清热解毒化瘀法治疗寻常性痤疮的理论与实验研究
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摘要
本论文以中医基础理论为指导,系统回顾了中西医学防治痤疮的相关文献,根据中医学和现代医学有关痤疮的研究,结合导师的学术观点,对痤疮的发病机理及治疗方法作了初步探讨,认为素体阳盛,火热内蕴是痤疮的发病基础,火热并邪,化生毒气,上攻头面是痤疮的病理关键,热盛毒凝,内外合邪,瘀血停滞,是痤疮病情加重及反复的核心环节,提出清热解毒化瘀法是防治痤疮的重要治法之一。
根据这一法则,以金银花、丹参、蒲公英、白花蛇舌草、生山楂等药配伍组成清热解毒化瘀复方,借助实验研究探讨了清热解毒化瘀法防治痤疮的作用及机理。
动物实验结果显示,该复方对兔耳痤疮模型有较好的治疗作用,能明显缩小毛囊面积和皮脂腺直径,降低SP表达,降低血黏度,其作用机制可能与该复方抑菌抗炎、调节免疫,减轻局部炎症反应;调节内分泌,抑制皮脂腺分泌;活血化瘀,降低血黏度,改善局部微循环有关。据此认为,清热解毒化瘀法防治痤疮有一定的科学根据,值得进一步研究。
Guided by the Basic theory of Traditional Chinese Medicine (TCM),reviewing of the literature of modern medicine and TCM about the treatment of acne baced on the theories about acne in TCM and modern medicine ,combing with instructor's viewpoint, this article explores on the pathogenic mechanism and the therapeutic method of acne through theory and experimental study. The author regards that hot inner were the pathogenic fundamental of acne ;heat and toxin upward to the face were the pathogenic key of acne and heat ,toxin bring on blood stagnation , which were the focus pathogenic of acne .therefore ,remove heat and clear toxin and active blood circulation was one of the important treatment methods of acne.
Complex prescription of remove heat and clear toxin and active Blood circulation ,which is prepared according to the treatment principal ,consists of flos lonicerae japonicae、radix et rhizom salviae miltiorhizae、herbataraxaci、hedyotis diffusa、fructus crataegi etc. Using morden scientific research, the paper discussed the mechanism of the aprescription .
Animal experiment revealed that the prescription has a good effect in rabbit ear model. That can significantly reduce the size of hair follicles and sebaceous glands in diameter, reducing the expression of Substance P, reduce blood viscosity and its mechanism may be related to the inhibitory anti-inflammatory compound, regulating immunity, reduce the local inflammatory response; Regulation of the endocrine and suppress sebaceous gland secretion; promoting blood circulation and reduce blood viscosity, improve local micro-circulation related .Therefore the therapeutic method of remove heat ,clear toxin and active Blood circulation has certain scientific evidences and is worth being studied further.
根据这一法则,以金银花、丹参、蒲公英、白花蛇舌草、生山楂等药配伍组成清热解毒化瘀复方,借助实验研究探讨了清热解毒化瘀法防治痤疮的作用及机理。
动物实验结果显示,该复方对兔耳痤疮模型有较好的治疗作用,能明显缩小毛囊面积和皮脂腺直径,降低SP表达,降低血黏度,其作用机制可能与该复方抑菌抗炎、调节免疫,减轻局部炎症反应;调节内分泌,抑制皮脂腺分泌;活血化瘀,降低血黏度,改善局部微循环有关。据此认为,清热解毒化瘀法防治痤疮有一定的科学根据,值得进一步研究。
Guided by the Basic theory of Traditional Chinese Medicine (TCM),reviewing of the literature of modern medicine and TCM about the treatment of acne baced on the theories about acne in TCM and modern medicine ,combing with instructor's viewpoint, this article explores on the pathogenic mechanism and the therapeutic method of acne through theory and experimental study. The author regards that hot inner were the pathogenic fundamental of acne ;heat and toxin upward to the face were the pathogenic key of acne and heat ,toxin bring on blood stagnation , which were the focus pathogenic of acne .therefore ,remove heat and clear toxin and active blood circulation was one of the important treatment methods of acne.
Complex prescription of remove heat and clear toxin and active Blood circulation ,which is prepared according to the treatment principal ,consists of flos lonicerae japonicae、radix et rhizom salviae miltiorhizae、herbataraxaci、hedyotis diffusa、fructus crataegi etc. Using morden scientific research, the paper discussed the mechanism of the aprescription .
Animal experiment revealed that the prescription has a good effect in rabbit ear model. That can significantly reduce the size of hair follicles and sebaceous glands in diameter, reducing the expression of Substance P, reduce blood viscosity and its mechanism may be related to the inhibitory anti-inflammatory compound, regulating immunity, reduce the local inflammatory response; Regulation of the endocrine and suppress sebaceous gland secretion; promoting blood circulation and reduce blood viscosity, improve local micro-circulation related .Therefore the therapeutic method of remove heat ,clear toxin and active Blood circulation has certain scientific evidences and is worth being studied further.
引文
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