姜黄素提取分离及其体内外分析方法的研究进展
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摘要
姜黄素是WHO和FDA公认的食品、化妆品天然添加剂,具有降血脂、抗肿瘤、抗炎、抗氧化、抗肝细胞毒性、抑菌等广泛的药理作用,而且毒性低,临床应用前景良好。本文对近10年来有关姜黄素的国内外文献进行归纳,评价其现有提取分离方法,以及在体内外含有量测定中各种方法的优势与不足,为今后相关产品及制剂的深入研发提供参考依据。
引文
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[3] 杨柳.姜黄中的姜黄素提取工艺研究进展[J].农业科技与装备,2017(5):89-90.
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[9] Wulandari M,Urraca J L,Descalzo A B,et al.Molecularly imprinted polymers for cleanup and selective extraction of curcuminoids in medicinal herbal extracts[J].Anal Bioanal Chem,2015,407(3):803-812.
[10] Sedghi R,Yassari M,Heidari B.Thermo-responsive molecularly imprinted polymer containing magnetic nanoparticles:Synthesis,characterization and adsorption properties for curcumin[J].Colloids Surf B Biointerfaces,2018,162(52):154-162.
[11] 杨海玲,吴丽丹,覃德杰,等.一测多评法同时测定广西姜黄饮片中3种姜黄素类成分含量[J].药物分析杂志,2016,36(9):1571-1577.
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[21] 梁冰,覃兰芳,赖茂祥,等.高效液相色谱法测定广西壮药毛郁金中姜黄素的含量[J].广西科学,2012,19(2):149-151.
[22] 叶优苗,张建方,陈宗良.高效液相色谱法测定九味肝泰胶囊中姜黄素含量[J].中国药业,2013,22(11):41-42.
[23] 史晶晶,冯素香,郝蕊,等.姜黄提取物中姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素的含量测定[J].中医学报,2015,30(6):853-855.
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[25] 方恩华,陈鹭平,吴茗梅,等.高效液相色谱法检测果冻中的姜黄素类化合物[J].食品安全质量检测学报,2015,6(12):4980-4984.
[26] Osorio-Tobón J F,Carvalho P I,Barbero G F,et al.Fast analysis of curcuminoids from turmeric (Curcuma longa L.) by high-performance liquid chromatography using a fused-core column[J].Food Chem,2016,200:167-174.
[27] 张春辉,于毓,王国平,等.UPLC测定跌打丸中血竭素与姜黄素的含量[J].中国药师,2016,19(6):1206-1208.
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[29] Caballero-Casero N,Ocak M,Ocak ü,et al.Quick supramolecular solvent-based microextraction for quantification of low curcuminoid content in food[J].Anal Bioanal Chem,2014,406(8):2179-2187.
[30] 徐仲溪,王坤波.姜黄素的高效薄层色谱分析[J].食品科学,2004,25(6):156-159.
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[32] 冯朝军,潘建明.姜黄中姜黄素的提取及电化学测定[J].化学研究,2009,20(1):69-73.
[33] 史明彪,张文,刘河,等.紫外-可见分光光度法定量测定姜黄素及其载体药物方法的优化[J].国际药学研究杂志,2017,44(4):366-368.
[34] Aydin F,Yilmaz E,Soylak M.Vortex assisted deep eutectic solvent (DES)-emulsification liquid-liquid microextraction of trace curcumin in food and herbal tea samples[J].Food Chem,2018,243:442-447.
[35] 万坤,孙立力,胡雪原,等.姜黄素纳米结构脂质载体的药动学[J].中成药,2014,36(12):2503-2507.
[36] 戚爱棣,于虹,朱晨.薄层扫描法测定姜黄、郁金、莪术中姜黄素的含量[J].天津中医学院学报,2002,21(2):32-33.
[37] 李晓霞,漆红兰,朱立新,等.反相流动注射化学发光法测定姜黄素的研究[J].陕西师范大学学报(自然科学版),2003,31(3):85-88.
[38] 张苗,吕庆銮,岳宁宁,等.酶催化-荧光猝灭法测定药物中的姜黄素[J].化学分析计量,2008,17(6):22-25.
[39] Unsal Y E,Tuzen M,Soylak M.Ultrasound-assisted ionic liquid-dispersive liquid-liquid of curcumin in food samples microextraction and its spectrophotometric determination[J].J AOAC Int,2018,102(1):18.
[40] 任杰,王明强,姬良亮,等.利用BZ化学振荡体系检测中草药中的姜黄素[J].甘肃农业大学学报,2013,48(3):172-175,180.
[41] Zhang J,Jinnai S,Ikeda R,et al.A simple HPLC-fluorescence method for quantitation of curcuminoids and its application to turmeric products[J].Anal Sci,2009,25(3):385-388.
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[43] 许汉林,孙芸,邵继征,等.姜黄素脂质体在大鼠体内药代动力学研究[J].湖北中医学院学报,2007,9(1):42-43.
[44] 袁凯龙,翁前锋,张宏颖,等.毛细管电泳法测定尿中的姜黄素[J].色谱,2004,22(6):609-612.
[45] Li J,Jiang Y Y,Wen J,et al.A rapid and simple HPLC method for the determination of curcumin in rat plasma:assay development,validation and application to a pharmacokinetic study of curcumin liposome[J].Biomed Chromatogr,2009,23(11):1201-1207.
[46] 张一唱,龚元,方慧琼,等.姜黄胶囊中姜黄素在大鼠体内药动学和组织分布[J].中国药师,2018,21(1):65-68.
[47] 张晓燕,于莹,刘磊,等.克癌素结肠包衣滴丸中姜黄素在家兔体内的药动学研究[J].药物评价研究,2018,41(1):88-92.
[48] 张聪聪,金若敏.HPLC法测定大鼠血浆中姜黄素的含量及其药动学研究[J].中国新药杂志,2014,23(15):1829-1832.
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[2] Sundar Dhilip Kumar S,Houreld N N,Abrahamse H.Therapeutic potential and recent advances of curcumin in the treatment of aging-associated diseases[J].Molecules,2018,23(4):835.
[3] 杨柳.姜黄中的姜黄素提取工艺研究进展[J].农业科技与装备,2017(5):89-90.
[4] Yadav D K,Sharma K,Dutta A,et al.Purity evaluation of curcuminoids in the turmeric extract obtained by accelerated solvent extraction[J].J AOAC Int,2017,100(3):586-591.
[5] D’Archivio A A,Maggi M A,Ruggieri F.Extraction of curcuminoids by using ethyl lactate and its optimisation by response surface methodology[J].J Pharm Biomed Anal,2018,149:89-95.
[6] Shirsath S R,Sable S S,Gaikwad S G,et al.Intensification of extraction of curcumin from Curcuma amada using ultrasound assisted approach:Effect of different operating parameters[J].Ultrason Sonochem,2017,38:437-445.
[7] Kwon H L,Chung M S.Pilot-scale subcritical solvent extraction of curcuminoids from Curcuma long L[J].Food Chem,2015,185:58-64.
[8] Inoue K,Nomura C,Ito S,et al.Purification of curcumin,demethoxycurcumin,and bisdemethoxycurcumin by high-speed countercurrent chromatography[J].J Agric Food Chem,2008,56(20):9328-9336.
[9] Wulandari M,Urraca J L,Descalzo A B,et al.Molecularly imprinted polymers for cleanup and selective extraction of curcuminoids in medicinal herbal extracts[J].Anal Bioanal Chem,2015,407(3):803-812.
[10] Sedghi R,Yassari M,Heidari B.Thermo-responsive molecularly imprinted polymer containing magnetic nanoparticles:Synthesis,characterization and adsorption properties for curcumin[J].Colloids Surf B Biointerfaces,2018,162(52):154-162.
[11] 杨海玲,吴丽丹,覃德杰,等.一测多评法同时测定广西姜黄饮片中3种姜黄素类成分含量[J].药物分析杂志,2016,36(9):1571-1577.
[12] Anubala S,Sekar R,Nagaiah K.Development and validation of an analytical method for the separation and determination of major bioactive curcuminoids in Curcuma longa rhizomes and herbal products using non-aqueous capillary electrophoresis[J].Talanta,2014,123:10-17.
[13] Shen Y,Han C,Chen X,et al.Simultaneous determination of three curcuminoids in Curcuma wenyujin Y.H.chen et C.Ling.by liquid chromatography-tandem mass spectrometry combined with pressurized liquid extraction[J].J Pharm Biomed Anal,2013,81-82:146-150.
[14] 严建伟,鲍慰文,梁炳圻,等.荧光分光光度法测定姜黄制剂中的姜黄素[J].中国现代应用药学,1998,15(2):44-45.
[15] 黄宝美,莫金垣.毛细管电泳安培法测定脂可平胶囊中的姜黄素[J].分析试验室,2006,25(7):1-4.
[16] 肖会敏,段维勋,何悦,等.复方姜黄片质量标准研究[J].解放军药学学报,2018,34(1):60-63.
[17] 冯雪妍,康宏亮.蒙药地格达—13中姜黄素含量测定[J].中国民族民间医药,2012,21(6):4-5.
[18] 张国梅,张舟艺,徐水祥,等.HPLC法测定保健食品中姜黄素含量及稳定性研究[J].中国卫生检验杂志,2017,27(24):3543-3544,3557.
[19] 金岩,赵铁,姜清华,等.HPLC法测定消瘤丸中姜黄素的含量[J].中国药师,2012,15(7):980-981.
[20] 雷昌,孟盼,谢瑜,等.HPLC法同时测定百事乐胶囊中5种成分的含量[J].中药材,2017,40(1):143-146.
[21] 梁冰,覃兰芳,赖茂祥,等.高效液相色谱法测定广西壮药毛郁金中姜黄素的含量[J].广西科学,2012,19(2):149-151.
[22] 叶优苗,张建方,陈宗良.高效液相色谱法测定九味肝泰胶囊中姜黄素含量[J].中国药业,2013,22(11):41-42.
[23] 史晶晶,冯素香,郝蕊,等.姜黄提取物中姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素的含量测定[J].中医学报,2015,30(6):853-855.
[24] Monton C,Charoenchai L,Suksaeree J,et al.Quantitation of curcuminoid contents,dissolution profile,and volatile oil content of turmeric capsules produced at some secondary government hospitals[J].J Food Drug Anal,2016,24(3):493-499.
[25] 方恩华,陈鹭平,吴茗梅,等.高效液相色谱法检测果冻中的姜黄素类化合物[J].食品安全质量检测学报,2015,6(12):4980-4984.
[26] Osorio-Tobón J F,Carvalho P I,Barbero G F,et al.Fast analysis of curcuminoids from turmeric (Curcuma longa L.) by high-performance liquid chromatography using a fused-core column[J].Food Chem,2016,200:167-174.
[27] 张春辉,于毓,王国平,等.UPLC测定跌打丸中血竭素与姜黄素的含量[J].中国药师,2016,19(6):1206-1208.
[28] Jaiswal Y,Liang Z,Ho A,et al.Tissue-specific metabolite profiling of turmeric by using laser micro-dissection,ultra-high performance liquid chromatography-quadrupole time of fight-mass spectrometry and liquid chromatography-tandem mass spectrometry[J].Eur J Mass Spectrom (Chichester),2014,20(5):383-393.
[29] Caballero-Casero N,Ocak M,Ocak ü,et al.Quick supramolecular solvent-based microextraction for quantification of low curcuminoid content in food[J].Anal Bioanal Chem,2014,406(8):2179-2187.
[30] 徐仲溪,王坤波.姜黄素的高效薄层色谱分析[J].食品科学,2004,25(6):156-159.
[31] 丁良,杨慧,于朝云,等.高效毛细管电泳法测定中药莪术中的姜黄素[J].中成药,2008,30(10):1506-1509.
[32] 冯朝军,潘建明.姜黄中姜黄素的提取及电化学测定[J].化学研究,2009,20(1):69-73.
[33] 史明彪,张文,刘河,等.紫外-可见分光光度法定量测定姜黄素及其载体药物方法的优化[J].国际药学研究杂志,2017,44(4):366-368.
[34] Aydin F,Yilmaz E,Soylak M.Vortex assisted deep eutectic solvent (DES)-emulsification liquid-liquid microextraction of trace curcumin in food and herbal tea samples[J].Food Chem,2018,243:442-447.
[35] 万坤,孙立力,胡雪原,等.姜黄素纳米结构脂质载体的药动学[J].中成药,2014,36(12):2503-2507.
[36] 戚爱棣,于虹,朱晨.薄层扫描法测定姜黄、郁金、莪术中姜黄素的含量[J].天津中医学院学报,2002,21(2):32-33.
[37] 李晓霞,漆红兰,朱立新,等.反相流动注射化学发光法测定姜黄素的研究[J].陕西师范大学学报(自然科学版),2003,31(3):85-88.
[38] 张苗,吕庆銮,岳宁宁,等.酶催化-荧光猝灭法测定药物中的姜黄素[J].化学分析计量,2008,17(6):22-25.
[39] Unsal Y E,Tuzen M,Soylak M.Ultrasound-assisted ionic liquid-dispersive liquid-liquid of curcumin in food samples microextraction and its spectrophotometric determination[J].J AOAC Int,2018,102(1):18.
[40] 任杰,王明强,姬良亮,等.利用BZ化学振荡体系检测中草药中的姜黄素[J].甘肃农业大学学报,2013,48(3):172-175,180.
[41] Zhang J,Jinnai S,Ikeda R,et al.A simple HPLC-fluorescence method for quantitation of curcuminoids and its application to turmeric products[J].Anal Sci,2009,25(3):385-388.
[42] Qin N Y,Yang F Q,Wang Y T,et al.Quantitative determination of eight components in rhizome (Jianghuang) and tuberous root (Yujin) of Curcuma longa using pressurized liquid extraction and gas chromatography-mass spectrometry[J].J Pharm Biomed Anal,2007,43(2):486-492.
[43] 许汉林,孙芸,邵继征,等.姜黄素脂质体在大鼠体内药代动力学研究[J].湖北中医学院学报,2007,9(1):42-43.
[44] 袁凯龙,翁前锋,张宏颖,等.毛细管电泳法测定尿中的姜黄素[J].色谱,2004,22(6):609-612.
[45] Li J,Jiang Y Y,Wen J,et al.A rapid and simple HPLC method for the determination of curcumin in rat plasma:assay development,validation and application to a pharmacokinetic study of curcumin liposome[J].Biomed Chromatogr,2009,23(11):1201-1207.
[46] 张一唱,龚元,方慧琼,等.姜黄胶囊中姜黄素在大鼠体内药动学和组织分布[J].中国药师,2018,21(1):65-68.
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