更年乐治疗更年期综合征的实验研究
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摘要
更年期综合征是一种临床常见病、多发病，导师吴高媛教授
在中医理论指导下，总结多年临证心得，认为“肾虚肝郁、冲
任虚损”是其主要病机，并据此确立了“滋肾柔肝、调补冲任”
的治疗大法，自创更年乐治疗本病，临床取得了很好的疗效。
本文通过实验研究进一步证实其临床疗效，并揭示其作用机理。
结果表明，更年乐可降低更年期大鼠血中FSH、LH水平，
提高下丘脑及血中的β-EP水平，增加子宫ER含量，从而调节
下丘脑—垂体—卵巢—子宫轴的功能。并通过增加脾细胞ER
水平，使雌激素更好地调节免疫功能，提高机体的免疫力，进
而使神经—内分泌—免疫网络处于一种稳态。
Climacteric Syndrome (C 5) is a kind of common and recurrent
disease clinically. On the basis of T C M theory and clinical
experience of many years, professor Wu Gaoyuan pointed out that
“kidney-asthenia and liver depression, impairment of chong and ren
channels”is the main pathogenesis of C S. Then, She proposed the
“nourish the kidney and soothe the liver, invigorate Chong and ren
channels”treatment principle. According to this principle, “Geng
Nian Le”was made to treat C S and acquired a good curative effect.
This thesis went a step further to demonstrate its curative effect and
reveal its mechanism of action through experimental research.
The results showed that“Geng Nian Le”can reduce the serum
FSH and LH level of menopausal rats, raise their β-EP level of
hypothalamus and serum while improve their ER level of uterus, and
then regulate the function of hypothalamus-hypophysis-ovary-uterus
axis. It also can make estrogen regulate immune function through
improving ER level of spleen. Thus, the Neuroendocrine-immune
Network will be in stable state.
在中医理论指导下，总结多年临证心得，认为“肾虚肝郁、冲
任虚损”是其主要病机，并据此确立了“滋肾柔肝、调补冲任”
的治疗大法，自创更年乐治疗本病，临床取得了很好的疗效。
本文通过实验研究进一步证实其临床疗效，并揭示其作用机理。
结果表明，更年乐可降低更年期大鼠血中FSH、LH水平，
提高下丘脑及血中的β-EP水平，增加子宫ER含量，从而调节
下丘脑—垂体—卵巢—子宫轴的功能。并通过增加脾细胞ER
水平，使雌激素更好地调节免疫功能，提高机体的免疫力，进
而使神经—内分泌—免疫网络处于一种稳态。
Climacteric Syndrome (C 5) is a kind of common and recurrent
disease clinically. On the basis of T C M theory and clinical
experience of many years, professor Wu Gaoyuan pointed out that
“kidney-asthenia and liver depression, impairment of chong and ren
channels”is the main pathogenesis of C S. Then, She proposed the
“nourish the kidney and soothe the liver, invigorate Chong and ren
channels”treatment principle. According to this principle, “Geng
Nian Le”was made to treat C S and acquired a good curative effect.
This thesis went a step further to demonstrate its curative effect and
reveal its mechanism of action through experimental research.
The results showed that“Geng Nian Le”can reduce the serum
FSH and LH level of menopausal rats, raise their β-EP level of
hypothalamus and serum while improve their ER level of uterus, and
then regulate the function of hypothalamus-hypophysis-ovary-uterus
axis. It also can make estrogen regulate immune function through
improving ER level of spleen. Thus, the Neuroendocrine-immune
Network will be in stable state.
引文
1．戴德英．《现代中医药应用与研究大系·妇科》．第一版．上海：上海中医药大学出版社，1995；174-182．
2．全国围绝经期及绝经后期有关问题学术研讨会纪要．中华妇产科杂志，1997；32(9)：520-523．
3．张以文．绝经妇女激素替代治疗的新进展．中华内分泌代谢杂志，1996；12(3)：181-183．
4. Bergkvist L, et al: The risk of breast cancer after estrogen and estrogen-progestin replacement. The New England Journal of Med. 1989; 321: 293.
5. Voigt, Weiss N, et al: progestogen supplement action of exogenous oestrogens and risk of endometrial cancer. Lancet 1991; 338: 274.
6．程化奇，等．大鼠更年期实验模型究．上海实验动物科学，1993；13(4)：192-196．
7．张丽蓉．求子必读·妇宝良方．第一版．天津：天津科技翻译出版公司，1994：553．
8. R.H. Casper and S. S. C. Yen, Neuroendocrinology of menopausal flushes: an hypothesis of flush mechanism. Clinical Endocrinology 1985; 22: 293-312.
9．韩济生，等．中枢神经介质概论．第二版．北京：科学出版社，1980；453-461．
10．夏融．更年期综合征侧重治心的理论与实践．江苏中医，1996；17(2)：41-43．
11．王大增．清心平肝法治疗更年期综合征．中医杂志，1989；(1)：30-32．
12．夏桂成．更年Ⅰ号新方治疗更年期综合征120例．中国医药学报，1995；10(4)：8-11．
13．陈慧侬．更年期综合征与肾虚血瘀的关系．广西中医药，1992；15(6)：28-29．
14．姚寓晨．更年期综合征证治．中医杂志，1987；(10)：10．
15．李炳如，等．补肾药对下丘脑—垂体—性腺轴功能影响．中药研究，1984；(7)：63-65．
16．刘惠霞，等．再生丸对小鼠免疫功能的影响．中医研究，1997；(1)：19．
17．周志峰．内源性阿片样肽与性腺轴系功能．国外医学(计划生育分册)，1988；(1)：23．
18. Belisle A et al. Effect of aging on the clissociation kinetics and estrogen receptor-nuclear interactions in mouse uteri: correlation with biological effect.Endocrinology 1986; 118: 750.
19. Han Z, et al. Effect of aging on population of estrogen receptor-containing cells in the rat uterus. Exp cell Res 1989; 180: 234.
20. Crossman C J, et al. Rat thymic estrogen receptor-I. Preparation, location and physiochemical properties. J Steroid Biochem 1979; 11:1233.
21. Danel L, et al. Special estrogen binding site in human lymphoid cells and thymic cells. J Steroid Biochem 1983; 18: 559.
22．李大金，等．中药复方对更年期综合征妇女生殖内分泌—免疫功能的调节．上海免疫学杂志，1995；15(5)：257-260．
23．王文君，等．中药复方“更年健”对雌性大鼠老化过程中脾细胞雌激素受体的影响．生殖与避孕，1996；16(4)：263-267．
2．全国围绝经期及绝经后期有关问题学术研讨会纪要．中华妇产科杂志，1997；32(9)：520-523．
3．张以文．绝经妇女激素替代治疗的新进展．中华内分泌代谢杂志，1996；12(3)：181-183．
4. Bergkvist L, et al: The risk of breast cancer after estrogen and estrogen-progestin replacement. The New England Journal of Med. 1989; 321: 293.
5. Voigt, Weiss N, et al: progestogen supplement action of exogenous oestrogens and risk of endometrial cancer. Lancet 1991; 338: 274.
6．程化奇，等．大鼠更年期实验模型究．上海实验动物科学，1993；13(4)：192-196．
7．张丽蓉．求子必读·妇宝良方．第一版．天津：天津科技翻译出版公司，1994：553．
8. R.H. Casper and S. S. C. Yen, Neuroendocrinology of menopausal flushes: an hypothesis of flush mechanism. Clinical Endocrinology 1985; 22: 293-312.
9．韩济生，等．中枢神经介质概论．第二版．北京：科学出版社，1980；453-461．
10．夏融．更年期综合征侧重治心的理论与实践．江苏中医，1996；17(2)：41-43．
11．王大增．清心平肝法治疗更年期综合征．中医杂志，1989；(1)：30-32．
12．夏桂成．更年Ⅰ号新方治疗更年期综合征120例．中国医药学报，1995；10(4)：8-11．
13．陈慧侬．更年期综合征与肾虚血瘀的关系．广西中医药，1992；15(6)：28-29．
14．姚寓晨．更年期综合征证治．中医杂志，1987；(10)：10．
15．李炳如，等．补肾药对下丘脑—垂体—性腺轴功能影响．中药研究，1984；(7)：63-65．
16．刘惠霞，等．再生丸对小鼠免疫功能的影响．中医研究，1997；(1)：19．
17．周志峰．内源性阿片样肽与性腺轴系功能．国外医学(计划生育分册)，1988；(1)：23．
18. Belisle A et al. Effect of aging on the clissociation kinetics and estrogen receptor-nuclear interactions in mouse uteri: correlation with biological effect.Endocrinology 1986; 118: 750.
19. Han Z, et al. Effect of aging on population of estrogen receptor-containing cells in the rat uterus. Exp cell Res 1989; 180: 234.
20. Crossman C J, et al. Rat thymic estrogen receptor-I. Preparation, location and physiochemical properties. J Steroid Biochem 1979; 11:1233.
21. Danel L, et al. Special estrogen binding site in human lymphoid cells and thymic cells. J Steroid Biochem 1983; 18: 559.
22．李大金，等．中药复方对更年期综合征妇女生殖内分泌—免疫功能的调节．上海免疫学杂志，1995；15(5)：257-260．
23．王文君，等．中药复方“更年健”对雌性大鼠老化过程中脾细胞雌激素受体的影响．生殖与避孕，1996；16(4)：263-267．
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