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中药饲料添加剂在肉猪生产中的应用研究
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摘要
选用45头平均体重为10kg左右的杜长大三元杂交断奶仔猪进行试验。试验分3组,通过在基础日粮中分别添加研制加工成的中药饲料添加剂Ⅰ、Ⅱ号(称中药Ⅰ、Ⅱ组)和抗生素等化学合成药物,比较它们之间对猪体生长性能(日增重等)、腹泻率及血液生化、免疫机能指标(IgG、IgM、IgA、总蛋白、白蛋白、补体3、补体4、IL-2、淋巴细胞阳性率等)等的影响。全程试验分10—20kg、20—40kg、40—70kg、70—90kg四个阶段,中药Ⅰ、Ⅱ组与对照组相比,生长性能结果如下:中药Ⅰ组日增重分别提高了6.54%、5.01%、4.49%和4.74%,料重比分别降低了1.55%、8.25%、5.65%和-0.03%;中药Ⅱ组日增重分别提高了1.44%、2.24%、4.12%和4.55%,料重比分别降低了-2.50%、6.01%、6.21%和1.08%,且两个中药处理组还能有效防止10—40kg阶段猪只发生腹泻。在10—20kg、20—40kg、40—65kg三个阶段,中药试验Ⅰ组、Ⅱ组与对照组相比,血液生化及免疫机能指标方面结果如下:血清IgG水平,分别提高了10.15%(P<0.05),18.06%(P<0.01),12.28%(P<0.01);8.07%(P<0.05),9.47%(P<0.05),6.71%(P<0.05)。IgM水平,分别提高了11.37%(P<0.05),10.78%(P<0.05),11.83%(P<0.05):5.88%(P>0.05),9.95%(P<0.05),9.67%(P<0.05)。IgA水平,分别提高了2.82%(P>0.05),9.97%(P<0.05)9.21%(P<0.05);1.69%(P>0.05),8.39%(P<0.05),7.89%(P<0.05)。总蛋白水平,分别提高了16.05%(P<0.01),10.92%(P<0.01),22.38%(P<0.01);8.90%(P<0.05),6.85%(P<0.05),15.57%(P<0.05)。白蛋白水平,分别提高了18.23%(P<0.05),20.34%(P<0.01),21.69%(P<0.05);8.90%(P>0.05),10.39%(P<0.05),9.28%(P>0.05)。血清C_3含量分别提高了17.56%(P<0.05),22.32%(P<0.05),16.53%(P>0.05);12.56%(P<0.05),11.16%(P>0.05),9.83%(P>0.05)。血清C_4含量分别提高了42.11%(P>0.05),59.09%(P<0.05),56.47%(P<0.01);31.58%(P>0.05),54.55%(P<0.05),38.82%(P<0.05)。血清IL-2含量分别提高了8.66%(P<0.05),6.93%(P<0.05),9.36%(P<0.01);5.80%(P>0.05),6.02%(P>0.05),6.29%(P<0.05)。在猪只20—40Kg阶段,与对照组相比,中药Ⅰ组、Ⅱ组的T淋巴细胞(ANAE)阳性
    
     福建农林大学硕士论文
    率水平,分别提高了6.56%(P>0.05)和2.1叽(p>0.05)。
     试验结果表明,中药饲料添加剂I、n号的应用,与对照组比较,可以显著提
    高肉猪的生长性能;显著影响血液生化指标并明显提高猪只的免疫机能。试验还证
    实中药饲料添加剂在肉猪的促长、提高抗病力方面的作用相当并优于部分抗生素及
    化学合成药物。试验结果为中药饲料添加剂在药残控制无公害生猪生产的应用推广
    提供了科学理论依据。
A total of 45 D*L*Y crossbred weaned piglets with average weight of about 10 Kg were selected and assigned to three groups. Two different kinds of Chinese herb feed additives(I and II) and antibiotic(chemical medicament) were supplemented respectively to 3 groups (Group I, Group II and Control Group ) to investigate the effects on the growing characteristics (i.e. daily weight gains, etc), diarrhea rate and biochemical quota of blood and function quota of immunity (IgG, IgM, IgA, Total protein, albumin,alexin3(C3), alexin4(C4), IL-2, positive ratio of T-lymphocytes). The whole feeding experiments divides into 4 stages, namely 10-20 Kg, 20-40 Kg, 40-70 Kg, 70-90 Kg. Compared with the Control Group, the results of the growing characteristics shows as follows:
    Daily weight gain in Group I increases by 6.54%,5.01%, 4.49% and 4.74% respectively in the four stages, while the feed conversion ratio decreases by 1.55%, 8.25%, 5.65% -0.03%respectively. Daily weight gain in Group II increases by 1.44%, 2.24%, 4.12% and 4.55% respectively, while the feed conversion ratio decreases by -2.50%> 6.01%> 6.21% 1.08%. The two treatment groups were found to be able to prevent piglets weighing 10-40 Kg from diarrhea effectively. Compared with the Control Group, in the stage of 10-20 Kg, 20-40 Kg, 40-70 Kg, Group I and Group II both get the blood biochemical quota and immunity function quota as follows: IgG of serum increases by 10.15% (PO.05) , 18.06% (P<0.01) and 12.28% (P<0.01) ; 8.07% (P<0.05), 9.47% (P<0.05) and 6.71% (P<0.05)o IgM increases by 11.37% (P<0.05), 10.78% (P>.05) and 11.83% (P<0.05); 5.88% (P<0.05), 9.95%(P<0.05) and 9.67% (P<0.05), IgA increases by 2.82% (P>.05) , 9.97% (P<0.05) and 9.21% (PO.05) ; 1.69% (P>.05), 8.39% (P<0.05) and 7.89% (P<0.05). Total protei
    n increases by 16.05% (P<0.01) , 10.92% (P<0.01) and 22.38% (P<0.01) ; 8.90% (P<0.05), 6.85% (P<0.05) and 15.57%
    
    
    (P<0.05). Albumin increases by 18.23% (PO.05) , 20.34% (P>.01) and 21.69% (P<0.05) ; 8.90% (P>.05), 10.39%(P<0.05) and 9.28% (P>.05)? C3 of serum increases by 17.56% (P<0.05) , 22.32% (P<0.05) and 16.53% (P>.05); 12.56% (P<0.05), 11.16% (P>.05)and 9.83% (P>.05). C4of serum increases by 42.11% (P>0.05) , 59.09% (P<0.05) and 56.47% (P<0.01) : 31.58% (P>.05), 54.55% (P<0.05) and 38.82% (P<0.05). IL-2 increases by 8.66% (PO.05) , 6.93% (PO.05) and 9.36% (P<0.01) ; 5.80% (P>.05), 6.02% (P>.05)and 6.29% (P<0.05). During the growth stage of 20-40 Kg, compared with the Control Group, the positive rate of T-lymphocytes in Group I and Group II increases by 6.56% (P>0.05) and 2.19% (P>0.05) respectively.
    The results indicated that compared with Control Group, the supplement of Chinese herb feed additives I and n can improve obviously the piglets' the growing characteristics, effect the blood biochemical quota noticeably , thus upgrade the immunity function of piglets. It is also proved that the supplement of Chinese herb feed additives is equivalent or superior to parts of antibiotic (chemical medicament) in terms of the growth promotion, disease resistance. It provides the scientific theory basis for the popularizing applications of Chinese herb feed additives in porker production of non-environmental pollution and control of residues of medicine.
引文
1.邱水平.动物性食品药物残留.江西畜牧兽医[J].2000(5):37~39
    2.刘莲之等.动物性食品的化学污染、药物残留及其防制对策[J].河南畜牧兽医.2001,22(1):17
    3.班付国.动物源食品的安全性及药物残留监控现状[J].河南畜牧兽医.2001.22(1):5~7
    4.齐志翔等.如何降低禽产品的药物残留量[J].禽业科技,1998,14(3):10~11
    5.闻爱友等.中草药对断奶仔猪生长性状的影响[J].安徽农业技术师范学院学报,2000,14(3):21~22
    6.张秀英.中草药添加剂仔猪健预防仔猪黄白痢及增重作用研究[J].中兽医医药杂志,2001,(3):12~13
    7.吴立夫等.几种中草药的抗腹泻作用治疗仔猪白痢及其机理的研究[J].畜牧兽医学报,1998,29(6).553~559
    8.曹庆森.中草药预防猪水肿病[J].云南畜牧兽医,2000,(1):44
    9.高凳慧等.复合中草药添加剂饲喂生长猪的效果比较[J].山西农业生物学报,1998,17(4):197~199
    10.张林等.中草药饲料添加剂对商品猪的饲喂效果[J].畜禽业,1998,(7):34
    11.金岭梅等.抗热应激中草药饲料添加剂对猪血液生理常数的影响[J].家畜生态,1999,20(1):10~12
    12.侯建军等,中草药饲料添加剂推广的效果研究[J].湖北民族学院学报(自然科学版),2001,19(1):34~36
    13.许琳等.清热药抗畜禽病毒感染的机理研究进展[J].中兽医医药杂志,2003,(5):20~21
    14.张克家.21世纪兽医中药发展的思考[J].中国兽医杂志,2000,26(12):3~4
    15.胡庭俊等.中草药对机体免疫细胞凋亡影响的研究概况[J].中兽医医杂志,2001,(6):18~20
    16.胡庭俊等.黄芪多糖对小鼠脾淋巴细胞蛋白激酶C活性的影响[J].中兽医医药杂志,2003,(2):11~12
    17.黄一帆.浅谈21世纪中兽医学的发展[J].福建畜牧兽医,2000,(1):15~16
    18.朴香淑等.中草药饲料添加剂促进畜禽生长性能研究现状及展望[J].2002,23(1):12~14
    19.黄一帆.天然药物免疫促进剂和调节剂开发应用研究展望[J].福建畜牧兽医,1999,(1):37~38
    20.贾玉山等.中草药饲料添加刺的分析与研究[J].内蒙古畜牧科学,1999,(2):22~25
    21.和绍禹等.中草药添加剂对生长育肥猪生长性能的影响研究[J].云南农业大学学报,2002,3(1):75~80
    22.张科仁,翟旭久等鸡猪等动物中草药饲料添加剂的研究现状[J].中兽医药杂志.1990(4):17~19
    23.杨志强.谈谈中草药饲料添加剂及其应用[J].农业科技通讯.1990(1):22~23
    24.葛长荣,田允波等.中草药添加剂研究现状与发展趋势[J].云南畜牧兽医,1998,(4):10~16.
    25.武端,康世良.中草药添加剂与绿色生态畜牧业[J].饲料博览,2001,(2):19~20.
    26.袁书林等.中草药饮料添加剂在养猪业中的应用[J].养猪业,2002,(6):18~22
    27.刘素洁.中草药对断奶仔猪促生长防腹泻作用的研究[J].黑龙江畜牧兽医,2001,(12):28~29
    28.刘俊达.衰老的免疫指标及中药对老年人淋巴细胞免疫功能失调的调控作用[J].医学研究通讯,2000,29(8):10~13
    29.张运芳等.几种茶叶多糖对佐剂性关节炎大鼠免疫指标的影响[J].安徽医科大学学报,2000,35(1)27~28
    30. Yamamcto I, Chmori H, Seasano M. ConA~induced proliferative response of splerocytes from arthritis ra[J]t. Drugs Exptl Clin Res, 1982, 8(1):5
    31.李繁等.免疫增强剂对鸡球虫体液免疫指标的影响[J].中国兽医杂志,2000,26(8):9~1l
    32. Danforth HD. Use of live oocyst-based vaxxines in avian coccidiosis cintrol [A].Proceedings of the Vith International Coccidiosis Conference, London 1997, 95~96
    33. Onaga H, Saeki H, Hoshi, et al. [J]Avian Diseases, 1986, 30(4):658~661
    
    
    34. Trees AJ,Crozier SJ, Mckllar SB, et al. [J]Vet. Parasitology, 1994. 109:551~557
    35. Lillehoi HS, Trout JM. [J]Avian Pathology. 1993, 22:3~31
    36.曹国文等.中药添加剂对生长猪肠道菌群与生长性能的影响[J].四川畜牧兽医.2003,30(10):19~20
    37. Zuckenmann F A, Husmann R J. The human and swine CD_4/CD_3 double positive T lymphocyte. Advances in Swine in Biomedical Research[J]. New York; Plenam, Press, 1996:331~343
    38. MNφTaXYTJnHOB, H. T. :BeTe-PNHaHR, (2) :63, 1983
    39. Lipstein, B. :Brit. Poultry, Sci, (2) : 159, 1984
    40. Zorikov, P. S. et al. :CA, (86) :1119732f, 1977
    41. Khanoi, M. T. et al. :CA, (77):17,1972.
    42.黄一帆,陈大勋.哺乳仔猪肠型大肠杆菌病防治药物的新剂型[J].福建农业大学学报,1996,25(2):226~229
    43.黄一帆,姚金水.中草药饲料添加剂对蛋用雏鸡免疫功能的影响[J].中兽医医药杂志,1996(5):10~12
    44.马玉芳,刘建成,黄一帆等.中药饲料添加剂对仔猪生长性能和免疫功能的影响[J].福建农林大学学报(自然科学版),2003,32(4):496~499
    45.马玉芳,黄一帆.中草药治疗仔猪自痢试验[J].中国兽医科技,2003,33(7):71~72
    46.马玉芳,黄一帆.母猪喂服黄白痢散对仔猪黄白痢的预防效果[J].中国兽医杂志,2003,39(5):34~35
    47.黄一帆,马汉理.中草药饲料添加剂对肉鸡生长的影响[J].福建农学院学报,1992,21(1):93~96
    48.黄一帆,吴德峰.复方中草药添加剂对猪霉形体肺炎发病率及生长性能的影响[J].中兽医医药杂志,1991(6):2~3
    49.姚金水,黄一帆.免疫增强剂对蛋用雏鸡免疫功能的影响[J].福建农业大学学报,1994,23(2):199~202
    50.黄一帆,周金泰.中草药饲料添加剂提高蛋鸡产蛋性能的试验研究[J].福建农学院学报,1993,22(2):220~224
    51.马玉芳,黄一帆.中草药防治牛羊传染病概况[J].中兽医医药杂志,2000,19(6):36~38
    52.黄一帆.中药防治鸡传染病的现状及展望[J].福建畜牧兽医,1999,21(3):12~13
    53.马玉芳,黄一帆.母猪喂服中药“黄白痢散”对仔猪黄白痢的预防效果[J].中兽医医药杂志,2003,22(3):11~14
    54.王武军,黄一帆.免疫调节剂研究进展[J1.福建畜牧兽医,2001,23(6):11~12
    55.黄瑞锦,黄一帆.益生素在动物营养上的应用[J].福建畜牧兽医,2001,23(3):5~6
    56.马玉芳,黄一帆.中草药治疗牛,羊中毒病的现状[J].福建畜牧兽医,2000,22(5):18~19
    57.马玉芳,黄一帆.中草药防治猪传染病的研究概况[J].中兽医学杂志,2000(4):33~35
    58.张铁英等.猪用中草药饲料添加剂质量标准的研究[J].饲料工业,2003(03):1~5
    59.张铁英等.猪用中草药饲料添加剂浸提工艺的研究[J].中国畜牧兽医,2003(03):25~26
    60.陈炅然等.中草药饲料添加剂质量控制与产业化发展[J].兽药与饲料添加剂,2002(03):7~9
    61.莫伟仁等.中草药饲料添加剂加工工艺及应用效果[J].中国饲料,1997(11):34~35
    62.钱莘莘等.高效素中药饲料添加剂质量控制方法的研究[J].中国兽医杂志,2001(6):28~29
    63.成都中医学院主编.常用中药学.上海人民出版社[M].1973
    64.重医附院内科中医中药研究组等.科学技术论文集(中医)药[M].1959
    65.徐锦奋等.中医药资料汇编(吉林医大)[M],工业.1973
    66.竺稽能等.中西医结合资料汇编[M],第二集(湖北中医学院附院).1979
    
    
    67.王浴生等.中药药理与应用[M].北京:人民卫生出版社.1983
    68.李希贤.中国药学会1962年学术会议论文摘要集[M].342
    69.宫绎摄夫.日本东洋医学会志[M],1962,13(1):5
    70.四川省中药研究所钩体研究组.中草药研究资料[M],1971,(6):34
    71. CA, 1956, 47:8175
    72. 小菅卓夫他.J Pharm Soc Japan[M], 1953, 73(5): 435 1956,76(4): 386; 1954, 74(8): 819; 1956, 76(4): 390; 1954, (10): 1086; 1956, 76(4): 393
    73. Yagi et al.J Nutr Sci Vit, 1979, 25 (2): 127
    74. Sharma OP. Biochem Pharmacol, 1976, 25 (15): 1811
    75.富泽摄夫.日本东洋医学会志[M].1962
    76.高桥真太郎.药学研究[M]. 1968
    77. Kaminaga T Phytother Res, 1996, 10(7): 581
    78. Konoahima Takao et al. J Nat Prod, 1991, 54(3): 816
    79. Konlahima T. Pianta Medica, 1990, 56(6): 653
    80.哈尔滨医科大学.中西医结合研究论文集[M],1961
    81.松田久司等.日本药学会第1100次年会论文摘要[M]
    82. Watanabe H et al. J Pharmacobil-Dyn, 1975, 25(5): 605
    83. Teng Che Ming et al. Throm Res, 1988, 50(6): 757
    84. Takao K et al. Journal of Natural Products, 1991,54(3): 816
    85.张纲纲等.常用中草药新用途手册[M].中国中医药出版社,1993
    86.中国草药汇编(上册)[M],北京:人民卫生出版社,1975
    87. Li D.F. etal,1990, Transient hypersensitivity to soybean meal in the early-weaned pig [3]. J. Anim, Sci. 68:1790
    88. Lindemann, M. D. et al. Dietary chromium picolinate additions improve gain: feed and carcass characteristics in growing~fmishing pigs and increase litter size in reproducing sows [J]. J. Anim. Sci., 1995, 73:457~465
    89. Mooney, K. W. and G. L. Gromwell. Efficacy of chromium picolinate and chromium chloride as potential carcass modifiers in swine [J]. J. Anita. Sci., 1997, 75:2661~2671
    90. Mconey, K. W. and G. L. Cromwell. Efficacy of chromium picolinate on performance and tessue accretion in pigs [J].J. Anim.Sci., 1999, 77:1188~1198
    91. Lindemann, M. D. Supplemental chromium may provide benefits, butcosts must be weighted [J]. Feedstuffs, 1996, 68(53):14~17
    92. National Resenreh Council. Nutrient Requirements of Swine [M].National Academy press, Washington, DC. 1988
    93. Crow, S. D. et al. Effect of dietary chromium addition on the growing characteristics and careass characteristics of growing and finishing pigs [J]. J. Anim. Sci., 1997a, 75(suppl. 1 ): 79(Abstr.)
    94. Lindemann, M. D. and K. W. Purser. Evaluation of dietary chromium picolinate supplement for growing~finishing pigs in a commercial setting [J]. J. Anita. Sci., 1997, 75(suppl. 1) :67(Abstr.).
    95. Neshiem M. C. ET AL. 1964. Interrelationship between dietary levels of sodium, chloride. And
    
    potassium [J].J Nutr. 84:361
    96. Patience JFRE. Et al. 1987. Effect of dietary electrolyte balance on growth and acid~base status and performance in pigs [J].J Nutr. 120:579~589
    97. Seidel A, Arolt V et al. Increased CD56+ natural killer ceils and related cytokines in major depression [J]. Clin Immunol Imrnunopathol, 1996, Jan, 78(1):83
    98. WOOD P R, SEOW H F. T cellcytokines and disease Prevention[J]. Vet Immunol, Immunopathol, 1996, 54:33~34

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