Technology, 2011, 45(2):418-24.
[33] AAS S, YOUNESSI N. Antibiotic resistance of bacteria isolated from heavy metal-polluted soils with different land uses[J]. J Glob Antimicrob Resist, 2017, 10:247-255
[34] BERG J, THORSEN M K, HOLM P E, et al. Cu Exposure under Field Conditions Coselects for Antibiotic Resistance as Determined by a Novel Cultivation-Independent Bacterial Community Tolerance Assay[J]. Environmental Science&Technology, 2010, 44(22):8724-8728.
[35] ALONSO A, SANCHEZ P, MARTINEZ J L. Environmental selection of antibiotic resistance genes[J]. Environmental Microbiology, 2001, 3(1):1-9.
[36] HU H W, WANG J T, LI J, et al. Long-Term Nickel Contamination Increases the Occurrence of Antibiotic Resistance Genes in Agricultural Soils[J]. Environmental Science&Technology, 2017, 51(2):790-800.
[37] HE X, XU Y, CHEN J, et al. Evolution of corresponding resistance genes in the water of fish tanks with multiple stresses of antibiotics and heavy metals[J]. Water Research, 2017, 124:39-48.
[38] TOM PETERSEN A, LESER T D, MARSH T L, et al. Effects of copper amendment on the bacterial community in agricultural soil analyzed by the T-RFLP technique[J]. Fems Microbiology Ecology,2003, 46(1):53-62.
[39] RANJARD L, ECHAIRI A, NOWAK V, et al. Field and microcosm experiments to evaluate the effects of agricultural Cu treatment on the density and genetic structure of microbial communities in two different soils[J]. Fems Microbiology Ecology, 2006, 58(2):303-315.
[2] HE L Y, YING G G, LIU Y S, et al. Discharge of swine wastes risks water quality and food safety:Antibiotics and antibiotic resistance genes from swine sources to the receiving environments.[J].Environment International, 2016, s 92–93:210-219.
[3] FERNANDEZ CALVINO D, BAATH E. Co-selection for antibiotic tolerance in Cu-polluted soil is detected at higher Cuconcentrations than increased Cu-tolerance[J]. Soil Biology&Biochemistry, 2013, 57(3):953-956.
[4] XU Y, XU J, MAO D, et al. Effect of the selective pressure of sublethal level of heavy metals on the fate and distribution of ARGs in the catchment scale[J]. Environmental Pollution, 2016, 220(Pt B):900-908.
[5] MU Q, LI J, SUN Y, et al. Occurrence of sulfonamide-, tetracycline-,plasmid-mediated quinolone-and macrolide-resistance genes in livestock feedlots in Northern China[J].Environmental Science&Pollution Research, 2015, 22(9):6932-6940.
[6]张兰河,王佳佳,哈雪姣,等.北京地区菜田土壤抗生素抗性基因的分布特征[J].环境科学, 2016, 37(11):4395-4401.
[7] PAN M, CHU L M. Occurrence of antibiotics and antibiotic resistance genes in soils from wastewater irrigation areas in the Pearl River Delta region, southern China[J]. Science of the Total Environment,2017, 624:145-152.
[8] KNAPP C W, Mccluskey S M, Singh B K, et al. Antibiotic resistance gene abundances correlate with metal and geochemical conditions in Scottish soils[J]. Plos One, 2011, 6(11):1119-1119.
[9] KNAPP C W, Callan A C, Aitken B, et al. Relationship between antibiotic resistance genes and metals in residential soil samples from Western Australia[J]. Environmental Science and Pollution Research,2017, 24(3):2484-2494.
[10] GUO T, LOU C, ZHAI W, et al. Increased occurrence of heavy metals, antibiotics and resistance genes in surface soil after longterm application of manure[J]. Science of The Total Environment,2018, 635:995-1003.
[11] KONG W D, ZHU Y G, FU B J, et al. The veterinary antibiotic oxytetracycline and Cu influence functional diversity of the soil microbial community.[J]. Environmental Pollution, 2006, 143(1):0-137.
[12] HAMSCHER G, PAWELZICK H T, HOPER H, et al. Different behavior of tetracyclines and sulfonamides in sandy soils after repeated fertilization with liquid manure.[J]. Environmental Toxicology&Chemistry, 2005, 24(4):861-868.
[13] HOU J, WAN W, MAO D, et al. Occurrence and distribution of sulfonamides, tetracyclines, quinolones, macrolides, and nitrofurans in livestock manure and amended soils of Northern China[J].Environmental Science&Pollution Research International, 2015, 22(6):4545-4554.
[14]何良英.典型畜禽养殖环境中抗生素耐药基因的污染特征与扩散机理研究[D].中国科学院大学, 2016.
[15]邵云,郝真真,王文斐,等.土壤重金属污染现状及修复技术研究进展[J].北方园艺, 2016(17):193-196.
[16]陆安祥,孙江,王纪华,等.北京农田土壤重金属年际变化及其特征分析[J].中国农业科学, 2011, 44(18):3778-3789.
[17]王瑾,韩剑众.饲料中重金属和抗生素对土壤和蔬菜的影响[J].生态与农村环境学报, 2008, 24(4):90-93.
[18] WANG Y J, JIA D A, SUN R J, et al. Adsorption and Cosorption of Tetracycline and Copper(II)on Montmorillonite as Affected by Solution p H[J]. Environmental Science&Technology, 2008, 42(9):3254-3259.
[19]周启星,程云,张倩茹,等.复合污染生态毒理效应的定量关系分析[J].中国科学, 2003, 33(6):566-573.
[20] UDIKOVICKOLIC N, WICHMANN F, BRODERICK N A, et al.Bloom of resident antibiotic-resistant bacteria in soil following manure fertilization.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(42):15202-15207.
[21] YANG Q, WANG R, REN S, et al. Practical survey on antibioticresistant bacterial communities in livestock manure and manureamended soil[J]. Journal of Environmental Science&Health.part.b Pesticides Food Contaminants&Agricultural Wastes, 2016, 51(1):14-23.
[22] AKINBOWALE O L, PENG H, M. D. BARTON. Diversity of tetracycline resistance genes in bacteria from aquaculture sources in Australia[J]. Journal of Applied Microbiology, 2007, 103(5):2016-2025.
[23] TAN L, LI L, Ashbolt N, et al. Arctic antibiotic resistance gene contamination, a result of anthropogenic activities and natural origin[J]. Science of the Total Environment, 2018, 621:1176-1184.
[24] ALLEN H K, MOE L A, RODBUMRER J, et al. Functional metagenomics reveals diverse|[beta]|-lactamases in a remote Alaskan soil[J]. Isme Journal, 2009, 3(2):243-251.
[25] LIAO M, XIE X M. Effect of heavy metals on substrate utilization pattern, biomass, and activity of microbial communities in a reclaimed mining wasteland of red soil area.[J]. Ecotoxicology&Environmental Safety, 2007, 66(2):217-223.
[26]闫雷,毕世欣,赵启慧,等.土霉素及镉污染对土壤呼吸及酶活性的影响[J].水土保持通报, 2014, 34(6):101-108.
[27]刘爱菊,刘敏,李梦红,等. Cu、抗生素协同污染对土壤微生物活性的影响[J].生态环境学报, 2013,(11):1825-1829.
[28]魏子艳.土霉素、恩诺沙星、磺胺二甲嘧啶与铜单一及复合污染对土壤微生物的影响[D].山东农业大学, 2014.
[29] IGLESIA R D L, VALENZUELAHERDIA D, PAVISSICH J P, et al.Novel polymerase chain reaction primers for the specific detection of bacterial copper P-type ATPases gene sequences in environmental isolates and metagenomic DNA.[J]. Letters in Applied Microbiology,2010, 50(6):552-562.
[30] ZHANG F, ZHAO X, LI Q, et al. Bacterial community structure and abundances of antibiotic resistance genes in heavy metals contaminated agricultural soil.[J]. Environmental Science&Pollution Research International, 2018(1):1-9.
[31] SEILER C, BERENDONK T U. Heavy metal driven co-selection of antibiotic resistance in soil and water bodies impacted by agriculture and aquaculture[J]. Frontiers in Microbiology, 2012, 3(69):399-409.
[32] GRAHAM D W, OLIVARESRIEUMONT S, KNAPP C W, et al.Antibiotic Resistance Gene Abundances Associated with Waste Discharges to the Almendares River near Havana, Cuba[J].Environmental Science&Technology, 2011, 45(2):418-24.
[33] AAS S, YOUNESSI N. Antibiotic resistance of bacteria isolated from heavy metal-polluted soils with different land uses[J]. J Glob Antimicrob Resist, 2017, 10:247-255
[34] BERG J, THORSEN M K, HOLM P E, et al. Cu Exposure under Field Conditions Coselects for Antibiotic Resistance as Determined by a Novel Cultivation-Independent Bacterial Community Tolerance Assay[J]. Environmental Science&Technology, 2010, 44(22):8724-8728.
[35] ALONSO A, SANCHEZ P, MARTINEZ J L. Environmental selection of antibiotic resistance genes[J]. Environmental Microbiology, 2001, 3(1):1-9.
[36] HU H W, WANG J T, LI J, et al. Long-Term Nickel Contamination Increases the Occurrence of Antibiotic Resistance Genes in Agricultural Soils[J]. Environmental Science&Technology, 2017, 51(2):790-800.
[37] HE X, XU Y, CHEN J, et al. Evolution of corresponding resistance genes in the water of fish tanks with multiple stresses of antibiotics and heavy metals[J]. Water Research, 2017, 124:39-48.
[38] TOM PETERSEN A, LESER T D, MARSH T L, et al. Effects of copper amendment on the bacterial community in agricultural soil analyzed by the T-RFLP technique[J]. Fems Microbiology Ecology,2003, 46(1):53-62.
[39] RANJARD L, ECHAIRI A, NOWAK V, et al. Field and microcosm experiments to evaluate the effects of agricultural Cu treatment on the density and genetic structure of microbial communities in two different soils[J]. Fems Microbiology Ecology, 2006, 58(2):303-315.
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