痰热清注射液生产过程质量控制方法研究
|
摘要
当前中药工业面临的严峻挑战是：中药质量评价方法落后,生产过程缺乏先进的质量监控手段,药品质量难以提高。为此,本文围绕中药生产过程质控这一重要科技难题,以痰热清注射液为具体研究对象,综合运用现代仪器分析、药物分析信息学等技术,着重开展中药材及中药提取物质量近红外光谱快速分析方法、中药注射剂配液过程质量监控方法研究,建立了中药生产过程质控方法,并将研究成果与工业生产实践结合。主要研究内容及成果如下
1.建立了基于NIR光谱技术的原料药材质量控制方法。对熊胆粉的真伪进行了判别分析；对黄芩药材生长方式和产地进行了鉴别,并对其中的4种黄酮类化合物的含量进行了快速测定；对金银花药材的产地进行了鉴别,并对其中的6种有机酸类化合物进行了快速测定；对连翘药材采收时期和产地进行了判别分析,并对原料药材中的青翘与黄翘的比例进行了快速分析。以上研究有助于工厂的原料采购和投料前检验,确保原料的质量稳定。
2.利用NIR光谱技术对中药提取物进行了快速分析。建立了5种中药提取物中水分含量的测定模型；建立了熊胆粉提取物中2种胆酸、金银花提取物中6种有机酸、以及山羊角提取物中12种氨基酸的快速测定方法。
3.研究了痰热清注射液成品中多项内控指标的快速测定方法。利用自制的配件实现了痰热清注射液的不开瓶检验；由于建模样品中待测指标波动较小,不利于建立稳健模型,为此配制了不同浓度的样品以扩大建模样品的代表性；进行了模型转移研究,扩大了所建模型的适用性。本部分研究可减轻成品检验的工作量,并可适当提高成品的抽检比例,以提高分析结果的可靠性。
4.对痰热清注射液的配液过程进行了研究。建立了判别分析模型,用于识别不同浓度和pH值的总混液；建立了配液过程中4种中间体的快速定量分析方法,并对所建模型进行了更新。
Currently, the big challenges in the traditional Chinese Medicine (TCM) industry are lacking of advanced manufacturing process supervisory techniques to renew the backward quality evaluation methods, so that the quality of TCMs is hard to be improved. For this reason, taking a TCM preparation, Tanreqing injection as the research carrier, this paper accordingly focused on the investigation of rapid analysis method for the quality assessment of TCM raw materials and extracts with near infrared spectroscopy (NIRS), and also the Process quality control methods for the liquid preparation process, by combination of the modern instrument analytical techniques and pharmaceutical analysis information technologies. Ultimately, the process quality control method of TCM was established, and the research findings were used in industrial practice. The main innovation and academic contributions of this dissertation are presented as follows:
1. The rapid quality control methods for the TCM materials were established. Firstly, an NIRS method was developed for the authentication of bear bile powder; Secondly, an NIRS method was developed for the growth pattern and geographical origin discrimination and content determination of 4 flavonoids in Radix Scutellariae; Thirdly, an NIRS method was developed for the geographical origin discrimination and content determination of 6 organic acids in Lonicera japonica; Finally, the discrimination method of Fructus Forsythiae from different geographical origin and different harvesting stages was developed, and the proportion of Green forsythia in the raw materials was determined. This research is helpful to the raw material purchase and the quality testing before the raw materials put into production.
2. The quality control method based on the NIRS technology for the TCM extracts is researched. An NIRS method was established for the measurement of moisture contents in 5 kinds of TCM extracts, and rapid analysis methods for the determination of UDCA and CDCA in the bear gall powder extracts,6 organic acids in Lonicera japonica extracts, and 12 amino acids in the Cornus Caprae Hircus extracts were also developed.
3. The rapid NIRS determination method of the final product was established. A homemade accessory was used for the non-invasive analysis. And with the accessory, several internal control indexes were determined without opening the vials. Generally speaking, the quality of Tanreqing injection is stable, which will make the robust calibration models not easily to be developed. To resolve this issue, more representative samples were prepared, which can increase the representativeness of the calibration set effectively. The calibration transfer method was also researched for the more widely use of the models. This research can reduce the workload of product inspection to a large extent, and the sampling proportion can be increased properly, which will contribute to improve the reliability of determination results.
4. Focus studies on the liquid preparation process were done to enhance the process understanding. Firstly, the method of discriminant analysis was established for the total mixing liquid samples with different concentration and pH values. Secondly, A method for rapid quantitative analysis of 4 kinds of Tanreqing injection intermediates was developed.
1.建立了基于NIR光谱技术的原料药材质量控制方法。对熊胆粉的真伪进行了判别分析；对黄芩药材生长方式和产地进行了鉴别,并对其中的4种黄酮类化合物的含量进行了快速测定；对金银花药材的产地进行了鉴别,并对其中的6种有机酸类化合物进行了快速测定；对连翘药材采收时期和产地进行了判别分析,并对原料药材中的青翘与黄翘的比例进行了快速分析。以上研究有助于工厂的原料采购和投料前检验,确保原料的质量稳定。
2.利用NIR光谱技术对中药提取物进行了快速分析。建立了5种中药提取物中水分含量的测定模型；建立了熊胆粉提取物中2种胆酸、金银花提取物中6种有机酸、以及山羊角提取物中12种氨基酸的快速测定方法。
3.研究了痰热清注射液成品中多项内控指标的快速测定方法。利用自制的配件实现了痰热清注射液的不开瓶检验；由于建模样品中待测指标波动较小,不利于建立稳健模型,为此配制了不同浓度的样品以扩大建模样品的代表性；进行了模型转移研究,扩大了所建模型的适用性。本部分研究可减轻成品检验的工作量,并可适当提高成品的抽检比例,以提高分析结果的可靠性。
4.对痰热清注射液的配液过程进行了研究。建立了判别分析模型,用于识别不同浓度和pH值的总混液；建立了配液过程中4种中间体的快速定量分析方法,并对所建模型进行了更新。
Currently, the big challenges in the traditional Chinese Medicine (TCM) industry are lacking of advanced manufacturing process supervisory techniques to renew the backward quality evaluation methods, so that the quality of TCMs is hard to be improved. For this reason, taking a TCM preparation, Tanreqing injection as the research carrier, this paper accordingly focused on the investigation of rapid analysis method for the quality assessment of TCM raw materials and extracts with near infrared spectroscopy (NIRS), and also the Process quality control methods for the liquid preparation process, by combination of the modern instrument analytical techniques and pharmaceutical analysis information technologies. Ultimately, the process quality control method of TCM was established, and the research findings were used in industrial practice. The main innovation and academic contributions of this dissertation are presented as follows:
1. The rapid quality control methods for the TCM materials were established. Firstly, an NIRS method was developed for the authentication of bear bile powder; Secondly, an NIRS method was developed for the growth pattern and geographical origin discrimination and content determination of 4 flavonoids in Radix Scutellariae; Thirdly, an NIRS method was developed for the geographical origin discrimination and content determination of 6 organic acids in Lonicera japonica; Finally, the discrimination method of Fructus Forsythiae from different geographical origin and different harvesting stages was developed, and the proportion of Green forsythia in the raw materials was determined. This research is helpful to the raw material purchase and the quality testing before the raw materials put into production.
2. The quality control method based on the NIRS technology for the TCM extracts is researched. An NIRS method was established for the measurement of moisture contents in 5 kinds of TCM extracts, and rapid analysis methods for the determination of UDCA and CDCA in the bear gall powder extracts,6 organic acids in Lonicera japonica extracts, and 12 amino acids in the Cornus Caprae Hircus extracts were also developed.
3. The rapid NIRS determination method of the final product was established. A homemade accessory was used for the non-invasive analysis. And with the accessory, several internal control indexes were determined without opening the vials. Generally speaking, the quality of Tanreqing injection is stable, which will make the robust calibration models not easily to be developed. To resolve this issue, more representative samples were prepared, which can increase the representativeness of the calibration set effectively. The calibration transfer method was also researched for the more widely use of the models. This research can reduce the workload of product inspection to a large extent, and the sampling proportion can be increased properly, which will contribute to improve the reliability of determination results.
4. Focus studies on the liquid preparation process were done to enhance the process understanding. Firstly, the method of discriminant analysis was established for the total mixing liquid samples with different concentration and pH values. Secondly, A method for rapid quantitative analysis of 4 kinds of Tanreqing injection intermediates was developed.
引文
[1]刘春平,易智彪.关于中药注射剂研究开发及安全性问题的思考[J].中草药,2009,40(7)：1162-1166
[2]高素强,胡咏川.中药注射剂的应用现状与上市后再评价[J].中国中药杂志,2007,32(13)：1370-1372
[3]钱忠直.建立符合中医药特点的中药质量标准-解读2010年版《中国药典》[J].中国中药杂志,2010,35(16)：2048-2051
[4]谢培山.中药色谱指纹图谱质量控制模式的研究和应用—若干实质性问题的探讨(二)[J世界科学技术-中药现代化,2001,3(6)：28-32
[5]P. Xie, S. Chen, Y. Liang, X. Wang, R. Tian, R. Upton. Chromatographic fingerprint analysis- a rational approach for quality assessment of traditional Chinese herbal medicine[J]. Journal of Chromatography A,2006,1112(1-2):171-180
[6]邵建强.中药指纹图谱的研究进展[J].中草药,2009,40(6)：994-998
[7]Y. Chang, X. Ding, J. Qi, J. Cao, L. Kang, D. Zhu, B. Zhang, B. Yu. The antioxidant- activity-integrated fingerprint:An advantageous tool for the evaluation of quality of herbal medicines[J]. Journal of Chromatography A,2008,1208(1-2):76-82
[8]冯启余,曹玉华,龚立冬.综合利用色谱多维信息建立中药指纹图谱[J].计算机与应用化学,2009,26(5)：561-565
[9]刘岩,刘顺航,王俊全,孙素琴.红外光谱应用新进展及其与色谱指纹图谱对比分析[J].光谱学与光谱分析,2007,27(6)：1093-1097
[10]张泰铭,梁逸曾,袁斌,丁峰,张亚朋,魏满琼,陈旭.中药电化学指纹图谱的检测方法和条件因素[J].科学通报,2007,52(9)：1012-1020
[11]Guidance for Industry:PAT- A Framework for Innovative Pharmaceutical Development, Manufacturing and Quality Assurance[R]. Food and Drug Administration, Washington, D.C., U.S.A,2004
[12]P. Gemperline, G. Puxty, M. Maeder. Calibration-free estimates of batch process yields and detection of process upsets using in situ spectroscopic measurements and nonisothermal kinetic models:4-(dimethylamino) pyridine-catalyzed esterification of butanol[J]. Analytical Chemistry,2004,76(9):2575-2582
[13]L.X. Yu, R.A. Lionberger, A.S. Raw, R. Costa, H. Wu, A. Hussain. Applications of process analytical technology to crystallization processes[J]. Advanced Drug Delivery Reviews, 2004,56 (3):349-369
[14]C. Buschmuller, W. Wiedey, C. Doscher, J. Dressier, J. Breitkreutz. In-line monitoring of granule moisture in fluidized-bed dryers using microwave resonance technology[J]. European Journal of Pharmaceutics and Biopharmaceutics,2008,69(1):380-387
[15]W. Li, M.C. Johnson, R. Bruce, S. Ulrich, H. Rasmussen, C.D. Worosila. Mass-balanced blend uniformity analysis of pharmaceutical powders by at-line near- infrared spectroscopy with a fiber-optic probe[J]. International Journal of Pharmaceutics,2006,326 (1-2):182-185
[16]J. Rantanen, E. Rasanen, J. Tenhunen, M. Kansakoski, J. Mannermaa, J. Yliruusi. In-line moisture measurement during granulation with a four-wavelength near infrared sensor:An evaluation of particle size and binder effects[J]. European Journal of Pharmaceutics and Biopharmaceutics,2000,50(2):271-276
[17]于晓辉,张卓勇,马群,范国强.径向基函数神经网络和近红外光谱用于大黄中有效成分的定量预测[J].光谱学与光谱分析,2007,27(3)：481-485
[18]W. Li, H. Qu. Rapid quantification of phenolic acids in Radix Salvia Miltrorrhiza extract solutions by FT-NIR spectroscopy in transflective mode[J]. Journal of Pharmaceutical and Biomedical Analysis,2010,52(4):425-431
[19]蒋受军,刘丽娜,朱斌,王英新,王钢力,林瑞超.近红外光谱法测定注射用丹参(冻干)中丹参素、原儿茶醛及总酚含量的初步研究[J].药物分析杂志,2008,28(7)：1094-1098
[20]L. Wang, F.S.C. Lee, X. Wang. Near-infrared spectroscopy for classification of licorice (Glycyrrhizia uralensis Fisch) and prediction of the glycyrrhizic acid (GA) content[J]. LWT- Food Science and Technology,2007,40 (1):83-88
[21]Y. Chen, M. Xie, Y. Yan, S. Zhu, S. Nie, C. Li, Y. Wang, X. Gong. Discrimination of Ganoderma lucidum according to geographical origin with near infrared diffuse reflectance spectroscopy and pattern recognition techniques[J]. Analytica Chimica Acta,2008,618(2): 121-130
[22]W. Li, L. Xing, Y. Cai, H. Qu. Classification and quantification analysis of Radix scutellariae from different origins with near infrared diffuse reflection spectroscopy[J]]. Vibrational Spectroscopy,2011,55(1):58-64
[23]马群,郝贵奇,乔延江,张卓勇,张孝芳.近红外光谱法结合支持向量机测定天然牛黄粉中人工牛黄的掺入量[J].光谱学与光谱分析,2006,26(10)：1842-1845
[24]瞿海斌,叶颖雅,程翼宇.近红外光谱快速评价丹参基地药材[J].药物分析杂志,2006,26(10)：1413-1416
[25]张延莹,张金巍,刘岩.近红外技术在白芍醇提在线质量监控中的应用[J].中国医药工业杂志,2010,41(9)：662-665
[26]覃锋,杨辉华,吕琳昂,师涛,梁琼麟,王义明,罗国安.NIR光谱结合LLE-PLS建模用于安神补脑液提取过程分析的研究[J].中成药,2008,30(10)：1465-1468
[27]杨辉华,王勇,吴云鸣,史晓浩,胡坪,梁琼麟,王义明,罗国安.丹参多酚酸盐柱层析过程的近红外光谱在线检测及质量控制[J].中成药,2008,30(3)：409-412
[28]陈雪英,陈勇,王龙虎,孙长海,刘雪松.红花醇沉液浓缩除醇过程中多元质控指标的 近红外快速检测[J].药物分析杂志,2010,30(11)：2086-2092
[29]李云霞,鲍建才,李沈明,郭艳玲,刘玺.近红外在线检测控制中药药粉二维混合的均匀度的方法[P].中国专利：CN101832921A,2010-09-15
[30]朱向荣.化学计量学方法在清开灵注射液与国公酒光谱分析中的应用研究[D],首都师范大学,2008年
[31]褚小立,袁洪福,王艳斌,陆婉珍.近红外稳健分析校正模型的建立(Ⅰ)-样品温度的影响[J].光谱学与光谱分析,2004,24(6)：666-671
[32]徐志龙,赵龙莲,严衍禄.减小样品温度对近红外定量分析数学模型影响的建模方法[J].现代仪器,2004,10(54)：29-31
[33]王一兵,王红宇,翟宏菊,芦菲,吴卫红,王海水,席时权.近红外光谱分辨率对定量分析的影响[J].分析化学,2006,34(5)：699-701
[34]谢丽娟,刘东红,张宇环,徐惠荣,叶兴乾,应义斌.分辨率对近红外光谱和定量分析的影响研究[J].光谱学与光谱分析,2007,27(8)：1489-1492
[35]祝诗平,王刚,杨飞,阚建全,郭静.粉末样品颗粒大小对花椒挥发油近红外光谱定量预测的影响研究[J].光谱学与光谱分析,2008,28(4)：775-779
[36]赵枝新,金岭梅.粉碎粒度对近红外分析仪测定饲料样品干物质和粗蛋白含量的影响[J].中国饲料,2002,3：35-36
[37]林涛,于海燕,徐惠荣,应义斌.光程变化对基于近红外光谱的黄酒品质检测的影响[J].光谱学与光谱分析,2009,29(4)：950-955
[38]姜礼义,刘福莉,陈华才,尹军锋.绿茶汤中茶多酚近红外定量分析的光程选择[J].中国计量学院学报,2009,20(2)：135-138
[39]Q. Zhou, S. Cai, J. Wang, S. Sun. A rapid method to determine the harpagoside and cinnamic acid in radix scrphulariae by NIR spectroscpy[J]. Analytical Science,2001,Vol.17(Suppl.) 443-446
[40]闵顺耕,李宁,张明祥.近红外光谱分析中异常值的判别与定量模型优化[J].光谱学与光谱分析,2004,24(10)：1205-1209
[41]芦永军,曲艳玲,朴仁官,张军.近红外光谱分析技术定标和预测中的相似样品剔除算法[J].光谱学与光谱分析,2004,24(2)：158-161
[42]吴静珠,王一鸣,张小超,张巧杰.近红外光谱分析中定标集样品挑选方法研究[J].农业机械学报,2006,37(4)：80-83
[43]X. Zou, J. Zhao, M.J.W. Povey, M. Holmes, H. Mao. Variables selection methods in near-infrared spectroscopy[J]. Analytica Chimica Acta,2010,667 (1-2):14-32
[44]鲍峰伟,彭黔荣,刘景艳,蔡元青,毛寒冰.唐珂,吕燕文.潜变量聚类分析法在近红外光谱波长范围选择中的应用研究[J].光谱学与光谱分析,2008,28(5)：1057-1061
[45]X. Li, Y. He, C. Wu, D. Sun. Nondestructive measurement and fingerprint analysis of soluble solid content of tea soft drink based on Vis/NIR spectroscopy[J]. Journal of Food Engineering,2007,82(3):316-323.
[46]Y. Roggo, P. Chalus, L. Maurer, C. Lema-Martinez, A. Edmond, N. Jent. A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies[J]. Journal of Pharmaceutical and Biomedical Analysis,2007,44(2):683-700
[47]M. Daszykowski, B.Walczak, D.L. Massart. Representative subset selection[J]. Analytica Chimica Acta,2002,468(1):91-103
[48]X. Song, P. K. Hopke, Kohonen neural network as a pattern recognition method based on the weight interpretation[J]. Analytica Chimica Acta,1996,334(1-2):57-66
[49]W. Wu, D. L. Massart, Regularised nearest neighbour classification method for pattern recognition of near infrared spectra[J]. Analytica Chimica Acta,1997,349(1-3):253-261
[50]R.M. Balabin, R.Z. Safieva, E.I. Lomakina. Gasoline classification using near infrared (NIR) spectroscopy data:Comparison of multivariate techniques[J]. Analytica Chimica Acta, 2010,671(1-2):27-35
[51]O. Galtier, O. Abbas, Y. Le Dreau, C. Rebufa, J. Kister, J. Artaud, N. Dupuy. Comparison of PLS1-DA, PLS2-DA and SIMCA for classification by origin of crude petroleum oils by MIR and virgin olive oils by NIR for different spectral regions[J]. Vibrational Spectroscopy[J].2011,55(1):132-140
[52]K.G. Adamopoulos, A.M. Goula. Application of near-infrared reflectance spectroscopy in the determination of major components in taramosalata[J]. Journal of Food Engineering,2004, 63(2):199-207
[53]M. Otsuka. Comparative particle size determination of phenacetin bulk powder by using Kubelka-Munk theory and principal component regression analysis based on near-infrared spectroscopy[J]. Powder Technology,2004,141(3):244-250
[54]张琳,张黎明,李燕,刘丙萍,王晓斐,王俊德.偏最小二乘法在傅里叶变换红外光谱中的应用及进展[J].光谱学与光谱分析,2005,25(10)：1610-1613
[55]F. Despagne, D. L. Massart. Neural networks in multivariate calibration[J]. Analyst,1998, 123:157-178
[56]R.G. Brereton, G.R. Lloyd. Support Vector Machines for classification and regression[J]. Analyst,2010,135:230-267
[57]X. Shao, W. Wang, Z.u Hou, W. Cai. A new regression method based on independent component analysis[J]. Talanta,2006,69(3):676-680
[58]T. Chen, J. Morris, E. Martin. Gaussian process regression for multivariate spectroscopic calibration[J]. Chemometrics and Intelligent Laboratory Systems,2007,87(1):85-97
[59]A.M.K. Pedro, M.M.C. Ferreira. Simultaneously calibrating solids, sugars and acidity of tomato products using PLS2 and NIR spectroscopy [J]. Analytica Chimica Acta,2007, 595(1):221-227
[60]L. Xu, J. Jiang, H. Wu, G. Shen, R. Yu. Variable-weighted PLS[J]. Chemometrics and Intelligent Laboratory Systems,2007,85 (1):140-143
[61]H. Xu, W. Cai, X. Shao. Weighted partial least squares regression by variable grouping strategy for multivariate calibration of near infrared spectra[J]. Analytical Methods,2010,2: 289-294
[62]R.M. Balabin, R.Z. Safieva, E. I. Lomakina. Comparison of linear and nonlinear calibration models based on near infrared (NIR) spectroscopy data for gasoline properties prediction[J]. Chemometrics and Intelligent Laboratory Systems,2007,88 (2):183-188
[63]H. Yu, X. Niu, H. Lin, Y. Ying, B. Li, X. Pan. A feasibility study on on-line determination of rice wine composition by Vis-NIR spectroscopy and least-squares support vector machines[J]. Food Chemistry,2009,113 (1) 291-296
[64]R.N. Feudale, N.A. Woody, H. Tan, A.J. Myles, S.D. Brown, J.Ferre. Transfer of multivariate calibration models:a review[J]. Chemometrics and Intelligent Laboratory Systems,2002, 64(2):181-192
[65]王家俊,刘巍.Karl Norris导数滤波器结合主成分分析转移NIR模型[J].烟草科技,2007,3：31-35
[66]W. Fan, Y. Liang, D. Yuan, J. Wang. Calibration model transfer for near-infrared spectra based on canonical correlation analysis[J]. Analytica Chimica Acta,2008,623(1):22-29
[67]严衍禄,近红外光谱分析基础与应用[M].北京：中国轻工业出版社,2005
[68]D.A. Burns, E.W. Ciurczak. Handbook of Near-Infrared Analysis[M]. Third Edition, CRC Press, New York, USA,2007:380
[69]H. Lin, Q. Chen, J. Zhao, P. Zhou. Determination of free amino acid content in Radix Pseudostellariae using near infrared (NIR) spectroscopy and different multivariate calibrations[J]. Journal of Pharmaceutical and Biomedical Analysis,2009,50 (5):803-808
[70]Q. Chen, P. Jiang, J. Zhao. Measurement of total flavone content in snow lotus (Saussurea involucrate) using near infrared spectroscopy combined with interval PLS and genetic algorithm[J]. Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy,2010, 76(1):50-55
[71]赵琛,瞿海斌,程翼宇.虫草氨基酸的人工神经网络-近红外光谱快速测定方法[J].光谱学与光谱分析,2004,24(1)：50-53
[72]杨南林,程翼宇,瞿海斌.用人工神经网络-近红外光谱法测定冬虫夏草中的甘露醇[J].分析化学,2003,31(6)：664-668
[73]X. Luo, X. Yu, X.Wu, Y. Cheng, H. Qu. Rapid determination of Paeoniae Radix using near infrared spectroscopy [J]. Microchemical Journal,2008,90(1):8-12
[74]杨南林,瞿海斌,程翼字.近红外光谱法快速测定三七总皂苷的方法研究[J].浙江大学 学报(工学版),2002,36(4)：463-466
[75]杨南林,程翼宇,吴永江.中药材三七中皂苷类成分的近红外光谱快速无损分析新方法[J].化学学报,2003,61(3)：393-398
[76]C.W. Huck, G. Abel, M. Popp, G.K. Bonn. Comparative analysis of naphthodianthrone and phloroglucine derivatives in St. John's Wort extracts by near infrared spectroscopy, high-performance liquid chromatography and capillary electrophoresis[J]. Analytica Chimica Acta,2006,580 (2):223-230
[77]I. Rager, G. Roos, P.C. Schmidt, K.A. Kovar. Rapid quantification of constituents in St. John's wort extracts by NIR spectroscopy[J]. Journal of Pharmaceutical and Biomedical Analysis,2008,28 (3-4):439-446
[78]Y. Geng, B. Xiang, Simultaneous quantitation of flavonol aglycones in Ginkgo biloba leaf extracts applying moving window partial least squares regression models[J]. Jouranl of Near Infrared Spectroscopy,2008,16(6):551-559
[79]胡钢亮,吕秀阳,罗玲,徐铸德.近红外光谱法同时测定银杏提取液中总黄酮和总内酯含量[J].分析化学,2004,32(8)：1061-1063
[80]M. Gaub, C. Roeseler, G. Roos, K.A. Kovar. Analysis of plant extracts by NIRS: simultaneous determination of kavapyrones and water in dry extracts of Piper methysticum Forst[J]. Journal of Pharmaceutical and Biomedical Analysis,2004,36 (4):859-864
[81]朱向荣,李娜,史新元,乔延江,张卓勇.近红外光谱与组合的间隔偏最小二乘法测定清开灵四混液中总氮和栀子苷的含量[J].高等学校化学学报,2008,29(5)：906-911
[82]Y. Wu, S. Sun, Q. Zhou, H. Leung. Fourier transform mid-infrared (MIR) and near-infrared (NIR) spectroscopy for rapid quality assessment of Chinese medicine preparation Honghua Oil[J]. Journal of Pharmaceutical and Biomedical Analysis,2008,46 (3):498-504
[83]聂黎行,王钢力,李志猛,林瑞超.近红外光谱法对同仁乌鸡白凤丸的定性和定量分析[J].红外与毫米波学报,2008,27(3)：205-209
[84]柯博克,刘雪松,陈勇,李文,瞿海斌,程翼宇.近红外光谱快速测定复方丹参滴丸的包衣厚度[J].中草药,2006,37(5)：685-688
[85]瞿海斌,杨海雷,程翼宇.近红外漫反射光谱法快速无损鉴别阿胶真伪[J].光谱学与光谱分析,2006,26(1)：60-62
[86]钟建理,侥伟文,谢黔峰,吴萌.沉香的近红外光谱法鉴别初探[J].西北药学杂志,2010,25(4)：273-275
[87]赵龙莲,张录达,李军会,杨帆.小波包熵和Fisher判别在近红外光谱法鉴别中药大黄真伪中的应用[J].光谱学与光谱分析,2008,28(4)：817-820
[88]C. Chu, D. Mok, F. Chau. Analysis of berberine and total alkaloid content in Cortex Phellodendri by near infrared spectroscopy compared with high-performance liquid chromatography coupled with ultra-visible spectrometric detection[J]. Analytica Chimica Acta,2007,592 (2):121-131
[89]C. Lau, C. Chan, F. Chau, D. Mok. Rapid analysis of Radix puerariae by near-infrared spectroscopy[J], Journal of Chromatography A,2009,1216 (11):2130-2135
[90]Q. Fan, Y. Wang, P. Sun, S. Liu, Y. Li. Discrimination of Ephedra plants with diffuse reflectance FT-NIR and multivariate analysis[J]. Talanta,2010,80(3):1245-1250
[91]M. Laasonen, T. Harmia-Pulkkinen, C.L. Simard, E. Michiels, M. Rasanen, H. Vuorela. Fast identification of Echinacea purpurea dried roots using Near-Infrared spectroscopy[J]. Analytical Chemistry,2002,74:2493-2499
[92]高越,柴逸峰,吴玉田.近红外漫反射光谱法鉴别贝母药材的研究[J].中成药,2005,27(12)：1440-1443
[93]朱斌,郑清明,秦路平,郑汉臣,年华,刘荔荔.20种金丝桃属植物的近红外漫反射光谱法鉴别[J].第二军医大学学报,2003,24(4)：455-456
[94]孙国明,刘国林.近红外光谱技术在独活属药用植物分类中的应用[J].中国中药杂志,2006,31(23)：1996-1998
[95]黄宝康,黄流清,秦路平,赵忠新,陆峰,郑汉臣.四种缬草属药用植物的近红外漫反射指纹图谱聚类分析[J].中药材,2008,31(10)：1494-1496
[96]辛海量,胡园,张巧艳,郑汉臣,秦路平.4种牡荆属植物来源生药的近红外漫反射指纹图谱聚类分析[J].时珍国医国药,2008,19(12)：3037-3038
[97]Y. Woo, H. Kim, K. Ze, H. Chung. Near-infrared (NIR) spectroscopy for the non- destructive and fast determination of geographical origin of Angelicae gigantis Radix[J]. Journal of Pharmaceutical and Biomedical Analysis,2005,36 (5):955-959
[98]Y. Woo, C. Cho, H. Kim, H. Chung Classification of cultivation area of ginseng by near infrared spectroscopy and ICP-AES[J]. Microchemical Journal,2002,73(3):299-306
[99]C. Cho, Y. Woo, H. Kim, Y. Chung, S. Chang, H. Chung. Rapid qualitative and quantitative evaluation of deer antler (Cervus elaphus) using near-infrared reflectance spectroscopy [J]. Microchemical Journal,2001,68(2-3):189-195
[100]Y. Woo, H. Kim, J. Cho, H. Chung. Discrimination of herbal medicines according to geographical origin with near infrared reflectance spectroscopy and pattern recognition techniques[J]. Journal of Pharmaceutical and Biomedical Analysis,1999,21(2):407-413
[101]Y. Woo, H. Kim, J. Cho. Identification of herbal medicines using pattern recognition techniques with near-infrared reflectance spectra[J]. Microchemical Journal,1999,63(1): 61-67
[102]J. Lu, B. Xiang, H. Liu, S. Xiang, S. Xie, H. Deng. Application of two-dimensional near-infrared correlation spectroscopy to the discrimination of Chinese herbal medicine of different geographic regions[J]. Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy,2008,69(2):580-586
[103]杨海雷,刘雪松,瞿海斌,程翼宇.一种基于近红外的红参药材质量快速评价方法[J]. 中草药,2005,36(6)：912-915
[104]K. Yu, Y. Cheng. Discriminating the genuineness of Chinese medicines using Least Squares Support Vector Machines[J]. Chinese Journal of Analytical Chemistry,2006,34(4):561-564
[105]叶正良,虞科,程翼宇.一种基于小波变换的近红外化学指纹图谱分析方法[J].高等学校化学学报,2007,28(3)：441-444
[106]刘雪松,施朝晟,程翼宇,瞿海斌.基于自组织映射神经网络的中药注射剂质量快速鉴别方法[J].分析化学,2007,35(10)：1483-1486
[107]刘雪松,程翼宇.用于中药药品质量快速检测的近红外光谱模糊神经元分类方法[J].化学学报,2005,63(24)：2216-2220
[108]严诗楷,罗国安,王义明,程翼宇.栀子药材提取工艺的近红外光谱实时控制方法研究[J].光谱学与光谱分析,2006,26(1)：1026-1030
[109]陈雪英,李页瑞,陈勇,王龙虎,孙长海,刘雪松.近红外光谱分析技术在赤芍提取过程质量监控中的应用研究[J].中国中药杂志,2009,34(11)：1355-1358
[110]陈雪英,李页瑞,陈勇,王龙虎,丁玲,孙长海,闫文杰,刘雪松.近红外光谱快速测定红花逆流提取过程中羟基红花黄色素A的含量[J].分析化学,2009,37(10)：1451-1456
[111]施朝晟,刘雪松,陈勇,瞿海斌,程翼宇.一种丹参提取过程终点快速判断方法[J].中国药学杂志,2006,41(23)：1771-1774
[112]刘全,瞿海斌,程翼宇.用于渗漉提取过程分析的中药有效组分近红外光谱快速测定法[J].化工学报,2003,54(11)：1586-1590
[113]蔡绍松,武卫红,王宁,董海平.黄芪水提液浓缩过程的AOTF-近红外光谱法在线析[J].中国医药工业杂志,2008,39(7)：527-529
[114]瞿海斌,李斌,刘雪松,程翼宇.红参醇提液浓缩过程近红外光谱在线分析方法[J].中国药学杂志,2005,40(24)：1897-1899
[115]刘冰,毕开顺,孙立新,史新元,乔延江,刘珍清.近红外光谱结合不同偏最小二乘法测定乳块消片醇沉液中丹参素和橙皮苷含量[J].世界科学技术-中医药现代化,2009,11(3)：388-394
[116]邢丽红,徐金钟,瞿海斌.近红外光谱法快速测定丹参醇沉过程中的鞣质[J].药物分析杂志,2010,30(10)：1813-1816
[117]张延莹,张金巍,张培,刘岩.近红外光谱技术在丹酚酸B纯化在线质控中的应用研究[J].时珍国医国药,2010,21(1)：220-222
[118]杨志斌,栾连军.近红外透射光谱用于积壳提取物纯化过程快速分析[J].中国药学杂志,2005,40(8)：615-618
[119]蒋雪,张经硕,邱敏,谢洪平,郭莉萍.重楼皂甙提取工艺优化与近红外光谱在线质量控制[J].分析化学,2006,34(9)：171-174
[120]杨南林,程翼宇,瞿海斌.一种用于中药纯化过程的近红外光谱分析新方法[J].化学学报,2003,61(5)：742-747
[121]徐晓杰,宋丽丽,朱新科,范丙义,郭辉,相秉仁.近红外光谱法用于六味地黄丸粉末混合过程的质量控制研究[J].中国现代应用药学杂志,2006,23(7)：644-646
[122]龚益飞,刘雪松,章顺楠,瞿海斌,程翼宇.近红外光谱法在线判断滴丸料液混合终点[J].中国药学杂志,2007,42(7)：509-511
[123]王春全.痰热清注射液的方解及功效[J].现代医药卫生,2006,22(5)：720-720
[124]温华珍,肖盛元,王义明,罗国安.黄芩化学成分及炮制学研究[J].天然产物研究与开发,2004,16(6)：575-579
[125]C. Li, L. Zhou, G. Lin, Z. Zuo. Contents of major bioactive flavones in proprietary traditional Chinese medicine products and reference herb of Radix Scutellariae[J]. Journal of Pharmaceutical and Biomedical Analysis,2009,50(3):298-306
[126]H. Li, Y. Jiang, F. Chen. Separation methods used for Scutellaria baicalensis active components[J]. Journal of Chromatography B,2004,812(1-2):277-290
[127]C.R. Horvath, P.A. Martos, P.K. Saxena. Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant Huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection[J]. Journal of Chromatography A,2005,1062(2):199-207
[128]赵勇,昝丽霞,孙文基.HPLC-ELSD法测定熊胆粉中牛磺熊去氧胆酸和牛磺鹅去氧胆酸的含量[J].药物分析杂志,2006,26(1)：127-129
[129]刘力,张辉,胡嵘,李民熙,李有才.山羊角研究概述[J].长春中医学院学报,1994,10(41)：109
[130]J. Xu, J. Shen, Y. Cheng, H. Qu. GC-MS analysis of amino acids in extract of cornus caprae hircus[J]. Chemical Research in Chinese Universities,2009,25(6):812-816
[131]黄丽瑛,吕植祯,李继彪,周炳南.中药金银花化学成分的研究[J].中草药,1996,27(11)：645-647
[132]J. Chen, Y. Song, P. Li. Capillary high-performance liquid chromatography with mass spectrometry for simultaneous determination of major flavonoids, iridoid glucosides and saponins in Flos Lonicerae [J]. Journal of Chromatography A,2007,1157 (1-2):217-226
[133]H. Li, P. Li, W. Ye. Determination of five major iridoid glucosides in Flos Lonicerae by high-performance liquid chromatography coupled with evaporative light scattering detection [J]. Journal of Chromatography A,2003,1008 (2):167-172
[134]Y. Song, S. Li, M. Wu, H. Li, P. Li. Qualitative and quantitative analysis of iridoid glycosides in the flower buds of Lonicera species by capillary high performance liquid chromatography coupled with mass spectrometric detector[J]. Analytica Chimica Acta, 2006,564 (2):211-218
[135]M. Ren, J. Chen, Y., L. Sheng, P. Li, L. Qi. Identification and quantification of 32 bioactive compounds in Lonicera species by high performance liquid chromatography coupled with time-of-flight mass spectrometry[J]. Journal of Pharmaceutical and Biomedical Analysis, 2008,48(5):1351-1360
[136]李倩,冯卫生.连翘的化学成分研究进展[J].河南中医学院学报,2005,20(117)：78-80
[137]吴伟明,陈丽佳,诸乐恺.高效液相色谱法测定痰热清注射液中黄芩苷和绿原酸的含量[J].儿科药学杂志,2006,12(4)：38-40
[138]娄玉霞,聂桂华,刘乃强.HPLC-ELSD法测定痰热清注射液中黄芩苷、熊去氧胆酸、鹅去氧胆酸3种成分的含量[J].中国中药杂志,2009,34(14)：1862-1864
[139]王珏,瞿海斌,邵青.HPLC-UV-ELSD法同时测定痰热清注射液中主成分含量[J].药物分析杂志,2009,29(11)：1084-1087
[140]杨南林.基于近红外光谱的中药过程分析方法研究[D],浙江大学,2003
[141]刘全.近红外光谱技术在中药生产过程质量分析中的应用研究[D],浙江大学,2004
[142]刘晓宣.近红外光谱定性定量技术在中药质量控制中的应用研究[D],浙江大学,2004
[143]刘雪松.中药的近红外光谱计算分析方法学研究[D],浙江大学,2005
[144]施朝晟.模式识别技术在中药近红外光谱分析中的应用研究[D],浙江大学,2006
[145]李斌.近红外光谱技术在中药制药过程在线质量分析中的应用研究[D],浙江大学,2005
[146]杨志斌.近红外光谱技术在中药制剂制备过程中的应用[D],浙江大学,2005年
[147]戚毅.近红外光谱分析技术在葛根提取物生产过程中的应用研究[D],浙江大学,2007
[148]赵琛.用于中药分析的近红外光谱多元校正方法学研究[D],浙江大学,2003
[149]柯博克.近红外光谱在硅胶柱层析过程分析中的应用研究[D],浙江大学,2006
[150]杨海雷.近红外光谱技术在中药质量分析中的若干应用研究[D],浙江大学,2005
[151]俞翔.丹参提取和醇沉过程的质量控制技术研究[D],浙江大学,2008
[152]罗晓芳.统计过程控制在丹参注射液生产质量控制中的应用研究[D],浙江大学,2008
[153]王丽影,高昕,佟子林,王喜军.熊胆的化学成分,药理作用及临床研究概况[J].中医药信息,2005,22(4)：30-33
[154]张贇华,刘建忠,彭霞,李忠琼,张雯洁.HPLC法比较熊胆粉及猪胆粉、牛胆粉、羊胆粉和鸡胆粉中胆汁酸类成分[J].药物分析杂志,2009,29(3)：487-490
[155]朱丽玢,洪筱坤.HPLC去定量分析熊胆中胆酸类化合物[J].中草药,2004,35(11)：1255-1257
[156]E.K. Kemsley. Discriminant analysis of high-dimensional data:a comparison of principal components analysis and partial least squares data reduction methods[J]. Chemometrics and Intelligent Laboratory Systems,1996,33(1):47-61
[157]张春凤,张永清.黄岑炮制沿革[J].中药材,2003,26(12)：890-892
[158]张家辉,杨蕊,邓洪平.缙云黄芩HPLC指纹图谱的建立及其不同部位活性成分含量研究[J].中国中药杂志,2009,34(19)：21-24
[159]符洪,肖新月,张南平,林瑞超,盛龙生.药用黄芩中主要化学成分分析[J].药物分析杂志,2003,3：33-38
[160]黄倩倩,潘瑞乐,魏建和,吴严巍,张录达.近红外漫反射光谱法测定黄芩中总黄酮及黄芩苷的含量[J].光谱学与光谱分析,2009,29(9)：2425-2428
[161]白雁,刘乐,王东,樊克锋.近红外光谱技术对黄芩浸膏中黄芩苷含量的快速检测[J].中成药,2009,31(9)：1375-1378
[162]R. Miyahara, T. Yoshimoto, K. Asawa, M. Gakkaishi. Chemical structures and changes of extracts during growth of Reishi(Ganoderma lucidum)[J]. Mokuzai Gakkaishi,1987,33 (5):416-422
[163]X. Niu, H. Yu, Y. Ying. The application of Near-infrared spectroscopy and Chemometrics to classify Shaoxing wines from different breweries[J]. Transactions of the AS ABE, 51(2008)1371-1376.
[164]M.C. Ortiz, L. Sarabia, R. Garcia-Rey, M.D.L. de Castro. Sensitivity and specificity of PLS-class modelling for five sensory characteristics of dry-cured ham using visible and near infrared spectroscopy[J]. Analytica Chimica Acta,2006,558 (1-2):125-131
[165]R.W. Kennard, L.A. Stone. Computer aided design of experiments[J]. Technometrics,1969, 11(1):137-148
[166]陈俊.金银花提取物的物质基础和制备工艺研究[D],浙江大学,2010年
[167]中国药典(2010版).一部[S].205
[168]李庆波,张广军,徐可欣.DS算法在近红外光谱多元校正模型传递中的应用[J].光谱学与光谱分析,2007,27(5)：873-876
[169]中国药典(2010版).一部[S].159
[170]张玲,单卫华,时延增,徐新刚,李春玲.青翘和老翘中连翘苷的含量测定[J].中国现代应用药学杂志,1999,16(1)：45-46
[171]陈随清,王三姓,董诚明,王欣,冯卫生.连翘果实化学成分积累动态的研究[J].中国中药杂志,2007,32(11)：1096-1097
[172]郑晓珂,魏悦,冯卫生.不同采收期连翘的HPLC指纹图谱研究[J].中国实验方剂学杂志,2007,13(3)：1-4
[173]张晓慧,刘建学.近红外光谱技术鉴别连翘产地[J].激光与红外,2008,38(4)：342-344
[174]白雁,王星,陈志红,龚海燕,张威.近红外光谱法测定连翘药材中连翘苷含量[J].中成药,2009,31(11)：1755-1759
[175]王星,白雁,陈志红,龚海燕,张威.近红外光谱法测定连翘中连翘酯苷含量[J].中国中药杂志,2009,34(16)：2071-2075
[176]M. Brulls, S. Folestad, A. Sparen, A. Rasmuson, J. Salomonsson. Applying spectral peak area analysis in near-infrared spectroscopy moisture assays[J]. Journal of Pharmaceutical and Biomedical Analysis,2007,44(1):127-136
[177]X. Zhang, Y. Feng, C.Hu. Feasibility and extension of universal quantitative models for moisture content determination in beta-lactam powder injections by near-infrared spectroscopy [J]. Analytica Chimica Acta,2008,630(2):131-140
[178]冯军勤,周誉昌,吕华,李海.运用近红外漫反射光谱技术检测中药水分含量[J].大众科技,2006,2：46-47
[179]W. Yu, Q. Fu, W. Dai, Z. Li. Study on correlation between effective ingredients of Dogwood Fruit from genuine producing regions and trait[J]. China Journal of Chinese Materia Medica,2008,33(23):2751-2755
[180]S. Skeie, G. Feten, T. Alm(?)y, H.(?)stlie, T. Isaksson. The use of near infrared spectroscopy to predict selected free amino acids during cheese ripening[J].International Dairy Journal, 2006,16(3):236-242
[181]牛智有,韩鲁佳.鱼粉中氨基酸近红外光谱定量分析[J].农业机械学报,2007,38(5)：114-117
[182]H. Yu, Y. Ying, T. Sun, X. Niu, X. Pan. Vintage year determination of bottled Chinese rice wine by VIS-NIR spectroscopy [J]. Journal of Food Science,2007,72(3):125-129
[183]O.Y. Rodionova, Y.V. Sokovikov, A.L. Pomerantsev. Quality control of packed raw materials in pharmaceutical industry[J]. Analytica Chimica Acta,2009,642(1-2):222-227
[184]H. Cen, Y. He, Theory and application of near infrared reflectance spectroscopy in determination of food quality[J]. Trends in Food Science & Technology,2007,18(2):72-83
[185]刘燕德.水果糖度和酸度的近红外光谱无损检测研究[D].浙江大学,2006
[186]Y. Wang, D.J. Veltkamp, B.R. Kowalski. Multivariate instrument standardization[J]. Analytical Chemistry,1991,63 (23):2750-2756
[187]朱向荣,李娜,史新元.支持向量机与紫外光谱法用于鉴别清开灵注射液六混中间体[J].光谱学与光谱分析,2008,28(7)：1626-1629
[188]朱向荣,李娜,史新元.最小二乘支持向量机算法与紫外光谱法用于鉴别清开灵注射液四混中间体[J].分析化学,2008,28(6)：770-774
[2]高素强,胡咏川.中药注射剂的应用现状与上市后再评价[J].中国中药杂志,2007,32(13)：1370-1372
[3]钱忠直.建立符合中医药特点的中药质量标准-解读2010年版《中国药典》[J].中国中药杂志,2010,35(16)：2048-2051
[4]谢培山.中药色谱指纹图谱质量控制模式的研究和应用—若干实质性问题的探讨(二)[J世界科学技术-中药现代化,2001,3(6)：28-32
[5]P. Xie, S. Chen, Y. Liang, X. Wang, R. Tian, R. Upton. Chromatographic fingerprint analysis- a rational approach for quality assessment of traditional Chinese herbal medicine[J]. Journal of Chromatography A,2006,1112(1-2):171-180
[6]邵建强.中药指纹图谱的研究进展[J].中草药,2009,40(6)：994-998
[7]Y. Chang, X. Ding, J. Qi, J. Cao, L. Kang, D. Zhu, B. Zhang, B. Yu. The antioxidant- activity-integrated fingerprint:An advantageous tool for the evaluation of quality of herbal medicines[J]. Journal of Chromatography A,2008,1208(1-2):76-82
[8]冯启余,曹玉华,龚立冬.综合利用色谱多维信息建立中药指纹图谱[J].计算机与应用化学,2009,26(5)：561-565
[9]刘岩,刘顺航,王俊全,孙素琴.红外光谱应用新进展及其与色谱指纹图谱对比分析[J].光谱学与光谱分析,2007,27(6)：1093-1097
[10]张泰铭,梁逸曾,袁斌,丁峰,张亚朋,魏满琼,陈旭.中药电化学指纹图谱的检测方法和条件因素[J].科学通报,2007,52(9)：1012-1020
[11]Guidance for Industry:PAT- A Framework for Innovative Pharmaceutical Development, Manufacturing and Quality Assurance[R]. Food and Drug Administration, Washington, D.C., U.S.A,2004
[12]P. Gemperline, G. Puxty, M. Maeder. Calibration-free estimates of batch process yields and detection of process upsets using in situ spectroscopic measurements and nonisothermal kinetic models:4-(dimethylamino) pyridine-catalyzed esterification of butanol[J]. Analytical Chemistry,2004,76(9):2575-2582
[13]L.X. Yu, R.A. Lionberger, A.S. Raw, R. Costa, H. Wu, A. Hussain. Applications of process analytical technology to crystallization processes[J]. Advanced Drug Delivery Reviews, 2004,56 (3):349-369
[14]C. Buschmuller, W. Wiedey, C. Doscher, J. Dressier, J. Breitkreutz. In-line monitoring of granule moisture in fluidized-bed dryers using microwave resonance technology[J]. European Journal of Pharmaceutics and Biopharmaceutics,2008,69(1):380-387
[15]W. Li, M.C. Johnson, R. Bruce, S. Ulrich, H. Rasmussen, C.D. Worosila. Mass-balanced blend uniformity analysis of pharmaceutical powders by at-line near- infrared spectroscopy with a fiber-optic probe[J]. International Journal of Pharmaceutics,2006,326 (1-2):182-185
[16]J. Rantanen, E. Rasanen, J. Tenhunen, M. Kansakoski, J. Mannermaa, J. Yliruusi. In-line moisture measurement during granulation with a four-wavelength near infrared sensor:An evaluation of particle size and binder effects[J]. European Journal of Pharmaceutics and Biopharmaceutics,2000,50(2):271-276
[17]于晓辉,张卓勇,马群,范国强.径向基函数神经网络和近红外光谱用于大黄中有效成分的定量预测[J].光谱学与光谱分析,2007,27(3)：481-485
[18]W. Li, H. Qu. Rapid quantification of phenolic acids in Radix Salvia Miltrorrhiza extract solutions by FT-NIR spectroscopy in transflective mode[J]. Journal of Pharmaceutical and Biomedical Analysis,2010,52(4):425-431
[19]蒋受军,刘丽娜,朱斌,王英新,王钢力,林瑞超.近红外光谱法测定注射用丹参(冻干)中丹参素、原儿茶醛及总酚含量的初步研究[J].药物分析杂志,2008,28(7)：1094-1098
[20]L. Wang, F.S.C. Lee, X. Wang. Near-infrared spectroscopy for classification of licorice (Glycyrrhizia uralensis Fisch) and prediction of the glycyrrhizic acid (GA) content[J]. LWT- Food Science and Technology,2007,40 (1):83-88
[21]Y. Chen, M. Xie, Y. Yan, S. Zhu, S. Nie, C. Li, Y. Wang, X. Gong. Discrimination of Ganoderma lucidum according to geographical origin with near infrared diffuse reflectance spectroscopy and pattern recognition techniques[J]. Analytica Chimica Acta,2008,618(2): 121-130
[22]W. Li, L. Xing, Y. Cai, H. Qu. Classification and quantification analysis of Radix scutellariae from different origins with near infrared diffuse reflection spectroscopy[J]]. Vibrational Spectroscopy,2011,55(1):58-64
[23]马群,郝贵奇,乔延江,张卓勇,张孝芳.近红外光谱法结合支持向量机测定天然牛黄粉中人工牛黄的掺入量[J].光谱学与光谱分析,2006,26(10)：1842-1845
[24]瞿海斌,叶颖雅,程翼宇.近红外光谱快速评价丹参基地药材[J].药物分析杂志,2006,26(10)：1413-1416
[25]张延莹,张金巍,刘岩.近红外技术在白芍醇提在线质量监控中的应用[J].中国医药工业杂志,2010,41(9)：662-665
[26]覃锋,杨辉华,吕琳昂,师涛,梁琼麟,王义明,罗国安.NIR光谱结合LLE-PLS建模用于安神补脑液提取过程分析的研究[J].中成药,2008,30(10)：1465-1468
[27]杨辉华,王勇,吴云鸣,史晓浩,胡坪,梁琼麟,王义明,罗国安.丹参多酚酸盐柱层析过程的近红外光谱在线检测及质量控制[J].中成药,2008,30(3)：409-412
[28]陈雪英,陈勇,王龙虎,孙长海,刘雪松.红花醇沉液浓缩除醇过程中多元质控指标的 近红外快速检测[J].药物分析杂志,2010,30(11)：2086-2092
[29]李云霞,鲍建才,李沈明,郭艳玲,刘玺.近红外在线检测控制中药药粉二维混合的均匀度的方法[P].中国专利：CN101832921A,2010-09-15
[30]朱向荣.化学计量学方法在清开灵注射液与国公酒光谱分析中的应用研究[D],首都师范大学,2008年
[31]褚小立,袁洪福,王艳斌,陆婉珍.近红外稳健分析校正模型的建立(Ⅰ)-样品温度的影响[J].光谱学与光谱分析,2004,24(6)：666-671
[32]徐志龙,赵龙莲,严衍禄.减小样品温度对近红外定量分析数学模型影响的建模方法[J].现代仪器,2004,10(54)：29-31
[33]王一兵,王红宇,翟宏菊,芦菲,吴卫红,王海水,席时权.近红外光谱分辨率对定量分析的影响[J].分析化学,2006,34(5)：699-701
[34]谢丽娟,刘东红,张宇环,徐惠荣,叶兴乾,应义斌.分辨率对近红外光谱和定量分析的影响研究[J].光谱学与光谱分析,2007,27(8)：1489-1492
[35]祝诗平,王刚,杨飞,阚建全,郭静.粉末样品颗粒大小对花椒挥发油近红外光谱定量预测的影响研究[J].光谱学与光谱分析,2008,28(4)：775-779
[36]赵枝新,金岭梅.粉碎粒度对近红外分析仪测定饲料样品干物质和粗蛋白含量的影响[J].中国饲料,2002,3：35-36
[37]林涛,于海燕,徐惠荣,应义斌.光程变化对基于近红外光谱的黄酒品质检测的影响[J].光谱学与光谱分析,2009,29(4)：950-955
[38]姜礼义,刘福莉,陈华才,尹军锋.绿茶汤中茶多酚近红外定量分析的光程选择[J].中国计量学院学报,2009,20(2)：135-138
[39]Q. Zhou, S. Cai, J. Wang, S. Sun. A rapid method to determine the harpagoside and cinnamic acid in radix scrphulariae by NIR spectroscpy[J]. Analytical Science,2001,Vol.17(Suppl.) 443-446
[40]闵顺耕,李宁,张明祥.近红外光谱分析中异常值的判别与定量模型优化[J].光谱学与光谱分析,2004,24(10)：1205-1209
[41]芦永军,曲艳玲,朴仁官,张军.近红外光谱分析技术定标和预测中的相似样品剔除算法[J].光谱学与光谱分析,2004,24(2)：158-161
[42]吴静珠,王一鸣,张小超,张巧杰.近红外光谱分析中定标集样品挑选方法研究[J].农业机械学报,2006,37(4)：80-83
[43]X. Zou, J. Zhao, M.J.W. Povey, M. Holmes, H. Mao. Variables selection methods in near-infrared spectroscopy[J]. Analytica Chimica Acta,2010,667 (1-2):14-32
[44]鲍峰伟,彭黔荣,刘景艳,蔡元青,毛寒冰.唐珂,吕燕文.潜变量聚类分析法在近红外光谱波长范围选择中的应用研究[J].光谱学与光谱分析,2008,28(5)：1057-1061
[45]X. Li, Y. He, C. Wu, D. Sun. Nondestructive measurement and fingerprint analysis of soluble solid content of tea soft drink based on Vis/NIR spectroscopy[J]. Journal of Food Engineering,2007,82(3):316-323.
[46]Y. Roggo, P. Chalus, L. Maurer, C. Lema-Martinez, A. Edmond, N. Jent. A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies[J]. Journal of Pharmaceutical and Biomedical Analysis,2007,44(2):683-700
[47]M. Daszykowski, B.Walczak, D.L. Massart. Representative subset selection[J]. Analytica Chimica Acta,2002,468(1):91-103
[48]X. Song, P. K. Hopke, Kohonen neural network as a pattern recognition method based on the weight interpretation[J]. Analytica Chimica Acta,1996,334(1-2):57-66
[49]W. Wu, D. L. Massart, Regularised nearest neighbour classification method for pattern recognition of near infrared spectra[J]. Analytica Chimica Acta,1997,349(1-3):253-261
[50]R.M. Balabin, R.Z. Safieva, E.I. Lomakina. Gasoline classification using near infrared (NIR) spectroscopy data:Comparison of multivariate techniques[J]. Analytica Chimica Acta, 2010,671(1-2):27-35
[51]O. Galtier, O. Abbas, Y. Le Dreau, C. Rebufa, J. Kister, J. Artaud, N. Dupuy. Comparison of PLS1-DA, PLS2-DA and SIMCA for classification by origin of crude petroleum oils by MIR and virgin olive oils by NIR for different spectral regions[J]. Vibrational Spectroscopy[J].2011,55(1):132-140
[52]K.G. Adamopoulos, A.M. Goula. Application of near-infrared reflectance spectroscopy in the determination of major components in taramosalata[J]. Journal of Food Engineering,2004, 63(2):199-207
[53]M. Otsuka. Comparative particle size determination of phenacetin bulk powder by using Kubelka-Munk theory and principal component regression analysis based on near-infrared spectroscopy[J]. Powder Technology,2004,141(3):244-250
[54]张琳,张黎明,李燕,刘丙萍,王晓斐,王俊德.偏最小二乘法在傅里叶变换红外光谱中的应用及进展[J].光谱学与光谱分析,2005,25(10)：1610-1613
[55]F. Despagne, D. L. Massart. Neural networks in multivariate calibration[J]. Analyst,1998, 123:157-178
[56]R.G. Brereton, G.R. Lloyd. Support Vector Machines for classification and regression[J]. Analyst,2010,135:230-267
[57]X. Shao, W. Wang, Z.u Hou, W. Cai. A new regression method based on independent component analysis[J]. Talanta,2006,69(3):676-680
[58]T. Chen, J. Morris, E. Martin. Gaussian process regression for multivariate spectroscopic calibration[J]. Chemometrics and Intelligent Laboratory Systems,2007,87(1):85-97
[59]A.M.K. Pedro, M.M.C. Ferreira. Simultaneously calibrating solids, sugars and acidity of tomato products using PLS2 and NIR spectroscopy [J]. Analytica Chimica Acta,2007, 595(1):221-227
[60]L. Xu, J. Jiang, H. Wu, G. Shen, R. Yu. Variable-weighted PLS[J]. Chemometrics and Intelligent Laboratory Systems,2007,85 (1):140-143
[61]H. Xu, W. Cai, X. Shao. Weighted partial least squares regression by variable grouping strategy for multivariate calibration of near infrared spectra[J]. Analytical Methods,2010,2: 289-294
[62]R.M. Balabin, R.Z. Safieva, E. I. Lomakina. Comparison of linear and nonlinear calibration models based on near infrared (NIR) spectroscopy data for gasoline properties prediction[J]. Chemometrics and Intelligent Laboratory Systems,2007,88 (2):183-188
[63]H. Yu, X. Niu, H. Lin, Y. Ying, B. Li, X. Pan. A feasibility study on on-line determination of rice wine composition by Vis-NIR spectroscopy and least-squares support vector machines[J]. Food Chemistry,2009,113 (1) 291-296
[64]R.N. Feudale, N.A. Woody, H. Tan, A.J. Myles, S.D. Brown, J.Ferre. Transfer of multivariate calibration models:a review[J]. Chemometrics and Intelligent Laboratory Systems,2002, 64(2):181-192
[65]王家俊,刘巍.Karl Norris导数滤波器结合主成分分析转移NIR模型[J].烟草科技,2007,3：31-35
[66]W. Fan, Y. Liang, D. Yuan, J. Wang. Calibration model transfer for near-infrared spectra based on canonical correlation analysis[J]. Analytica Chimica Acta,2008,623(1):22-29
[67]严衍禄,近红外光谱分析基础与应用[M].北京：中国轻工业出版社,2005
[68]D.A. Burns, E.W. Ciurczak. Handbook of Near-Infrared Analysis[M]. Third Edition, CRC Press, New York, USA,2007:380
[69]H. Lin, Q. Chen, J. Zhao, P. Zhou. Determination of free amino acid content in Radix Pseudostellariae using near infrared (NIR) spectroscopy and different multivariate calibrations[J]. Journal of Pharmaceutical and Biomedical Analysis,2009,50 (5):803-808
[70]Q. Chen, P. Jiang, J. Zhao. Measurement of total flavone content in snow lotus (Saussurea involucrate) using near infrared spectroscopy combined with interval PLS and genetic algorithm[J]. Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy,2010, 76(1):50-55
[71]赵琛,瞿海斌,程翼宇.虫草氨基酸的人工神经网络-近红外光谱快速测定方法[J].光谱学与光谱分析,2004,24(1)：50-53
[72]杨南林,程翼宇,瞿海斌.用人工神经网络-近红外光谱法测定冬虫夏草中的甘露醇[J].分析化学,2003,31(6)：664-668
[73]X. Luo, X. Yu, X.Wu, Y. Cheng, H. Qu. Rapid determination of Paeoniae Radix using near infrared spectroscopy [J]. Microchemical Journal,2008,90(1):8-12
[74]杨南林,瞿海斌,程翼字.近红外光谱法快速测定三七总皂苷的方法研究[J].浙江大学 学报(工学版),2002,36(4)：463-466
[75]杨南林,程翼宇,吴永江.中药材三七中皂苷类成分的近红外光谱快速无损分析新方法[J].化学学报,2003,61(3)：393-398
[76]C.W. Huck, G. Abel, M. Popp, G.K. Bonn. Comparative analysis of naphthodianthrone and phloroglucine derivatives in St. John's Wort extracts by near infrared spectroscopy, high-performance liquid chromatography and capillary electrophoresis[J]. Analytica Chimica Acta,2006,580 (2):223-230
[77]I. Rager, G. Roos, P.C. Schmidt, K.A. Kovar. Rapid quantification of constituents in St. John's wort extracts by NIR spectroscopy[J]. Journal of Pharmaceutical and Biomedical Analysis,2008,28 (3-4):439-446
[78]Y. Geng, B. Xiang, Simultaneous quantitation of flavonol aglycones in Ginkgo biloba leaf extracts applying moving window partial least squares regression models[J]. Jouranl of Near Infrared Spectroscopy,2008,16(6):551-559
[79]胡钢亮,吕秀阳,罗玲,徐铸德.近红外光谱法同时测定银杏提取液中总黄酮和总内酯含量[J].分析化学,2004,32(8)：1061-1063
[80]M. Gaub, C. Roeseler, G. Roos, K.A. Kovar. Analysis of plant extracts by NIRS: simultaneous determination of kavapyrones and water in dry extracts of Piper methysticum Forst[J]. Journal of Pharmaceutical and Biomedical Analysis,2004,36 (4):859-864
[81]朱向荣,李娜,史新元,乔延江,张卓勇.近红外光谱与组合的间隔偏最小二乘法测定清开灵四混液中总氮和栀子苷的含量[J].高等学校化学学报,2008,29(5)：906-911
[82]Y. Wu, S. Sun, Q. Zhou, H. Leung. Fourier transform mid-infrared (MIR) and near-infrared (NIR) spectroscopy for rapid quality assessment of Chinese medicine preparation Honghua Oil[J]. Journal of Pharmaceutical and Biomedical Analysis,2008,46 (3):498-504
[83]聂黎行,王钢力,李志猛,林瑞超.近红外光谱法对同仁乌鸡白凤丸的定性和定量分析[J].红外与毫米波学报,2008,27(3)：205-209
[84]柯博克,刘雪松,陈勇,李文,瞿海斌,程翼宇.近红外光谱快速测定复方丹参滴丸的包衣厚度[J].中草药,2006,37(5)：685-688
[85]瞿海斌,杨海雷,程翼宇.近红外漫反射光谱法快速无损鉴别阿胶真伪[J].光谱学与光谱分析,2006,26(1)：60-62
[86]钟建理,侥伟文,谢黔峰,吴萌.沉香的近红外光谱法鉴别初探[J].西北药学杂志,2010,25(4)：273-275
[87]赵龙莲,张录达,李军会,杨帆.小波包熵和Fisher判别在近红外光谱法鉴别中药大黄真伪中的应用[J].光谱学与光谱分析,2008,28(4)：817-820
[88]C. Chu, D. Mok, F. Chau. Analysis of berberine and total alkaloid content in Cortex Phellodendri by near infrared spectroscopy compared with high-performance liquid chromatography coupled with ultra-visible spectrometric detection[J]. Analytica Chimica Acta,2007,592 (2):121-131
[89]C. Lau, C. Chan, F. Chau, D. Mok. Rapid analysis of Radix puerariae by near-infrared spectroscopy[J], Journal of Chromatography A,2009,1216 (11):2130-2135
[90]Q. Fan, Y. Wang, P. Sun, S. Liu, Y. Li. Discrimination of Ephedra plants with diffuse reflectance FT-NIR and multivariate analysis[J]. Talanta,2010,80(3):1245-1250
[91]M. Laasonen, T. Harmia-Pulkkinen, C.L. Simard, E. Michiels, M. Rasanen, H. Vuorela. Fast identification of Echinacea purpurea dried roots using Near-Infrared spectroscopy[J]. Analytical Chemistry,2002,74:2493-2499
[92]高越,柴逸峰,吴玉田.近红外漫反射光谱法鉴别贝母药材的研究[J].中成药,2005,27(12)：1440-1443
[93]朱斌,郑清明,秦路平,郑汉臣,年华,刘荔荔.20种金丝桃属植物的近红外漫反射光谱法鉴别[J].第二军医大学学报,2003,24(4)：455-456
[94]孙国明,刘国林.近红外光谱技术在独活属药用植物分类中的应用[J].中国中药杂志,2006,31(23)：1996-1998
[95]黄宝康,黄流清,秦路平,赵忠新,陆峰,郑汉臣.四种缬草属药用植物的近红外漫反射指纹图谱聚类分析[J].中药材,2008,31(10)：1494-1496
[96]辛海量,胡园,张巧艳,郑汉臣,秦路平.4种牡荆属植物来源生药的近红外漫反射指纹图谱聚类分析[J].时珍国医国药,2008,19(12)：3037-3038
[97]Y. Woo, H. Kim, K. Ze, H. Chung. Near-infrared (NIR) spectroscopy for the non- destructive and fast determination of geographical origin of Angelicae gigantis Radix[J]. Journal of Pharmaceutical and Biomedical Analysis,2005,36 (5):955-959
[98]Y. Woo, C. Cho, H. Kim, H. Chung Classification of cultivation area of ginseng by near infrared spectroscopy and ICP-AES[J]. Microchemical Journal,2002,73(3):299-306
[99]C. Cho, Y. Woo, H. Kim, Y. Chung, S. Chang, H. Chung. Rapid qualitative and quantitative evaluation of deer antler (Cervus elaphus) using near-infrared reflectance spectroscopy [J]. Microchemical Journal,2001,68(2-3):189-195
[100]Y. Woo, H. Kim, J. Cho, H. Chung. Discrimination of herbal medicines according to geographical origin with near infrared reflectance spectroscopy and pattern recognition techniques[J]. Journal of Pharmaceutical and Biomedical Analysis,1999,21(2):407-413
[101]Y. Woo, H. Kim, J. Cho. Identification of herbal medicines using pattern recognition techniques with near-infrared reflectance spectra[J]. Microchemical Journal,1999,63(1): 61-67
[102]J. Lu, B. Xiang, H. Liu, S. Xiang, S. Xie, H. Deng. Application of two-dimensional near-infrared correlation spectroscopy to the discrimination of Chinese herbal medicine of different geographic regions[J]. Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy,2008,69(2):580-586
[103]杨海雷,刘雪松,瞿海斌,程翼宇.一种基于近红外的红参药材质量快速评价方法[J]. 中草药,2005,36(6)：912-915
[104]K. Yu, Y. Cheng. Discriminating the genuineness of Chinese medicines using Least Squares Support Vector Machines[J]. Chinese Journal of Analytical Chemistry,2006,34(4):561-564
[105]叶正良,虞科,程翼宇.一种基于小波变换的近红外化学指纹图谱分析方法[J].高等学校化学学报,2007,28(3)：441-444
[106]刘雪松,施朝晟,程翼宇,瞿海斌.基于自组织映射神经网络的中药注射剂质量快速鉴别方法[J].分析化学,2007,35(10)：1483-1486
[107]刘雪松,程翼宇.用于中药药品质量快速检测的近红外光谱模糊神经元分类方法[J].化学学报,2005,63(24)：2216-2220
[108]严诗楷,罗国安,王义明,程翼宇.栀子药材提取工艺的近红外光谱实时控制方法研究[J].光谱学与光谱分析,2006,26(1)：1026-1030
[109]陈雪英,李页瑞,陈勇,王龙虎,孙长海,刘雪松.近红外光谱分析技术在赤芍提取过程质量监控中的应用研究[J].中国中药杂志,2009,34(11)：1355-1358
[110]陈雪英,李页瑞,陈勇,王龙虎,丁玲,孙长海,闫文杰,刘雪松.近红外光谱快速测定红花逆流提取过程中羟基红花黄色素A的含量[J].分析化学,2009,37(10)：1451-1456
[111]施朝晟,刘雪松,陈勇,瞿海斌,程翼宇.一种丹参提取过程终点快速判断方法[J].中国药学杂志,2006,41(23)：1771-1774
[112]刘全,瞿海斌,程翼宇.用于渗漉提取过程分析的中药有效组分近红外光谱快速测定法[J].化工学报,2003,54(11)：1586-1590
[113]蔡绍松,武卫红,王宁,董海平.黄芪水提液浓缩过程的AOTF-近红外光谱法在线析[J].中国医药工业杂志,2008,39(7)：527-529
[114]瞿海斌,李斌,刘雪松,程翼宇.红参醇提液浓缩过程近红外光谱在线分析方法[J].中国药学杂志,2005,40(24)：1897-1899
[115]刘冰,毕开顺,孙立新,史新元,乔延江,刘珍清.近红外光谱结合不同偏最小二乘法测定乳块消片醇沉液中丹参素和橙皮苷含量[J].世界科学技术-中医药现代化,2009,11(3)：388-394
[116]邢丽红,徐金钟,瞿海斌.近红外光谱法快速测定丹参醇沉过程中的鞣质[J].药物分析杂志,2010,30(10)：1813-1816
[117]张延莹,张金巍,张培,刘岩.近红外光谱技术在丹酚酸B纯化在线质控中的应用研究[J].时珍国医国药,2010,21(1)：220-222
[118]杨志斌,栾连军.近红外透射光谱用于积壳提取物纯化过程快速分析[J].中国药学杂志,2005,40(8)：615-618
[119]蒋雪,张经硕,邱敏,谢洪平,郭莉萍.重楼皂甙提取工艺优化与近红外光谱在线质量控制[J].分析化学,2006,34(9)：171-174
[120]杨南林,程翼宇,瞿海斌.一种用于中药纯化过程的近红外光谱分析新方法[J].化学学报,2003,61(5)：742-747
[121]徐晓杰,宋丽丽,朱新科,范丙义,郭辉,相秉仁.近红外光谱法用于六味地黄丸粉末混合过程的质量控制研究[J].中国现代应用药学杂志,2006,23(7)：644-646
[122]龚益飞,刘雪松,章顺楠,瞿海斌,程翼宇.近红外光谱法在线判断滴丸料液混合终点[J].中国药学杂志,2007,42(7)：509-511
[123]王春全.痰热清注射液的方解及功效[J].现代医药卫生,2006,22(5)：720-720
[124]温华珍,肖盛元,王义明,罗国安.黄芩化学成分及炮制学研究[J].天然产物研究与开发,2004,16(6)：575-579
[125]C. Li, L. Zhou, G. Lin, Z. Zuo. Contents of major bioactive flavones in proprietary traditional Chinese medicine products and reference herb of Radix Scutellariae[J]. Journal of Pharmaceutical and Biomedical Analysis,2009,50(3):298-306
[126]H. Li, Y. Jiang, F. Chen. Separation methods used for Scutellaria baicalensis active components[J]. Journal of Chromatography B,2004,812(1-2):277-290
[127]C.R. Horvath, P.A. Martos, P.K. Saxena. Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant Huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection[J]. Journal of Chromatography A,2005,1062(2):199-207
[128]赵勇,昝丽霞,孙文基.HPLC-ELSD法测定熊胆粉中牛磺熊去氧胆酸和牛磺鹅去氧胆酸的含量[J].药物分析杂志,2006,26(1)：127-129
[129]刘力,张辉,胡嵘,李民熙,李有才.山羊角研究概述[J].长春中医学院学报,1994,10(41)：109
[130]J. Xu, J. Shen, Y. Cheng, H. Qu. GC-MS analysis of amino acids in extract of cornus caprae hircus[J]. Chemical Research in Chinese Universities,2009,25(6):812-816
[131]黄丽瑛,吕植祯,李继彪,周炳南.中药金银花化学成分的研究[J].中草药,1996,27(11)：645-647
[132]J. Chen, Y. Song, P. Li. Capillary high-performance liquid chromatography with mass spectrometry for simultaneous determination of major flavonoids, iridoid glucosides and saponins in Flos Lonicerae [J]. Journal of Chromatography A,2007,1157 (1-2):217-226
[133]H. Li, P. Li, W. Ye. Determination of five major iridoid glucosides in Flos Lonicerae by high-performance liquid chromatography coupled with evaporative light scattering detection [J]. Journal of Chromatography A,2003,1008 (2):167-172
[134]Y. Song, S. Li, M. Wu, H. Li, P. Li. Qualitative and quantitative analysis of iridoid glycosides in the flower buds of Lonicera species by capillary high performance liquid chromatography coupled with mass spectrometric detector[J]. Analytica Chimica Acta, 2006,564 (2):211-218
[135]M. Ren, J. Chen, Y., L. Sheng, P. Li, L. Qi. Identification and quantification of 32 bioactive compounds in Lonicera species by high performance liquid chromatography coupled with time-of-flight mass spectrometry[J]. Journal of Pharmaceutical and Biomedical Analysis, 2008,48(5):1351-1360
[136]李倩,冯卫生.连翘的化学成分研究进展[J].河南中医学院学报,2005,20(117)：78-80
[137]吴伟明,陈丽佳,诸乐恺.高效液相色谱法测定痰热清注射液中黄芩苷和绿原酸的含量[J].儿科药学杂志,2006,12(4)：38-40
[138]娄玉霞,聂桂华,刘乃强.HPLC-ELSD法测定痰热清注射液中黄芩苷、熊去氧胆酸、鹅去氧胆酸3种成分的含量[J].中国中药杂志,2009,34(14)：1862-1864
[139]王珏,瞿海斌,邵青.HPLC-UV-ELSD法同时测定痰热清注射液中主成分含量[J].药物分析杂志,2009,29(11)：1084-1087
[140]杨南林.基于近红外光谱的中药过程分析方法研究[D],浙江大学,2003
[141]刘全.近红外光谱技术在中药生产过程质量分析中的应用研究[D],浙江大学,2004
[142]刘晓宣.近红外光谱定性定量技术在中药质量控制中的应用研究[D],浙江大学,2004
[143]刘雪松.中药的近红外光谱计算分析方法学研究[D],浙江大学,2005
[144]施朝晟.模式识别技术在中药近红外光谱分析中的应用研究[D],浙江大学,2006
[145]李斌.近红外光谱技术在中药制药过程在线质量分析中的应用研究[D],浙江大学,2005
[146]杨志斌.近红外光谱技术在中药制剂制备过程中的应用[D],浙江大学,2005年
[147]戚毅.近红外光谱分析技术在葛根提取物生产过程中的应用研究[D],浙江大学,2007
[148]赵琛.用于中药分析的近红外光谱多元校正方法学研究[D],浙江大学,2003
[149]柯博克.近红外光谱在硅胶柱层析过程分析中的应用研究[D],浙江大学,2006
[150]杨海雷.近红外光谱技术在中药质量分析中的若干应用研究[D],浙江大学,2005
[151]俞翔.丹参提取和醇沉过程的质量控制技术研究[D],浙江大学,2008
[152]罗晓芳.统计过程控制在丹参注射液生产质量控制中的应用研究[D],浙江大学,2008
[153]王丽影,高昕,佟子林,王喜军.熊胆的化学成分,药理作用及临床研究概况[J].中医药信息,2005,22(4)：30-33
[154]张贇华,刘建忠,彭霞,李忠琼,张雯洁.HPLC法比较熊胆粉及猪胆粉、牛胆粉、羊胆粉和鸡胆粉中胆汁酸类成分[J].药物分析杂志,2009,29(3)：487-490
[155]朱丽玢,洪筱坤.HPLC去定量分析熊胆中胆酸类化合物[J].中草药,2004,35(11)：1255-1257
[156]E.K. Kemsley. Discriminant analysis of high-dimensional data:a comparison of principal components analysis and partial least squares data reduction methods[J]. Chemometrics and Intelligent Laboratory Systems,1996,33(1):47-61
[157]张春凤,张永清.黄岑炮制沿革[J].中药材,2003,26(12)：890-892
[158]张家辉,杨蕊,邓洪平.缙云黄芩HPLC指纹图谱的建立及其不同部位活性成分含量研究[J].中国中药杂志,2009,34(19)：21-24
[159]符洪,肖新月,张南平,林瑞超,盛龙生.药用黄芩中主要化学成分分析[J].药物分析杂志,2003,3：33-38
[160]黄倩倩,潘瑞乐,魏建和,吴严巍,张录达.近红外漫反射光谱法测定黄芩中总黄酮及黄芩苷的含量[J].光谱学与光谱分析,2009,29(9)：2425-2428
[161]白雁,刘乐,王东,樊克锋.近红外光谱技术对黄芩浸膏中黄芩苷含量的快速检测[J].中成药,2009,31(9)：1375-1378
[162]R. Miyahara, T. Yoshimoto, K. Asawa, M. Gakkaishi. Chemical structures and changes of extracts during growth of Reishi(Ganoderma lucidum)[J]. Mokuzai Gakkaishi,1987,33 (5):416-422
[163]X. Niu, H. Yu, Y. Ying. The application of Near-infrared spectroscopy and Chemometrics to classify Shaoxing wines from different breweries[J]. Transactions of the AS ABE, 51(2008)1371-1376.
[164]M.C. Ortiz, L. Sarabia, R. Garcia-Rey, M.D.L. de Castro. Sensitivity and specificity of PLS-class modelling for five sensory characteristics of dry-cured ham using visible and near infrared spectroscopy[J]. Analytica Chimica Acta,2006,558 (1-2):125-131
[165]R.W. Kennard, L.A. Stone. Computer aided design of experiments[J]. Technometrics,1969, 11(1):137-148
[166]陈俊.金银花提取物的物质基础和制备工艺研究[D],浙江大学,2010年
[167]中国药典(2010版).一部[S].205
[168]李庆波,张广军,徐可欣.DS算法在近红外光谱多元校正模型传递中的应用[J].光谱学与光谱分析,2007,27(5)：873-876
[169]中国药典(2010版).一部[S].159
[170]张玲,单卫华,时延增,徐新刚,李春玲.青翘和老翘中连翘苷的含量测定[J].中国现代应用药学杂志,1999,16(1)：45-46
[171]陈随清,王三姓,董诚明,王欣,冯卫生.连翘果实化学成分积累动态的研究[J].中国中药杂志,2007,32(11)：1096-1097
[172]郑晓珂,魏悦,冯卫生.不同采收期连翘的HPLC指纹图谱研究[J].中国实验方剂学杂志,2007,13(3)：1-4
[173]张晓慧,刘建学.近红外光谱技术鉴别连翘产地[J].激光与红外,2008,38(4)：342-344
[174]白雁,王星,陈志红,龚海燕,张威.近红外光谱法测定连翘药材中连翘苷含量[J].中成药,2009,31(11)：1755-1759
[175]王星,白雁,陈志红,龚海燕,张威.近红外光谱法测定连翘中连翘酯苷含量[J].中国中药杂志,2009,34(16)：2071-2075
[176]M. Brulls, S. Folestad, A. Sparen, A. Rasmuson, J. Salomonsson. Applying spectral peak area analysis in near-infrared spectroscopy moisture assays[J]. Journal of Pharmaceutical and Biomedical Analysis,2007,44(1):127-136
[177]X. Zhang, Y. Feng, C.Hu. Feasibility and extension of universal quantitative models for moisture content determination in beta-lactam powder injections by near-infrared spectroscopy [J]. Analytica Chimica Acta,2008,630(2):131-140
[178]冯军勤,周誉昌,吕华,李海.运用近红外漫反射光谱技术检测中药水分含量[J].大众科技,2006,2：46-47
[179]W. Yu, Q. Fu, W. Dai, Z. Li. Study on correlation between effective ingredients of Dogwood Fruit from genuine producing regions and trait[J]. China Journal of Chinese Materia Medica,2008,33(23):2751-2755
[180]S. Skeie, G. Feten, T. Alm(?)y, H.(?)stlie, T. Isaksson. The use of near infrared spectroscopy to predict selected free amino acids during cheese ripening[J].International Dairy Journal, 2006,16(3):236-242
[181]牛智有,韩鲁佳.鱼粉中氨基酸近红外光谱定量分析[J].农业机械学报,2007,38(5)：114-117
[182]H. Yu, Y. Ying, T. Sun, X. Niu, X. Pan. Vintage year determination of bottled Chinese rice wine by VIS-NIR spectroscopy [J]. Journal of Food Science,2007,72(3):125-129
[183]O.Y. Rodionova, Y.V. Sokovikov, A.L. Pomerantsev. Quality control of packed raw materials in pharmaceutical industry[J]. Analytica Chimica Acta,2009,642(1-2):222-227
[184]H. Cen, Y. He, Theory and application of near infrared reflectance spectroscopy in determination of food quality[J]. Trends in Food Science & Technology,2007,18(2):72-83
[185]刘燕德.水果糖度和酸度的近红外光谱无损检测研究[D].浙江大学,2006
[186]Y. Wang, D.J. Veltkamp, B.R. Kowalski. Multivariate instrument standardization[J]. Analytical Chemistry,1991,63 (23):2750-2756
[187]朱向荣,李娜,史新元.支持向量机与紫外光谱法用于鉴别清开灵注射液六混中间体[J].光谱学与光谱分析,2008,28(7)：1626-1629
[188]朱向荣,李娜,史新元.最小二乘支持向量机算法与紫外光谱法用于鉴别清开灵注射液四混中间体[J].分析化学,2008,28(6)：770-774
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |