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铁缺乏对学生认知能力的影响
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摘要
研究背景
     随着我国改革开放和经济的快速发展,人口的流动不断增加。截至2007年6月底,公安部等相关部门调查显示:北京市总人口数量已经突破1700万人,其中,北京市户籍人口1204万人,流动人口数量已达到510万人,约占总人口数的三分之一。
     流动人口子女的教育是社会上普遍关注的问题,而他们的健康状况也受到相关部门的关注。2002年11~12月国务院妇儿工委办公室、中国儿童中心及UNICEF在全国九市进行了流动人口儿童健康状况抽样调查。结果显示:流动人口儿童的死亡率较高,常见病发病率较高,营养状况较差,卫生保健知识缺乏。调查流动人口儿童的主要食物的摄入情况与2000年全国14省城市儿童情况相比,其奶类、肉类、鱼虾类、蛋类、水果蔬菜每日食用的情况均低于城市常住儿童,导致流动人口儿童贫血、佝偻病、营养不良、生长发育迟缓等营养性疾病明显高于城市儿童。
     在形成人口素质的三个要素(遗传、营养和教育)中,营养状况对于人的智力和发展潜能的制约作用非常显著。生长发育时期膳食中长期营养素摄入不足,不仅影响机体的体格发育,还会影响认知能力的发育,尤其是铁缺乏。铁缺乏可引起一系列中枢神经系统功能的紊乱,包括情绪、运动和认知等多个方面。认知能力包括智力、注意力、记忆力等。缺铁可导致认知能力和学习成绩减退。且铁缺乏越严重,认知能力和学习成绩就越低下。
     为提高政府相关部门及社会群体对流动人口特别是他们子女健康的关注程度,我们需要进一步了解城市打工子弟学校学生的营养状况,通过系统的认知能力测试探讨铁缺乏及不同程度铁缺乏对青少年认知能力的制约作用。
     研究目的
     了解北京市大兴区蒲公英中学学生的营养和健康状况,调查学生认知能力及学习成绩,探讨铁缺乏及不同程度铁缺乏对学生认知能力及学习成绩的影响。并有针对性地提出科学合理的干预措施,为学校安排集体的膳食提供帮助。
     方法和对象
     选取北京市大兴区蒲公英中学在校学生,采用横断面调查方法于2007年6月及10月分别对学生进行营养调查,包括膳食调查(寄宿学生采用查帐法、非寄宿学生采用三日24小时膳食回顾法,计算学生膳食营养素摄入量,评价其营养状况,分析影响因素),体格检查(身高、体重),实验室生化检测(血红蛋白、血清铁、血清铁蛋白、血清转铁蛋白受体、血清锌、血清维生素A、尿中硫胺素及核黄素),问卷调查(包括学生性别、年龄、民族;家庭收入;学生父母年龄、文化程度、职业等),并对学生进行《托尼非语文智力测验》和《基本认知能力测验》,收集学生2007年6月的期末语文、数学、英语、思品、地理、历史等考试成绩。
     结果
     1、城市打工子弟学校学生营养状况
     1.1营养素摄入量不足:膳食营养素达到90%以上RNI/AI的有维生素C、镁、钾。达到RNI 80~90%的有能量、蛋白质。摄入不足的有维生素A、维生素B_1、维生素B_2、钙、铁、锌和硒,尤其是钙、锌和铁只有RNI/AI的32.0%、63.7%和64.9%。维生素A缺乏率为7.0%,维生素B_1缺乏率为7.4%,维生素B_2缺乏率为8.7%,34.8%的学生血清锌低于正常水平。铁缺乏较为严重,贫血率达到11.3%。
     1.2学生生长发育状况差:各年龄组男、女生身高和体重均值均低于北京市及大兴区总体水平。学生营养不良率高达30.3%。
     2、铁缺乏及不同程度铁缺乏对学生认知能力及学习成绩的影响
     铁缺乏学生相对于铁正常学生,认知能力差。铁缺乏学生按照贫血与否进一步分为严重铁缺乏和边缘铁缺乏。严重铁缺乏通常是指缺铁性贫血,而边缘铁缺乏通常是指缺铁不贫血。在注意力、记忆力、智力方面,平均得分最低都是缺铁性贫血学生,其次为缺铁不贫血学生,得分最高的都是铁状态正常学生。说明铁缺乏越严重,认知能力就越低下。调整社会人口学资料等混杂因素后,铁缺乏学生相对铁正常学生在记忆力、智力及认知能力总分方面有更高的不及格风险。
     学生的考试成绩包括语文、数学、英语和思品。其中语文和数学成绩铁缺乏学生低于铁正常学生,且差异有统计学意义。把铁缺乏学生进一步分为缺铁性贫血学生和缺铁不贫血学生,语文和数学成绩平均分缺铁性贫血学生最低,缺铁不贫血学生其次,铁正常学生最高。说明铁缺乏越严重,语文和数学成绩就越低。调整社会人口学资料等混杂因素后,铁缺乏学生相对铁正常学生在语文和数学方面有更高的不及格风险。
     结论
     1、城市打工子弟学校学生的营养状况差。营养不良、贫血、营养素缺乏率(包括铁缺乏率、锌缺乏率、维生素A缺乏率、维生素B_1缺乏率、维生素B_2缺乏率)明显高于北京市同龄学生。
     2、长期营养素缺乏,尤其是铁缺乏,使机体处于铁缺乏状态,导致学生认知能力,包括注意力、记忆力、智力及学习成绩差,且铁缺乏越严重,认知能力及学习成绩就越低下。
Background
     As china's reform opening up and rapid economic development,population mobility isincreasing. As by the end of June 2007, The Ministry of Public Security, and other relevant departments investigate: Beijing's total population of over 17,000,000 people. Among them, Beijing household registration of the population has reached 12,040,000, the number of floating population breakthrough 5,100,000, accounting for about one-third of the total population.
     Migrant children's education is widespread concern in society, they are also the health status of the same by the relevant departments. In November 2002 to December,women and children, the State Council Work Committee Office, UNICEF and the China Children's Center in Kowloon City, the country had a floating population of children of a sample survey. The results showed that: Floating population of high child mortality rate, high incidence of diseases, poor nutrition, lack of health knowledge. Investigation of the floating population of children within 1 week of the main food intake in 2000 and 14 cities in the province of children within 1 week diet shows that their milk, meat, fish and shrimp, eggs, fruits and vegetables daily consumption of the situation Lower than those in urban resident children, migrant children leading to anemia, rickets, malnutrition, stunted growth, and other nutritional disorders were significantly higher than urban children.
     The quality of the population in the form of three elements (genetic, nutrition and education), the nutritional status of the person's intellectual development and the potential constraints of a very significant role. Dietary intake of nutrients and long-term shortage not only affects the body's physical development, but will also affect cognitive development, especially iron deficiency. Iron deficiency can cause a range of functions of the central nervous system disorders, including emotional, physical and cognitive, and other aspects. cognitive including attention, memory, learning ability, and so on. Iron deficiency can lead to cognitive and learning ability decreased, especially in math dropped. And the more severe iron deficiency, cognitive and mathematical results will be lower.
     In order to enhance the relevant government departments and social groups on the movement of the population, especially the health of their children, we need a better understanding of urban school students work in the nutritional status, through the system of cognitive tests to explore varying degrees of iron deficiency and iron deficiency on the Juvenile cognitive constraints of the role.
     Objective
     Understanding of the Beijing Daxing District Pu gongying middle Schoo students nutritional and health status of the investigation and the academic ability of students to understand and explore varying degrees of iron deficiency and iron deficiency on cognitive and academic performance of students. And put forward scientific and reasonable intervention, the collective arrangements for the school meals to help.
     Method
     Cross-sectional survey methodology used in June 2007 and October respectively, the students carried out a nutrition survey, including physical examination (height, weight), biological and chemical detection laboratory (hemoglobin, hematocrit, serum iron, serum ferritin, serum transferrin Receptor, serum zinc and serum vitamin A, thiamine in the urine, riboflavin), Dietary surveys (selected Pu gongying middle schools in September 2007 the food consumption records of students,calculated dietary nutrient intake, nutritional status of its evaluation, impact analysis. and sampling method used for three consecutive days, the students measured in actual food intake of nutrients), Survey (including ethnic, family income, parents of students age, educational level, occupation), "Toni2 test of nonverbal intelligence " and "the basic cognitive tests," student survey on Chinese, mathematics, English, Moral Character,geography and history test scores in June 2007 at the end. of semester.
     Results
     1. Nutritional status of the students in Beijing Pu Gongying middle school
     1.1 Inadequate intake of nutrients: dietary more than 90% RNI/AI of vitamin C, magnesium and potassium. Achieve RNI 80-90 % of energy and protein. Inadequate intake of vitamin A, vitamin B_1, vitamin B_2, calcium, iron, zinc and selenium. In particular, calcium, zinc and iron only RNI/AI of 32.0 %, 63.7 % and 64.9 %.A lack of vitamin rate of 7.0 %, a lack of vitamin B_1 was 7.4 %, a lack of vitamin B_2 rate of 8.7 %, 34.8 % of students in lower than normal levels of serum zinc. iron deficiency is more serious, and anemic rate of 11.3 %.
     1.2 Growth and development of poor students: All age groups of boys and girls average height and weight are lower than overall level of Beijing and Daxing District. Student's malnutrition rate as high as 30.3 %.
     2. Iron deficiency and iron deficiency in varying degrees of students affect on academic performance and cognitive ability.
     Through cognitive tests, the results showed that: Iron deficiency students opposed to normal students, poor cognitive ability. In accordance with anemia or not, the students further into marginal iron deficiency and serious iron deficiency. Severe iron deficiency usually refers to the iron deficiency anemia (IDA), and Marginal iron deficiency usually refers to the non-iron-deficiency anemia (ID). In attention, memory, intelligence, the lowest average score is IDA students, followed by ID students, the highest scores are the normal students. That the more severe iron deficiency, the more low cognitive ability. After social adjustment of demographic data, such as confounding factors, iron deficiency students relative normal students in memory, mental and cognitive scores have a higher failure risk.
     The test scores of students, including Chiese, mathematics, English and Moral Character. Among Chiese and mathematics iron deficiency students are worse than the normal students, and the difference was statistically significant. The students further divided into iron deficiency anemia(IDA) and non-iron-deficiency anemia(ID), the lowest average score is IDA students, followed by ID students, the highest scores are the normal students. That the more severe iron deficiency, the more low average score. After social adjustment of demographic data, such as confounding factors, iron deficiency students relative normal students in Chiese and mathematics have a higher failure risk.
     Conclusions
     City school students to work in malnutrition, anemia, a lack of nutrients (including iron deficiency, zinc deficiency, a lack of vitamin A, a lack of vitamin B_1, vitamin B_2 lack of rate) was significantly higher than local students of the same age.
     Long-term lack of nutrients, especially iron deficiency,iron deficiency in the body so that the state of cognitive,including attention, memory, intelligence and academic performance is poor, and the more severe iron deficiency, cognitive and academic performance will be lower.
引文
[1]吕绍青,张受礼.流动儿童教育:逐渐进入视野的探究课题.战略与管理,2001(4):5-7.
    [2]翟灿,朱灵芝,刘薇,金欣窈.城市边缘的流动人口子女教育问题调查.缭望新闻周刊,2003,30:46-48.
    [3]林良明,顾雪,米杰,等.流动人口妇女儿童健康及卫生保健状况.中国生育健康杂志,2005,16(1):50-54.
    [4]孙长颢主编.营养与食品卫生学.2007第6版.北京:北京人民卫生出版社.
    [5]Atamna H,Walter PB,Ames BN.The role of heme and iron-sulfur clusters in mitochondrial biogenesis,maintenance,and decay with age.Arch Biochem Biophys,2002,397(2):345-353.
    [6]Higdon J.An evidence-based approach to vitamins and minerals:health implications and intake recommendations.NewYork,NY:Thieme,2003.
    [7]Walter T,De Andraca I,Chadud P,Perales CG.Iron deficiency anemia:adverse effects on infant psychomotor development.Pediatrics,1989,84(1):7-17.
    [8]Yang Y,Liu J,Cui H.Effect of zinc on cadmium-induced fetal damage.Journal of Hygiene Research,1998,27(2):112-115.
    [9]石修权,王客跃.锌缺乏对脑发育的影响及机制研究.微量元素与健康研究,2004,21(1):46-48,60.
    [10]李合华,潘建平.锌缺乏对儿童智力发育的影响.中国公共卫生,2002,18(2):151-152.
    [11]王叶,邢杰.维生素A缺乏对儿童健康的影响.中国妇幼保健,2008,23(19):2760-2761.
    [12]楼辰军,冯桂玲.维生素与人体健康.公共卫生与预防医学,2007,18(1):50-51.
    [13]Bartzokis G,Beckson M,Hance DB,Marx P,Foster JA,Marder SR.Evaluation of age-related increase of brain iron in young adult and older normal males.Magn Reson Inaging,1997,15(1):29-35.
    [14]Rao R,Georgieff MK.Neonatal iron nutrition.Semin Neonatol,2001,6(5):425-435.
    [15]Tarohda T,Yamamoto M,Amamo R.Regional distribution of manganese,iron,copper,and zinc in the rat brain during development.Anal Bioanal Chem,2004,380(2):240-246.
    [16]吴玲玲,赵正言.铁缺乏对中枢神经系统髓鞘化的影响.中国妇幼健康研究,2006,17(1):35-37.
    [17]Cur R C.Brain maturation and its relevance to understanding criminal culpability of juveniles.Curr Psychiatry Rep,2005,7(4):292-296.
    [18]Erikson KM,Jones BC,Hess EJ,Zhang Q,Beard JL.Iron deficiency decreases dopamine Dland D2receptors in rat brain.Pharmacol Biochem Behav,2001,69(3-4):409-418.
    [19]Ben-Shachar D,Youdim MB.Neuroleptic-induced supersensitivity and brain iron deficiency and neuroleptic-induced dopamine D2 receptor supersensitivity.J Neurochem,1990,54(4):1136-1141.
    [20]Beard J L,Chen Q,Connor J.Altered monamine metabolism in caudate-putamen of iron-deficient rats.Pharmacol Biochem Behav,1994,48(3):621-624.
    [21]Lozoff B,Beard J,Connor J,Barbara F,Georgieff M,Schallert T.Long-lasting neural and behavioral effects of iron deficiency in infancy.Nutr Rev,2006,64(5 Pt 2):S34-43;discussion S72-91.
    [22]Grantham-McGregor S,Ani C.A review of studies on the effect of iron deficiency on cognitive development in children.J Nutr,2001,131(2S-2):649S-666S;discussion 666S-668S.
    [23]Sachdev H,Gera T,Nestel P.Effect of iron supplementation on mental and motor development in children:systematic review of randomised controlled trials.Public Health Nutr,2005,8(2):117-132.
    [24]Halterman JS,Kaczorowski JM,Aligne CA,Auinger P,Szilagyi PG.Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States.Pediatrics,2001,107(6):1381-1386.
    [25]Lozoff B,Jimenez E,Hagen J,Mollen E,Wolf AW.Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy.Pediatrics,2000,105(4):E51.
    [26]Lozoff B,Jimenez E,Smith JB.Double burden of iron deficiency in infancy and low socioeconomic status:a longitudinal analysis of cognitive test scores to age 19 years.Arch Pediatr Adolesc Med,2006,160(11):1108-1113.
    [27]Murray-Kolb LE,Beard JL.Iron treatment normalizes cognitive functioning in young women.Am J Clin Nutr,2007,85(3):778-787.
    [28]李石.缺铁及补铁对7-12岁学龄儿童认知功能的影响.临床脑电学杂志,1998,7(3):131.
    [29]马惠容,谭美珍,曾超谊.铁缺乏症对婴幼儿智能发育的影响.广东微量元素科学,2003,10(6):36-39.
    [30]Idris M,Anis-ur-Rehman,Iron deficiency anemia in moderate to severely anaemic patients.J Ayub Med Coil Abbottabad,2005,17(3):45-47.
    [31]葛可佑主编.中国营养科学全书,2006年.北京:人民卫生出版社.
    [32]王光亚,叶晓敏,陈君石.高效液相色谱法侧定人血浆中视黄醉和生育酚.营养学报,1988,10(3):272-279.
    [33]鲁长豪.食品理化检验学.1998年.北京:人民卫生出版社.
    [34]杨月欣,王光亚,潘兴昌主编.中国食物成分表.2002年.北京大学医学出版社.
    [35]WHO.Iron deficiency anemia,assessment,preventive and control.A guide for programme managers. 2001.
    [36]血清转铁蛋白受体试剂盒说明说.R&D Systems.Quantikine IVD.Human sTfR.
    [37]林晓明,田伟,郭燕梅,龙珠,沈小毅,王峙.北京山区学龄儿童机体锌状况及血清锌水平分析.中国儿童保健杂志,2002,10(4):227-229.
    [38]周子新,刘筱娴.维生素A缺乏的流行病学研究.国外医学社会医学分册,2001,18(2):74-77.
    [39]张爱珍.医学营养学.1998年.北京:人民卫生出版社.
    [40]中国营养学会.中国居民膳食营养素参考摄入量.营养学报,2001,23(3):193-196.
    [41]颜兴伟,王国平,杨玉金,刘菁萍,许秀柏,李小群,宋铭辉,黎国强.南昌地区中小学生生长发育现状.中国学校卫生,2006,27(1):12.
    [42]刘宝林.生长发育研究是生命科学领域的重要课题.中华预防医学杂志,2003,5(6):18-20.
    [43]段佳丽,刘峥,任振勇,,庞星火,赵锐,时颖,韦萧,李晓梅,黄佳伟.2002年北京市居民生长发育现状分析.中国校医,2005,19(4):334-340.
    [44]张海涛,高洁,李冬梅,等.北京大兴区农村儿童青少年体格发育状况调查.中国学校卫生2008,(29)6:523-525.
    [45]杨晓光,翟凤英,葛可佑.中国居民营养与健康状况调查报告之三.居民体质与营养状况.2007年.北京:人民卫生出版社.
    [46]中国学生体质健康研究组.2005年中国学生体质与健康调研报告.北京:高等教育出版社.
    [47]殷秋香,刘家爱,徐春兰.金乡县城镇中小学生营养状况分析.华南预防医学,2004,30(2):40-42.
    [48]陈婉,陈建东,许汉忠.1997-2006年汕头市区中小学生营养不良状况分析.实用预防医学,2007,13(5):304-306.
    [49]项橘香.杭州市部分中小学生生长发育和营养状况分析.中国学校卫生,2004,25(5):570-571.
    [50]Yanovski JA,Yanovski SZ.Recent advances in basic obesity research.AMA,1999,282(16):1504-1506.
    [51]Mantzoros CS,Flier JS,Rogol AD.A longitudinal assessment of hormonal and physical alterations during normal puberty in boys.V.Rising leptin levels may signal the onset of puberty.J Clin Endocrinol Metab,1997,82(4):1066-1070.
    [52]于春媛,孙长颢,武衷斌.瘦素与其他激素水平在儿童青春期中的变化规律及相互关系研究.中国公共卫生,2001,17(8):704-706.
    [53]何志谦.人类营养学.2001第2版.北京:人民卫生出版社.
    [54]胡善明,荫士安,汤广文,谷秀芳,徐青梅,高翔.富含类胡萝卜素蔬菜在改善儿童维生素A营 养状况中的作用研究.营养学报,1999,21(4):455-461.
    [55]滕红红,王晓华.2000-2004年中国儿童维生素A缺乏状况研究.中国儿童保健杂志,2006,14(3):270-271.
    [56]赵丽云,于冬梅,刘爱东.2006年中国儿童与孕产妇营养健康状况调查结果分析.卫生研究.2008,37(1):65-67.
    [57]杨惠莲,文国颖,苏效东.西宁地区学生硫胺素与核黄素营养水平分析.青海医学院学报,2003,25(4):18-20.
    [58]楼辰军,冯桂玲.维生素与人体健康.公共卫生与预防医学,2007,18(1):50-51.
    [59]杜维蜻,马冠生.青少年钙需要量的影响因素.国外医学卫生学分册,2003,30(6):359-363.
    [60]Halterman JS,Kaczorowski JM,Aligne CA,Auinger P,Szilagyi PG.Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States.Pediatrics,2001,107(6):1381-1386.
    [61]Mason J,Bailes A,Beda-Andourou M,Copeland N,Curtis T,Deitchler M,Foster L,Hensley M,Horjus P,Johnson C,Lloren T,Mendez A,Munoz M,Rivers J,Vance G.Recent trends in malnutrition in developing regions:vitamin A deficiency,anemia,iodine deficiency,and child underweight.Food Nutr Bull,2005,26(1):59-108.
    [62]季成叶.我国中小学生贫血状况及程度构成.中国学校卫生,2008,29(2):111-113.
    [63]罗晓明.经济发达地区流动人口子女学校学生基本健康状况调查.医学文选,2005,24(6):890-891.
    [64]Stoltzfus RJ.Iron deficiency:Global prevalence and consequences.Food Nutr Bull,2003,24(4 Suppl):S99-S103.
    [65]International Nutritional Anemia Consultative Group(INACG).Integrating programs to move iron deficiency and anemia control forward.Report of the 2003 INAC Group Symposium.Washington DC:LSI Press,2003.
    [66]Sachdev H,Gera T,Nestel P.Effect of iron supplementation on physical growth in children:Systematic review of randomized controlled trials.Public Health Nutr,2006,9(7):904-920.
    [67]党京会,柯玲,李君雅.350例儿童血液中微量元素铁、锌、钙、硒临床分析.广东微量元素科学,2003,10(6):40-43.
    [68]Sandstead HH.Zinc deficiency:A public health problem.Am J dis Child,1991,145(8):853-859.
    [69]王丕玉,刘海潮.锌失衡与人体健康.中国食物与营养,2007,7:50-51.
    [70]林晓明,田伟,郭燕梅.北京山区学龄儿童机体锌状况及血清锌水平分析.中国儿童保健杂志, 2002,10(4):227-229.
    [71]李洪波.锌缺乏与营养不良.国外医学医学地理分册,2002,23(3):125-126.
    [72]Thu BD,Schultink W,Dillon D,Gross R,Leswara ND,Khoi HH.Effect of daily and weekly micronutrient supplementation on micronutrient deficiencies and growth in young Vietnamese children.Am J Nutr,1999,69(1):80-86.
    [73]李易方.乳及乳制品发展与膳食营养改善.中国居民膳食指南(1999.7).北京:中国检查出版社.
    [74]Martinez A,Knappskog PM,Haavik J.A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis.Curr Med Chem,2001,8(9):1077-1091.
    [75]Nagatsu T.Tyrosine hydroxylase:human isoforms,structure and regulation in physiology and pathology.Essays Biochem,1995,30:15-35.
    [76]Nelson C,Erikson K,Pinero DJ,Beard JL.In vivo dopamine metabolism is altered in iron-deficient anemic rats.J Nutr,1997,127(12):2282-2288.
    [77]Webb TE,Oski FA.Iron deficiency and scholastic achievement in young adolescents.J Pediatr,1973,82(5):827-830.
    [78]Soemantri AG,Pollitt E,Kim I.Iron deficiency anemia and educational achievement.Am J Clin Nutr,1985,42(6):1221-1228.
    [79]Pollitt E,Soemantri AG,Yunis F,Scrimshaw NS.Cognitive effects of iron deficiency anemia.Lancet,1985,1(8421):158.
    [80]Pollitt E,Hathirat P,Kotchabharkdi NH,Missel L,Valyasevi A.Iron deficiency and educational achievement in Thailand.Am J Clin Nutr,1989,50(3 Suppl):687-696;discussion 696-697.
    [81]Corapci F,Radan AE,Lozoff B.Iron deficiency in infancy and mother-child interaction at 5 years.J Behav Dev Pediatr,2006,27(5):371-378.
    [82]Stockard J,Pope-Stockard J,Sharbrough F.Brainstem auditory evoked potentials in neurology:methodology,interpretation,and clinical application.Aminoff M,ed.Electro-diagnosis in clinical neurology.3rd ed.New York,NY:Churchill Livingstone,1993:503-536.
    [83]Roncagliolo M,Garrido M,Walter T,Peirano P,Lozoff B.Evidence of altered central nervous system development in infants with iron deficiency anemia at 6 mo:delayed maturation of auditory brainstem responses.Am J Clin Nutr,1998,68(3):683-690.
    [84]Algarin C,Peirano P,Garrido M,Pizarro F,Lozoff B.Iron deficiency anemia in infancy:long-lasting effects on auditory and visual system functioning.Pediatr Res,2003,53(2):217-223.
    [85]Shankar N,Tandon OP,Bandhu R,Madan N,Gomber S.Brainstem auditory evoked potential responses in iron-deficient anemic children. Indian J Physiol Pharmacol, 2000,44(3): 297-303.
    
    [86] Kretsch MJ, Fong AK, Green MW, Johnson HL. Cognitive function, iron status, and hemoglobin concentration inobese dieting women. Eur J Chin Nutr, 1998,52(7): 512-518.
    
    [87] Bruner AB, Joffe A, Duggan AK, Casella JF, Brandt J. Randomised study of cognitive effects of iron supplementation in non-anaemiciron-deficient adolescent girls. Lancet, 1996, 348(9033): 992-996.
    
    [88] Murray-Kolb LE, Beard JL. Iron treatment normalizes cognitive functioning in young women. Am J Clin Nutr, 2007, 85(3): 778-787.
    
    [89] Penland JG Behavioral data and methodology issues in studiesof zinc nutrition in humans. J Nutr, 2000, 130(2S Suppl): 361S-364S.
    
    [90] Soemantri AG. Preliminary findings on iron supplementation and learning achievement of rural Indonesian children. Am J Clin Nutr, 1989, 50(3 Suppl): 698-701; discussion 701-702.
    [1]ATAMNA H,WALTER P B,AMES B N.The role of heme and iron-sulfur clusters in mitochondrial biogenesis,maintenance,and decay with age[J].Arch Biochem Biophys,2002,397:345-353.
    [2]HIGDON J.An evidence-based approach to vitamins and minerals:health implications and intake recommendations[M].NewYork,NY:Thieme,2003.
    [3]MARTINEZ A,KNAPPSKOG P M,HAAVIK J.A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis[J].Curr Med Chem,2001,8:1077-1091.
    [4]NAGATSU T.Tyrosine hydroxylase:human isoforms,structure and regulation in physiology and pathology[J].Essays Biochem,1995,30:15-35.
    [5]BARTZOKIS G,BECKSONM,HANCE D B,et al.MR evaluation of age-related increase of brain iron in young adult and older normal males[J].Magn Reson Inaging,1997,15:29-35.
    [6]RAO R,GEORGIEFF M K.Neonatal iron nutrition[J].Semin Neonatol,2001,6:425-435.
    [7]TAROHDA T,YAMAMOTO M,AMAMO R.Regional distribution of manganese,iron,copper,and zinc in the rat brain during development[J].Anal Bioanal Chem,2004,380:240-246.
    [8]ERIKSON K M,JONES B C,HESS E J,et al.Iron deficiency decreases dopamine Dland D2receptors in rat brain[J].Pharmacol Biochem Behav,2001,69:409-418.
    [9]SHACHAR B D,YOUDIM M B.Neuroleptic-induced supersensitivity and brain iron:Iron deficiency and neuroleptic-induced dopamine D2 receptor supersensitivity[J].J Neurochem,1990,54:1136-1141.
    [10]NELSON C,ERIKSON K,PINERO D J,et al.In vivo dopamine metabolism is altered in iron-deficient anemic rats[J].J Nutr,1997,127:2282-2288.
    [11]BEARD J L,CHEN Q,CONNOR J.Altered monamine metabolism in caudate-putamen of iron-deficient rats[J].Pharmacol Biochem Behav.1994,48:621-624.
    [12]LOZOFF B,BEARD J,CONNOR J,et al.Long-lasting neural and behavioral effects of iron deficiency in infancy[J].Nutr Rev,2006,64:S34-43.
    [13]GRANTHAM-MCGREGOR S,ANI C.A review of studies on the effect of iron deficiency on cognitive development in children[J].J Nutr,2001,131:649S-666S.
    [14]SACHDEV H, GERA T, NESTEL P. Effect of iron supplementation on mental and motor development in children:systematic review of randomised controlled trials [J]. Public Health Nutr,2005,8:117-132.
    
    [15]HALTERMAN J S, KACZOROWSKI J M, ALIGNE C A, et al. Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States [J]. Pediatrics, 2001,107:1381-1386.
    
    [16]FRIEL J K, AZIZ K, ANDREWS W L, et al. A double-masked, randomized control trial of iron supplementation in early infancy in healthy term breast-fed infants [J].J Pediatr,2003,143:582-586.
    
    [17]LOZOFF B, DE ANDRACA I, CASTILLO M, et al. Behavioral and developmental effects of preventing iron-deficiency anemia in healthy full-term infants [J]. Pediatrics, 2003,112:846-854.
    
    [18]CORAPCI F, RADAN A E, LOZOFF B. Iron deficiency in infancy and mother-child interaction at 5 years [J].J Behav Dev Pediatr, 2006,27:371-378.
    
    [19]LOZOFF B, JIMENEZ E, HAGEN J, et al. Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy [J]. Pediatrics, 2000,105:E51-62.
    
    [20]LOZOFF B, JIMENEZ E, WALTER T. Double burden of iron deficiency and low socio-economic status: a growth curve analysis of cognitive test scores to 19 years [J]. Arch Pediatr Adolesc Med,2006,160:1108-1113.
    
    [21]LOGAN S, MARTINS S, GILBERT R. Iron therapy for inproving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia [J]. Evid Based Ment Health, 2002, 5:17.
    
    [22]STOCKARD J, POPE-STOCKARD J, SHARBROUGH F. Brainstem auditory evoked potentials in neurology: methodology, interpretation, and clinical application [M]. Aminoff M, ed. Electro-diagnosis in clinical neurology. 3rd ed. New York, NY: Churchill Livingstone, 1993:503-536.
    
    [23]RONCAGLIOLO M, GARRIDO M, WALTER T, et al. Evidence of altered central nervous system development in infants with iron deficiency anemia at 6 mo: delayed maturation of auditory brainstem responses [J].Am J Clin Nutr,1998,68:683-690.
    
    [24]ALGARIN C, PEIRANO P, GARRIDO M, et al. Iron deficiency anemia in infancy: long-lasting effects on auditory and visual system functioning [J]. Pediatr Res, 2003,53:217-223.
    
    [25]SHANKAR N, TANDON 0 P, GARRIDO M, et al. Brainstem auditory evoked potential responses in iron-deficient anemic children [J]. Indian J Physiol Pharmacol,2000, 44:297-303.
    
    [26]SUNGTHONG R, MO-SUWAN L, CHONGSUVIVATWONG V C, et al. Once-weekly and 5-days iron supplementation differentially affect cognitive function but not school performance in Thai children [J]. J Nutr, 2004,134:2349- 2354.
    
    [27]BEARD J L, HENDRICKS M K, PEREZ E M, et al. Maternal iron deficiency anemia affects postpartum emotions and cognition [J].J Nutr,2005,135:267-272.
    
    [28]MURRAY-KOLB L E, BEARD J L. Iron treatment normalizes cognitive functioning in young women [J]. Am J Clin Nutr, 2007, 85:778-787.
    
    [29]BEARD J L,CONNOR J R. Iron status and neural functioning [J].Annu Rev Nutr, 2003, 23:41-58.
    
    [30]POLLITT E. Developmental sequel from early nutritional deficiencies: conclusive and probability judhements[J]. J Nutr, 2000,130:350S-353S.

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