老年人健步走的减脂效果与脂联素等基因多态性的关联性研究
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摘要
目的:研究健步走对中老年人BMI、体成分等体测量指标和血液、脂肪细胞因子的影响,及与过氧化物酶增殖物活化受体γ2、脂联素等基因多态性的关联性,探讨可用于制定中老年人个性化运动处方的分子标记。
方法:将92名中老年(50-65岁)单纯型肥胖患者,随机分为实验组(70人)和对照组(22人),实验组根据BMI进行分组,BMI≥25为肥胖组,23≤BMI＜25为超重组。通过递增负荷运动试验测定其功能能力F.C.,从而推算靶心率。有氧健步走作为主要方式,运动强度范围为开始的40%-50%F.C.至50%-65%F.C.,有效运动时间分别为40min/次,运动频率为5次/周,运动周期为3个月。
通过实验研究得出以下结论:
1.健步走可以降低中老年超重、肥胖人群的BMI、体重、腰围、腰臀比、腹部皮褶、游离脂肪酸。
2.健步走是中老年肥胖人群降低体脂%、血脂,提高脂联素水平,改善体测量指标的有效健身方法。
3.APM-1 T45G基因TT基因型与BMI、体重、血脂指标独立关联,TG基因型与体脂%、脂联素独立关联。TT、TG基因型均可考虑作为运动的基因敏感标记。APM-1基因G 276 T多态性变化规律与T45G多态性相似,运动后GT基因型与BMI、体重、体脂%、总胆固醇、低密度脂蛋白胆固醇独立关联。GT基因型可以考虑作为预测运动减脂敏感效果的基因标记。
4.PPARγ2 Pro12Ala基因CC基因型与BMI、体重、总胆固醇、低密度脂蛋白胆固醇独立关联。PPARγ2 C161T基因CC基因型与血脂、脂联素、游离脂肪酸独立关联。CC基因型可以考虑作为预测血液、体质量指标运动敏感效果的基因标记。
Objects:The paper is to find out how gene polymorphism sign follows the genovatiation and which genetype is more sensible to exercise,by exploring the relation between walking exercise,BIM,body constit, blood bodymeasure,and phenotype,also with the connection between PPARγ2 gene,adiponectin,and gene adipose cell factor being considered, thus to offer the theoretical basis for individualization exercise prescription of the old and the molecule signal
Method:By survey investigation and health examination,92 person(aged between 50-65),including fracture-type and adipositas-type,are choosen and randomly divided to EG(70) and CG(22).According BMI,those with BMI≥25 being adipositas,those with 23≤BMI＜25 being overweight.By taking the maximal cycle ergometer exercise,their functional capacity(F.C) and target heart rate are to be determined.It is set that the exercise intensity is 40%-50%F.C.-50%-65%,the efficient time of FC is 40min/once, exercise frequency is 5times/week,the exercise circle is 3months,all of which is to interview the connection between phenotype and gene polymorphism sign.
CONCLUSIONS:
1.walking Exercise can significant decrease the body fat,BIM, weight,WHR,WC,ABSW and FFA of overweight- group and obesity- group.
2.walking Exercise is a in effect method which can decrease the fat%,blood fat of the obesity people and increase the ADPN level, improve body measure index of the old fat people,
3.The correlation research between aerobic walking interfering the fat of the old and the APM-lgene T45G polymorphism shows,TT gene type have a independence correlation with BMI,weight,TC,LDLC.While TG gene type have a independence correlation with fat%,and ADPN.thus TT、 TG gene type are capable of being the sensitive gene signal of exercise,while it seems the principle of APM-1 geneG276 polymorphism' s change is the same as that of T45G.After exercise,GT gene have a independence correlation with BMI,weight,fat%,TC,and LDLC,thus GT gene type are capable of being the sensitive gene signal of exercise as estimation defatting
4.The correlation research between aerobic walking interfering the fat of the old and the PPARγ2 Pro12Ala polymorphism shows,CC gene type have a independence correlation with BMI,weight,TC,LDLC.The PPARγ2 C161T polymorphism shows,CC gene type have a independence correlation with blood fat,ADPN,FFA,thus CC gene type are capable of being the sensitive gene signal of exercise as estimation blood,body quality guideline
方法:将92名中老年(50-65岁)单纯型肥胖患者,随机分为实验组(70人)和对照组(22人),实验组根据BMI进行分组,BMI≥25为肥胖组,23≤BMI＜25为超重组。通过递增负荷运动试验测定其功能能力F.C.,从而推算靶心率。有氧健步走作为主要方式,运动强度范围为开始的40%-50%F.C.至50%-65%F.C.,有效运动时间分别为40min/次,运动频率为5次/周,运动周期为3个月。
通过实验研究得出以下结论:
1.健步走可以降低中老年超重、肥胖人群的BMI、体重、腰围、腰臀比、腹部皮褶、游离脂肪酸。
2.健步走是中老年肥胖人群降低体脂%、血脂,提高脂联素水平,改善体测量指标的有效健身方法。
3.APM-1 T45G基因TT基因型与BMI、体重、血脂指标独立关联,TG基因型与体脂%、脂联素独立关联。TT、TG基因型均可考虑作为运动的基因敏感标记。APM-1基因G 276 T多态性变化规律与T45G多态性相似,运动后GT基因型与BMI、体重、体脂%、总胆固醇、低密度脂蛋白胆固醇独立关联。GT基因型可以考虑作为预测运动减脂敏感效果的基因标记。
4.PPARγ2 Pro12Ala基因CC基因型与BMI、体重、总胆固醇、低密度脂蛋白胆固醇独立关联。PPARγ2 C161T基因CC基因型与血脂、脂联素、游离脂肪酸独立关联。CC基因型可以考虑作为预测血液、体质量指标运动敏感效果的基因标记。
Objects:The paper is to find out how gene polymorphism sign follows the genovatiation and which genetype is more sensible to exercise,by exploring the relation between walking exercise,BIM,body constit, blood bodymeasure,and phenotype,also with the connection between PPARγ2 gene,adiponectin,and gene adipose cell factor being considered, thus to offer the theoretical basis for individualization exercise prescription of the old and the molecule signal
Method:By survey investigation and health examination,92 person(aged between 50-65),including fracture-type and adipositas-type,are choosen and randomly divided to EG(70) and CG(22).According BMI,those with BMI≥25 being adipositas,those with 23≤BMI＜25 being overweight.By taking the maximal cycle ergometer exercise,their functional capacity(F.C) and target heart rate are to be determined.It is set that the exercise intensity is 40%-50%F.C.-50%-65%,the efficient time of FC is 40min/once, exercise frequency is 5times/week,the exercise circle is 3months,all of which is to interview the connection between phenotype and gene polymorphism sign.
CONCLUSIONS:
1.walking Exercise can significant decrease the body fat,BIM, weight,WHR,WC,ABSW and FFA of overweight- group and obesity- group.
2.walking Exercise is a in effect method which can decrease the fat%,blood fat of the obesity people and increase the ADPN level, improve body measure index of the old fat people,
3.The correlation research between aerobic walking interfering the fat of the old and the APM-lgene T45G polymorphism shows,TT gene type have a independence correlation with BMI,weight,TC,LDLC.While TG gene type have a independence correlation with fat%,and ADPN.thus TT、 TG gene type are capable of being the sensitive gene signal of exercise,while it seems the principle of APM-1 geneG276 polymorphism' s change is the same as that of T45G.After exercise,GT gene have a independence correlation with BMI,weight,fat%,TC,and LDLC,thus GT gene type are capable of being the sensitive gene signal of exercise as estimation defatting
4.The correlation research between aerobic walking interfering the fat of the old and the PPARγ2 Pro12Ala polymorphism shows,CC gene type have a independence correlation with BMI,weight,TC,LDLC.The PPARγ2 C161T polymorphism shows,CC gene type have a independence correlation with blood fat,ADPN,FFA,thus CC gene type are capable of being the sensitive gene signal of exercise as estimation blood,body quality guideline
引文
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