血小板反应蛋白在突触形成中的作用及机制研究进展
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摘要
目的对近年来血小板反应蛋白(thrombospondins,TSPs)在中枢神经系统(central nervous system,CNS)突触形成中的作用及机制进行综述。方法广泛查阅近年来与TSPs在CNS突触形成中有关的国内外文献,对TSPs结构特征、在CNS疾病中的作用及发生机制进行综述。结果 TSPs作为一种寡聚糖蛋白,在血管生成、炎症、成骨、细胞增殖和细胞凋亡等方面具有重要作用。在神经系统中,TSPs与电压依赖性钙通道、神经连接蛋白以及其他细胞外基质蛋白和细胞表面受体结合,参与和调节CNS中突触的形成、成熟以及功能等多个过程。结论 TSPs作为一种寡聚细胞外基质蛋白,在突触形成、CNS损伤后突触修复等方面发挥重要作用。
Objective To review the recent progress in the role of thrombospondins(TSPs) in synapse formation in the central nervous system(CNS). Methods A wide range of domestic and foreign literature on the role of TSPs in the synapse formation of the CNS was reviewed. The role of TSPs in structural features, molecules, and related diseases was reviewed. Results As an oligosaccharide protein, TSPs play important roles in angiogenesis, inflammation, osteogenesis,cell proliferation, and apoptosis. In the nervous system, they bind to voltage-dependent calcium channels, neuronectin,and other extracellular matrix proteins and cell surface receptors, and participate in and regulate multiple processes such as synapse formation, maturation, and function in the CNS. Conclusion TSPs as an oligomeric extracellular matrix protein play an important role in the formation of synapses and the repair of synapses after CNS injury.
Objective To review the recent progress in the role of thrombospondins(TSPs) in synapse formation in the central nervous system(CNS). Methods A wide range of domestic and foreign literature on the role of TSPs in the synapse formation of the CNS was reviewed. The role of TSPs in structural features, molecules, and related diseases was reviewed. Results As an oligosaccharide protein, TSPs play important roles in angiogenesis, inflammation, osteogenesis,cell proliferation, and apoptosis. In the nervous system, they bind to voltage-dependent calcium channels, neuronectin,and other extracellular matrix proteins and cell surface receptors, and participate in and regulate multiple processes such as synapse formation, maturation, and function in the CNS. Conclusion TSPs as an oligomeric extracellular matrix protein play an important role in the formation of synapses and the repair of synapses after CNS injury.
引文
1Mosher DF, Adams JC. Adhesion-modulating/matricellular ECM protein families:a structural, functional and evolutionary appraisal.Matrix Biol, 2012, 31(3):155-161.
2Masli S, Sheibani N, Cursiefen C, et al. Matricellular protein thrombospondins:influence on ocular angiogenesis, wound healing and immuneregulation. Curr Eye Res, 2014, 39(8):759-774.
3Ferrer-Ferrer M, Dityatev A. Shaping synapses by the neural extracellular matrix. Front Neuroanat, 2018, 12:40.
4Risher WC, Eroglu C. Thrombospondins as key regulators of synaptogenesis in the central nervous system. Matrix Biol, 2012,31(3):170-177.
5Wang B, Guo W, Huang Y. Thrombospondins and synaptogenesis.Neural Regen Res, 2012, 7(22):1737-1743.
6Farhy-Tselnicker I, Allen NJ. Astrocytes, neurons, synapses:a tripartite view on cortical circuit development. Neural Dev, 2018,13(1):7.
7Torres MD, Garcia O, Tang C, et al. Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome. Free Radic Biol Med, 2018, 114:10-14.
8Chistiakov DA, Melnichenko AA, Myasoedova VA, et al.Thrombospondins:a role in cardiovascular disease. Int J Mol Sci,2017, 18(7):pii:E1540.
9Yan Q, Murphy-Ullrich JE, Song Y. Molecular and structural insight into the role of key residues of thrombospondin-1 and calreticulin in thrombospondin-1-calreticulin binding.Biochemistry, 2011, 50(4):566-573.
10Huang T, Sun L, Yuan X, et al. Thrombospondin-1 is a multifaceted player in tumor progression. Oncotarget, 2017, 8(48):84546-84558.
11Calabro NE, Kristofik NJ, Kyriakides TR. Thrombospondin-2 and extracellular matrix assembly. Biochim Biophys Acta, 2014,1840(8):2396-2402.
12 Risher ML, Sexton HG, Risher WC, et al. Adolescent intermittent alcohol exposure:dysregulation of thrombospondins and synapse formation are associated with decreased neuronal density in the adult hippocampus. Alcohol Clin Exp Res, 2015, 39(12):2403-2413.
13Xu J, Xiao N, Xia J. Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1. Nat Neurosci, 2010,13(1):22-24.
14Ohnishi H, Kaneko Y, Okazawa H, et al. Differential localization of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 and CD47 and its molecular mechanisms in cultured hippocampal neurons. J Neurosci, 2005, 25(10):2702-2711.
15Abumrad NA, Ajmal M, Pothakos K, et al. CD36 expression and brain function:does CD36 deficiency impact learning ability?Prostaglandins Other Lipid Mediat, 2005, 77(1-4):77-83.
16Beumer K, Matthies HJ, Bradshaw A, et al. Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development. Development, 2002, 129(14):3381-3391.
17Herz J, Chen Y. Reelin, lipoprotein receptors and synaptic plasticity. Nat Rev Neurosci, 2006, 7(11):850-859.
18Ehlers MD. Synapse formation:astrocytes spout off. Curr Biol,2005, 15(4):R134-R137.
19Risher WC, Kim N, Koh S, et al. Thrombospondin receptorα2δ-1promotes synaptogenesis and spinogenesis via postsynaptic Rac1. J Cell Biol, 2018, 217(10):3747-3765.
20Christopherson KS, Ullian EM, Stokes CC, et al. Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis.Cell, 2005, 120(3):421-433.
21Eroglu C, Allen NJ, Susman MW, et al. Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell, 2009, 139(2):380-392.
22Liu Z, Jiang Y, Li X, et al. Embryonic stem cell-derived peripheral auditory neurons form neural connections with mouse central auditory neurons in vitro via theα2δ1 receptor. Stem Cell Reports,2018, 11(1):157-170.
23Arikkath J, Campbell KP. Auxiliary subunits:essential components of the voltage-gated calcium channel complex. Curr Opin Neurobiol, 2003, 13(3):298-307.
24Cole RL, Lechner SM, Williams ME, et al. Differential distribution of voltage-gated calcium channel alpha-2 delta(alpha2delta)subunit mRNA-containing cells in the rat central nervous system and the dorsal root ganglia. J Comp Neurol, 2005, 491(3):246-269.
25Davies A, Hendrich J, Van Minh AT, et al. Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels.Trends Pharmacol Sci, 2007, 28(5):220-228.
26Liu A, Garg P, Yang S, et al. Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation. J Biol Chem, 2009, 284(10):6389-6402.
27Crawford DC, Jiang X, Taylor A, et al. Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro. J Neurosci, 2012, 32(38):13100-13110.
28Faria LC, Gu F, Parada I, et al. Epileptiform activity and behavioral arrests in mice overexpressing the calcium channel subunitα2δ-1.Neurobiol Dis, 2017, 102:70-80.
29 Ma?kowiak M, Mordalska P, W?dzony K. Neuroligins, synapse balance and neuropsychiatric disorders. Pharmacol Rep, 2014,66(5):830-835.
30Singh SK, Eroglu C. Neuroligins provide molecular links between syndromic and nonsyndromic autism. Sci Signal, 2013, 6(283):re4.
31Hoon M, Soykan T, Falkenburger B, et al. Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.Proc Natl Acad Sci U S A, 2011, 108(7):3053-3058.
32Bemben MA, Shipman SL, Nicoll RA, et al. The cellular and molecular landscape of neuroligins. Trends Neurosci, 2015, 38(8):496-505.
33Kim DH, Lim H, Lee D, et al. Thrombospondin-1 secreted by human umbilical cord blood-derived mesenchymal stem cells rescues neurons from synaptic dysfunction in Alzheimer’s disease model. Sci Rep, 2018, 8(1):354.
34Wittenmayer N, K?rber C, Liu H, et al. Postsynaptic Neuroligin1regulates presynaptic maturation. Proc Natl Acad Sci U S A, 2009,106(32):13564-13569.
35Bilbo SD, Schwarz JM. Early-life programming of later-life brain and behavior:a critical role for the immune system. Front Behav Neurosci, 2009, 3:14.
36Yamauchi Y, Kuroki M, Imakiire T, et al. Thrombospondin-1differentially regulates release of IL-6 and IL-10 by human monocytic cell line U937. Biochemical and biophysical research communications, 2002, 290(5):1551-1557.
37Feng Z, Ko CP. Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1. J Neurosci, 2008, 28(39):9599-9609.
38Packard M, Mathew D, Budnik V. Wnts and TGF beta in synaptogenesis:old friends signalling at new places. Nat Rev Neurosci, 2003, 4(2):113-120.
39Krady MM, Zeng J, Yu J, et al. Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis.Am J Pathol, 2008, 173(3):879-891.
40Svitkina T, Lin WH, Webb DJ, et al. Regulation of the postsynaptic cytoskeleton:roles in development, plasticity, and disorders. J Neurosci, 2010, 30(45):14937-14942.
41Tashiro A, Yuste R. Regulation of dendritic spine motility and stability by Rac1 and Rho kinase:evidence for two forms of spine motility. Mol Cell Neurosci, 2004, 26(3):429-440.
42Sweetwyne MT, Murphy-Ullrich JE. Thrombospondin1 in tissue repair and fibrosis:TGF-β-dependent and independent mechanisms. Matrix Biol, 2012, 31(3):178-186.
43Zhao Y, Pu D, Sun Y, et al. High glucose-induced defective thrombospondin-1 release from astrocytes via TLR9 activation contributes to the synaptic protein loss. Exp Cell Res, 2018, 363(2):171-178.
44 Jayakumar AR, Tong XY, Curtis KM, et al. Decreased astrocytic thrombospondin-1 secretion after chronic ammonia treatment reduces the level of synaptic proteins:in vitro and in vivo studies. J Neurochem, 2014, 131(3):333-347.
2Masli S, Sheibani N, Cursiefen C, et al. Matricellular protein thrombospondins:influence on ocular angiogenesis, wound healing and immuneregulation. Curr Eye Res, 2014, 39(8):759-774.
3Ferrer-Ferrer M, Dityatev A. Shaping synapses by the neural extracellular matrix. Front Neuroanat, 2018, 12:40.
4Risher WC, Eroglu C. Thrombospondins as key regulators of synaptogenesis in the central nervous system. Matrix Biol, 2012,31(3):170-177.
5Wang B, Guo W, Huang Y. Thrombospondins and synaptogenesis.Neural Regen Res, 2012, 7(22):1737-1743.
6Farhy-Tselnicker I, Allen NJ. Astrocytes, neurons, synapses:a tripartite view on cortical circuit development. Neural Dev, 2018,13(1):7.
7Torres MD, Garcia O, Tang C, et al. Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome. Free Radic Biol Med, 2018, 114:10-14.
8Chistiakov DA, Melnichenko AA, Myasoedova VA, et al.Thrombospondins:a role in cardiovascular disease. Int J Mol Sci,2017, 18(7):pii:E1540.
9Yan Q, Murphy-Ullrich JE, Song Y. Molecular and structural insight into the role of key residues of thrombospondin-1 and calreticulin in thrombospondin-1-calreticulin binding.Biochemistry, 2011, 50(4):566-573.
10Huang T, Sun L, Yuan X, et al. Thrombospondin-1 is a multifaceted player in tumor progression. Oncotarget, 2017, 8(48):84546-84558.
11Calabro NE, Kristofik NJ, Kyriakides TR. Thrombospondin-2 and extracellular matrix assembly. Biochim Biophys Acta, 2014,1840(8):2396-2402.
12 Risher ML, Sexton HG, Risher WC, et al. Adolescent intermittent alcohol exposure:dysregulation of thrombospondins and synapse formation are associated with decreased neuronal density in the adult hippocampus. Alcohol Clin Exp Res, 2015, 39(12):2403-2413.
13Xu J, Xiao N, Xia J. Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1. Nat Neurosci, 2010,13(1):22-24.
14Ohnishi H, Kaneko Y, Okazawa H, et al. Differential localization of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 and CD47 and its molecular mechanisms in cultured hippocampal neurons. J Neurosci, 2005, 25(10):2702-2711.
15Abumrad NA, Ajmal M, Pothakos K, et al. CD36 expression and brain function:does CD36 deficiency impact learning ability?Prostaglandins Other Lipid Mediat, 2005, 77(1-4):77-83.
16Beumer K, Matthies HJ, Bradshaw A, et al. Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development. Development, 2002, 129(14):3381-3391.
17Herz J, Chen Y. Reelin, lipoprotein receptors and synaptic plasticity. Nat Rev Neurosci, 2006, 7(11):850-859.
18Ehlers MD. Synapse formation:astrocytes spout off. Curr Biol,2005, 15(4):R134-R137.
19Risher WC, Kim N, Koh S, et al. Thrombospondin receptorα2δ-1promotes synaptogenesis and spinogenesis via postsynaptic Rac1. J Cell Biol, 2018, 217(10):3747-3765.
20Christopherson KS, Ullian EM, Stokes CC, et al. Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis.Cell, 2005, 120(3):421-433.
21Eroglu C, Allen NJ, Susman MW, et al. Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell, 2009, 139(2):380-392.
22Liu Z, Jiang Y, Li X, et al. Embryonic stem cell-derived peripheral auditory neurons form neural connections with mouse central auditory neurons in vitro via theα2δ1 receptor. Stem Cell Reports,2018, 11(1):157-170.
23Arikkath J, Campbell KP. Auxiliary subunits:essential components of the voltage-gated calcium channel complex. Curr Opin Neurobiol, 2003, 13(3):298-307.
24Cole RL, Lechner SM, Williams ME, et al. Differential distribution of voltage-gated calcium channel alpha-2 delta(alpha2delta)subunit mRNA-containing cells in the rat central nervous system and the dorsal root ganglia. J Comp Neurol, 2005, 491(3):246-269.
25Davies A, Hendrich J, Van Minh AT, et al. Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels.Trends Pharmacol Sci, 2007, 28(5):220-228.
26Liu A, Garg P, Yang S, et al. Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation. J Biol Chem, 2009, 284(10):6389-6402.
27Crawford DC, Jiang X, Taylor A, et al. Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro. J Neurosci, 2012, 32(38):13100-13110.
28Faria LC, Gu F, Parada I, et al. Epileptiform activity and behavioral arrests in mice overexpressing the calcium channel subunitα2δ-1.Neurobiol Dis, 2017, 102:70-80.
29 Ma?kowiak M, Mordalska P, W?dzony K. Neuroligins, synapse balance and neuropsychiatric disorders. Pharmacol Rep, 2014,66(5):830-835.
30Singh SK, Eroglu C. Neuroligins provide molecular links between syndromic and nonsyndromic autism. Sci Signal, 2013, 6(283):re4.
31Hoon M, Soykan T, Falkenburger B, et al. Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.Proc Natl Acad Sci U S A, 2011, 108(7):3053-3058.
32Bemben MA, Shipman SL, Nicoll RA, et al. The cellular and molecular landscape of neuroligins. Trends Neurosci, 2015, 38(8):496-505.
33Kim DH, Lim H, Lee D, et al. Thrombospondin-1 secreted by human umbilical cord blood-derived mesenchymal stem cells rescues neurons from synaptic dysfunction in Alzheimer’s disease model. Sci Rep, 2018, 8(1):354.
34Wittenmayer N, K?rber C, Liu H, et al. Postsynaptic Neuroligin1regulates presynaptic maturation. Proc Natl Acad Sci U S A, 2009,106(32):13564-13569.
35Bilbo SD, Schwarz JM. Early-life programming of later-life brain and behavior:a critical role for the immune system. Front Behav Neurosci, 2009, 3:14.
36Yamauchi Y, Kuroki M, Imakiire T, et al. Thrombospondin-1differentially regulates release of IL-6 and IL-10 by human monocytic cell line U937. Biochemical and biophysical research communications, 2002, 290(5):1551-1557.
37Feng Z, Ko CP. Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1. J Neurosci, 2008, 28(39):9599-9609.
38Packard M, Mathew D, Budnik V. Wnts and TGF beta in synaptogenesis:old friends signalling at new places. Nat Rev Neurosci, 2003, 4(2):113-120.
39Krady MM, Zeng J, Yu J, et al. Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis.Am J Pathol, 2008, 173(3):879-891.
40Svitkina T, Lin WH, Webb DJ, et al. Regulation of the postsynaptic cytoskeleton:roles in development, plasticity, and disorders. J Neurosci, 2010, 30(45):14937-14942.
41Tashiro A, Yuste R. Regulation of dendritic spine motility and stability by Rac1 and Rho kinase:evidence for two forms of spine motility. Mol Cell Neurosci, 2004, 26(3):429-440.
42Sweetwyne MT, Murphy-Ullrich JE. Thrombospondin1 in tissue repair and fibrosis:TGF-β-dependent and independent mechanisms. Matrix Biol, 2012, 31(3):178-186.
43Zhao Y, Pu D, Sun Y, et al. High glucose-induced defective thrombospondin-1 release from astrocytes via TLR9 activation contributes to the synaptic protein loss. Exp Cell Res, 2018, 363(2):171-178.
44 Jayakumar AR, Tong XY, Curtis KM, et al. Decreased astrocytic thrombospondin-1 secretion after chronic ammonia treatment reduces the level of synaptic proteins:in vitro and in vivo studies. J Neurochem, 2014, 131(3):333-347.