GC-MS/MS法测定水中多种N-亚硝胺类化合物
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摘要
采用固相萃取-GC-MS/MS法测定水中10种N-亚硝胺类化合物,通过试验优化前处理和测定条件,使方法在0. 500μg/L～100μg/L范围内线性良好。方法检出限为0. 6 ng/L～2. 1 ng/L,混合标准溶液6次测定结果的RSD <5%。将该方法用于测定实际水样,结果除N-亚硝基二甲胺、N-亚硝基甲基乙基胺和N-亚硝基二丙胺以外,其余目标物均为未检出,加标回收率为73. 1%～97. 6%。
The solid phase extraction-GC-MS/MS method was used to determine 10 N-nitrosamines in water. The pretreatment and determination conditions were optimized by experiments. The linearity of the method was good in the range of 0. 500 μg/L to 100 μg/L. The method detection limits were 0. 6 ng/L ～ 2. 1 ng/L,the RSD of 6 duplicate measurements for mixed standard solution was less than 5%. The method was applied in actual water samples. The results showed that all the target compounds were undetected except N-nitroso-dimethylamine,N-nitroso-methyl ethylamine and N-nitroso-dipropylamine. The recoveries were in range of 73. 1% ～97. 6%.
The solid phase extraction-GC-MS/MS method was used to determine 10 N-nitrosamines in water. The pretreatment and determination conditions were optimized by experiments. The linearity of the method was good in the range of 0. 500 μg/L to 100 μg/L. The method detection limits were 0. 6 ng/L ～ 2. 1 ng/L,the RSD of 6 duplicate measurements for mixed standard solution was less than 5%. The method was applied in actual water samples. The results showed that all the target compounds were undetected except N-nitroso-dimethylamine,N-nitroso-methyl ethylamine and N-nitroso-dipropylamine. The recoveries were in range of 73. 1% ～97. 6%.
引文
[1]魏法山,徐幸莲,周光宏.挥发性N-亚硝基化合物的分析方法[J].食品科学,2008,29(7):479-484.
[2] WU D,LU Y,LIN H,et al. Selectiv determination of tobacco-specific nitrosamines in mainstrea-m cigarette somke by GC coupled to positive chemical ionization triple quadrupole MS:Gas chromatography[J]. Journal of Separation Science,2013,36(16):2615-2620.
[3] CHOWDHURY S. N-nitrosodimethylamine(NDMA)in food and beverages:A comparison in context to drinking water[J]. Human and Ecological Risk Assessment:An International Journal,2014,20(5):1291-1312.
[4]杨荣静,戴雪伟,卫碧文,等.固相萃取-气相色谱-质谱联用法检测婴儿奶嘴中11种N-亚硝胺物质的迁移量[J].环境化学,2012,31(8):1283-1286.
[5] MCCURRY D L,KRASNER S W,VON G U,et al. Determinants of disinfectant pretreatment efficacy for nitrosamine control in chloraminated drinking water[J]. Water Research,2015,84:161-170.
[6]李婷,鲜啟鸣,孙成,等.水中N-亚硝胺类消毒副产物的污染现状及分析技术[J].环境化学,2012,31(11):1767-1774.
[7] QIAN Y,WU M,WANG W,et al. Determination of 14 nitrosamines at nanogram per liter levels in drinking water[J]. Analytical Chemistry,2015,87(2):1330-1336.
[8] PRESSMAN J G,RICHARDSON S D,SPETH T F,et al. Concentration,chlorination,and chemical analysis of drinking water for disinfection by product mixtures health effects research:U. S.EPA's four lab study[J]. Evironmental Science&Technology,2010,44(19):7184-7192.
[9] Government of Ontario. Safe drinking water act[S]. Ontario:Ontario Regulation,2002.
[10] ZHAO Y Y,BOYD J M,WOODBECK M,et al. Formation of Nnitrosamines from eleven disinfection treatments of seven different surface waters[J]. Environmental Science&Technology,2008,42(13):4857-4862.
[11] WANG W,YU J,AN W,et al. Occurrence and profiling of multiple nitrosamines in source water and drinking water of China[J].Science of The Total Environment,2016,551-552:489-495.
[12] MA F,WAN Y,YUAN G,et al. Occurrence and source of nitrosamines and secondary amines in groundwater and tis adjacent Jialu River basin,China[J]. Environmental Science&Technology,2012,46(6):3236-3243.
[13]董军,武法伟,刘文,等.不同前处理方法对GC-MS法测定水中多种SVOCs效率的影响[J].环境监测管理与技术,2017,29(6):50-53.
[14]郭敏,吴文铸,宋宁慧,等.固相萃取-GC/MS法测定水中持久性有机污染物[J].环境监测管理与技术,2016,28(2):45-49.
[15]环境保护部. HJ 809—2016水质亚硝胺类化合物的测定气相色谱法[S].北京:中国标准出版社,2016.
[2] WU D,LU Y,LIN H,et al. Selectiv determination of tobacco-specific nitrosamines in mainstrea-m cigarette somke by GC coupled to positive chemical ionization triple quadrupole MS:Gas chromatography[J]. Journal of Separation Science,2013,36(16):2615-2620.
[3] CHOWDHURY S. N-nitrosodimethylamine(NDMA)in food and beverages:A comparison in context to drinking water[J]. Human and Ecological Risk Assessment:An International Journal,2014,20(5):1291-1312.
[4]杨荣静,戴雪伟,卫碧文,等.固相萃取-气相色谱-质谱联用法检测婴儿奶嘴中11种N-亚硝胺物质的迁移量[J].环境化学,2012,31(8):1283-1286.
[5] MCCURRY D L,KRASNER S W,VON G U,et al. Determinants of disinfectant pretreatment efficacy for nitrosamine control in chloraminated drinking water[J]. Water Research,2015,84:161-170.
[6]李婷,鲜啟鸣,孙成,等.水中N-亚硝胺类消毒副产物的污染现状及分析技术[J].环境化学,2012,31(11):1767-1774.
[7] QIAN Y,WU M,WANG W,et al. Determination of 14 nitrosamines at nanogram per liter levels in drinking water[J]. Analytical Chemistry,2015,87(2):1330-1336.
[8] PRESSMAN J G,RICHARDSON S D,SPETH T F,et al. Concentration,chlorination,and chemical analysis of drinking water for disinfection by product mixtures health effects research:U. S.EPA's four lab study[J]. Evironmental Science&Technology,2010,44(19):7184-7192.
[9] Government of Ontario. Safe drinking water act[S]. Ontario:Ontario Regulation,2002.
[10] ZHAO Y Y,BOYD J M,WOODBECK M,et al. Formation of Nnitrosamines from eleven disinfection treatments of seven different surface waters[J]. Environmental Science&Technology,2008,42(13):4857-4862.
[11] WANG W,YU J,AN W,et al. Occurrence and profiling of multiple nitrosamines in source water and drinking water of China[J].Science of The Total Environment,2016,551-552:489-495.
[12] MA F,WAN Y,YUAN G,et al. Occurrence and source of nitrosamines and secondary amines in groundwater and tis adjacent Jialu River basin,China[J]. Environmental Science&Technology,2012,46(6):3236-3243.
[13]董军,武法伟,刘文,等.不同前处理方法对GC-MS法测定水中多种SVOCs效率的影响[J].环境监测管理与技术,2017,29(6):50-53.
[14]郭敏,吴文铸,宋宁慧,等.固相萃取-GC/MS法测定水中持久性有机污染物[J].环境监测管理与技术,2016,28(2):45-49.
[15]环境保护部. HJ 809—2016水质亚硝胺类化合物的测定气相色谱法[S].北京:中国标准出版社,2016.
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