浅谈SNP类专利申请在NCBI、UCSC、ENSEMBL数据库的检索
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摘要
SNP作为分子标记,在生物等众多领域有着重要的研究和推广价值。因此,保护主题涉及SNP的发明专利申请量逐年上升,无论是对于专利审查员还是申请人,如何进行有效的SNP检索都是亟待解决的问题。本文简介了SNP的定义及特点,同时概述了SNP检索常用数据库,最后以具体案例介绍了SNP在NCBI、UCSC、ENSEMBL数据库的检索,以期为相关生物领域SNP专利审查工作和专利申请人提供借鉴。
As a molecular marker, SNP has important research and promotion value in many fields such as biology. Therefore, the number of patent applications for inventions related to SNP is increasing year by year. Whether for patent examiners or applicants, how to carry out effective SNP retrieval is an urgent problem to be solved. This paper brie?y introduces the de? nition and characteristics of SNP, and summarizes the common databases of SNP. Finally, it introduces the retrieval of SNP in NCBI, UCSC and ENSEMBL databases with actual cases, with a view to providing reference for patent examiners or applicants in SNP ?elds.
As a molecular marker, SNP has important research and promotion value in many fields such as biology. Therefore, the number of patent applications for inventions related to SNP is increasing year by year. Whether for patent examiners or applicants, how to carry out effective SNP retrieval is an urgent problem to be solved. This paper brie?y introduces the de? nition and characteristics of SNP, and summarizes the common databases of SNP. Finally, it introduces the retrieval of SNP in NCBI, UCSC and ENSEMBL databases with actual cases, with a view to providing reference for patent examiners or applicants in SNP ?elds.
引文
[1]唐立群,等.SNP分子标记的研究及其应用进展[J].中国农学通报,2012, 28(12):154-158.
[2]廖文勇,等.关于生物领域涉及SNP类专利申请的探讨,2014年中华全国专利代理人协会年会第五届知识产权论坛论文(第三部分),2014, 1-6.
[3]The International SNP Map Working Group. A map of human genome sequence variation containing 1.42million single nucleotide polymorphisms[J]. Nature,2001, 409:928-933.
[4]Chakravarti A. To a future of genetic medicine[J].Science, 2001, 409:822-823.
[5]O’Brien S J, Menotti-Raymond M, Murphy W J, et al. The promise of comparative genomics in mammals[J]. Science, 1999, 458-463.
[6]曾燕如,等.一种新的分子标记?——单核苷酸多态(SNP)[J].南京林业大学学报(自然科学版),2003, 27(3):84-88.
[7]Sherry ST, Ward MH, Kholodov M, et al. dbSNP:the NCBI database of genetic variation[J]. Nucleic Acids Research, 2001, 29:308-311.
[8]Marshall E. A second private genome project[J].Science, 1998, 281:1121.
[9]Hirakawa M, Tanaka T, Hashinoto Y, et al. JSNP:a database of common gene variations in the Japanese population[J]. Nucleic Acids Research, 2002, 30(1):611-616.
[10]Kim ChangKug, Yoon UngHan, Lee GangSeob, et al. Rice genetic marker database:an identification of single nucleotide polymorphism(SNP)and quantitative trait loci(QTL)markers[J]. African Journal of Biotechnology, 2009, 8(13):2963-2967.
[2]廖文勇,等.关于生物领域涉及SNP类专利申请的探讨,2014年中华全国专利代理人协会年会第五届知识产权论坛论文(第三部分),2014, 1-6.
[3]The International SNP Map Working Group. A map of human genome sequence variation containing 1.42million single nucleotide polymorphisms[J]. Nature,2001, 409:928-933.
[4]Chakravarti A. To a future of genetic medicine[J].Science, 2001, 409:822-823.
[5]O’Brien S J, Menotti-Raymond M, Murphy W J, et al. The promise of comparative genomics in mammals[J]. Science, 1999, 458-463.
[6]曾燕如,等.一种新的分子标记?——单核苷酸多态(SNP)[J].南京林业大学学报(自然科学版),2003, 27(3):84-88.
[7]Sherry ST, Ward MH, Kholodov M, et al. dbSNP:the NCBI database of genetic variation[J]. Nucleic Acids Research, 2001, 29:308-311.
[8]Marshall E. A second private genome project[J].Science, 1998, 281:1121.
[9]Hirakawa M, Tanaka T, Hashinoto Y, et al. JSNP:a database of common gene variations in the Japanese population[J]. Nucleic Acids Research, 2002, 30(1):611-616.
[10]Kim ChangKug, Yoon UngHan, Lee GangSeob, et al. Rice genetic marker database:an identification of single nucleotide polymorphism(SNP)and quantitative trait loci(QTL)markers[J]. African Journal of Biotechnology, 2009, 8(13):2963-2967.