用户名: 密码: 验证码:
中西医结合治疗重度直肠前突合并直肠内脱垂型便秘的临床研究
详细信息    本馆镜像全文|  推荐本文 |  |   获取CNKI官网全文
摘要
目的:便秘严重影响着患者的生活质量,极大地危害着患者的身心健康,因此对本病的研究日益受到人们的重视。临床医生提出了多种手术方式来纠正异常的解剖结构,各有特色,但近远期疗效不稳定,易复发,尤其对于重度直肠前突合并直肠内脱垂的出口梗阻型便秘。排便过程是人体中一系列复杂而协调的生理反射活动,人的全身功能状态和高级神经活动对其有很大的影响。因此中医的辩证论治、整体观念,能对重度直肠前突合并直肠内脱垂的出口梗阻型便秘起到标本兼治的作用。此论文旨在探讨“STARR术+消痔灵柱状注射+温肾运肠汤口服”联合治疗重度直肠前突合并直肠内脱垂所致出口梗阻型便秘的近远期疗效。
     方法:临床选择河北医科大学中医院肛肠科住院病人中经症状、体征、排粪造影示为重度直肠前突合并直肠内脱垂型便秘患者80例,采用“STARR术+消痔灵柱状注射+温肾运肠汤口服”,即先行STARR+消痔灵柱状注射术,术后将科室自拟中药方温肾运肠方制成袋装汤剂200ml每日两次,共服10天。观察治疗前后排便频率、排便时间、便不尽感、肛门下坠感、应用缓泻剂、排粪造影示前突深度等指标的改变情况。全部数据采用SPSS13.0软件统计包进行统计学处理,全部计量资料以平均值加减标准差(x士S)表示,符合正态分布采用配对t检验,不符合正态分布采用配对秩和检验。P<0.05为显著性差异的标准。通过统计学原理分析统计来判定近远期疗效。
     结果:80例患者经治疗后,治愈60例(75%),显效14例(17.5%),好转6例(7.5%),总有效率为100%。
     1、患者治疗前后排便频率积分数据经配对秩和检验得出P<0.05,具有显著性差异。治疗后患者的排便频率比治疗前明显增多。
     2、患者治疗前后排便时间积分数据经配对秩和检验得出P<0.05,具有显著性差异。治疗后患者的排便时间比治疗前明显缩短。
     3、患者治疗前后肛门下坠感积分数据经配对秩和检验得出P<0.05具有显著性差异。治疗后患者的肛门下坠感比治疗前明显减轻。
     4、患者治疗前后便不尽感积分数据经配对秩和检验得出P<0.05,具有显著性差异。治疗后患者的便不尽感比治疗前明显减轻。
     5、患者治疗前后应用缓泻剂积分数据经配对秩和检验得出P<0.05具有显著性差异。治疗后患者应用缓泻剂比治疗前明显减少。
     6、患者治疗前后前突深度数据经配对t检验得出P<0.05,具有显著性差异。治疗后患者的前突深度比治疗前明显缩小。
     结论:该治疗方案消除了直肠前突的囊袋样松弛粘膜,重构了直肠中下段的直肠内解剖结构,加强了直肠阴道隔。同时配合中药口服,补肾温阳、益气养血、润肠通便,改善了患者体质,增强了包括排便能力在内的内脏机能。充分发挥了中西医结合的优势,标本皆治,治疗效果显著,近远期疗效好。
Objective: Constipation seriously affect the patient's quality of life andendanger the patient's physical and mental health, so people pay moreattention on this disease. Clinicians proposed a variety of surgical procedureswhich have their own characteristics to correct the abnormal anatomicalstructure, but the short and long term efficacy is unstable and easy to recur,especially for the OOC of severe RC merger RRP. Systemic functional statusand higher nervous activity influence defecation process greatly which is aseries of complex and coordinated physiological reflex activity in human body.So Bianzheng Lunzhi and Zhengti Guannian of TCM has played the role ofboth the root causes of OOC of severe RC merger RRP.The purpose of thispaper is to explore the short and long term efficacy of OOC of severe RCmerger RRP with “STARR+Xiaozhiling columnar injection+WenshenYunpitang with oral”.
     Methods: We select80cases from Anorectal in-patients of HebeiMedical University Hospital which showed OOC of severe RC merger RRPby means of symptoms, signs, defecography. We study by “STARR+Xiaozhiling columnar injection+Wenshen Yunpitang with oral”. We usesurgical treatment and boil Wenshen Yunpitang into decoction, which makedinto of200ml one bag, twice a day,10days is one treatment. Observating thechange in the situation of index for defecation frequency、defecation time、poor stool、anal sense of falling、application of laxatives、defecography beforeand after treatment. All the data use SPSS13.0software statistical package forstatistical analysis and all the measurement data use the average士standarddeviation(x士S).If the line in normal distribution, we use paired t test, if not,we use the paired wilcoxon rank test. The standard of significant differencewas P <0.05. By statistical analysis of statistical principles to determine the short and long term efficacy.
     Results:80patients after treatment,60cases (75%) were recovered,14cases (17.5%) were cured,6cases (7.5%)were improved, total effective ratewas100%.1Defecation frequency score data of patients before and after treatmentderived by the paired wilcoxon rank test showed P <0.05, with significantdifferences. Number of bowel movements after treatment than beforetreatment was significantly increased.
     2Defecation time score data of patients before and after treatment derived bythe paired wilcoxon rank test showed P <0.05, with significant differences.Defecation time after treatment than before treatment was significantlyreduced.
     3Poor stool score data of patients before and after treatment derived by thepaired wilcoxon rank test showed P<0.05, with significant differences. Poorstool after treatment than before treatment was significantly reduced.
     4Anal sense of falling score data of patients before and after treatment derivedby the paired wilcoxon rank test showed P<0.05, with significant differences.Anal sense of falling after treatment than before treatment was significantlyreduced.
     5Application of laxatives score data of patients before and after treatmentderived by the paired wilcoxon rank test showed P<0.05, with significantdifferences. Application of laxatives after treatment than before treatment wassignificantly reduced.
     6The depth of Protrusion score data of patients before and after treatmentderived by the paired t test showed P<0.05, with significant differences. Thedepth of Protrusion after treatment than before treatment was significantlyreduced.
     Conclusion: The treatment program eliminated the pouch-likerelaxation mucosa of the rectocele, reconstructed the anatomical structures ofthe middle and lower segments of the rectum and strengthened therectovaginal septum. In conjunction with oral of traditional Chinese medicine: Bushen Wenyang、 Yiqi Yangxue、 Runchang Tongbian, improved thephysique of patients and enhanced the function of internal organs, includingdefecation ability. It played the advantages of combining Chinese and Westernmedicine. The short and long term efficacy was significant.
引文
1林友彬,杨中权.STARR手术在直肠前突治疗中的应用.结直肠肛门外科,2009,15(3):165-166
    2张虹玺,李彦龙.预防肛肠病术后便秘的心理行为干预研究.中华中医药学刊,2007,25(5):109-111
    3王章志.PPH并发症及分析.医学信息,2011,8
    4王连生.PPH术后吻合口狭窄的原因、预防与处理.结直肠肛门外科,2009,15(6):414-415
    5王丽峰.STARR手术在直肠前突治疗中的应用.社区医学杂志,2010,8(13):33-34
    6吴丹妮,范亚明,杨文治.STARR术结合中药辨证治疗直肠前突型便秘
    20例.中国中西医结合外科杂志,2011,17(3):303-304
    7周方.综述消痔灵注射液的应用现状.内蒙古中医药,2008,(6):62-63
    1张竑晞,曾宇彤,陈双.改良Block手术在治疗直肠前突致便秘的应用.岭南现代临床外科,2010,6(3):181
    2倪士昌,韩少良,宋华羽.肛门后方切开加改良Block修补术治疗直肠前突型便秘.中华普通外科杂志,2005,20(10):632-634
    3张玉清,刘煜.闭式修补治疗直肠前突体会.武警医学2002,9:555
    4余文芳,白凤全,杨超.RPH在直肠前突治疗中的应用.结直肠肛门外科,2010,16(6):373
    5廖治先,杨向东,张琦.自动痔疮套扎术(RPH)治疗Ⅱ、Ⅲ度直肠前突的临床观察.结直肠肛门外科,2007,13(3):138-140
    6高原,李占海.注射法治疗直肠前突37例.内蒙古中医药,2002,2:11
    7韩宝,史兆岐.消痔灵注射治疗直肠前突综合征44例.人民军医,1999,42(10):576-577
    8Maria G, Brisinda G, Bentivoglio Ar. Anterior rectocele due to obstructeddefecation relived by botulinum toxin.Surgery,2001,129:524-529
    9黄东,刘丹,屈振繁.经阴道折叠缝合治疗直肠前突92例分析.郧阳医学院学报,2007,4:217
    10杨向东,曹吉勋.功能性出口梗阻性便秘的研究进展.中国肛肠病杂志,1996,16(5):31-33
    11刘大勇,刘桂兰,黄华东.经阴道重叠荷包缝合治疗中重度直肠前突55例临床观察.宁夏医科大学学报,2009,10(5):638
    12丁义江,李柏年,叶辉等.直肠前突合并直肠内脱垂致便秘的临床研究.中国肛肠病杂志,1996,16(5):9
    13林晖,严旭阳,谈志秋.经会阴入路手术治疗直肠前突42例观察.中国实用外科杂志,2001,12(12):732-733
    14翟春宝,杨建永,田利军.经会阴治疗直肠前突临床分析.山西医药杂志,2008,1(1):68
    15曹绥平.经会阴行补片无张力修补术治疗直肠前突.延安大学学报,2009,10(4):48
    16张萍.PPH手术治疗直肠前突18例.现代中西医结合杂志,2008,5(17):2008-2009
    17代述东,陈朝辉,武琳琳.PPH联合消痔灵注射治疗直肠前突的临床研究.结直肠肛门外科,2008,14(4):265-266
    18李哲.STARR手术治疗直肠前突临床观察.济宁医学院学报,2008,6(2):159-160
    19汤献忠,李兴谦,杨清.STARR手术治疗排便障碍综合征的临床疗效观察.结直肠肛门外科,2010,16(4):217-219
    20黄从水,刘佃温.95%无水酒精粘膜下注射治疗直肠内脱垂48例临床体会.河南预防医学杂志,2004,15(2):86
    21孙秋云,宋宇辉,庄鑫.安痔注射液治疗直肠内脱垂208例.中日友好医院学报,2002,16(5-6):354
    22叶玲,高献明.消痔灵注射治疗直肠内脱垂型便秘148例临床观察.中国现代药物应用,2009,3(18):109-110
    23徐方明,李瑞吉.消痔注射液治疗直肠内脱垂48例.广西中医药,1999,22(4):19-20
    24严如好,段传谊.粘膜缝叠加消痔灵注射治疗直肠内脱垂.大肠肛门病外科杂志,2002,8(1):38-39
    25马普伟,陈金泉.点状结扎术治疗直肠内脱垂31例临床分析.现代中西医结合杂志,2007,16(19):2709-2710
    26张桢,郑发鹃,康健.间断纵行缝扎硬化注射治疗直肠粘膜内脱垂68例临床分析.结直肠肛门外科,2006,12(3):140-142
    27Berman IR, Harris MS,LeggettIT. Rectal reservoir reduction procedures forinternal rectal prolapse. DisColon Rectum,1987,30(10):765-771
    28乔翠霞,张立泽,赵刚.自动痔疮套扎术治疗直肠内脱垂型便秘32例临床观察.中国中西医结合外科杂志,2011,17(3):307-308
    29郭锡泉,曾兵,肖桂玲.自动痔疮套扎术(RPH)在直肠粘膜脱垂中的应用.结直肠肛门外科,2010,16(3):85-87
    30马慧.吻合器痔上粘膜环切治疗直肠内脱垂的效果.齐鲁医学杂志,2004,19(3):246-247
    31王志民,杨明利,陈现中.PPH技术在直肠粘膜内脱垂中的应用.中国医疗前沿,2007,2(14)
    32Watts AM,Thompson MR.Evaluation of Delorme's procedure a treatmentfor full thickness rectal prolapse. Br J Surg,2000,87(2):218-222
    33王立勇,杨新庆,丁步国.改良Delorme手术治疗直肠内套叠(附10例报告).中国实用外科杂志,1993,13(12):727-728
    34Liberman H,Hughes C, DippolitoA.Evaluation and outcome of the delormeprocedure in the treatment of rectal outlet obstruction. Dis Colon Rectum,2000,43(2):188-192
    35Berman IR, Harris MS, RabelerM B. Delorme'stransrectal excision forinternal rectal prolapse: patient selection, technique, and three year followup. Dis Colon Rectum,1990,33(7):573-580
    36Schultz I,MellgrenA,DolkA. Long term results and functional outcomeafter Ripstein rectopexy. Dis Colon Rectum,2000,43(1):35-43
    37Johansson C,Ihre T,Ahlback SO.Disturbances in the defecatio mechanismwith special reference to intussuscept of the rectum. Dis Colon Rectum,1958,28(12):920-924
    38张胜本,张连阳.直肠内脱垂的诊治进展.中国实用外科杂志,1993,13(12):715-717
    39张连阳,张胜本,黄显凯.功能性直肠悬吊术—改良Orr's直肠悬吊术治疗直肠内脱垂.中国普通外科杂志,1995,4(1):4-6
    40Heah S M, Hartley J E. Laparoscopic suture rectopexy without resection iseffective treatment for full thickness rectal prolapse. Dis Colon Recum,2000,43(5):638-643

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700