肝肾调补汤调治台湾地区绝经综合征的临床研究
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摘要
目的：
通过随机取样、对照分析,对自拟肝肾调补汤治疗肝肾阴虚型绝经综合征的临床疗效进行客观的评估,并尝试观察其对绝经期患者血糖、血脂代谢的干预作用,探讨自拟肝肾调补汤治疗绝经综合征的作用机理。
方法：
收集在2011年5月至2013年3月期间到台湾吉民中医诊所就诊的肝肾阴虚型绝经综合征患者60例,随机分为治疗组和对照组两组,每组各30例。治疗组给予自拟肝肾调补汤,对照组给予杞菊地黄丸,均共治疗三个月。比较两组治疗前后中医症状评分、改良Kupperman评分情况,比较两组治疗前后血清雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)、空腹血糖(FBG)、空腹胰岛素(FINS)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平。
结果：
1.治疗组总有效率96.7%,其中痊愈2例,显效20例,有效7例,无效1例；对照组总有效率86.7%,痊愈1例,显效17例,有效8例,无效4例。两组间总有效率比较差异有统计学意义(p<0.05)。
2.两组治疗后均能降低Kupperman积分,与治疗前相比较,差异均有统计学意义(p<0.05)。治疗组治疗后,潮热出汗、失眠、焦躁、头晕乏力、肌肉骨关节痛、性交困难等症状Kupperman积分均较治疗前减少,差异有统计学意义(p<0.05)；对照组治疗后,失眠、头晕、疲倦乏力、肌肉骨关节痛等症状Kupperman积分均较治疗前减少,差异有统计学意义(p<0.05)。治疗组治疗后,潮热汗出、焦躁、性交困难等症状Kupperman积分较对照组治疗后症状积分显著减少,差异有统计学意义(p<0.05)。
3.治疗组治疗后,对潮热汗出、失眠多梦、口燥咽干、五心烦热、腰膝酸软等症状方面有效率均在85%以上；对照组治疗后,经少经闭、腰膝酸软改善有效率在85%以上。
4.两组治疗后,FSH. LH均较治疗前显著下降,E2较治疗前显著提高,差异均有统计学意义(p<0.05)。两组间治疗前、后FSH、LH、E2水平均无明显差异(p>0.05)。
5.治疗组治疗后TC水平较治疗前明显下降,HDL水平则较治疗前明显提高,差异均有统计学意义(p<0.05), TG、LDL水平则与治疗前无显著差异(p>0.05)。对照组治疗前后TC、TG、LDL、HDL水平均未见明显差异(p>0.05)。两组间相比较,治疗后治疗组TC水平较对照组明显下降,HDL水平则较对照组明显提高,差异均有统计学意义(p<0.05)。
6.治疗组在治疗后FBG水平较治疗前显著下降,差异有统计学意义(p<0.05), FINS水平则与治疗前无显著差异(p>0.05)；对照组治疗前后FBG.F工NS水平无明显变化(p均>0.05)。
结论：
1.自拟肝肾调补汤和杞菊地黄丸均能够改善肝肾阴虚型绝经综合征患者Kupperman积分,自拟肝肾调补汤在潮热出汗、焦躁、性交困难等症状积分方面优于杞菊地黄丸。
2.自拟肝肾调补汤和杞菊地黄丸均能改善肝肾阴虚型绝经综合征患者FSH、LH和E2水平,但自拟肝肾调补汤在改善肝肾阴虚型绝经综合征中医证候方面优于杞菊地黄丸。
3.自拟肝肾调补汤能够有效改善肝肾阴虚型绝经综合征患者血脂代谢功能,在预防绝经综合征远期并发症方面有一定的优势。
Objective:
By random sampling, comparative analysis, on liver kidney and regulating complement of self-made Decoction for the treatment of liver and kidney yin deficiency type objective assessment of clinical effects of menopause syndrome, and try to observe its effect on long-term complications of menopause syndrome, discussion on self-made liver, kidney and regulating mechanism of nourishing Decoction for the treatment of Menopause Syndrome.
Method:
Collected in the outpatient clinics to Taiwan between may2011and march201360cases of syndrome of deficiency of liver and kidney in patients with Menopause Syndrome, randomly divided into treatment group and the control group two groups, each set of the30cases. Self-treatment group given liver, kidney and regulating nourishing soup, compared to Qi qijudihuang pills were treating a total of three months. Compare the two groups before and after treatment of TCM Symptom Score, improving kupperman score and compare the two groups before and after treatment with serum estradiol (e2), follicular stabbed hormone (fsh), luteinizing hormone (LH), fasting blood glucose (fbg), fasting Insulin (fins), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) levels.
Results:
1. Treatment of group96.7of the total efficiency, of which2cases of healing, a surge of20cases, effective in7cases,1cases of invalid; the control group,86.7per cent of efficient, cure1cases,17cases of bearing fruit, effective in8cases,4cases of invalid. Total efficiency comparison of differences between the two groups was statistically significant (p<0.05).
2. After two groups of treatment is to reduce kupperman points compared with the treatment, the differences were statistically significant (p<0.05). After group therapy, hot flashes, insomnia, irritability, sweating, dizziness, fatigue, muscle, bone and joint pain, symptoms such as sexual difficulty kupperman integral is less than before treatment, the difference was statistically significant (p<0.05); the control group after treatment, insomnia, dizziness, fatigue fatigue, muscle pain and other symptoms of Bone and Joint kupperman integral is less than before treatment, the difference was statistically significant (p<0.05). After group therapy, hot flashes, irritability, Khan, sexual difficulty, and other symptoms kupperman integral than the control group after treatment of integral significantly reduced, the difference was statistically significant (p<0.05).
3. After group therapy, hot sweats, insomnia, many dreams, upset mouth dry dry throat, five symptoms such as fever, soreness of the waist and the knees are more than85effective rate; the control group after treatment, the less the close, soreness of the waist and the knees to improve the effective rate above85.
4. Two sets of treatment, FSH and1h are higher than before the treatment of significant drop, E2than before treatment significantly increased the differences were statistically significant (p<0.05). Between the two treatments before and after fsh, LH, E2levels were not significantly different (p>0.05).
5.Before the TC levels after treatment group therapy in the treatment of decreased HDL levels were lower than before treatment significantly improved, the differences were statistically significant (p<0.05), TG, LDL levels and treatment of the former no significant differences (p>0.05). A control group before and after treatment with TC, TG, LDL, HDL levels were not significantly different (p>0.05). Comparison between the two groups, group TC levels than the control group after treatment decreased HDL levels compared with the control group markedly improved, the differences were statistically significant (p<0.05).
6.FBG levels after treatment group therapy in the treatment of significant decline before, the difference was statistically significant (p<0.05), there is no significant difference between the fins level and treatment (p>0.05); the control group before and after treatment with fbg, fins level had not changed significantly (p>0.05).
Conclusion:
1. Self-made regulating and nourishing liver-kidney soups and Qi Ju Huang pill all could improve kupperman index of menopausal syndrome of yin deficiency of liver and kidney type integrals, Self-made regulating and nourishing liver-kidney soups was better on improving single symptomkupperman index, such as hot flashes, irritability, sweating, sexual intercourse difficult than Qi dihuang.
2. Self-made regulating and nourishing liver-kidney soups and Qi qijudihuang pills could all improve FSH, LHand E2levels in patients with Menopause Syndrome of liver and kidney-yin deficiency type, but Self-made regulating and nourishing liver-kidney soups could improve the symptoms of yin deficiency of liver and kidney type of Menopause Syndrome better than Qi qijudihuang pill.
3. Self-made regulating and nourishing liver-kidney soups can effectively improve glucose and lipid metabolism in patients with Menopause Syndrome of liver and kidney-yin deficiency type. For prevention of long-term complications of menopause syndrome, Self-made regulating and nourishing liver-kidney soups would be better than Qi qijudihuang pill.
通过随机取样、对照分析,对自拟肝肾调补汤治疗肝肾阴虚型绝经综合征的临床疗效进行客观的评估,并尝试观察其对绝经期患者血糖、血脂代谢的干预作用,探讨自拟肝肾调补汤治疗绝经综合征的作用机理。
方法：
收集在2011年5月至2013年3月期间到台湾吉民中医诊所就诊的肝肾阴虚型绝经综合征患者60例,随机分为治疗组和对照组两组,每组各30例。治疗组给予自拟肝肾调补汤,对照组给予杞菊地黄丸,均共治疗三个月。比较两组治疗前后中医症状评分、改良Kupperman评分情况,比较两组治疗前后血清雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)、空腹血糖(FBG)、空腹胰岛素(FINS)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平。
结果：
1.治疗组总有效率96.7%,其中痊愈2例,显效20例,有效7例,无效1例；对照组总有效率86.7%,痊愈1例,显效17例,有效8例,无效4例。两组间总有效率比较差异有统计学意义(p<0.05)。
2.两组治疗后均能降低Kupperman积分,与治疗前相比较,差异均有统计学意义(p<0.05)。治疗组治疗后,潮热出汗、失眠、焦躁、头晕乏力、肌肉骨关节痛、性交困难等症状Kupperman积分均较治疗前减少,差异有统计学意义(p<0.05)；对照组治疗后,失眠、头晕、疲倦乏力、肌肉骨关节痛等症状Kupperman积分均较治疗前减少,差异有统计学意义(p<0.05)。治疗组治疗后,潮热汗出、焦躁、性交困难等症状Kupperman积分较对照组治疗后症状积分显著减少,差异有统计学意义(p<0.05)。
3.治疗组治疗后,对潮热汗出、失眠多梦、口燥咽干、五心烦热、腰膝酸软等症状方面有效率均在85%以上；对照组治疗后,经少经闭、腰膝酸软改善有效率在85%以上。
4.两组治疗后,FSH. LH均较治疗前显著下降,E2较治疗前显著提高,差异均有统计学意义(p<0.05)。两组间治疗前、后FSH、LH、E2水平均无明显差异(p>0.05)。
5.治疗组治疗后TC水平较治疗前明显下降,HDL水平则较治疗前明显提高,差异均有统计学意义(p<0.05), TG、LDL水平则与治疗前无显著差异(p>0.05)。对照组治疗前后TC、TG、LDL、HDL水平均未见明显差异(p>0.05)。两组间相比较,治疗后治疗组TC水平较对照组明显下降,HDL水平则较对照组明显提高,差异均有统计学意义(p<0.05)。
6.治疗组在治疗后FBG水平较治疗前显著下降,差异有统计学意义(p<0.05), FINS水平则与治疗前无显著差异(p>0.05)；对照组治疗前后FBG.F工NS水平无明显变化(p均>0.05)。
结论：
1.自拟肝肾调补汤和杞菊地黄丸均能够改善肝肾阴虚型绝经综合征患者Kupperman积分,自拟肝肾调补汤在潮热出汗、焦躁、性交困难等症状积分方面优于杞菊地黄丸。
2.自拟肝肾调补汤和杞菊地黄丸均能改善肝肾阴虚型绝经综合征患者FSH、LH和E2水平,但自拟肝肾调补汤在改善肝肾阴虚型绝经综合征中医证候方面优于杞菊地黄丸。
3.自拟肝肾调补汤能够有效改善肝肾阴虚型绝经综合征患者血脂代谢功能,在预防绝经综合征远期并发症方面有一定的优势。
Objective:
By random sampling, comparative analysis, on liver kidney and regulating complement of self-made Decoction for the treatment of liver and kidney yin deficiency type objective assessment of clinical effects of menopause syndrome, and try to observe its effect on long-term complications of menopause syndrome, discussion on self-made liver, kidney and regulating mechanism of nourishing Decoction for the treatment of Menopause Syndrome.
Method:
Collected in the outpatient clinics to Taiwan between may2011and march201360cases of syndrome of deficiency of liver and kidney in patients with Menopause Syndrome, randomly divided into treatment group and the control group two groups, each set of the30cases. Self-treatment group given liver, kidney and regulating nourishing soup, compared to Qi qijudihuang pills were treating a total of three months. Compare the two groups before and after treatment of TCM Symptom Score, improving kupperman score and compare the two groups before and after treatment with serum estradiol (e2), follicular stabbed hormone (fsh), luteinizing hormone (LH), fasting blood glucose (fbg), fasting Insulin (fins), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) levels.
Results:
1. Treatment of group96.7of the total efficiency, of which2cases of healing, a surge of20cases, effective in7cases,1cases of invalid; the control group,86.7per cent of efficient, cure1cases,17cases of bearing fruit, effective in8cases,4cases of invalid. Total efficiency comparison of differences between the two groups was statistically significant (p<0.05).
2. After two groups of treatment is to reduce kupperman points compared with the treatment, the differences were statistically significant (p<0.05). After group therapy, hot flashes, insomnia, irritability, sweating, dizziness, fatigue, muscle, bone and joint pain, symptoms such as sexual difficulty kupperman integral is less than before treatment, the difference was statistically significant (p<0.05); the control group after treatment, insomnia, dizziness, fatigue fatigue, muscle pain and other symptoms of Bone and Joint kupperman integral is less than before treatment, the difference was statistically significant (p<0.05). After group therapy, hot flashes, irritability, Khan, sexual difficulty, and other symptoms kupperman integral than the control group after treatment of integral significantly reduced, the difference was statistically significant (p<0.05).
3. After group therapy, hot sweats, insomnia, many dreams, upset mouth dry dry throat, five symptoms such as fever, soreness of the waist and the knees are more than85effective rate; the control group after treatment, the less the close, soreness of the waist and the knees to improve the effective rate above85.
4. Two sets of treatment, FSH and1h are higher than before the treatment of significant drop, E2than before treatment significantly increased the differences were statistically significant (p<0.05). Between the two treatments before and after fsh, LH, E2levels were not significantly different (p>0.05).
5.Before the TC levels after treatment group therapy in the treatment of decreased HDL levels were lower than before treatment significantly improved, the differences were statistically significant (p<0.05), TG, LDL levels and treatment of the former no significant differences (p>0.05). A control group before and after treatment with TC, TG, LDL, HDL levels were not significantly different (p>0.05). Comparison between the two groups, group TC levels than the control group after treatment decreased HDL levels compared with the control group markedly improved, the differences were statistically significant (p<0.05).
6.FBG levels after treatment group therapy in the treatment of significant decline before, the difference was statistically significant (p<0.05), there is no significant difference between the fins level and treatment (p>0.05); the control group before and after treatment with fbg, fins level had not changed significantly (p>0.05).
Conclusion:
1. Self-made regulating and nourishing liver-kidney soups and Qi Ju Huang pill all could improve kupperman index of menopausal syndrome of yin deficiency of liver and kidney type integrals, Self-made regulating and nourishing liver-kidney soups was better on improving single symptomkupperman index, such as hot flashes, irritability, sweating, sexual intercourse difficult than Qi dihuang.
2. Self-made regulating and nourishing liver-kidney soups and Qi qijudihuang pills could all improve FSH, LHand E2levels in patients with Menopause Syndrome of liver and kidney-yin deficiency type, but Self-made regulating and nourishing liver-kidney soups could improve the symptoms of yin deficiency of liver and kidney type of Menopause Syndrome better than Qi qijudihuang pill.
3. Self-made regulating and nourishing liver-kidney soups can effectively improve glucose and lipid metabolism in patients with Menopause Syndrome of liver and kidney-yin deficiency type. For prevention of long-term complications of menopause syndrome, Self-made regulating and nourishing liver-kidney soups would be better than Qi qijudihuang pill.
引文
1.丰有吉,沈铿.妇产科学.人民卫生出版社[M].2010.2(9)：263-267
2. Kailas NA, Sifakis S, Kounantakis E, et al. Contraception during perimenopause[J]. Eur J Contracept Reprod Health Care,2005,10(1):19-25
3.马红,吕晔,孙浩,王斌.立春胶囊治疗女性围绝经期综合征74例临床观察.天津中医,2002,(4)：55
4.田丰莲,詹新林,赵庆国,等.广东地区围绝经期综合征患病状况及其影响因素[J].中国妇幼保健,2004,19(7)：67
5.刘明兰,王馨园,熊丹,等.妇女围绝经期健康状况调查研究.中国妇幼保健,2012,27：4602-4605
6.王雪丹,张勇,杜慧玲,等.邯郸市社区围绝经期妇女代谢综合征流行病学调查.承德医学院学报,2012,29(2)：155
7.罗永玉,王小华.杭州市妇女围绝经期综合征发生情况分析.中国妇幼保健,2011,26(1)：141-142
8.滕振娟,战治家,薛巧梅,等.威海地区围绝经期妇女健康现状的流行病学调查.中国妇幼保健,2011,26(30)：4744-4747
9.李珍,黄皓,林小兰等.广东高校女教工围绝经期健康状况及相关因素调查.中国妇幼保健,2011,26(34)：5411-5414
10.初怡静,王福玲,娄艳辉,等.青岛地区女性围绝经期症状流行病学调查分析.现代妇产科进展,2012,21(7)：553-556
11.陆亦琼,汤振宇,许薇.上海市南京东路社区妇女围绝经期症状分析.中国临床医学,2011,18(2)：209-211
12.梁文郁.中西医结合防治更年期综合征.中国中医基础医学杂志,1999,5(3)：57-59
13. Steinberg EM, Rubinow DR, Bartko JJ, et al. A cross-sectionalevaluation of perimenopausal depression [J]. J Clin Psychiatry,2008,69(6):973 — 980.
14.陶晶,仇剑崟,顾红亮,等.上海某妇科门诊围绝经期及绝经后期抑郁症状检出率及相关因素[J].上海精神医学,2011,23(1)：31-37.
15. Cohen LS, Soares CN, Vitonis AF, et al. Risk for new onset ofdepression during the menopausal transition:the Harvard study ofmoods and cycles [J]. Arch Gen Psychiatry, 2006,63 (4):385-390.
16. Osterlund MK, Hurd YL. Estrogen receptors in the human forebrainand the relation to neuropsychiatric disorders [J]. Prog Neurobiol,2001,64(3):251 — 267.
17.秦家云,王艳,彭丹红,等.女性血清性激素水平与认知功能的相关性研究.实用妇产科杂志,2012,28(8)：682-685
18.施凤,任慕兰.围绝经期妇女围绝经期综合征及情绪障碍分析.江苏医药,2011,37(4)：430-432；
19.施凤,任慕兰.围绝经期妇女生殖激素水平与情绪障碍相关分析.实用医学杂志,2011,27(14)：2558-2559
20.陈亚琼,叶雪清.血浆吲哚类神经递质与围绝经期综合征症状的相关性分析.中华妇产科杂志,1996,31-41
21. Smith LJ, Henderson JA, Abell CW, et al. Effects of ovarian steroidsand raloxifene on proteins that synthesize, transport, anddegrade serotonin in the raphe region of macaques [J]. Neuropsychopharmacology,2004,29(11):2035 — 2045.
22.陶晶,仇剑崟.雌激素对5-羟色胺能神经元的作用机制及临床应用[J].上海精神医学,2010,22(4)：246-248.
23.李贺琦,陈霞.围绝经期综合征与神经递质(5-羟色胺)相关性的临床研究进展.中华中医药学刊,2011,29(2)：375-376
24.顾红亮,陶晶,仇剑釜,等.5-羟色胺转运体基因多态性与女性围绝经期及绝经后期首发抑郁障碍的关联研究.中国妇幼保健,2011,26：4377-4381。
25.陶晶,仇剑崟,顾红亮,等.ESRl基因与5-HTT基因多态性的交互作用对女性围绝经期抑郁障碍的影响.上海交通大学学报(医学版),2012,32(6)：766-770
26.吴小立,韩自力,钟智勇,等.围绝经期女性情绪障碍影响因素的综合探讨.中国病理生理杂志,2011,27(3)：599-602
27.江仙远,侯安继,程化奇.女性更年期综合征患者的情志改变与血浆儿茶酚胺含量的关系.美国中华心身医学杂志,1998,2(1)：49-50
28.王晓萍.更年期忧郁症的心理治疗.浙江预防医学,1998,(9)：575
29.赵更力,王临虹,渠川琰,等.妇女个性特征与更年期综合征初探.中国心理卫生杂志,1998,12(3)：136-137,168
30.李礼奎.中药药理实验方法学[M].上海科学技术出版社,2006：831-839.
31.程化奇,熊舜华,殷新尤,等.大鼠更年期实验模型研究[J].上海实验动物科学,1993,13(4)：192.
32.杨长群,汪向红,刘妮英,等.雌激素替代疗法对围绝经期综合征妇女Kupperma评分、HAMD评分及激素水平的影响.中国医院药学杂志,2012,32(18)：1481-1483
33.杨欣,白文佩,郑淑蓉,等.经皮使用苯甲酸雌二醇凝胶治疗更年期综合征临床研究[J].中国临床药理学杂志,1999,15(2)：101-105.
34.潘敏.维尼安治疗更年期症状的临床观察[J].安徽医科大学学报,2000,35(4)：323.
35.林守清,宫伟雁,陈瑛.更年期性激素治疗的进展[J].’国外医学.妇幼保健分册,2005,16(5)：318
36.黄璐,许良智.戊酸雌二醇预防围绝经期、绝经后骨质疏松的系统评价.中华妇幼临床医学杂志 (电子版),2012,8(6)：748-753
37.马建东,李玉凤,刘树芳.米氮平与氯丙咪嗪治疗妇女更年期情绪障碍的临床对照研究[J].健康心理学杂志,2004,12(3)：180.
38.林炫,陈丽平.米非司酮治疗更年期功血的临床研究[J].中国妇幼保健,2008,23(10)：1376.
39.赵子凤.文拉法辛缓释片治疗29例围绝经期女性抑郁症的疗效观察.华西药学杂志,2011,26(1)：094
40.吴小立,钟智勇,韩自力,等.三种方法治疗围绝经期女性情绪障碍的比较.中山大学学报(医学科学版),2011,32(1)：76-79
41. Keenan NL, Anderson LA, LaCroix AZ, et al. Helping women achievelong — term continuance of estrogen replacement therapy(ERT) and hormone replacement therapy (HRT). Menopause,1999,6(2):179.
42.汪远金,许金林,张杰,等.大豆异黄酮对去卵巢大鼠骨质疏松症防治作用的研究.中国中医药科技,2004,11(3)：156.
43.张文众,李宁,李蓉,等.大豆异黄酮雌激素样作用研究.卫生研究,2008,37(6)：707.
44.刘春龙,李思秋,孙海霞,等.大豆异黄酮的生理作用及其在医学方面的研究进展.大学科学,2008,27(4)：693.
45.匡野,庞海燕,肖晓辉,等.大豆异黄酮对围绝经期大鼠卵巢FSHR表达的影响.中国中医药科技,2011,18(4)：311-314
46. Bai W, Henneicke — von ZH, Wang S, et al. Efficacy and tolerabilityof a medicinal product containing an isopropanolic black cohoshextract in Chinese women with menopausal symptoms:a randomized, double blind, parallel — controlled study versus tibolone [J]. Maturitas,2007; 58:31-41.
47. Frei — Kleiner S, Schaffner W, Rahlfs VW, et al. Cimicifuga racemosadried ethanolic extract in menopausal disorders:a double — blindplacebo — controlled clinical trial [J]. Maturitas,2005; 51:397-404.
48. Liske E, Hanggi W, Henneicke — von ZH, et al. Physiological investigationof a unique extract of black cohosh (Cimicifugae racemoaerhizoma):a 6 — month clinical study demonstrates no systemicestrogenic effect [J]. J Womens Health Gend Based Med,2002; 11:163-174.
49.曹杰,赵纯全.莉芙敏治疗妇女围绝经期综合征的疗效研究.临床合理用药,2012,5(3C)：17-19
50.欧阳惠卿.中医妇科学.人民卫生出版社[M].2008.1(8)：123-128
51.刘敏如,谭万信.中医妇产科学.人民卫生出版社[M].2001(1)：403-416
52.魏升.围绝经期综合征从脾论治.新中医,1991,23(2)：8
53.崔国玲.甘温除热法治疗围绝经期综合征30例.山东中医杂志,1996,15(12)：544
54.陆启滨.围绝经期综合征病因病机探源,中医药学刊,2001 19(2)：139-140
55.姚石安.围绝经期综合征中医研究述评.中医杂志,1994,35(2)：112-114
56.吴丽芹.围绝经期综合征病因病机分析[J].山西中医.2011(11)：5-7
57.史玉梅,谈勇,夏桂成.夏桂成教授治疗围绝经期综合征经验举隅[J].南京中医药大学学报,2005：21(2)：116-117
58.王清.围绝经期综合征的中医认识述评[J].中医杂志,2006,47(2)：151-152
59.刘静君.更年期综合征与体质关系初探[J].山东中医杂志,2006,25(5)：298-299.
60.陆启滨.更年期综合征病因病机探源[J].中医药学刊,2001,19(2)：139.
61.刘光伟.更年期综合征营卫失和病机初探[J].中医杂志,2002：43(6)：405-406.
62.王晓萍.从奇经论治妇女更年期综合征[J].中国医药学报,1995,10(4)：43-45.
63.高平,万德光.中医药治疗围绝经期综合征机制研究进展[J].现代中西医结合杂志,2004,13(4)：551.
64.夏桂成.更年1号新方治疗围绝经期综合征120例.中国医药学报,1994,14(7)：396)
65.李建生.补阴更年方治疗围绝经期综合临床疗效观察.辽宁中医杂志,1994,21(3)：119
66.黎烈荣.更年安怡片治疗围绝经期综合征的临床观察.中国中西医结合杂志,1999,19(4)：235
67.冯培贤.更年乐治疗围绝经期综合征中医药研究.1996,12(30)：40
68.朱慧.滋肾清心汤治疗围绝经期综合征的体会.陕西中医学院学报,1993,16(2)：22)
69.朱雄华.益肾变平汤治疗围绝经期综合征105例.江苏中医,1997,17-19
70.陈丽文.当归六黄汤治疗围绝经期综合征30例.中国中医药现代远程教育,2011,10(01)：130-140
71.任晓鸣,党晓玲,高显兰.归芍地黄汤合生脉散治疗围绝经期综合征73例临床观察.新疆中医药,2011,29(2)：14-16
72.李俊箐.保更汤治疗围绝经期综合征疗效观察.上海中医药杂志,2011,45(2)：41-42
73.赵建英,史樱,王洁意.围绝经期妇女血清FSH、LH、E2、P水平测定分析[J].实用妇产科杂志,2002,18(6)：360.
74.张蓉,宋李冬.柴胡加龙骨牡蛎汤治疗围绝经期患者失眠的疗效.中国临床医学,2012,19(2)：175-176
75.居跃君.从肝肾论治围绝经期失眠症临床观察.光明中医,2011,26(7)：1403-1404
76.朱耿.更年助眠饮治疗围绝经期妇女的失眠.50例临床观察.江苏中医药杂志,2003：24(2)：29
77.马亮,王宗仁,马静.二仙汤加味治疗围绝经期高血压的临床观察.贵阳中医学院学报,2011,33(4)：13-14
78.侣雪平,丛慧芳,王虹.黄连阿胶汤加减治疗围绝经期抑郁症30例.中国中医药现代远程教育,2011,9(09)：43-44
79.王全利,姚石安.静顺袋泡茶治疗女性围绝经期焦虑疗效观察.现代中西医结合杂志,2012, 21(5)：515
80.林守清,宫伟雁,陈瑛.更年期性激素治疗的进展[J].国外医学.妇幼保健分册,2005,16(5)：318
81.李汉明.辨证分型治疗更年期综合征75例.湖南中医学院学报,1995,15(20)：31
82.张法荣.更年期综合征从肾施治山东中医药大学学报1999：(5)336-367
83.罗颂平.罗元恺女科述要.广州东高等教育出版社,1993：83-86
84.王桂生.妇女绝经前后诸症从肝论治106例.光明中医,1994(5)：227-229
85.梅冬艳.中医药治疗女性更年期综合征89例[J].中医中药杂志,2007,4(17)：87
86.彭光超.柴胡加龙骨牡蛎汤加减治疗更年期综合征385例[J].河南中医,2006,26(9)：13-14.
87.刘丁风,粱晓星,李萍,等.金水相生论治更年期综合征[J].中华中医药杂志,2006,21(2)107-108.
88.沈星颖,沈华军.从痰论治更年期综合征68例[J].浙江中医药大学学报,2008,32(5)630-631.
90.余谦,黄泳,张和嫒,等.针刺调补冲任法对女性内分泌轴功能的影响附25例临床分析[J].中国针灸,2001,21(3)：69-170.
91.欧洪琼,方廖琼,白晋,等.超声刺激关元穴对自然围绝经期大鼠卵泡发育的影响.南方医科大学学报,2012；32(7)：937-939
92.王玉香.围绝经期综合征的针灸治疗.天津中医药,2012,29(1)：86-87
93.程彬彬,朱玲,李长征,等.左归丸对雌性阴虚小鼠模型生殖内分泌的影响[J].现代中西医结合杂志,2003,12(13)：1362-1364.
94.朱玲,程彬彬,黄泉智,等.左归丸临床与实验研究进展[J].国医论坛,2003,18(2)：51-53.
95.傅萍,邓娟.中医药对围绝经期综合征治疗的实验研究集萃[J].中华中医药学刊,2007,25(9)：1789-1791
96.秦达念,佘白蓉,佘运初.菟丝子黄酮对实验动物及人绒毛组织生殖功能的影响[J].中药新药与临床药理,2000,11(6)：349-351
97.司徒仪.补肾法在妇科方面的现代研究及应用[J].黑龙江中医药,2000,17(3)：62.
98.韩冰,杨峻山.淫羊藿药理作用研究概况[J].中草药,2000,31(11)：873-875.
99.马慧萍,贾正平,葛欣,等.淫羊藿总黄酮抗大鼠实验性骨质疏松作用研究[J].华西药学杂志,2002,17(3)：163-167.
100.殷力,李月白,许建中,等.糖皮质激素对骨髓基质细胞增殖及分化的影响[J].中国临床康复,2002,6(3)：169.
101.张立,葛焕琦,赵丽娟.杜仲叶醇防治糖尿病合并去势大鼠骨质疏松的实验研究[J].中国老年学杂志,2003,23(6)：370-372.
102.鲁珊妹,许得盛,王文健,等.补肾健脾活血法对绝经后妇女性激素及免疫功能作用的观察 [J].上海中医药杂志,2001,35(12)：261.
103.陈颖异,曹华妹.围绝经期综合征中西医诊疗与调养[M].河北科学技术出版社,2008：184.
104.靳岭,王兴娟.不同生理阶段更年期综合征证候规律及治疗的临床研究.中华中医药杂志,2011,26(7)：1482-1485
105.李力,王天芳,吴秀艳,等.基于聚类分析的围绝经期综合征中医证候与证候要素的研究.中国中医基础医学杂志,2011,17(8)：855-856.
106.吴宏进,周昌乐,许家佗,等.围绝经期综合征中医证候分布特点文献研究.中国中医药信息杂志,2012,19(3)：22-25
107.林雪娟,李灿东,梁文娜,等.围绝经期综合征中医证素特点研究.辽宁中医药大学学报,2011,13(4)：101-103
108.杨敏,李灿东,李红,等.围绝经期综合征中医证素与性激素水平的相关研究.中华中医药杂志,2012,27(2)：366-368
109. Woods NF, Mitchell ES. Sleep symptoms during the menopausaltransition and early postmenopause:observations from the SeattleMidlife Women's Health Study [J].Sleep, 2010,33 (4):539-549.
110. Zaborowska E, Brynhildsen J, Damberg S, et al. Effects of acupuncture, applied relaxation, estrogens and placebo on hot flushes in postmenopausalwomen:an analysis of two prospective, parallel, randomizedstudies [J]. Climacteric,2007,10 (1):38-45.
111.张巧利,李芬,于英.围绝经期潮热妇女焦虑与抑郁状况的分析.生殖与避孕,2012,32(3)：205-207
112.邓小虹,张淞文.北京地区围绝经期妇女健康现状的流行病学调查[J].北京医学,2002,24(4)：235-238
113.蒋尚融,舒丹,何金彩.围绝经期妇女睡眠与雌二醇、卵泡刺激素及黄体生成素的关系.新医学,2012,43(7)：447-449
114.陈铭奇,黄俊山.围绝经期失眠患者证素的研究分析.中医药学报,2012,40(1)：51-53
115.张嗥珺,禄颖.肾为更年期失眠之本.长春中医药大学学报,2012,28(6)：1032-1033
116.罗元恺.中医妇科学[M].上海科学技术出版社,1996：86.
117.黄兆胜.中药学[M].人民卫生出版社,2004
118.梅全喜.现代中药药理临床应用手册.中国中医药出版社,2008
119. Elizabeth A. The Blatt-Kupperman menopausal index:acritique[J]. Maturitas,1998, 29:19-24
120.曹泽毅.中华妇产科学[M].北京：人民卫生出版社,2004：1156-1161,1548
121.李红,李灿东,任林,等.围绝经期阴虚体质妇女雌激素受体α基因多态性分析.中华中医药杂志,2011,26(5)：945-949
122.梁文娜,李灿东,甘慧娟,等.围绝经期综合征肝郁病理与雌性激素的相关性研究.中华中医 药杂志,2011,26(9)：1961-1963
123.王大伟.治疗更年期综合征常用中药雌激素样作用的实验研究[D].北京中医药大学,2006.
124.李颖,蔺敏,张关亭,等.补肾调冲法促排卵作用机理研究[J].湖北中医学院学报,2002,12(4)：21-22.
125.安胜军,李恩,赵京山.补肾方药对地塞米松所致实验性骨质疏松大鼠卵巢功能的影响[J].中国中西医结合杂志,2000,20(1)：46-48.
126.黄枫,唐勇,郑晓辉,等.补肾强膝方对绝经后膝骨性关节炎的影响[J].中医正骨,2002,14(4)：131
127.黄琼霞,曹继刚,舒劲松.补肾毓麟汤对肾虚性生殖功能障碍大鼠生殖激素影响的实验研究[J].湖北中医学院学报,2007,3(9)：22-24.
128.丁原全,刘鹏,马乾章.补肾复方对围绝经期大鼠卵巢超微结构的影响.齐鲁医学杂志,2012,27(4)：61-62
129.高慧,杨涓,夏天,等.补肾调冲方对卵巢早衰大鼠性激素水平和卵巢组织形态学的影响[J].国医论坛,2008,23(1)：35
130.胡冰,杨述华,邱幸凡,等.补肾健脾活血方对去卵巢大鼠骨转换主要生化指标的影响[J].湖北中医学院学报,2003,5(3)：20-22
131.步世忠,孙梅,张沉,等.更年健上调老年雌性大鼠下丘脑雌激素受体m R N A表达对P物质和p-内啡肽的影响[J].中国中西医结合杂志,1998,18(1)：28
132.董鹏,等.地锦止血作用研究[J].武警医学,1997,8(2)：1 17-119
133.李影林.中华医学检验全书[M].北京：人民卫生出版社,1996：211
134.王福玲,初怡静,赵军绩,等青岛市围绝经期妇女性激素及血脂血糖变化.青岛大学医学院学报,2012,48(3)：224-226
135.赖谦凯,张静,张晓丹.安度更年丸对围绝经期SD大鼠性激素及血脂代谢影响的实验研究.中医临床研究,2012,4(9)：29-33
136.王志国,张家明,万贵平.性激素水平对围绝经期抑郁症的影响.江苏医药,2012,38(16)：1910-1911
137.林雪,任玉汝,马丽,等.虚燥更平颗粒对阴虚内燥证女性高血压病(围绝经期)患者生活质量的影响.中华中医药杂志,547-550
138.金亚蓓,郑利芳,刘芳,等.穴位埋线对围绝经期月经失调患者Kupperman评分的影响.中华中医药学刊,2012,30(8)：1838-1840
139.王艳东.益经汤治疗绝经综合征56例.陕西中医,2011,32(3),327-328
140.陈昆仑.益气养阴安神法治疗围绝经期睡眠障碍76例临床观察.新中医,2011,43(6)：70-71
141.徐天舒,阮建国,戴玮,等.针刺与麦粒灸对围绝经期模型大鼠血清E2、FSH、LH水平的影响.南京中医药大学学报,2012,28(6)：564-566
142.张宁,胡静,王雁.针灸治疗围绝经期睡眠障碍随机对照研究Meta评价.中国中医药信息杂 志.2012,19(8)：24-26
2. Kailas NA, Sifakis S, Kounantakis E, et al. Contraception during perimenopause[J]. Eur J Contracept Reprod Health Care,2005,10(1):19-25
3.马红,吕晔,孙浩,王斌.立春胶囊治疗女性围绝经期综合征74例临床观察.天津中医,2002,(4)：55
4.田丰莲,詹新林,赵庆国,等.广东地区围绝经期综合征患病状况及其影响因素[J].中国妇幼保健,2004,19(7)：67
5.刘明兰,王馨园,熊丹,等.妇女围绝经期健康状况调查研究.中国妇幼保健,2012,27：4602-4605
6.王雪丹,张勇,杜慧玲,等.邯郸市社区围绝经期妇女代谢综合征流行病学调查.承德医学院学报,2012,29(2)：155
7.罗永玉,王小华.杭州市妇女围绝经期综合征发生情况分析.中国妇幼保健,2011,26(1)：141-142
8.滕振娟,战治家,薛巧梅,等.威海地区围绝经期妇女健康现状的流行病学调查.中国妇幼保健,2011,26(30)：4744-4747
9.李珍,黄皓,林小兰等.广东高校女教工围绝经期健康状况及相关因素调查.中国妇幼保健,2011,26(34)：5411-5414
10.初怡静,王福玲,娄艳辉,等.青岛地区女性围绝经期症状流行病学调查分析.现代妇产科进展,2012,21(7)：553-556
11.陆亦琼,汤振宇,许薇.上海市南京东路社区妇女围绝经期症状分析.中国临床医学,2011,18(2)：209-211
12.梁文郁.中西医结合防治更年期综合征.中国中医基础医学杂志,1999,5(3)：57-59
13. Steinberg EM, Rubinow DR, Bartko JJ, et al. A cross-sectionalevaluation of perimenopausal depression [J]. J Clin Psychiatry,2008,69(6):973 — 980.
14.陶晶,仇剑崟,顾红亮,等.上海某妇科门诊围绝经期及绝经后期抑郁症状检出率及相关因素[J].上海精神医学,2011,23(1)：31-37.
15. Cohen LS, Soares CN, Vitonis AF, et al. Risk for new onset ofdepression during the menopausal transition:the Harvard study ofmoods and cycles [J]. Arch Gen Psychiatry, 2006,63 (4):385-390.
16. Osterlund MK, Hurd YL. Estrogen receptors in the human forebrainand the relation to neuropsychiatric disorders [J]. Prog Neurobiol,2001,64(3):251 — 267.
17.秦家云,王艳,彭丹红,等.女性血清性激素水平与认知功能的相关性研究.实用妇产科杂志,2012,28(8)：682-685
18.施凤,任慕兰.围绝经期妇女围绝经期综合征及情绪障碍分析.江苏医药,2011,37(4)：430-432；
19.施凤,任慕兰.围绝经期妇女生殖激素水平与情绪障碍相关分析.实用医学杂志,2011,27(14)：2558-2559
20.陈亚琼,叶雪清.血浆吲哚类神经递质与围绝经期综合征症状的相关性分析.中华妇产科杂志,1996,31-41
21. Smith LJ, Henderson JA, Abell CW, et al. Effects of ovarian steroidsand raloxifene on proteins that synthesize, transport, anddegrade serotonin in the raphe region of macaques [J]. Neuropsychopharmacology,2004,29(11):2035 — 2045.
22.陶晶,仇剑崟.雌激素对5-羟色胺能神经元的作用机制及临床应用[J].上海精神医学,2010,22(4)：246-248.
23.李贺琦,陈霞.围绝经期综合征与神经递质(5-羟色胺)相关性的临床研究进展.中华中医药学刊,2011,29(2)：375-376
24.顾红亮,陶晶,仇剑釜,等.5-羟色胺转运体基因多态性与女性围绝经期及绝经后期首发抑郁障碍的关联研究.中国妇幼保健,2011,26：4377-4381。
25.陶晶,仇剑崟,顾红亮,等.ESRl基因与5-HTT基因多态性的交互作用对女性围绝经期抑郁障碍的影响.上海交通大学学报(医学版),2012,32(6)：766-770
26.吴小立,韩自力,钟智勇,等.围绝经期女性情绪障碍影响因素的综合探讨.中国病理生理杂志,2011,27(3)：599-602
27.江仙远,侯安继,程化奇.女性更年期综合征患者的情志改变与血浆儿茶酚胺含量的关系.美国中华心身医学杂志,1998,2(1)：49-50
28.王晓萍.更年期忧郁症的心理治疗.浙江预防医学,1998,(9)：575
29.赵更力,王临虹,渠川琰,等.妇女个性特征与更年期综合征初探.中国心理卫生杂志,1998,12(3)：136-137,168
30.李礼奎.中药药理实验方法学[M].上海科学技术出版社,2006：831-839.
31.程化奇,熊舜华,殷新尤,等.大鼠更年期实验模型研究[J].上海实验动物科学,1993,13(4)：192.
32.杨长群,汪向红,刘妮英,等.雌激素替代疗法对围绝经期综合征妇女Kupperma评分、HAMD评分及激素水平的影响.中国医院药学杂志,2012,32(18)：1481-1483
33.杨欣,白文佩,郑淑蓉,等.经皮使用苯甲酸雌二醇凝胶治疗更年期综合征临床研究[J].中国临床药理学杂志,1999,15(2)：101-105.
34.潘敏.维尼安治疗更年期症状的临床观察[J].安徽医科大学学报,2000,35(4)：323.
35.林守清,宫伟雁,陈瑛.更年期性激素治疗的进展[J].’国外医学.妇幼保健分册,2005,16(5)：318
36.黄璐,许良智.戊酸雌二醇预防围绝经期、绝经后骨质疏松的系统评价.中华妇幼临床医学杂志 (电子版),2012,8(6)：748-753
37.马建东,李玉凤,刘树芳.米氮平与氯丙咪嗪治疗妇女更年期情绪障碍的临床对照研究[J].健康心理学杂志,2004,12(3)：180.
38.林炫,陈丽平.米非司酮治疗更年期功血的临床研究[J].中国妇幼保健,2008,23(10)：1376.
39.赵子凤.文拉法辛缓释片治疗29例围绝经期女性抑郁症的疗效观察.华西药学杂志,2011,26(1)：094
40.吴小立,钟智勇,韩自力,等.三种方法治疗围绝经期女性情绪障碍的比较.中山大学学报(医学科学版),2011,32(1)：76-79
41. Keenan NL, Anderson LA, LaCroix AZ, et al. Helping women achievelong — term continuance of estrogen replacement therapy(ERT) and hormone replacement therapy (HRT). Menopause,1999,6(2):179.
42.汪远金,许金林,张杰,等.大豆异黄酮对去卵巢大鼠骨质疏松症防治作用的研究.中国中医药科技,2004,11(3)：156.
43.张文众,李宁,李蓉,等.大豆异黄酮雌激素样作用研究.卫生研究,2008,37(6)：707.
44.刘春龙,李思秋,孙海霞,等.大豆异黄酮的生理作用及其在医学方面的研究进展.大学科学,2008,27(4)：693.
45.匡野,庞海燕,肖晓辉,等.大豆异黄酮对围绝经期大鼠卵巢FSHR表达的影响.中国中医药科技,2011,18(4)：311-314
46. Bai W, Henneicke — von ZH, Wang S, et al. Efficacy and tolerabilityof a medicinal product containing an isopropanolic black cohoshextract in Chinese women with menopausal symptoms:a randomized, double blind, parallel — controlled study versus tibolone [J]. Maturitas,2007; 58:31-41.
47. Frei — Kleiner S, Schaffner W, Rahlfs VW, et al. Cimicifuga racemosadried ethanolic extract in menopausal disorders:a double — blindplacebo — controlled clinical trial [J]. Maturitas,2005; 51:397-404.
48. Liske E, Hanggi W, Henneicke — von ZH, et al. Physiological investigationof a unique extract of black cohosh (Cimicifugae racemoaerhizoma):a 6 — month clinical study demonstrates no systemicestrogenic effect [J]. J Womens Health Gend Based Med,2002; 11:163-174.
49.曹杰,赵纯全.莉芙敏治疗妇女围绝经期综合征的疗效研究.临床合理用药,2012,5(3C)：17-19
50.欧阳惠卿.中医妇科学.人民卫生出版社[M].2008.1(8)：123-128
51.刘敏如,谭万信.中医妇产科学.人民卫生出版社[M].2001(1)：403-416
52.魏升.围绝经期综合征从脾论治.新中医,1991,23(2)：8
53.崔国玲.甘温除热法治疗围绝经期综合征30例.山东中医杂志,1996,15(12)：544
54.陆启滨.围绝经期综合征病因病机探源,中医药学刊,2001 19(2)：139-140
55.姚石安.围绝经期综合征中医研究述评.中医杂志,1994,35(2)：112-114
56.吴丽芹.围绝经期综合征病因病机分析[J].山西中医.2011(11)：5-7
57.史玉梅,谈勇,夏桂成.夏桂成教授治疗围绝经期综合征经验举隅[J].南京中医药大学学报,2005：21(2)：116-117
58.王清.围绝经期综合征的中医认识述评[J].中医杂志,2006,47(2)：151-152
59.刘静君.更年期综合征与体质关系初探[J].山东中医杂志,2006,25(5)：298-299.
60.陆启滨.更年期综合征病因病机探源[J].中医药学刊,2001,19(2)：139.
61.刘光伟.更年期综合征营卫失和病机初探[J].中医杂志,2002：43(6)：405-406.
62.王晓萍.从奇经论治妇女更年期综合征[J].中国医药学报,1995,10(4)：43-45.
63.高平,万德光.中医药治疗围绝经期综合征机制研究进展[J].现代中西医结合杂志,2004,13(4)：551.
64.夏桂成.更年1号新方治疗围绝经期综合征120例.中国医药学报,1994,14(7)：396)
65.李建生.补阴更年方治疗围绝经期综合临床疗效观察.辽宁中医杂志,1994,21(3)：119
66.黎烈荣.更年安怡片治疗围绝经期综合征的临床观察.中国中西医结合杂志,1999,19(4)：235
67.冯培贤.更年乐治疗围绝经期综合征中医药研究.1996,12(30)：40
68.朱慧.滋肾清心汤治疗围绝经期综合征的体会.陕西中医学院学报,1993,16(2)：22)
69.朱雄华.益肾变平汤治疗围绝经期综合征105例.江苏中医,1997,17-19
70.陈丽文.当归六黄汤治疗围绝经期综合征30例.中国中医药现代远程教育,2011,10(01)：130-140
71.任晓鸣,党晓玲,高显兰.归芍地黄汤合生脉散治疗围绝经期综合征73例临床观察.新疆中医药,2011,29(2)：14-16
72.李俊箐.保更汤治疗围绝经期综合征疗效观察.上海中医药杂志,2011,45(2)：41-42
73.赵建英,史樱,王洁意.围绝经期妇女血清FSH、LH、E2、P水平测定分析[J].实用妇产科杂志,2002,18(6)：360.
74.张蓉,宋李冬.柴胡加龙骨牡蛎汤治疗围绝经期患者失眠的疗效.中国临床医学,2012,19(2)：175-176
75.居跃君.从肝肾论治围绝经期失眠症临床观察.光明中医,2011,26(7)：1403-1404
76.朱耿.更年助眠饮治疗围绝经期妇女的失眠.50例临床观察.江苏中医药杂志,2003：24(2)：29
77.马亮,王宗仁,马静.二仙汤加味治疗围绝经期高血压的临床观察.贵阳中医学院学报,2011,33(4)：13-14
78.侣雪平,丛慧芳,王虹.黄连阿胶汤加减治疗围绝经期抑郁症30例.中国中医药现代远程教育,2011,9(09)：43-44
79.王全利,姚石安.静顺袋泡茶治疗女性围绝经期焦虑疗效观察.现代中西医结合杂志,2012, 21(5)：515
80.林守清,宫伟雁,陈瑛.更年期性激素治疗的进展[J].国外医学.妇幼保健分册,2005,16(5)：318
81.李汉明.辨证分型治疗更年期综合征75例.湖南中医学院学报,1995,15(20)：31
82.张法荣.更年期综合征从肾施治山东中医药大学学报1999：(5)336-367
83.罗颂平.罗元恺女科述要.广州东高等教育出版社,1993：83-86
84.王桂生.妇女绝经前后诸症从肝论治106例.光明中医,1994(5)：227-229
85.梅冬艳.中医药治疗女性更年期综合征89例[J].中医中药杂志,2007,4(17)：87
86.彭光超.柴胡加龙骨牡蛎汤加减治疗更年期综合征385例[J].河南中医,2006,26(9)：13-14.
87.刘丁风,粱晓星,李萍,等.金水相生论治更年期综合征[J].中华中医药杂志,2006,21(2)107-108.
88.沈星颖,沈华军.从痰论治更年期综合征68例[J].浙江中医药大学学报,2008,32(5)630-631.
90.余谦,黄泳,张和嫒,等.针刺调补冲任法对女性内分泌轴功能的影响附25例临床分析[J].中国针灸,2001,21(3)：69-170.
91.欧洪琼,方廖琼,白晋,等.超声刺激关元穴对自然围绝经期大鼠卵泡发育的影响.南方医科大学学报,2012；32(7)：937-939
92.王玉香.围绝经期综合征的针灸治疗.天津中医药,2012,29(1)：86-87
93.程彬彬,朱玲,李长征,等.左归丸对雌性阴虚小鼠模型生殖内分泌的影响[J].现代中西医结合杂志,2003,12(13)：1362-1364.
94.朱玲,程彬彬,黄泉智,等.左归丸临床与实验研究进展[J].国医论坛,2003,18(2)：51-53.
95.傅萍,邓娟.中医药对围绝经期综合征治疗的实验研究集萃[J].中华中医药学刊,2007,25(9)：1789-1791
96.秦达念,佘白蓉,佘运初.菟丝子黄酮对实验动物及人绒毛组织生殖功能的影响[J].中药新药与临床药理,2000,11(6)：349-351
97.司徒仪.补肾法在妇科方面的现代研究及应用[J].黑龙江中医药,2000,17(3)：62.
98.韩冰,杨峻山.淫羊藿药理作用研究概况[J].中草药,2000,31(11)：873-875.
99.马慧萍,贾正平,葛欣,等.淫羊藿总黄酮抗大鼠实验性骨质疏松作用研究[J].华西药学杂志,2002,17(3)：163-167.
100.殷力,李月白,许建中,等.糖皮质激素对骨髓基质细胞增殖及分化的影响[J].中国临床康复,2002,6(3)：169.
101.张立,葛焕琦,赵丽娟.杜仲叶醇防治糖尿病合并去势大鼠骨质疏松的实验研究[J].中国老年学杂志,2003,23(6)：370-372.
102.鲁珊妹,许得盛,王文健,等.补肾健脾活血法对绝经后妇女性激素及免疫功能作用的观察 [J].上海中医药杂志,2001,35(12)：261.
103.陈颖异,曹华妹.围绝经期综合征中西医诊疗与调养[M].河北科学技术出版社,2008：184.
104.靳岭,王兴娟.不同生理阶段更年期综合征证候规律及治疗的临床研究.中华中医药杂志,2011,26(7)：1482-1485
105.李力,王天芳,吴秀艳,等.基于聚类分析的围绝经期综合征中医证候与证候要素的研究.中国中医基础医学杂志,2011,17(8)：855-856.
106.吴宏进,周昌乐,许家佗,等.围绝经期综合征中医证候分布特点文献研究.中国中医药信息杂志,2012,19(3)：22-25
107.林雪娟,李灿东,梁文娜,等.围绝经期综合征中医证素特点研究.辽宁中医药大学学报,2011,13(4)：101-103
108.杨敏,李灿东,李红,等.围绝经期综合征中医证素与性激素水平的相关研究.中华中医药杂志,2012,27(2)：366-368
109. Woods NF, Mitchell ES. Sleep symptoms during the menopausaltransition and early postmenopause:observations from the SeattleMidlife Women's Health Study [J].Sleep, 2010,33 (4):539-549.
110. Zaborowska E, Brynhildsen J, Damberg S, et al. Effects of acupuncture, applied relaxation, estrogens and placebo on hot flushes in postmenopausalwomen:an analysis of two prospective, parallel, randomizedstudies [J]. Climacteric,2007,10 (1):38-45.
111.张巧利,李芬,于英.围绝经期潮热妇女焦虑与抑郁状况的分析.生殖与避孕,2012,32(3)：205-207
112.邓小虹,张淞文.北京地区围绝经期妇女健康现状的流行病学调查[J].北京医学,2002,24(4)：235-238
113.蒋尚融,舒丹,何金彩.围绝经期妇女睡眠与雌二醇、卵泡刺激素及黄体生成素的关系.新医学,2012,43(7)：447-449
114.陈铭奇,黄俊山.围绝经期失眠患者证素的研究分析.中医药学报,2012,40(1)：51-53
115.张嗥珺,禄颖.肾为更年期失眠之本.长春中医药大学学报,2012,28(6)：1032-1033
116.罗元恺.中医妇科学[M].上海科学技术出版社,1996：86.
117.黄兆胜.中药学[M].人民卫生出版社,2004
118.梅全喜.现代中药药理临床应用手册.中国中医药出版社,2008
119. Elizabeth A. The Blatt-Kupperman menopausal index:acritique[J]. Maturitas,1998, 29:19-24
120.曹泽毅.中华妇产科学[M].北京：人民卫生出版社,2004：1156-1161,1548
121.李红,李灿东,任林,等.围绝经期阴虚体质妇女雌激素受体α基因多态性分析.中华中医药杂志,2011,26(5)：945-949
122.梁文娜,李灿东,甘慧娟,等.围绝经期综合征肝郁病理与雌性激素的相关性研究.中华中医 药杂志,2011,26(9)：1961-1963
123.王大伟.治疗更年期综合征常用中药雌激素样作用的实验研究[D].北京中医药大学,2006.
124.李颖,蔺敏,张关亭,等.补肾调冲法促排卵作用机理研究[J].湖北中医学院学报,2002,12(4)：21-22.
125.安胜军,李恩,赵京山.补肾方药对地塞米松所致实验性骨质疏松大鼠卵巢功能的影响[J].中国中西医结合杂志,2000,20(1)：46-48.
126.黄枫,唐勇,郑晓辉,等.补肾强膝方对绝经后膝骨性关节炎的影响[J].中医正骨,2002,14(4)：131
127.黄琼霞,曹继刚,舒劲松.补肾毓麟汤对肾虚性生殖功能障碍大鼠生殖激素影响的实验研究[J].湖北中医学院学报,2007,3(9)：22-24.
128.丁原全,刘鹏,马乾章.补肾复方对围绝经期大鼠卵巢超微结构的影响.齐鲁医学杂志,2012,27(4)：61-62
129.高慧,杨涓,夏天,等.补肾调冲方对卵巢早衰大鼠性激素水平和卵巢组织形态学的影响[J].国医论坛,2008,23(1)：35
130.胡冰,杨述华,邱幸凡,等.补肾健脾活血方对去卵巢大鼠骨转换主要生化指标的影响[J].湖北中医学院学报,2003,5(3)：20-22
131.步世忠,孙梅,张沉,等.更年健上调老年雌性大鼠下丘脑雌激素受体m R N A表达对P物质和p-内啡肽的影响[J].中国中西医结合杂志,1998,18(1)：28
132.董鹏,等.地锦止血作用研究[J].武警医学,1997,8(2)：1 17-119
133.李影林.中华医学检验全书[M].北京：人民卫生出版社,1996：211
134.王福玲,初怡静,赵军绩,等青岛市围绝经期妇女性激素及血脂血糖变化.青岛大学医学院学报,2012,48(3)：224-226
135.赖谦凯,张静,张晓丹.安度更年丸对围绝经期SD大鼠性激素及血脂代谢影响的实验研究.中医临床研究,2012,4(9)：29-33
136.王志国,张家明,万贵平.性激素水平对围绝经期抑郁症的影响.江苏医药,2012,38(16)：1910-1911
137.林雪,任玉汝,马丽,等.虚燥更平颗粒对阴虚内燥证女性高血压病(围绝经期)患者生活质量的影响.中华中医药杂志,547-550
138.金亚蓓,郑利芳,刘芳,等.穴位埋线对围绝经期月经失调患者Kupperman评分的影响.中华中医药学刊,2012,30(8)：1838-1840
139.王艳东.益经汤治疗绝经综合征56例.陕西中医,2011,32(3),327-328
140.陈昆仑.益气养阴安神法治疗围绝经期睡眠障碍76例临床观察.新中医,2011,43(6)：70-71
141.徐天舒,阮建国,戴玮,等.针刺与麦粒灸对围绝经期模型大鼠血清E2、FSH、LH水平的影响.南京中医药大学学报,2012,28(6)：564-566
142.张宁,胡静,王雁.针灸治疗围绝经期睡眠障碍随机对照研究Meta评价.中国中医药信息杂 志.2012,19(8)：24-26
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