中西医结合治疗膝骨关节炎的临床观察
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摘要
骨关节炎(OA),亦称退行性关节炎、骨关节病,是滑膜关节伴有关节周围骨质增生为特点的软骨丧失所致疾病,呈慢性、进行性改变。膝骨关节炎作为最常见的骨性关节炎之一,越来越受到社会各方面的重视。现代医学从流行病学、病理生理学及影像学等方面对其进行了大量的研究,但其发病机制至今仍没有阐明。中医学认为本病的病因病机以肝肾亏虚,气血不足为本,风寒湿邪内蕴,瘀血阻络为标,即为“本虚标实”。目前,无论西医还是中医,对本病的治疗方法丰富多样,但临床疗效仍难以达到令患者满意的程度。为寻求一种疗效更好的、令患者更加满意的治疗方法,2007年4月至2007年10月我们采用了中西医结合疗法治疗本病。
目的:观察中药内服、关节腔内注射透明质酸钠配合关节镜清理灌洗术治疗膝骨关节炎的临床疗效。
方法:将90例膝骨关节炎患者随机分为中药治疗组、西医治疗组和中西医结合治疗组。中药治疗组,给予中药内服治疗;西医治疗组,给予关节内注射透明质酸钠配合关节镜清理灌洗术治疗;中西医结合治疗组,给予中药内服、关节内注射透明质酸钠配合关节镜清理灌洗术治疗。中药内服,30天为1个疗程;透明质酸钠每周注射1次,连续5周。
结果:治疗结束后,临床疗效评定为:中药治疗组(A组)优良率73.42%;西医治疗组(B组)优良率82.86%;中西医结合治疗组(C组)优良率94.59%。每两组之间行χ~2检验,A组和B组临床疗效无统计学意义(P>0.05),A组和C组、B组和C组临床疗效均有统计学意义(P<0.05)。膝关节功能评分(采用Lysholm-Ⅱ评分标准):治疗前三组之间比较无统计学意义(P>0.05),具有可比性;各组治疗前后比较有统计学意义(P<0.05);治疗后,A组和B组之间比较无统计学意义(P>0.05),A组和C组、B组和C组之间比较均有统计学意义(P<0.05);治疗前后差值,A组和B组之间比较无统计学意义(P>0.05),A组和C组、B组和C组之间比较均有统计学意义(P<0.05)。
结论:3种方法对膝骨关节炎均有明显疗效,中西医结合治疗组在临床疗效方面明显优于其他两组。
The osteoarthritis,also called recession arthritis,osteoarthropathy,are the synovial membrane joint are accompanied by around the joint the ossein proliferation to lose the result disease for the characteristic cartilage,assumes the chronicity, carries on the change.The knee osteoarthritis took one of most common osseous arthritises,more and more receives the social various aspects the value.The modern medicine from the epidemiology,the pathophysiology and aspects and so on the phantom study has conducted the massive research to it,but its pathogenesis still had not expounded until now.The traditional Chinese medicine thought this gets sick cause of disease pathogenesis by liver deficiency of vitalness of the kidneys empty,the vitality for this,the cold wet evil embodiment,the ecchymosis anti-winds insufficient for the sign,is "this empty sign is solid".At present,regardless of the doctor practicing western medicine or the Chinese medicine,to the method of treatment which this gets sick is bountiful,but the clinical curative effect still with difficulty achieved is satisfied the patient the degree.In order to seek one kind of curative effect well,makes the patient more satisfactory method of treatment,from April,2007 we used the cooperation of Chinese and Western medicine therapy to October,2007 to treat this sickness.
Objective:To study the curative effect of Chinese native medicine internal medicine,intra-articular sodium hyaluronate in jection and arthroscopic debride-ment for patients suffering from knee osteoarthritis。
Method:Will be 90 cases of knee osteoarthritis were randomly divided into treatment group of Chinese medicine,Western medicine treatment group and TCM-WM treatment group.Chinese medicine treatment group given the Chinese native medicine internal medicine treatment;Western medicine treatment group given intra-articular injection of sodium hyaluronate with the clean-up arthroscopic lavage treatment; TCM-WM treatment group,to give medicine intake into the body,intra-articular injection of sodium hyaluronate with arthroscopy lavage treatment of clean-up. Internal medicine,30 days for a course of treatment;sodium hyaluronate injection one time per week,for five weeks.
Result:After treatment,clinical efficacy assessed as:Chinese medicine treatment group(A group) excellent and good rate of 73.42%;Western medicine treatment group (B group) excellent and good rate of 82.86%;TCM-WM treatment group(C group) excellent and good rate of 94.59%.Each x~2 test line between the two groups,A group of and B group of clinical curative effect does not have statistics significance(P>0.05),A group of and C group of,B group of and C group of clinical curative effect has statistics significance(P<0.05).Knee joint function grading(Uses Lysholm-ⅡGrading standard):Before the treatment,between three groups compares the non-statistics significance(P>0.05),has the commeasurability; Around each group of treatments the comparison has statistics significance(P<0.05); After the treatment,between A group and B group,the comparison has non-statistics significance(P>0.05),A group and C group,B group and between C group quite is even has statistics signif icance(P<0.05);around treatment interpolation,between A group and B group,the comparison has non-statistics significance(P>0.05),A group and G group,B group and between C group quite is even has statistics significance(P<0.05).
Conclusion:Three methods have the obvious curative effect to the knee osseous arthritis,the cooperation of Chinese and Western medicine treatment group surpasses other two groups obviously in the clinical curative effect aspect.
目的:观察中药内服、关节腔内注射透明质酸钠配合关节镜清理灌洗术治疗膝骨关节炎的临床疗效。
方法:将90例膝骨关节炎患者随机分为中药治疗组、西医治疗组和中西医结合治疗组。中药治疗组,给予中药内服治疗;西医治疗组,给予关节内注射透明质酸钠配合关节镜清理灌洗术治疗;中西医结合治疗组,给予中药内服、关节内注射透明质酸钠配合关节镜清理灌洗术治疗。中药内服,30天为1个疗程;透明质酸钠每周注射1次,连续5周。
结果:治疗结束后,临床疗效评定为:中药治疗组(A组)优良率73.42%;西医治疗组(B组)优良率82.86%;中西医结合治疗组(C组)优良率94.59%。每两组之间行χ~2检验,A组和B组临床疗效无统计学意义(P>0.05),A组和C组、B组和C组临床疗效均有统计学意义(P<0.05)。膝关节功能评分(采用Lysholm-Ⅱ评分标准):治疗前三组之间比较无统计学意义(P>0.05),具有可比性;各组治疗前后比较有统计学意义(P<0.05);治疗后,A组和B组之间比较无统计学意义(P>0.05),A组和C组、B组和C组之间比较均有统计学意义(P<0.05);治疗前后差值,A组和B组之间比较无统计学意义(P>0.05),A组和C组、B组和C组之间比较均有统计学意义(P<0.05)。
结论:3种方法对膝骨关节炎均有明显疗效,中西医结合治疗组在临床疗效方面明显优于其他两组。
The osteoarthritis,also called recession arthritis,osteoarthropathy,are the synovial membrane joint are accompanied by around the joint the ossein proliferation to lose the result disease for the characteristic cartilage,assumes the chronicity, carries on the change.The knee osteoarthritis took one of most common osseous arthritises,more and more receives the social various aspects the value.The modern medicine from the epidemiology,the pathophysiology and aspects and so on the phantom study has conducted the massive research to it,but its pathogenesis still had not expounded until now.The traditional Chinese medicine thought this gets sick cause of disease pathogenesis by liver deficiency of vitalness of the kidneys empty,the vitality for this,the cold wet evil embodiment,the ecchymosis anti-winds insufficient for the sign,is "this empty sign is solid".At present,regardless of the doctor practicing western medicine or the Chinese medicine,to the method of treatment which this gets sick is bountiful,but the clinical curative effect still with difficulty achieved is satisfied the patient the degree.In order to seek one kind of curative effect well,makes the patient more satisfactory method of treatment,from April,2007 we used the cooperation of Chinese and Western medicine therapy to October,2007 to treat this sickness.
Objective:To study the curative effect of Chinese native medicine internal medicine,intra-articular sodium hyaluronate in jection and arthroscopic debride-ment for patients suffering from knee osteoarthritis。
Method:Will be 90 cases of knee osteoarthritis were randomly divided into treatment group of Chinese medicine,Western medicine treatment group and TCM-WM treatment group.Chinese medicine treatment group given the Chinese native medicine internal medicine treatment;Western medicine treatment group given intra-articular injection of sodium hyaluronate with the clean-up arthroscopic lavage treatment; TCM-WM treatment group,to give medicine intake into the body,intra-articular injection of sodium hyaluronate with arthroscopy lavage treatment of clean-up. Internal medicine,30 days for a course of treatment;sodium hyaluronate injection one time per week,for five weeks.
Result:After treatment,clinical efficacy assessed as:Chinese medicine treatment group(A group) excellent and good rate of 73.42%;Western medicine treatment group (B group) excellent and good rate of 82.86%;TCM-WM treatment group(C group) excellent and good rate of 94.59%.Each x~2 test line between the two groups,A group of and B group of clinical curative effect does not have statistics significance(P>0.05),A group of and C group of,B group of and C group of clinical curative effect has statistics significance(P<0.05).Knee joint function grading(Uses Lysholm-ⅡGrading standard):Before the treatment,between three groups compares the non-statistics significance(P>0.05),has the commeasurability; Around each group of treatments the comparison has statistics significance(P<0.05); After the treatment,between A group and B group,the comparison has non-statistics significance(P>0.05),A group and C group,B group and between C group quite is even has statistics signif icance(P<0.05);around treatment interpolation,between A group and B group,the comparison has non-statistics significance(P>0.05),A group and G group,B group and between C group quite is even has statistics significance(P<0.05).
Conclusion:Three methods have the obvious curative effect to the knee osseous arthritis,the cooperation of Chinese and Western medicine treatment group surpasses other two groups obviously in the clinical curative effect aspect.
引文
1.Davis MA,Ettinger WH,Neuhaus JM,et al.The association of knee injury and obesity with unilateral and bilateral osteoarthritis of the knee.Am J Epidemiol 1989,130:278-288.
2.Felson DT,Zhang Y,Hannan MT,et al.The incidence and natural history of knee osteoarthritis in the elderly:the Framingham osteoarthritis study.Arthritis Rheum 1995,38:1500-1505.
3.Cooper C,Egger P,Coggon D,et al.Generalized osteoarthritis in women:pattern of joint involvement and approaches to definition for epidemiological studies.J Rheumatol 1996,23:1938-1942.
4.Spector TD,Hart DJ,Doyle DV.Incidence and progression of osteoarthritis in women with unilateral knee disease in the general population:the effect of obesity.Ann Rheum Dis 1994,53:565-568.
5.Spector TD,Dacre JE,Harris RA,et al.Radiological progression of osteoarthritis:an 11 year follow up study of the knee.Ann Rheum Dis 1992,51:1107-1110.
6.McAlindon T,Zhang Y,Hannan M,et al.Are risk factors for patellofemoral and tibiofemoral knee osteoarthritis different?J Rheumatol 1996,23:332-337.
7.McAlindon TE,Snow S,Cooper C,et al.Radiographic patterns of osteoarthritis of the knee joint in the community:the importance of the patellofemoral joint.Ann Rheum Dis 1992,51:844-849.
8.Neame R,Zhang W,Deighton C,et al.Distribution of Radiographic osteoarthritis between the right and left hands,hips and knees.Arthritis Rheum 2004,50:1487-1490.
9.Schouten JSAG.A 12-year follow-up study on osteoarthritis of the knee in the general population.An epidemiological study of classification criteria,risk factors and prognostic factors.Dissertation,Erasmus University Medical School,Rotterdam,1991.
10.林锦洪,李敏健,许智源等。广州市社区18个居委会45岁以上人群退行性膝关节病的流行病学调查。中国临床康复,2005;9(47):8-9.
11.Van Saase JL,Van Romunde LK,Cats A,et al.Epidemiology of osteoarthritis:Zoetermeer survey.Comparison of radiographical osteoarthritis in a Dutch population with that in 10 other populations.Ann Rheum Dis 1989,48:271-280.
12.Lawrence JS,Bremner JM,Bier E.Osteoarthrosis,prevalence in the popula- tion and relationship between symptoms and x-ray changes.Ann Rheum Dis 1966,25:1-23.
13.Felson DT,Naimark A,Anderson J,et al.The prevalence of knee osteoar-thritis in the elderly.Arthritis Rheum 1987,30:914-918.
14.Anderson JJ,Felson DT.Factors associated with osteoarthritis of the knee in the first National Health and Nutrition Examination Survey(HANES Ⅰ),evidence for an association with overweight,race,and physical demands of work.Am J Epidemiol 1988,128:179-189.
15.Zhang Y,Xu L,Nevitt MC,et al.Comparison of the prevalence of knee osteo-arthritis between elderly Chinese population in Beijing and whites in the United States:The Beijing Osteoarthritis Study.Arthritis Rheum 2001,44:2065-2071.
16.余卫,徐苓,秦明伟。北京市城区老年人膝关节骨关节炎流行病学调查——与美国白种人膝关节骨关节炎的临床和x线比较分析。中华放射学杂志,2005;39(1):67-71.
17.Felson DT,Zhang Y,Hannan MT,et al.Risk factors for incident radiographic knee osteoarthritis in the elderly.Arthritis Rheum 1997,40:728-733.
18.颜贻站,曾云记,谢作完等。农村50岁以上5016人退行性膝关节病流行病学调查。浙江中西医结合杂志,2007;17(7):422,456.
19.Hart DJ,Doyle DV,Spector TD.Incidence and risk factors for radiographic knee osteoarthritis in middleaged women,the Chingford Study.Arthritis Rheum 1999,42:17-24.
20.Sharma L,Lou C,Felson DT,et al.Laxity in health and osteoarthritis knees.Arthritis Rheum,in press.
21.Slemenda C,Heilman DK,Brandt KD,et al.Reduced quadriceps strength relative to body weight:a risk factor for knee osteoarthritis in women?Arthritis Rheum 1998,41:1951-1959.
22.Kivimakj J,Riihimaki H,Hanninen K.Knee disorders in carpet and floor layers and painters.Scand J Work Environ Health 18:310-316,1992.
23.Cooper C,McAlindon T,Coggon D,et al.Occupational activity and osteoarthritis of the knee.Ann Rheum Dis 1994,53:90-93.
24.Kujala UM,Kettunen J,Paananen H,et al.Knee osteoarthritis in former runners,soccer players,weight lifters and shooters.Arthritis Rheum 1995,38:539-546.
25.Panush RS,Schmidt C,Caldwell JR,et al.Is running associated with degenerative joint disease?JAMA.1986,255:1152-1154.
26.Hannan MT,Felson DT,Anderson JJ,et al.Habitual physical activity is not associated with knee osteoarthritis:the Framingham Study.J Rheumatol 1993,20:704-709.
27.Bagge E,Bjelle A,Eden S,et al.Factors associated with radiographic osteoarthritis:results from the population study 70-year-old people in Goteborg.J Rheumatol 1991,18:1218-1222.
28.Hart DJ,Mootoosamy I,Doyle DV,et al.The relationship between osteoarthritis and osteoporosis in the general population:the Chingford Study.Ann Rheum Dis 1994,53:158-162.
29.Hannan MT,Anderson JJ,Zhang Y,et al.Bone mineral density and knee osteoarthritis in elderly men and women,the Framingham Study.Arthritis Rheum, 1993,36:1671-1680.
30.Wluka AE,Davis SR,Bailey M,et al.Users of oestrogen replacement therapy have more knee cartilage than non-users.Ann Rheum Dis 2001,60:332—336.
31.Spector TD,Cicuttini F,Baker J,et al.Genetic influences on osteoarthritis in women:a twin study.BMJ 1996,312:940-943.
32.Felson DT,Couropmitree NN,Chaisson CE,et al.Evidence for a mendelian gene in a segregation analysis of generalized radiographic osteoarthritis.Arthritis Rheum 1998,41:1064-1071.
33.Keen RW,Hart DJ,Lanchbury JS,et al.Association of early osteoarthritis of the knee with a Taq I polymorphism of the vitamin D receptor gene.Arthritis Rheum 1997,40:1444-1449.
34.Uitterlinden AG,Burger H,Huang Q,et al.Vitamin D receptor genotype is associated with radiographic osteoarthritis at the knee.J Clin Invest 1997,100:259-263.
35.Loughlin J,Polymorphism in signal transduction is a major route through which osteoarthritis susceptibility is acting.Curr Opin Rheumatol 2005,17:629-633.
36.Loughlin J,Dowling B,Chapman K,et al.Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.Proc Natl Acad Sci USA 2004,101:9757-9762.
37.Min JL,Meulenbelt I.Riyazi N,et al.Association of the frizzled-related protein gene with symptomatic osteoarthritis at multiple sites.Arthritis Rheum 2005,52:1077-1080.
38.Kizawa H,Kou I,Iida A,et al.An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis.Nat Genet 2005,37:138-144.
39.Mustafa Z,Dowling B,Chapman K,et al.Investigating the aspartic acid(D) repeat of asporin as a risk factor for osteoarthritis in a U.K.Caucasian population.Arthritis Rheum 2005,52:3502-3506.
40.Cooper C.McAlindon T,Snow S,et al.Mechanical and constitutional risk factors for symptomatic knee osteoarthritis:differences between medial tibiofemoral and patellofemoral disease.J Rheumatol 1994,21:307-313.
41.Englund M,Lohmander LS.Risk factors for symptomatic knee osteoarthritis fifteen to twenty-two years after meniscectomy.Arthritis Rheum 2004,50:2811-2819.
42.Sharma L,Song J,Felson DT,et al.The role of knee alignment in disease progression and functional decline in knee osteoarthritis.JAMA 2001,286:188-195.
43.Miyazaki T,Wada M,Kawahara H,et al.Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis.Ann Rheum Dis 2002,61:617-622.
44.Cahue S,Dunlop D,Hayes K,et al.Varus-valgus alignment in the pro-gression of patellofemoral osteoarthritis.Arthritis Rheum 2004,50:2184-2190.
45.Felson DT,Goggins J,Niu J,et al.The effect of body weight on progression of knee osteoarthritis is dependent on alignment.Arthritis Rheum 2004,50:3904-3909.
46.McAlindon TE,Felson DT,Zhang Y,et al.Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among partici-pants in the Framingham study.Ann Intern Med 1996,125:353-359.
47.Brandt KD,Heilman DK,Slemenda C,et al.Quadriceps strength in women with radiographically progressive osteoarthritis of the knee and those with stable radiographic changes.J Rheumatol 1999,2.6:2431-2437.
48.Sharma L,Dunlop DD,Cahue S,et al.Quadreceps strength and osteoarthritis progression in malaligned and lax knees.Ann Int Med 2003,138:613-619.
49.Dieppe P.Subchondral bone should be the main target for the treatment of pain and disease progression in osteoarthritis.Osteoarthritis Cartilage 1999,7:325-326.
50.Zhang Y,Hannan MT,Chaisson CE,et al.Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women:the Framing-ham Study.J Rheumatol 2000,27:1032-1039.
51.Felson D.McLahughlin S,Goggins J,et al.Bone marrow edema and its relation to progression of knee osteoarthritis.Ann Intern Med 2003,139:330-336.
52．Roland W,Roy D,Mare C,Joseph A,Victor M．骨关节炎诊断与治疗。第4版。谢利民主译。北京：人民卫生出版社,2008．16．
53.Berhiaume MJ,Raynauld JP,Martel-Pelletier,et al.Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging.Ann Rheum Dis 64:556-563,2005.Epub 2004 Sep 16.
54.Chang A,Hayes K,Dunlop D,et al.Hip abduction moment and protection against medial tibiofemoral osteoarthritis progression.Arthritis Rheum 2005,52:3515-3519.
55.Davis MA,Ettinger WH,Neuhaus JM,et al.Correlates of knee pain among U.S.adults with and without radiographic knee osteoarthritis.J Rheumatol 1992,19:1943-1949.
56.Hill CL,Gale DG,Chaisson CE,et al.Knee effusions,popliteal cysts,and synovial thickening:association with knee pain in osteoarthritis.J Rheumatol 2001,28:1330-1337.
57.Sowers MF,Hayes C,Jamadar D,et al.Magnetic resonance detected subchondral bone marrow and cartilage defect characteristics associated with pain and x-ray defined knee osteoarthritis.Osteoarthritis Cartilage 2003,11:387-393.
58.Hochberg MC,Lawrence RC,Evefett DF,et al.Epidemiologic associations of pain in osteoarthritis of the knee:data from the National Health and Nutrition Examination Survey and the National Health and Nutrition Examination-1 Epidemiologic Followup Survey.Semin Arthritis Rheum 1989,18:4—9.
59.Summers MN,Haley WE,Reveille JD,et al.Radiographic assessment and psychologic variables as predictors of pain and functional impairment in osteoarthritis of the knee or hip.Arthritis Rheum 31:204-209,1988.
60.Lunghi ME,Miller PM,McQuillan WM.Psychological factors in osteoa rthritis of the hip.J Psychosom Res 1978,22:57-63.
61.O'Reilly SC,Jones A,Muir KR,et al.Quadriceps weakness in knee osteoarthritis:the effect on pain and disability.Ann Rheum Dis 199-8,57:588—594.
62.Lichtenberg PA,Skehan MW,Swensen CH.The role of personality,recent life stress and arthritic severity in predicting pain.J Psychosom Res 1984,28:231-236.
63.Lankhorst GJ,van de Stadt,vari der Korst.The relationships of functional capacity of the knee.Scand J Rehabil Med 1985,17:167-172.
64.Miller ME,Rejeski WJ,Messier SP,et al.Modifiers of change in physical functioning in older adults with knee pain:the Observational Arthritis Study in Seniors(OASIS).Arthritis Care Res 2001;45:331-339.
65.Sharma L,Cahue S,Song J,et al.Physical functioning over 3 years in knee osteoarthritis.Arthritis Rheum 2003,48:3359-3370.
66.Rejeski WJ,Miller ME,Foy C,et al.Self-efficacy and the progression of functional limitations and self-reported disability in adults with knee pain.J Gerontol 2001,56B:S261-265.
67．叶永平,蒋垚,曾炳芳。膝骨关节炎病因、X线片及临床表现分析。临床骨科杂志,2000,3(3)：169-173．
68.Evans CH,Brown TD.Role of physical and mechanical agents in degrading the matrix.In:Woessner JFJ,Howell DS,eds.Joint Cartilage Degradation;Basic and Clinical Aspects.New York:Marcel Dekker;1993:187-208.
69.Redin EL,Burr DB,Caterson B,et al.Mechanical determinants of oste oarthritis.Semin Arthritis Rheum 1991,21:12-21.
70.Buckwalter JA.Osteoarthritis and articular cartilage use,disuse,and abuse:experimental studies.J Rheumatol Suppl 1995,43:13-15.
71.Palmoski MJ,Brandt KD.Running inhibits the reversal of atrophic changes in canine knee,cartilage after removal of a leg cast.Arthritis Rheum 1981,24:1329—1337.
72.Setton LA,Elliott DM.Mow VC.Altered mechanics of cartilage with osteoarthritis:human osteoarthritis and an experimental model of joint degeneration.Osteoarthritis Cartilage 1999,7:2-14.
73.Setton LA,Mow VC,Muller FJ,et al.Mechanical properties of canine articular cartilage are significantly altered following transection of the anterior cruciate ligament.J Orthop Res 1994,12:451-463.
74.Setton LA,Mow VC,Muller FJ,et al.Mechanical behavior and biochemical composition of canine knee cartilage following periods of joint disuse and disuse with remobilization.Osteoarthritis Cartilage 1997,5:1-16.
75.Grumbles RM,Howell DS,Howard GA,et al.Cartilage metalloproteases in disuse atrophy.J Rheumatol Suppl 1995,43:146-148.
76.Lammi MJ,Hakkinen TP,Parkkinen JJ,et al.Effects of long-term running exercise on canine femoral head articular cartilage.Agents& Actions-Supplements 1993,39:95-99.
77.Lane NE,Buckwalter JA.Exercise:a cause of osteoarthritis?Rheum Dis Clin North Am 1993,19:617-633.
78.Kraus VB.Pathogenesis and treatment of osteoarthritis.Med Clin North Am 1997,81:85-112.
79.Griffin TM,Guilak F.The role of mechanical loading in the onset and progression of osteoarthritis.Exerc Sport Sci Rev 2005,33:195—200.
80.Lane JM,Chisena E,Black J.Experimental knee instability:Early mechanical property changes in articular cartilage in a rabbit model.Clin Orthop Rel Res 1979,140:262-265.
81.Howell DS,Treadwell BV.Trippel SB.Etiopathogenesis of osteoarthritis.In:Moskowitz RW,Howell DS,Goldberg VM,et al.,eds.Osteoarthri tis,Diagnosis and Medical/Surgical Management.2~(nd) ed.Philadelphia:W.B.Saunders;pp 1992,233-252.
82.Pond MJ,Nuki G.Experimentally induced osteoarthritis in the dog.Ann Rheum Dis 1973,32:387-388.
83.Moskowitz RW,Davis W,Sammarco J.Experimentally induced degenerative joint lesions following partial meniscectomy in the rabbit.Arthritis Rheum 1973,16:397-405.
84.McDevitt C,Gilbertson E,Muir H.An experimental model of osteoar thritis;early morphological and biochemical changes.J Bone Joint Surg 1977,59B:24-35.
85.Eyre DR,McDevitt CA,Billingham ME,et al.Biosynthesis of collagen and other matrix proteins by articular cartilage in experimental osteoarthritis.Biochem J 1980,188:823-837.
86.Altman RD,Tenenbaum J,Latta L,et al.Biomechanical and biochemical properties of dog cartilage in experimentally induced osteoarthritis.Ann Rheum Dis 1984,43:83-90.
87.Sandy JD,Adams ME,Billingham ME,et al.In vivo and in vitro stimulation of chondrocyte biosynthetic activity in early experimental osteoarthritis.Arthritis Rheum 1984,27:388-397.
88.Guilak F,Ratcliffe A,Lane N,et al.Mechanical and biochemical changes in the superficial zone of articular cartilage in canine experimental osteoarthritis.J Orthop Res 1994,12:474-484.
89.Messier SP.Osteoarthritis of the knee and associated factors of age and obesity:effects on gait.Med Sci Sports Exerc 1994,26:1446-1452.
90.Das UN.Obesity,metabolic syndrome X,and inflammation.Nutrition 2002,18:430-432.
91.O'Connor BL,Palmoski MJ,Brandt KD.Neurogenic acceleration of degenerative joint lesions.J Bone Joint Surg Am 1985,67:562—572.
92.Yang KH,Riegger CL,Rodgers MM.Diminished lower limb deceleration as a factor in early stage osteoarthritis.Trans Orthop Res Soc 1989,14:52.
93.O'Reilly SC,Jones A,Muir KR,et al.Quadriceps weakness in knee osteoarthritis:the effect on pain and disability.Ann Rheum Dis 1998,57:588-594.
94.McAlindon T,Felson DT.Nutrition:risk factors for osteoarthritis.Ann Rheum Dis 1997,56:397-400.
95.Aurich M,Squires GR,Reiner A,et al.Differential matrix degradation and turnover in early cartilagr lesions of human knee and ankle joints.Arthritis Rheum 2005,52:112-119.
96.Hardingham TE,Fosang AJ,Dudhia J.The structure,function and turnover of aggrecan,the large aggregating proteoglycan from cartilage.Eur J Clin Chem Clin Biochem 1994,32:249-257.
97.Maroudas A.Physicochemical properties of articular cartilage.In:Freeman M,ed.Adult Articular Cartilage.Tunbridge Wells:Pitman Medical;1979,pp 215-290.
98.Mow VC,Kuer SC,Lai WM,et al.Biphasic creep and stress relaxation of articular cartilage in compression:Theory and experiments.J Biomech Eng 1980,102:73-84.
99.Kempson GE,Muir H,Pollard C,et al.The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans.Biochim Biophys Acta 1973,297:456-472.
100.Roth V.Mow VC.The intrinsic tensile behavior of the matrix of bovine articular cartilage and its variation with age.J Bone Joint Surg 1980,62:1102—1117.
101.Chen AC,Temple MM,Ng DM,et al.Induction of advanced glycation end products and alterations of the tensile properties of articular cartilage.Arthritis Rheum 2002,46:3212-3217.
102.Poole AR.Cartilage in health and disease.In:Koopman WJ.Moreland LW,eds.Arthritis and Allied Conditions.A Textbook of Rheumatology.15th ed.Baltimore:Williams&Williams;2005,pp 223-269.
103.Setton LA,Tohyama H,Mow VC.Swelling and curling behaviors of articular cartilage.J Biomech Eng,1998,120:355-361.
104.Narmoneva DA,Wang JY,Set ton LA.Nonuniform swelling induced residual strains in articular cartilage.J Biomech 1999,32:401-408.
105.Flahiff CM,Kraus VB,Huebner JL,et al.Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic loading method.Osteoarthritis Cartilage 2004,12:383-388.
106.Alexopoulos LG,Setton LA,Guilak F.The biomechanical role of the chondrocyte pericellular matrix in articular cartilage.Acta Biomater 2005,1:317-325.
107.Mow VC,Ateshian GA.Lubrication and wear of diarthrodial joints.In:Mow VC,Hayes WC,eds.Basic Orthopaedic Biomechanics,2~(nd) Ed.Philadelphia:Lippincott-Raven;1997,pp 275-315.
108.Malcom LL.An experimental investigation of the frictional and deformational responses of articular cartilage interfaces to static and dynamic loading[dissertation].San Diego,University of California,San Diego,1976.
109.Park S,Krishnan R,Nicoll SB,et al.Cartilage interstitial fluid load support in unconfined compression.J Biomech 2003,36:1785-1796.
110.McCutchen CW.Joint lubrication.Bull Hosp Jt Dis Orthop Inst 1983,43:118-129.
111.Hou JS,Mow VC,Lai WM,et al.An analysis of the squeezefilm lubrication mechanism for articular cartilage.J Biomech 1992,25:247-259.
112.Helminen HJ,Jurvelin J,Kiviranta I,et al.Joint loading effects on articular cartilage:A historical review.In:Helminen HJ,Kiviranta I,Tammi M,et al.,eds.Joint Loading:Biology and Health of Articular Structures.Bristol:Wright and Sons;1987,1-46.
113.Guilak F,Sah RL,Setton LA.Physical regulation of cartilage metabolism.In:Mow VC,Hayes WC,eds.Basic Orthopaedic Biomechanics.2~(nd)ed.Philadelphia:Lippincott-Raven,1997,179-207.
114.Gray ML,Pizzanelli AM,Grodzinsky AJ,et al.Mechanical and physiochemical determinants of the chondrocyte biosynthetic response.J Orthop Res 1988,6:777-92.
115.Sah RL,Doong JY,Grodzinsky AJ,et al.Effects of compression on the loss of newly synthesized proteoglycans and proteins from cartilage explants.Arch Biochem Biophys 1991,286:20-29.
116.Guilak E,Meyer BC,Ratcliffe A,et al.The effects of matrix compression on proteoglycan metabolism in articular cartilage explants.Osteoarthritis Cartilage 1994,2:91-101.
117.Torzilli PA,Grigiene R,Huang C,et al.Characterization of cartilage metabolic response to static and dynamic stress using a mechanical explant test system.J Biomech 1997,30:1-9.
118.Farquhar T,Xia Y,Mann K,et al.Swelling and fibronectin accumulation in articular cartilage explants after cyclical impact.J Orthop Res 1996,14:417-423.
119.Chen C-T,Burton-Wurster N,Borden C,et al.Chondrocyte necrosis and apoptosis in impact damaged articular cartilage.J Orthop Res 2001,19:703-711.
120.Loening AM,James IE,Levenston ME,et al.Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis.Arch Biochem Biophys 2000,381:205-212.
121.Nishida Y,Shinomura T,Iwata H,et al.Abnormal occurrence of a large chondroitin sulfate proteoglycan,PG-M/versican in osteoarthritis cartilage.Osteoarthritis Cartilage 1994,2:43-49.
122.Brandt K.Paracetamol in the treatment of osteOArthritis pain.Drugs,2003;63:23-41.
123.Nelaon E,Billinghurst RC,Pidoux I,et al.Early posttraumatic osteoarthr-itis-like changes in human articular cartilage following rupture of the anterior cruciate ligament.Osteoarthritis Cartilage 2006,14:114-119.
124.Adams ME,Brandt KD.Hyperteophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection.J Rheumatol 1991,18:428-435.
125.Brandt KD,Braunstein EM,Visco DM,et al.Anterior(cranial)of osteoarthritis,not merely of cartilage injury and repair.J Rheumatol 1991,18:436-446.
126.张超,王旭等。NNP-1、-13mRNA和DDR2表达与关节软骨退变的关系。复旦学报(医学粕,2007,34(1):126-128.
127.Krzeski P,Buckland-Wright C,Bá lint G,et al.Development of musculo-skeletal toxicity without clear benefit after administration of PG-116800,a matrix metalloproteinase inhibitor,to patients with knee osteoarthritis:a randomized,12-month,double-blind,placebocontrolled study.Arthritis Res Ther 2007;9(5):R109.
128.BlomAB,van Lent PL,Libregts S,et al.Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis:involvement of matrix metalloproteinase 3.Arthritis Rheum.2007;56(1):147-157.
129.Lohmander LS,Brandt KD,Mazzuca SA,et al.Use of the plasma stromelysin (matrix metalloproteinase 3) concentration to predict joint space narrowing in knee osteoarthritis.Arthritis Rheum.2005;52(10):3160-3167.
130.闫训友,薛冲,刘志敏等。基质金属蛋白酶及其组织抑制剂研究进展。生物技术通讯,2004,15(3):302-305.
131.孙永生,娄思权。骨性关节炎发病分子机制研究进展。中国骨与关节损伤杂志,2005,20(8):571-573.
132.Mitchell PG,Magna HA,Reeves LM,et al.Cloning expression,and type Ⅱcollagenolytic activity of matrix metal loproteinase-13 from human osteoarthritis cartilage.J Clin Invest 1996,97:761-768.
133.Billinghurst.RC,Dahlbert L,Ionescu M,et al.Enhanced cleavage of type Ⅱcollagen by collagenases in osteoarthritis articular cartilage.J Clin Invest 1997,99:1534-1545.
134.Dahlberg L,Billinghurst RC,Manner P,et al.Selective enhancement of coll-agenasemediated cleavage of resident type Ⅱ collagen in cultured osteoarthritis cartilage and arrest with a synthetic inhibitor that spares collagenasa 1(matrix metalloproteinase 1).Arthritis Rheum 2000,43:673-682.
135.管剑龙,施桂英,韩星海等。骨关节炎关节软骨和滑膜MMP-1、-3表达。中华内科杂志,2000,39(9):62-631.
136.吴宏斌,杜靖远,胡勇等。兔前交叉韧带切断骨关节炎模型中MMP-1、-13及TIMP-1的表达研究。中华风湿病学杂志,2002,6(3):169-173.
137.王爱民,王宝恩.基质金属蛋白酶.国外医学:临床生化与检验学分册,1995,16(6):246.
138.Sondergaard BC,Henriksen K,Wulf H,et al.Relative contribution of matrix metalloprotease and cysteine protease activities to cytokinestimulated articular cartilage degradation.Osteoarthritis Cartilage 2006;14(8):738-748.
139.Zhao HB,Du JY.Guowai Yixue:Chuangshang yu Waike Jiben Wenti Fence 1996;17(1):27赵海波,杜靖远.基质金属蛋白酶及其中骨吸收中的作用.国外医学:创伤与外科基本问题分册,1996,17(1):27.
140.Kafienah W,BrommeD,Buttle DJ,et al.Human cathepsin K cleaves native type Ⅰ and Ⅱ col lagens at the N-terminal end of the triple helix.Biochem J 1998,331(Pt 3):727-732.
141.Konttinen YT,Mandelin J,Li TF,et al.Acidic cysteine endoprotei- nase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis.Arthritis Rheum 2002,46:953-960.
142.Kevorkian L,Young DA,Darrah C,et al.Expression profiling of metallo-proteinases and their inhibiors in cartilage.Arthritis Rheum 2004,50:131-141.
143.Bau B,Gebhard PM,Haag J,et al.Relative messenger RNA expression profi- ling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro.Arthritis Rheum 2002,46:2648-2657.
144.Wu CW,Tchetina EV,Mwale F,et al.Proteolysis involving matrix metalloproteinase 13(collagenase-3)is required for chondrocyte differentiation that is associated with matrix mineralization.J Bone Miner Res 2002,17:639-651.
145.Tchetina EV,Squires G,Poole AR.Increased type Ⅱ collagen degradation and very early focal cartilage degegeration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.J Rheumatol 2005,32:876-886.
146.Martel-Pelletier J,Faure MP,McCollum R,et al.Plasminogen activators and inhibitor in human osteoarthritic cartilage.J Rheumatol 1991,18:1863-1871.
147.Baici A,Horler D,Lang A,et al.Cathepsin B in osteoarthritis:zonal variation of enzyme activity in human femoral head cartilage.Ann Rheum Dis 1995,54:281-288.
148.Mehraban F,Tindal MH,Proffitt MM,et al.Temporal pattern of cysteine endopeptidase(cathepsin B)expression in cartilage and synovium from rabbit knees with experimental osteoarthritis:gene expression in chondrocytes in response to interleukin-1 and matrix depletion.Ann Rheum Dis 1997,56:108-115.
149.Hollander AP,Healthfield TE,Webber C,et al.Increased damage to type Ⅱ collagen in osteoarthritic articular cartilage detected by a new immunoassay.J Clin Invest 1994,93:1722-1732.
150.Hollander AP,Pidoux Ⅰ,Reiner A,et al.Damage to type Ⅱ collagen in aging and osteoarthtitis starts at the articular surface,originates around chondrocytes,and extends into the cartilage with progressive degeneration.J Clin Invest 1995,96:2859-2869.
151.Squires GR,Okouneff S,Ionescu M,et al.The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes charcateristic of osteoarthritis.Arthritis Rheum 2003,48:1261-1270.
152.Poole AR.Biochemical/immunochemical biomarkers of osteoarthritis:utility for prediction of incident or progressive osteoarthritis.Rheum Dis Clin North Am 2003,29:803-818.
153.Price JS,Till SH,Bickerstaff DR,et al.Degradation of cartilage type Ⅱ collagen precedes the onset of osteoarthritis following anterior cruciate ligament rupture.Arthritis Rheum 1999,42:2390-2398.
154.Aigner T,Bertling W,Stoss H,et al.Independent expression of f ibrilfor-ming collagens Ⅰ、Ⅱ and Ⅲ in chondrocytes of human osteoarthritis cartilage.J Clin Invest 1993,91:829-837.
155.Matyas JR,Adams ME,Huang D,et al.Major role of collagen ⅡB in the elevation of type II procollagen messenger RNA in the hypertrophic phase of experimental osteoarthritis.Arthritis Rheum 1997,40:1046-1049.
156.Nelson F,Dahlberg L,Laverty S,et al.Evidence for altered synthesis of type II collagen in patients with osteoarthritis.J Clin Invest 1998,102:2115-2125.
157.Rizkalla G,Reiner A.Bogoch E,et al.Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis.Evidence for molecular heterogeneity and extensive molecular changes in disease.J Clin Invest 1992,90: 2268-2277.
158.Tortorella MD,Burn TC,Pratta MA,et al.Purification and cloning of aggrecanase-1:a member of the ADAMTS family of proteins.Science 1999,284:1664-1666.
159.Poole AR,Alini M.Hollander AP.Cellular biology of cartilage degradation.In:Henderson B.Edwards JCW,Pettipher ER,eds.Mechanisms and Models in Rheumatoid Arthritis.London:Academic Press,1995,pp 163-204.
160.Lark MW,Bayne EK,Flanagan J,et al.Aggrecan degradarion in human cartilage.Evidence for both matrix metalloproteinase and aggrecanase activity in normal,osteoarthritic,and rheumatoid joints.J Clin Invest 1997,100:93-106.
161.Glasson SS,Askew R,Sheppard B,et al.Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.Nature 2005,434:644-648.
162.Stanton H,Rogerson FM,East CJ,et al.ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.Nature 2005,434:648-652.
163.Gao G,Plaas A,Thomopson VP,et al.ADAMTS4(aggrecanase-1)activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositola-nchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.J Biol Chem 2004,279:10042-10051.
164.Hollander AP,Heathfied TF,Webber C,et al.Increased damage to type Ⅱcollagen in osteoarthritic cartilage detected by a new immunoassay.J Clin Invest 1998;93(4):1722-1732.
165.Krzeski P,Buckland-Wright C,Bá lint G,et al.Development of musculo-skeletal toxicity without clear benefit after administration of PG-116800,a matrix metalloproteinase inhibitor,to patients with knee osteoarthritis:a randomized,12-month,double-blind,placebo-controlled study.Arthritis Res Ther 2007;9(5):R109。
166.Diab M.The role of type IX collagen in osteoarthritis and rheumatoid arthritis.Orthop Rev 1998;222(2):165-170.
167.Kobayashi A,Naito S,Enomoto H,et al.Serum levels of matrix metalloproteinase 3(stromelysin 1) for monitoring synovitis in rheumatoid arthritis.Arch Pathol Lab Med 2007;131(4):563-570.
168.邓廉夫,柴本甫.正常关节软骨的胶原表型与骨关节炎关节软骨的表型异常.国外医学:创伤与外科基本问题分册,1996,17(3):152-155.
169.Homandberg GA,Meyers R,Xie DL.Fibronection fragments cause chondrolysis of bovine articular cartilage slices in culture.J Biol Chem 1992,267:3597-3604.
170.Yasuda T,Poole AR.A fibronectin fragment induces type Ⅱ collagen degradation by collagenase through an interleukin-1-mediated pathway.Arthritis Rheum 2002,46:138-148.
171.Yasuda T,Poole AR,Shimizu M,et al.Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparinbinding fragment of fibrone- ction in human articular cartilage in culture.Arthritis Rheum 2003,48:1271-1280.
172.Chevalier X,Claudepierre P,Groult N,et al.Presence of ED-A contaning fibronectin in human articular cartilage from patients with osteoarthritis and rheumatoid arthritis.J.Rheumatol 1996,23:1022-1030.
173.Arner EC,Tortorella MD.Signal transduction through chondrocyte integrin receptors induces matrix metallopfoteinase synthesis and synergizes with interleukin-1.Arthritis Rheum 1995,38:1304-1314.
174.孙廓,张键。细胞因子在骨关节炎中的作用研究进展。中国临床医学,2007,14(5):690-692.
175.Yasuda T,Tchetina E,Ohsawa K,et al.Peptides of type II collagen can induce the cleavage of type Ⅱ collagen and aggrecan in articular cartilage.Matrix Biol,In press,2006.
176.Fichter M,Korner U,Schomburg J,et al.Collagen degradation products modulate matrix metallopteinase expression in cultured articular chondrocytes.J Orthop Res 2006,24:63-70.
177.Martel-Pelletier J,McCollum R,DiBattista J,et al.The interleukin-1receptor in normal and osteoarthritis human articular chondrocytes.Identifica-tion as the type I receptor and anaysis of binding kinetics and biologic function.Arthritis Rheum 1992,35:530-540.
178.Webb GR,Westacott CJ,Elson CJ.Chondrocyte tumor necrosis factor recep-tors and focal loss of cartilage in osteoarthritis.Osteoarthritis Cartilage 1997,5:427-437.
179.Shlopov BV,Gumanovskaya ML,Hasty KA.Autocrine regulation of collagenase 3(matrix metalloproteinase 13) during osteoarthritis.Arthritis Rheum 2000,43:195-205.
180.Sandra K,Leo ABJ,Alison MB,et al.Different roles of tumour necrosis factor a and interleukin-1 in murine streptococcal cell wall arthritis.Cytokine,1998,10:690-702.
181.Murakami S,Lefebvre V,de Crombrugge B.Potent inhibition of the master chondrogenic factor Sox9 gene by inteleukin-1 and tumor necrosis factor-alpha.Biol Chem,2000,275(5):3687-3692.
182.王晶,肖德明。性激素与骨关节炎。中华骨科杂志,2001,21(1):50-52.
183.乔礼芬,刘晓晴。前列腺素2对人成骨样细胞白介素IL-6、骨保护素配体/骨保护素mRNA表达的影响。中国老年学杂志,2005,25:1468-1471.
184.Cawston TE,Curry VA,Summers CA,et al.The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint.Arthritis Rheum 1998,41:1760-1771.
185.Kobayashi M,Squires GR,Mousa A,et al.Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarth- ritic cartilage.Arthritis Rheum 2005,52:128-135.
186.Amin AR,Di Cesare PE,Vyas P,et al.The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes:evidence for up-regulated neuronal nitric oxide synthase.J Exp Med 1995,182:2097-2102.
187.Palmer RM,Hickery MS,Charles IG,et al.Induction of nitric oxide synthase in human chondrocytes.Biochem Biophys Res Commun 1993,193:398-405.
188.Attur MG,Dave MN,Stuchin S,et al.Osteopontin:an intrinsic inhibitor of inflammation in cartilage.Arthritis Rheum 2001,44:578-584.
189.Nakamura S,Kamihagj K,Satakeda H,et al.Enhancement of SPARC(osteonectin)synthesis in arthritic cartilage.Increased levels in synovial fluids from patients with rheumatoid arthritis and regulation by growth factors and cytokines in chondrocyte cultures.Arthritis Rheum 1996,39:539-551.
190.Melchiorri C,Meliconi R,Frizziero L,et al.Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocy- tes from patients with osteoarthritis.Arthritis Rheum 1998,41:2165-2174.
191.Taskiran D,Stefanovic-Racic M,Georgescu H,et al.Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1.Biochem Biophys Res Commun 1994,200:142-148.
192.Stefanovic-Racic M,Morales TI,Taskiran D,et al.The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures.J Immunol 1996,156:1213-1220.
193.Clements KM,Price JS,Chambers MG,et al.Gene deletion of either interleukin-lbeta,interleukin-lbeta-converting enzyme,inducible nitric oxide synthase,or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy.Arthritis Rheum 2003,48:3452-3463.
194.张辉,田学忠,梁茂华等。诱导型一氧化氮合酶在关节软骨缺血再灌注损伤及软骨细胞凋亡中的作用。中国临床康复,2006,10(5):102-104.
195.赵程,王成琪,王继芳等。肢体缺血再灌注后关节软骨细胞凋亡的规律。中国临床康复,2005,9(2):106-108.
196.Rowan AD,Young DA.Collagenase gene regulation by proinflammatory cytokines in cartilage.Front Biosci 2007;12:536-550.
197.Pelletier JP,Jovanovic DV,Lascau-Coman V,et al.Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoar- thritis in vivo:possible link with the reduction in chondrocyte apoptosis and caspase 3 level.Arthritis Rheum 2000,43:1290-1299.
198.孙炜,王吉兴,金大地等。软骨修复组织蛋白多糖代谢与一氧化氮合酶抑制剂的影响。中国组织工程研究与临床康复,2007,11(45):9063-9066.
199.Gulilak F,Fermor B,Keefe FJ,et al.The role of biomechanics and inflammation in cartilage injury and repair.Clin Orthop Relat Res 2004,17-26.
200.Fermor B,Weinberg JB,Pisetsky DS,et al.The influence of oxygen tension on the induction of nitric oxide and prostaglandin E_2 by mechanical stress in articular cartilage.Osteoarthritis Cartilage 2005,.13:935-941.
201.Fermor B,Weinberg JB,Pisetsky DS,et al.Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway.Osteoarthritis Cartilage 2002,10:792-798.
202.Dean DD,Martel-Pelletier J,Pelletier JP,et al.Evidence for mentallopro-teinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage.J Clin Invest 1989,84:678-685.
203.Yamada H,Nakagawa T,Stephens RW,et al.Proteinases and their inhibitors in normal and osteoarthritic articular cartilage.Biomed Res 1987,8:289-300.
204.Gendron C,Kashiwagi M,Hughes C,et al.TIMP-3 inhibits aggrecanasemediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors.FEBS Lett 2003,555:431-436.
205.Moulharat N,LesurC,Thomas M,et al.Effects of transforming growth factor-beta on aggrecanase production and proteoglycan degradation by human chondrocytes in vitro.Osteoarthritis Cartilage 2004,12:296-305.
206.Tchetina EV,Antoniou J,Tanzer M,et al.Transforming growth factor-beta2suppresses collagen cleavage in cultured human osteoarthritic cartilage,reduces expression of genes associated with chondrocyte hypertrophy and degradarion,and increases prostaglandin E(2) production.Am J Pathol 2006,168:131-140.
207.Ling H,Recklies AD.The Chitinase 3-1ike protein human cartilage glycopr-otein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1and tummour necrosis factor-alpha.Biochem J 2004,380:651-659.
208.Poole AR,Rosenberg LC,Reiner A,et al.Contents and distributions of the proteoglycans decor in and biglycan in normal and osreoarthritic human articular cartilage.J Orthop Res 1996,14:681-689.
209.Lefkoe TP,Nalin AM,Clark JM,et al.Gene expression of collagen types ⅡA and IX correlates wi th ultrastructural events in early osteoarthrosis:new applications of the rabbit meniscectomy model.J Rheumatol 1997,24:1155-1163.
210.Aigner T,Zhu T,Chansky,HH,et al.Reexpression of type ⅡA procollagen by adult articular chondrocytes in osteoarthritic cartilage.Arthritis Rheum 1999,42: 1443-1450.
211.Sandel1 LJ,Morris N,Robbins JR,et al.Alternatively spliced type Ⅱ procollagen mRNAs define distinct populations of cells during vertebral development:differential expression of the aminopropeptide.J Cell Biol 1991,114:1307—1319.
212.McDevitt CA,Pahl JA,Ayad S,et al.Expermental osteoarthritic articular cartilage is enriched in guanidine soluble type Ⅵ collagen.Biochem Biophys Res Commun 1988,157:250-255.
213.Ronziere MC,Ricard-Blum S,Tiollier J,et al.Commparative analysis of collagens solubilized from human foetal,and normal and osteoarthritic adult articular cartilage,wrth emphasis on type Ⅵ collagen.Bioclim Biophys Acta.1990,1038:222-230.
214.Hambach L,Neureiter D,Zeiler G,et al.Severe disturbance of the distribution and expression of type Ⅵ collagen chains in osteoarthritic articular cartilage.Arthritis Rheum 1998,41:986-996.
215.Soder S,Hambach L,Lissner R,et al.Ultrastructural localization of type Ⅵ collagen in normal adult and osteoarthritic human articular cartilage.Osteoarthritis Cartilage 2002,10:464-470.
216.Lee CM,Paul TA,Slabaugh M,et al.The pericellular matrix is enlarged in osteoarthritic cartilage.Trans Orthop Res Soc 1997,22:495.
217.Alexopoulos LG,Williams GM,Upton ML,et al.Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrixinarti-cular cartilage.J Biomech 2005,38:509-517.
218.Alexopoulos LG,Haider MA,Vail TP,et al.Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis.J Biomech Eng 2003,125:323-333.
219.Cs-Szabo G,Roughley,PJ,Plaas AH,et al.Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage.Arthritis Rheum 1995,38:660-668.
220.Cs-Szabo G,Melching LI,Roughley,et al.Changes in messenger RNA and pro-tein levels of proteoglycans and link protein in human osteoarthritic cartilage samples.Arthritis Rheum 1997,40:1037-1045.
221.Nishida Y,Shinomura T,Iwata H,et al.Abnormal occurrence of a large chondroitin sulfate proteoglycan,PG-M/versican in osteoarthritic cartilage.Osteoarthritis Cartilage 1994,2:43-49.
222.Schneiderman R,Rosenberg N,Hiss J,et al.Concentration and size distribution of insulin-like growth factor-1 in human normal and osteoarthritic synovial fluid and cartilage.Arch Biochem Biophys 324:1995,173-188.
223.Dore S,Pelletier JP,DiBattista JA,et al.Human osteoarthritic chondrocy-tes possess an increased number of insulin-like growth factor 1 binding sites but are unresponsive to its stimulation.Possible role of IGF-1-blinding proteins.Arthritis Rheum 1994,37:253-263.
224.田华,Carrie Fang,Paul E。骨形态发生蛋白-2对软骨寡聚基质蛋白在软骨细胞内表达的影响。北京大学学报(医学片反),2003,35(3):317.
225.Chen AL,Fang G,Liu C,et al.Expression of bone morphogeneric proteins,receptors,and tissue inhibitors in human fetal,adult,and osteoarthritic articular cartilage.J Orthop Res 2004,22:1188-1192.
226.Di Cesare PE,Carlson CS,Stolerman ES,et al.Increased degradation and altered tissue distribution of cartilage oligoneric matrix protein in human rheumatoid and osteoarthritic cartilage.J Orthop Res 1996,14:946-955.
227.Okimura A,Okada Y,Makihira S,et al.Enhancement of cartilage matrix protein synthesis in arthritic cartilage.Arthritis Rheum 1997,40:1029-1036.
228.Chevalier X,Groult N,Larget-Piet B,et al.Tenascin distribution in articular cartilage from normal subjects and from patients with osteoarthritis and rheumatoid arthritis.Arthritis Rheum 1994,37:1013-1022.
229.Recklies AD,White C,Ling H.The Chitinase 3-like protein human cartilage glycoprotein 39(HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase and protein kinase B-mediated signalling pathways.Biochem J 2002,365:119-126.
230.Marshall KW,Zhang H,Yager TD,et al.Blood-based biomarkers for detecting mild osteoarthritis in the human knee.Osteoarthritis Cartilage 2005,13:861-871.
231.van den Berg WB,van der Kraan PM,van Beuningen HM.Synovial mediators of cartilage damage and repair in OA.In:Brandt KD,Doherty M,Lohmander LS,eds.Osteoarthritis.Oxford:Oxford University Press,1998.
232.Goldring MB.Osteoarthritis and cartilage:the role of cytokines.Curr Rheumatol Rep 2000,2:459-465.
233.Morales T,I.The role of signaling factors in articular cartilage homeos-tasis and osteoarthritis.In:Osteoarthritic Disorders.Rosemont,IL:American Academy of Orthopaedic Surgeons,1995,pp 261-270.
234.Middleton JF,Tyler JA.Upregulation of insulin-like growth factor 1 gene expression in the lesions of osteoarthritic human articular cartilage.Ann Rheum Dis 1992,51:440-447.
235.Tyler JA.Insulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines.Biochem J 1989,260:543-548.
236.Trippel SB,Corvol MT,Dumontier ME,et al.Effect of somatomedin-C/ insulin- like growth factor 1 and growth hormone on cultured growth plate and articular chondrocytes.Pediatr Res 1989,25:76-82.
237.Im HJ,Pacione C,Chubinskaya S,et al.Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment and interleukin-1 stimulated matrix metalloproteinase-13 expression in human chondrocytes.Biol Chem,2003,278(28):25386-25394.
238.Sachs BL,Goldberg VM,Moskowitz RW,et al.Response of articular chondrocytes to pituitary fibroblast growth factor(FGF).J Cell Physiol 1982,112:51-59.
239.Kato Y,Gospodarowicz D.Sulfated proteoglycan synthesis by confluent cultures of rabbit costal chondrocytes grown in the presence of fibroblast growth factor.J Cell Biol 1985,100:477-485.
240.郑召民,董天华,刘纪思。骨性关节炎病人肿瘤坏死因子和白细胞介素-6的测定及意义。中国矫形外科杂志,1998,5(6):544-545.
241.Xiao YT,Xiang LX,Shao JZ.Bone morphogenetic protein.Biochem Biophys,Res Commun,2007;362(3):550-553.
242.Campbell IK,Wojta J,Novak U,et al.Cytokine modulation of plasminogen activator inhibitor-1(PAI-1)production by human articular cartilage and chondrocytes.Down-regulation by tumor necrosis factor alpha and up-regulation by transforming growth factor-B basic fibro- blast growth factor.Biochin Biophs Acta 1994,1226:277-285.
243.王卫国,娄思权,余华等。TGF-β2转染关节软骨细胞的实验研究。中华骨科杂志,2003,23(2):434.
244.von der Mark K,Kirsch T,Nerlich A,et al.Type Xcollagen synthesis in human osteoarthritic cartilage.Indication of chondrocytes hypertrophy.Arthri- tis Rheum 1992,35:806-811.
245.Hashimoto S,Ochs RL,Komiya S,et al.Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis.Arthritis Rheum 1998,41:1632-1638.
246.Blanco FJ,Guitian R,Vazquez-Martul E,et al.Osteoarthritis chondroeytes die by apoptosis.A possible pathway for osteoarthritis pathology.Arthritis Rheum 1998,41:284-289.
247.Sharif M,Whitehouse A,Sharman P,et al.Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3.Arthritis Rheum 2004,50:507-515.
248.Mollenhauer J,Mok MT,King KB,et al.Expression of anchorin C Ⅱ(cartilage annexin Ⅴ)in human young,normal adult,and osteoarthritic cartilage.J Histochem Cytochem 1999,47:209- 220.
249.邓廉夫,柴本甫,杨庆铭。肿瘤坏死因子α对骨关节炎滑膜细胞增殖和表达的影响。中国药理学通报,1998,14(6):506-508.
250.Wu W,Billinghurst RC^Pidoux I,et al.Sites of collagenase cleavage and denaturat'ion of type Ⅱ collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13.Arthritis Rheum 2002,46:2087-2094.
251.Shlopov RV,Lie WR,Mainardi CL,et al.Osteoarthritic lesions:involvement of three different collagenases.Arthritis Rheum 1997,40:2065-2074.
252.Reboul P,Pelletier JP,Tardif G,et al.The new collagenase,collagenase-3,is expressed and synthesized by human chondrocytes but not by synoviocytes.A role in osteoarthritis.J Clin Invest 1996,97:2011-2019.
253.Wang FL,Connor JR,Dodds RA,et al.Differential expression of egr-1 in osteoarthritic compared to normal adult human articular cartilage.Osteoarthri-tis Cartilage 2000,8:161-169.
254.Gordon GV,Villanueva T,Schumacher HR,et al.Autopsy study correlating degree of osteoarthritis,synovitis and evidence of articular calcification.J Rheumatol 1984,11:681-686.
255.Ali SY,Rees JA,Scotchford CA.Microcrystal deposition in cartilage and in osteoarthritis.Bone Miner 1992,17:115-118.
256.Swan A,Chapman B,Heap P,et al.Submicroscopic crystals in osteoarthritic synovial fluids.Ann Rheum Dis 1994,53:467-470.
257.Derfus B,Steinberg M,Mandel N,et al.Characterization of an additional articular cartilage vesicle fraction that generates calcium pyrophosphate dihydrate crystals in vitro.J Rheumatol 1995,22:1514-1519.
258.Hashimoto S,Ochs RL,Rosen F,et al.Chondrocyte-derived apoptotic bodies and calcification of articular cartilage.Proc Natl Acad Sci USA 1998,95:3094-3099.
259.Terkeltaub RA.What does cartilage calcification tell us about osteoarthritis?J Rheumatol 2002,29:411-415.
260.Johnson K,Terkeltaub R.Upregulated ank expression in osteoarthritis can promote both chondrocyte MMP-13 expression and calcification via chondrocyte extracellular Ppi excess.Osteoarthritis Cartilage 2004,12:321-335.
261.Hart DJ,Cronin C,Daniels M,et al.The relationship of bone density and fracture to incident and progessive radiographic osteoarthritis of the knee:the Chingford Study.Arthritis Rheum 2002,46:92-99.
262.Dieppe P,Cushnaghan J,Young P,et al.Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy.Ann Rheum Dis 1993,52:557-563.
263.Huebner JL,Hannes MA,Beekman B,et al.A compatative analysis of bone and cartilage metabolism in two strains of guineapig with varying degrees of naturally occutting osteoarthritis.Osteoarthritis Cartilage 2002,10:758-767.
264.Matsui H,Shimizu M,Tsuji H.Cartilage and subchondral bone interaction in osteoarthrosis of human knee joint:a histological and histomorphometric study.Microsc Res Tech 1997,37:333-342.
265.Burr DB,Schaffler MB.The involvement of subchondral mineralized tissues in osteoarthrosis:quantitative microscopic evidence.Microsc Res Tech 1997,37:343-357.
266.Watson PJ,Hall LD,Malcolm A,et al.Degenerative joint disease in the guinea pig.Use of magnetic resonance imaging to monitor progression of bone pathology.Arthritis Rheum 1996,39:1327-1337.
267.van Osch GJ,van der Kraan PM,van Valburg AA,et al.The relation between cartilage damage and osteophyte size in a murine model for osteoarthritis in the knee.Rheumatol Int 1996,16:115-119.
268.Garnero P.Mazieres B,Gueguen A,at al.Cross-sectional association of 10 molecular markers of bone,cartilage,and synovium with hip osteoarthritis:the ECHODIAH cohort.J Rheumatol 2005,32:697-703.
269.Behets C,Williams JM,Chappard D,et al.Effects of calcitonin on subchondral trabecular bone changes and on osteoarthritis cartilage lesions after acute acterior cruciate ligament defiviency.J Bone Miner Res 2004,19:1821—1826.
270.Hayami T.Pickarski M,Wesolowski GA,et al.The role of subchondral bone remodeling in osteoarthritis:reduction of cartilage degeneration and prevention of osteophyte formation by alensronate in the rat anterior cruciate ligament transection model.Arthritis Rheum 2004,50:1193-1206.
271.Smith MD,Triantaf illou S,Parker A,et al.Synovial membrane inflammation and cytokine production in patients with early osteoarthritis.J Rheumatol 1997,24:365-371.
272.Pelletier JP,Martel-Pelletier J.Abramson SB.Osteoarthritis,an inflammatory disease:potential implication for the selection of new therapeutic targets.Arthritis Rheum 2001,44:1237-1247.
273.Lindblad S,Hedfors E.Arthroscopic and immunohistologic characterization of knee joint synovitis in osteoarthritis.Arthritis Rheum 1987,30:1081-1088.
274.Ayral X,Pickering EH,Woodworth TG,et al.Synovitis:a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis—results of al year longitudinal arthroscopic study in 422 patients.Osteoar-thritis Cartilage 2005,13:361-367.
275．邓廉夫,柴本甫,杨庆铭。骨关节炎滑膜细胞分泌肿瘤坏死因子的生物学特征研究。中华骨科杂志,1999,19(12)：726-729．
276.Hedbom E,Hauselmann HJ.Molecular aspects of pathogenesis in osteoarthritis:the role of inflammation.Cell Mol Life Sci,2002,59(1):45-53.
277.Oliver JC,Bland LA,Oettinger CW,et al.Cytokine kinetics in an in vitro whole blood model following an endotoxin challenge.Lymphokine Cytokine Res,1993,12(2):115-120.
278.Martel-Pelletier J,Alaaeddine N,Pelletier JP.Cytokines and their role in the pathophysiology of osteoarthritis.Front Biosci 1999,4:D694703.
279.Alaaeddine N,Di Battisa JA,Pelletier JP,et al.Inhibition of humor necrosis factor alpha-induced prostaglandin E2 production by the antiinflamma-tory cytokines interleukin-4,interleukin-10,and inter-leukin-13 in osteoarthri-tic synovial fibroblasts:distinct targeting in the signaling pathways.Arthritis Rheum 1999,42:710-718.
280.Recklies AD,Baillargeon L,White C.Regulation of cartilage oligoneric matrix protein synthesis in human synovial cells and articular chondrocytes.Arthritis Rheum 1998,41:997-1.006.
281.Sharif M,Saxne T,Shepstone L,et al.Relationship between serum cartilage oligomeric matrix protein levels and disease progression in osteoarthritis of the knee joint.Br J Rheumatol 1995,34:306-310.
282.Petersson IF,Boegard T,Svensson B,et al.Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint.Br,Rheumatol 1998,37:46-50.
283.Conrozier T,Saxne T,Fan CS,et al.Serum concentrations of cartilage oligomeric matrix protein and bone sialoprotein in hip osteoarthritis:a one year prospective study.Ann Rheum Dis 1998,57:527-535.
284.Vilim V,Olejarova M,Machacek S,et al.Serum levels of cartilage oligom-ericl matrix protein(COMP)correlate with radiographic progression of knee osteoarthritis.Osteoarthritis Cartilage 2002,10:707-713.
285.Jordan KM,Syddall HE,Garnero P,et al.Urinary CTX-Ⅱ and glucosyl-galactosyl-pytidinoline are associated with the presence and severity of radiographic knee osteoarthritis in men.Ann Rheum Dis 2006,65:871—877.
286.Koch AE,Kunkel SL,Shah MR,et al.Macrophage inflammatory protein-1 beta:a C-C chemokine in osteoarthritis.Clin Immunol Immunopa-thol 1995,77:307-314.
287.Hsu YH,Hsieh MS,Liang YC,et al.Production of the chemokine eotaxin-1 in osteoarthritis and its role in cartilage degradarion.J Cell Biochem 2004,93:929-939.
288.Hashimoto H,Tanaka M,Suda T,et al.Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis.Arthritis Rheum 1998,41:657-662.
289.Torres L,Dunlop DD,Peterfy C,et al.The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis.Osteoar-thritis Cartilage 2006.
290.Garabedian BV,Lemaigre-Dubreuil Y,Mariani J.Central origin of IL-lbeta produced during peripheral inflammation:role of meninges.Brain Res Mol Brain Res 2000,75:259-263.
291.Dieppe PA,Lohmander LS.Pathogenesis and management of pain in osteoarthritis.Lancet 2005,365:965-973.
292.Woolf CJ,Chong MS.Preemptive analgesia:treating postoperative pain by preventing the establishment of central sensitization.Anesth Analg 1993,77:362-379.
293.Lotz M,Carson DA,Vaughan JH.Substance P activation of rheumatoid synoviocytes:neural in pathogenesis of arthritis.Science 1987,235:893-895.
294.Kimball ES.Substance P,cytokines,and arthritis.Ann N Y Acad Sci 1990,594:293-308.
295.Takeba T,Suzuki N,Kaneko A,et al.Evidence for neural regulation of inflammatory synovial cell functions by secreting calcitonin generelated peptide and vasoactive intestinal peptide in patients with rheu-matoid arthritis.Arthritis Rheum 1999,42:2418-2429.
296.Takeba Y,Suzuki N,Takeno M,et al.Modulation of synovial cell functions by somatostatin in patients with rheumatoid arthritis.Arthritis Rheum 1997,40:2128-2138.
297.Wang H,Yu M,Ochani M,et al.Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammtion.Nature 2003,421:384-388.
298.Kondo H,Nifuji A,Takeda S,et al.Unloading induces osteoblastic cell suppression osteoclastic cell activation to lead to bone loss via sympathetic nervous system.J Biol Chem 2005,280:30192-30200.
299.Elef teriou F,Ann JD,Takeda S,et al.Leptin regulation of bone resorption by the sympathetic nervous system and CART.Nature 2005,434:514-520.
300.Persson E,Lerner UH.The neuropeptide VIP potentiates IL-6 production induced by proinflammatory osteotropic cytokines in calvarial osteoblasts and the osteoblastic cell line MC3T3-E1.Biochem Biophys Res Commum 2005,335:705-711.
301.Matayoshi T,Goto T,Fukuhara E,et al.Neuropeptide substance P stimulates the formation of osteoclasts via synovial fibroblastic cells.Biochem Biophys Res Commun 2005,327:756-764.
302.Elvenes J,Andjelkov N,Figenschau Y,et al.Expression of functional mu-opioid receptors in human osteoarthritic cartilage and chondrocytes.Biochem Biophys Res Commun 2003,311:202-207.
303.Andjelkow N,Elvenes J,Martin J,et al.Opiate regulation of IL-lbeta and TNF-alpha in cultured human articular chondrocytes.Biochem Biophys Res Commun 2005,333:1295-1299.
304.Fieisch H,Russell RGG,Straumann F.Effect of pyrophosphate on hydroxyapa-tite and its complications in calcium homeostasis.Nature,1966,212:901-903.
305.赵文国,张柳,梁春雨等。降钙素对膝前交叉韧带切断大鼠股骨远段骨组织结构的影响。山东医药,2008,48(6):9-11.
306.刘志翔,张柳,张楠。降钙素对兔骨关节炎软骨基质金属蛋白酶1的影响。中国矫形外科杂志,2006,14(22):1741-1743.
307.陆圣君,杨述华。降钙素对大鼠骨关节炎关节软骨和软骨下骨的影响。中国骨质疏松杂志,2008,14(3):182-186.
308.Roland W,Roy D.Mare C,Joseph A,Victor M.骨关节炎诊断与治疗。第4版。谢利民主译。北京:人民卫生出版社,2008.47-50.
309.Burr DB,Radin EL.Microfractures and mircocracks in subchondral bone:are they relevant to osteoarthrosis?Rheum Dis Clin North Am 2003,29:675-685.
310.Rosai J.Bone and joints In Rosai I ed.Ackeman' s surgical pathology.9~(th) ed Philadelphia:Mosby,2004,2137-2208.
311.Neuman P,Hulth A,Linden B,et al.The role of osteophytic growth in hip osteoarthritis.Int Orthop 27:262-266,2003.
312.Hameman D.The biology of osteoarthritis N Engl J Med,1989,320:1322-1330.
313.Sokoloff L.Pathology and pathogenesis of osteoarthritis.In McCarty DJ.Arthritis and applied conditions 9th ed.Philadelphia:lea & Febiger,1979,1135-1153.
314.Goldenberg DL,Egan MS,Cohen AS,Inflammatory synovitis in degenerative joint disease.J Rheumatol 1982,9:204-209.
315.Dijkgraaf LC,Liem RS,de Bont LG.Ultrastructural characterstics of the synovial membrane in osteoarthritic temporomandibular joints.J Oral Maxillofac Surg 1997,55:1269-1279.
316.Resnik D,Vint V.The "tunnel" view in assessment of cartilage loss in osteoarthritis of the knee.Radiology 1980,137:547-548.
317.Roland W,Roy D,Mare C,Joseph A,Victor M.骨关节炎诊断与治疗。第4版。谢利民主译。北京:人民卫生出版社,2008.331.
318.李焯洪,MRI在膝关节退行性骨关节病诊断中的价值。临床和实验医学杂志,2008,7(4).127-128.
319.王运昌,张米荣。高频超声对膝骨性关节炎的诊断价值。中医正骨,2007,19(5).
320.Passariello R,Trecco F,De Paulis F,et al.Computed tomography of the knee joint:clinical results.J Comput Assist Tomogr 1983,7(6):1043-1049.
321.Dye S,Chew M.The use of scintigraphy to detect increased osseous meta- bolic activity about the knee.J Bone Joint Surg Am 1993,75:1388-1406.
322.Wolfe F.The C-reactive protein but not erythrocyte sedimentation rate is associated with clinical severity in patients with osteoarthritis of the knee or hip.J Rheumatol 1997,24:1486-1488.
323.Schouten JS,Van den Ouweland FA,Valkenburg HA,et al.Insulin-like growth factor-l:a prognostic factor of knee osteoarthritis.Br Rheumatol 1993,32:274-280.
324.Sharif M,Kirwan JR,Elson CJ,et al.Suggestion of nonliner or phasic progression of knee osteoarthritis based on measurements of serum cartilage oligomeric matrix protein levels over five years.Arthritis Rheum 2004,50:2479-2488.
325.Elliott AL,Kraus VB,Luta G,et al.Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project.Arthritis Rheum 2005,52:105-111.
326.Petersson IF,Sandqvist L,Svensson B,et al.Cartilage markers in synovial fluid in symptomatic knee osteoarthritis.Ann Rheum Dis 1997,56:64-67.
327.Hasegawa M,Hirata H,Sudo A,et al.Tenascin-C concentration in synovial fluid correlates with radiographic progression of knee osteoarthriris.J Rheumatol 2004,31:2021-2026.
328.Fuchs S,Rolauffs B,Arndt S,et al.CD44H and the isoforms CD44v6 and CD44v6in the synovial fluid of osteoarthritic human knee joint.Osteoarthritis Cartilage 2003,11:839-844.
329.Saito S,Kondo S,Mishima S,et al.Analysis of cartilage-derived retinoic-acid-sensitive protein(CD-RAP) in synovial fluid from patients with osteoarthritis and rheumatoid arthritis.J Bone Joint Surg Br 2002,84:1066-1069.
330.彭成忠,曹建民,肖涛等。骨关节炎关节滑液中IL-18与PGE_2含量的测定及意义。中南大学学报(医学版),2006,31(6):862-865.
331:中华医学会骨科分会。骨关节炎诊治指南(2007版)。中华骨科杂志,2007,27(10):793-796.
332.施桂英。关节炎概要。第1版。北京:中国医药科技出版社,2000,327-340.
333.倪家骧,樊碧发,薛富善。临床疼痛治疗技术。北京:科学技术文献出版社,2003:170。
334.周迎光,夏建龙。膝关节骨性关节炎的治疗进展。辽宁中医药大学学报,2006,8(6):156.
335.徐桂莲。膝关节骨性关节炎的治疗进展。贵州医药,2006,30(12):1142-1143.
336.张英泽,冯和林,李增炎.膝关节周围骨折术后综合康复训练的临床疗效.中国康复医学杂志,2006,21(2):154-155.
337.杨丹丹,徐琳峰,陈丽娜。以运动疗法为主治疗膝关节骨关节炎的疗效观察。中国康复医学杂志,2008,23(5):428-430.
338.杜杰,张福金。膝关节骨性关节炎治疗进展。临床军医杂志,2008,36(2):301-304.
339.Phan T,Maillefert JF,Hudry C,et al.Laterally elevated wedged insoles in the treatment of medial knee osteoarthritis:a two-year prospective randomized controlled study.Osteoarthritis Cartilage 2004,12:46-55.
340.Chan AT,Manson JE,Albert CM,et al.Nonsteroidal antiliflammatory drugs,acetaminophen and the risk of cardiovascular events.Circula- tion 2006,113:1578-1587.
341.Roland W,Roy D,Mare C,Joseph A,Victor M.骨关节炎诊断与治疗。第4版。谢利民主译。北京:人民卫生出版社,2008.223-233.
342.Ghosh S,Paul S,Das N,et al.A study on the effects of diclofenac sodium and etoricoxib in the treatment of osteoarthritis.J Indian Med Assoc,2007,105(5):260.
343.Roland W,Roy D,Mare C,Joseph A,Victor M.骨关节炎诊断与治疗。第4版。谢利民主译。北京:人民卫生出版社,2008.233.
344.Turajane T,Tanavaree A,Labpiboonpong V,et al.Outcomes of intraarticular injection of sodium hyaluronate for the treatment of osteoarthritis of the knee.J Med Assoc Thai,2007,90(9):1845-52.
345.饶余波,王元利,闫志刚等。透明质酸钠对膝关节炎患者生存质量的影响(附220例报告)。北京医学,2007,29(11):675-677.
346.陈磊,凌沛学,张天民。硫酸软骨素在骨关节炎防治中的作用。中国生化药物杂志,2008,29(2):137-139.
347.王虹蕾。硫酸氨基葡萄糖治疗骨关节炎。医药论坛杂志,2006,27(8):46-47.
348.江相保,高李侠。盐酸氨基葡萄糖治疗膝退行性骨性关节炎的临床观察。中国修复重建外科杂志,2008,22(1):29-31.
349.施宇翔,熊利泽,董海龙等。玻璃酸钠与得宝松关节腔内注射治疗膝骨关节炎的临床应用观察。中国综合临床,2007,23(6):551-552.
350.黄乔东,何雁冰,陈金生等。生长抑素关节腔内注射治疗膝关节骨性关节炎的疗效观察[J]。广东医学,2006,27(1):8-9.
351.王君,何炳书,李笑萍。四环素对骨关节炎模型的作用观察。山东医药,2008,48(3):33-34.
352.沈彦,袁建迪,朱少兵。膝骨关节炎治疗进展。光明中医,2008,23(5):700-702.
353.陈述祥。关节镜下清理术治疗骨性关节炎。中国内镜杂志,2003,9(12):156.
354.郭磊,白希壮,张世亮等。关节镜下关节灌洗清理术对老年性膝关节骨关节炎的疗效分析。中国医科大学学报,2007,36(5):584-586.
355.王卫国,岳德波,郭万首等。关节镜清理术治疗Kellgren-LawrenceⅢ级以上膝关节骨关节炎。中国内镜杂志,2008,14(2):185-187,190.
356.Day B.The indications for arthroscopic debridement for osteoarthritis of the knee.Orthop Clin North Am,2005,36(4):413-417.
357.Arnoldi CC,Lemperg K,Linderholm H.Intraosseous hypertension and pain in the knee.J Bone Joint Surg(Br),1975,57(3):360-363.
358.Phillips Rs.Phlebographies in osteoarthritis of the hip.J Bone Joint Surg,1996,482B:280.
359.陈学明,卢森桂,唐焕章。钻孔减压治疗早期退行性膝关节炎。中国矫形外科杂志,2000,7(2):115-116.
360.朱建军,刘自建,宗兆凯。钻孔减压后冲洗治疗膝关节骨性关节炎62例报告。山东医药,2001,41(2):49.
361.Bae DK,Yoon KH,Song SJ.Cartilage healing after micro fracture in osteoarthritic knees.Arthroscopy,2006,.22(4):367-374.
362.Kreuz PC,Erggelet C,Steinwachs MR,et al.Is microfracture of chondral defects in the knee associated with different results in patients aged 40 years or younger.Arthroscopy,2006,22(11):1180-1186.
363.Miller BS,Steadman,Briggs KK,et al.Patient satisfaction and outcome after microfracture of the degenerative knee.J Knee Surg,2004,17(1):13-17.
364.李海鹏,刘玉杰,王志刚。关节镜下微骨折术治疗膝关节软骨损伤。中国矫形外科杂志,2007,15(10):731-733.
365.王彦明,余家阔,于长隆等。关节镜下微骨折术修复膝关节软骨全层缺损的临床疗效观察。中国运动医学杂志,2006,25(6):651-654,724.
366.Miller BS,Steadman,Briggs KK,et al.Patient satisfaction and outcome after microfracture of the degenerative knee.J Knee Surg,2004,17(1):13-17.
367.Steadman,Rodkey WG,Briggs KK.Microfracture to treat fullthickness chondral defects:surgical technique,rehabilitation,and outcomes.J Knee Surg,2002,15(3):170-176.
368.陈意磊,程飚。膝骨关节炎的关节镜治疗进展。复旦学报(医学版),2008,35(1):148-151,160.
369.Peterson L,Minas T,BrittbergM,et al.Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation:results at twp to ten years.J Bone Joint Sutg Am 2003;85-A Suppl 2:17-24.
370.刘尚礼,李卫平,宋卫东。软骨细胞移植治疗关节软骨缺损。广州医药,2000,31:1-4.
371.Marlovits S,Striessnig G,Kutscha-Lissberg F,et al.Early postoperative adherence of matrix-induced autologous chondrocyte implantation for the treatment of full-thickness cartilage defects of the femoral condyle.Knee Surg Sports Traumatol Arthrosa 2005;13(6):451-457.
372.杨造成,张仲文,侯世科等。移植基质诱导的自体软骨细胞修复关节软骨缺损临床研究。武警医学,2007,18(4).249-253.
373.Bartlett W,Skinner JA,Gooding CR,et al.Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee:a prospective,randomised study.J Bone Joint Surg Br 2005,879(5):640-645.
374.Hangody L,Kish G,Karpati Z,et al.Arthroscopic autogenous osteochondral mosaicplasty for the treatment of femoral condylararticular defects.A prelinary report.Knee Surg Sports Traumatol Arthrosc 1997,5(4),262-267.
375.Barber FA,Chow JC.Arthroscopic osteochondral transplantation:histolo- gic results.Arthroscopy 2001,17(8):832-835.
376.徐东潭,臧洪敏,徐光辉。自体骨软骨移植修复股骨髁关节软骨缺损:应用关节镜治疗的可行性。中国组织工程研究与临床康复,2007,11(47):9532-9534.
377.钟建明,王丹,杨文龙等。关节镜下自体镶嵌式骨软骨移植治疗膝关节软骨缺损。浙江临床医学,2008,1(3):299-300.
378.SHASHA N,KRYWULAK S,BACKSTEIN D,et al.Long-term follow-up of fresh tibial osteochondral allografts for failed tibial plateau fractures.J Bone Joint Surg Am,2003,85(Suppl2):33-39.
379.王洪,周游,李宝兴等。冷冻同种异体骨软骨移植修复大面积关节软骨缺损的可行性研究。华中科技大学学报(医学版),2007,36(4):485-488.
380.余家阔,于长隆,敖英芳。关节镜辅助下的同种异体半月板移植(附4例术后20个月以上随访报告)。中国运动医学杂志,2007,26(3):261-265.
381于至悌,张雪华,张书永等。自体软骨膜、骨膜游离移植修复软骨缺损治疗骨性关节炎[J]。临床骨科杂志,1998,1(1):13-16.
382.吕厚山。髋、膝关节骨性关节炎的研究现状和进展。实用老年医学,2001,15(5):229-233.
383.曹立峰,裴宪武,李延明等。改良胫骨高位截骨术治疗膝骨性关节炎32例报告。北京医学,2008,30(3):187-188.
384.张功林,章鸣,蔡国荣等。胫骨高位截骨治疗膝关节骨性关节炎。中国骨伤,2008,21(3):211-212.
385.武东升,李玉民,刘铁战等。胫骨高位球形截骨术治疗膝骨关节炎。实用骨科杂志,2008,14(5):305-306.
386.Finkelstein A,Gross A,Davis A.Varus osteotomy of the distal part of the femur:a survivorship analysis.J Bone Joint Surg Am 78:1348-1352,1996.
387.韩一生。慢性关节炎的外科治疗。中国临床康复,2002,6(5):629.
388.于德刚,董纪元,王岩。人工膝关节单髁置换术36例临床应用特点:1年随访影像学及膝关节功能评估。中国组织工程研究与临床康复,11(51):10246-10250.
389.Berger RA,Meneghini RM,Jacobs JJ,et al.Results of unicompartmental knee arthroplasty at a minimum of ten years of followup.J Bone Joint Surg AM 2005,87(5):999-1006.
390.陈云苏,Andrew A Freiber。膝关节单髁置换术23例分析。中国临床医学,2004,11(5):787-788.
391.黄霄汉,于海峰。膝关节表面置换术治疗膝关节骨关节炎31例近期疗效观察。中国矫形外科杂志,2008,16(7):548-550.
392.王英振,王湘达,吕成昱等。人工全膝关节置换术治疗膝关节骨关节炎。中国矫形外科杂志,2006,14(23).1784-1786.
393.Hass SB,Cook S,Beksac B.Minimally invasive total knee replacement through a minimidvastus a pproach:a comparative study.Clinorthop Relat Res,2004,(428):68-73.
394.Laskin RS,Beksac.B,Phong junakom A,et al.Minimally invasive total knee replacement through a mini-midvastus incision:an out-come study.Clin Orthop Relat Res,2004,(428):74-81.
395.何森,曹文,李刚等。QS微创全膝关节置换术的早期疗效观察。第三军医大学学报。2007,29(23):2283-2285.
396.Wakitani S,Imoto K,Yamamoto T,et al.Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees.Osteoarthritis Cartilage,2002,10(3):199-206.
397.林智军,王万明,刘航涛。组织工程化关节软骨的研究进展。实用医学杂志,2007,23(19):2963-2965.
398.赵钟岳,李世民,娄思权,等。关节外科学[M]。天津:天津科学技术出版社,2002:1283-1284.
399.高益民。膝关节骨关节炎Ⅱ期临床试验方案。中药新药与临床药理,1998,9(1):16.
400.李平,韩明向,孔秀媞。肾虚络阻是骨关节炎的病机特点。中医药临床杂志,2006,18(1):89.
401.贺宪,魏春山,蔡智刚。膝骨性关节炎的病机和防治机制探讨。山东中医杂志,2005,24(2):73.
402.徐传毅,樊粤光,宁显明。肾虚血瘀与膝骨性关节炎关系初探。新中医,2002,34(3):7.
403.陈龙全,郝双阶。方竹节参片配合穴位注射治疗膝骨性关节炎82例。陕西中医,2004,25(8):716.
404.章建华,童培建,陈俊杰等。膝关节骨性关节炎的综合治疗。中医正骨,2005,17(7):25-26.
405.胡敏,杨军平,邱丽瑛。中药调节兔膝骨关节软骨代谢作用的研究。北京中医药大学学报。2006,29(12):830-832.
406.陈述祥,司徒坚,杨运东等。自制复方中药对膝骨性关节炎家兔血液流变及病理形态的影响。中国临床康复,2005,9(30):147-149.
407.石关桐,韩大鹏,郑昱新等。补肾和柔肝中药对C57黑鼠膝骨关节炎滑膜中COMP 基因表达的影响。上海中医药大学学报,2007,21(3):55-58.
408.汪青春,沈培芝,徐宇,等。不同方药治疗膝骨关节炎的组织形态学对比研究。中国中医骨伤科杂志,1998,6(2):1-3.
409.冯伟,石印玉,沈培芝,等.中药对软骨细胞代谢的影响.中国中医骨伤科杂志,2000,8(2):9-11.
410.祁传才,于宝云,王伟卓。附桂骨痛胶囊对膝关节骨性关节炎NO及iNOS影响的实 验研究。陕西中医学院学报,2007,30(4):65-67.
411.韩大鹏,郑昱新,石关桐。化痰中药对C57黑鼠膝骨关节炎滑膜中COMP表达的影响。中国中医骨伤科杂志,2007,15(8):9-12.
412.毕荣修,殷惠芬,王式鲁。关节止痛胶囊对兔膝骨性关节炎模型血清和关节液中自由基水平的影响。中医正骨,2004,16(11):3-4.
413.熊鹏程,寿折星,熊昌源。伤科薰洗方对实验性兔膝骨性关节炎软骨组织形态学的影响。中国中医骨伤科杂志,2008,16(5):19-21.
414.郭颖杰。鹿茸多肽对骨、软骨细胞增殖的实验研究。中国生化药物杂志,1998,19(2):74-75.
415.王文瑞,刘宏泽,卫小春等。川芎嗪防治膝关节软骨退变的实验研究。中国骨伤,2004,17(2):80-82.
416.郑召民,许振华。骨内高压与活血化瘀。中国中医骨伤科,1994,2(3):43-47.
417.周尊谦,谢林,孙达武。丹柴康膝冲剂治疗膝关节退行性骨关节病的临床研究。中国骨伤,1999,12(2):49-50.
418.吴驶,高翔,王拥军等。益气化瘀利水方对骨关节炎兔前列腺素代谢的影响。老年医学与保健,2004,10(1):24-26.
419.童敏,王静,向大雄等。骨康合剂对兔实验性膝骨关节炎血液流变性的影响。中南药学,2007,5(3):227-230.
420.李巍,吴国志,陈德喜等。熏蒸一、二号方治疗膝骨性关节炎的药效学研究。中医外治杂志,2007,16(2):5-7.
421.黄涛,徐传毅,邹季等。活血止痛汤治疗早期骨性关节炎的实验研究[J]。中医正骨,1999,11(5):3-5.
422.毛小兵,邹季。风湿骨痛药酒药槌外治法防治关节软骨退变的实验研究[J]。中医骨伤,2002,15(4):220-221.
423.徐卫东,侯铁胜,张春才等。FGF对关节软骨细胞基质及其TGF-β1表达的作用[J]。第二军医大学学报,1999,20(10):773-774.
424.王本祥。现代中药药理与临床。天津:天津科技翻译出版公司,2004:322-325.
425.李珍娟,黄红英。羌活的药理作用及临床新用概述。实用中医药杂志,2004,20(2):108-109.
426.于慧敏,聂英坤,王璟璐。白芍总苷对膝骨性关节炎患者血清一氧化氮和白细胞介素-1β水平的影响。2007,41(5):455-456,459.
427.宁显明,樊粤光,徐传毅。补肾中药对膝骨关节炎软骨TGF-β1表达的影响。中国中医骨伤科杂志,2004,12(1):36-38.
428.唐勇,姜杰,孟辉等。补肾益气活血方含药血清对兔软骨细胞增殖和bFGF-mRNA表达的影响。时珍国医国药,2006,17(5):686-687.
429.张炳冉。补肾壮筋汤对膝骨关节炎患者血清肿瘤坏死因子-α与白细胞介素-6水平的影响。中草药,2006,37(9):1389-1390.
430.安莉萍,卫荣,魏晓丽等。益肾通痹方对膝关节骨性关节炎兔血清和膝关节腔液 中炎性细胞因子和一氧化氮含量的影响。中国临床康复,2006,10(15):79-81.
431.卢思俭,邵璟,梁梅荣。益肾方对兔膝骨关节炎模型关节滑液中TNF-α、IL-1β水平的影响。浙江中医杂志,2006,41(5):292-293.
432.汪青春,石印玉,沈培芝等。中药对膝骨关节炎小鼠关节软骨IL-1、iNOS基因表达的影响。山西医药杂志,1999,28(5):381-383.
433.苏友新,陈顺有,林清坚等。壮骨健膝方对膝骨性关节炎患者关节滑液细胞因子、NO的影响。福建中医学院学报,2006,16(2):38-40.
434.高翔,吴驶,王拥军等。益气化瘀利水方干预兔膝骨关节炎软骨中胰岛素样生长因子1的变化。中国临床康复,2006,10(39):95-97.
435.吴弢,高翔,王拥军等。益气化瘀利水方干预后兔膝骨关节炎软骨中转化生长因子β1的变化。中国临床康复,2006,10(3):118-119.
436.孟祥奇,惠礽华,姜宏等。化痰祛湿剂对兔膝骨性关节炎细胞因子IL-1、IL-6、TNF-α的影响。中国骨伤,2007,20(8):575-576.
437.刘英杰,马利杰,王相利。独活寄生汤对兔膝骨性关节炎关节液白细胞介素-1和肿瘤坏死因子的影响。河北中医,2007,29(8):748-750.
438.钟玉,李荣亨,周小莉等。复元胶囊对实验性兔骨关节炎白介素1及转化生长因子β2的调节作用。重庆医科大学学报,2007,32(8):856-861.
439.郭礼跃,胡慧华,米健国。古方豨莶丸对膝骨性关节炎模型家兔关节液中IL-1β、TNF-α含量及关节软骨细胞形态学的影响。中国骨伤,2006,19(6):377-378.
440.陈朝蔚,陈永强。阳和汤干预兔骨关节炎软骨细胞中血管内皮生长因子变化。中西医结合学报,2008,6(4):372-375.
441.陈朝蔚,陈永强。阳和汤治疗兔膝骨性关节炎的作用机制。中医正骨,2008,20(4):11-12.
442.杨惠琴,陈礼荣。青藤碱注射液对兔膝骨性关节炎关节液及血清IL-6水平的影响。中医药导报,2007,13(10):62-63.
443.曲俊才。膝骨关节炎模型兔关节液中细胞因子白细胞介素1水平及复方归芪液的干预效应。中国组织工程研究与临床康复,2008,12(20):3845-3848.
444.廖八根,徐勇,高鹏吉。中医外治法干预运动创伤性膝关节炎模型兔膝关节滑膜中碱性成纤维细胞生长因子的表达。中国组织工程研究与临床康复,2008,12(11):2047-2050.
445.郑曙光,陈波,马四补等。艾灸治疗对兔膝关节骨性关节炎调节作用的实验研究。北京中医药大学学报,2008,31(5):358-360.
446.田丰玮,宋军,杨金蓉。艾叶油乳膏剂对兔膝骨性关节炎关节冲洗液中细胞因子含量的影响。中医正骨,2005,17(12):15-16.
447.包飞,王道海,王凤琴等。电针对实验性膝骨关节炎大鼠软骨转化生长因子β1表达的影响。中国康复理论与实践,2008,14(4):345-346.
448.黄剑,卓廉士,王永渝等。电针对膝骨关节炎家兔关节液中自由基的影响。针刺研究,2007,4(32):115-118.
449.吴洪,徐华洲,韦哲。十一方酒对兔膝骨性关节炎TGF-β1以及病理形态学的影响。 中国医药导报,2007,4(20):134-135.
450.俞杰,明顺培,张秀芬。针刀疗法对兔膝骨关节炎关节液中IL-1β、IL-6和TNF-α水平的影响。中国中医骨伤科杂志,2002,10(4):15-18.
451.关建军,张智慧,姬军风等。地黄膝龙颗粒对家兔骨性关节炎的实验研究。陕西中医,2007,28(7):922-923.
452.姬军风,关建军,张智慧等。地黄膝龙颗粒治疗兔实验性膝骨关节炎的实验研究。辽宁中医杂志,2008,35(2):296-298.
453.关建军,张智慧,姬军风等。地黄膝龙颗粒对家兔骨性关节炎的实验研究。陕西中医,2007,28(7):922-923.
454.刘春芳,林娜,陈卫衡等。骨痹散防治小鼠膝骨关节炎的实验研究。中国实验方剂学杂志,2008,14(1):55-58.
455.周尊谦,谢林,孙达武。丹柴康膝冲剂治疗膝关节退行性骨关节病的临床研究。中国骨伤,1999,12(2):49-50.
456.任芳,邹季。丹紫康膝冲剂对家兔实验性膝骨关节炎氧自由基代谢的影响。中国中医骨伤科杂志,2008,16(3):39-41.
457.周达岸,蔡玉文。骨痹消对兔实验性膝关节骨性关节炎氧自由基代谢的影响。数理医药学杂志,2008,21(2):179-180.
458.孟祥奇,惠礽华,姜宏等。化痰祛湿剂对兔膝骨性关节炎血清中SOD、NO的影响。中医药学报,2007,35(2):21-23.
459.程传国,龚权,程龙等。肌松Ⅱ号胶囊对实验性骨关节炎氧自由基代谢的影响。颈腰痛杂志,2005,26(1):19-21.
460.姚啸生,李洪久,宋雅梅等。加味补肾壮筋汤对膝骨关节炎氧自由基代谢的影响。中医正骨,2005,17(9):5-6.
461.任芳,李勇光。雪莲注射液对兔膝关节骨性关节炎模型动物血清NO和滑膜组织SOD、MDA的影响。中国中医骨伤科杂志,2008,16(5):22-24.
462.马建兵,刘德玉,李堪印等。中药对家兔实验性膝关节骨性关节炎氧自由基代谢的影响。中医正骨,2000,12(1):8-9.
463.Nakazawa T,Xui N,Hesong Z,et al.Danshen inhibits oxysterol-induced endothelial cell apoptosis in vivo.J Atheroscler Thromb,2005,12(3):132.
464.戴七一,刘靖,王大伟。手法对兔膝骨性关节炎软骨细胞DNA氧化性损伤的防治作用。中医正骨,2006,18(3):6-7.
465.黄剑,卓廉士,王永渝等。电针对膝骨关节炎家兔关节液中自由基的影响。针刺研究,2008,33(2):116-119.
466.韩崑,熊昌源。“三联疗法”对兔膝关节骨关节炎氧自由基代谢的影响。湖北中医杂志,2006,28(3):9-10.
467.张劫,张闻生,邹季。风湿骨痛药酒药槌外治法治疗兔膝关节骨关节炎的实验研究。中医正骨,2001,13(7):9-10.
468.唐勇,姜杰,孟辉等。补肾益气活血方对兔软骨细胞凋亡和bcl-2mRNA表达的影响。 中国中医基础医学杂志,2006,12(3):174-175.
469.唐勇,姜杰,孟辉等。骨炎定对兔实验性膝骨关节炎关节软骨细胞中bcl-2mRNA表达的影响。山东中医杂志,2004,23(3):169-171.
470.Kim HA,Lee YJ,Seong SC,et al.Apoptotic chondrocyte death in human osteoarthritis[J].J Rheumatol,2000,27(2):455.
471.Pan H,Li X F.Bian H G.Effect of Bu Shen Zhuang Jin Tang Decoctioin on chondrocyte apoptosis and NO of experimental osteoarthritis.Chin J Surg Integrat Tradit Chin West Med,2005,11(3):238-242.
472.赵瑜,陈华燕,刘日光。补肾康膝方对家兔软骨细胞增殖与凋亡的影响。时珍国医国药,2008,19(5):1133-1134.
473.赵瑜,冯齐凤,朱祝生。中药补肾方对体外培养软骨细胞影响。时珍国医国药,2008,19(4):960-961.
474.饶咏梅,杜建时,赵晴等。白芍总苷对骨关节炎血清及关节液中一氧化氮及诱生型一氧化氮合酶的影响。中国实验诊断学,2006,10(12):1444-1445.
475.潘浩,胡庆丰,李雄峰等。补肾壮筋汤对兔早期实验性膝骨关节炎软骨细胞凋亡及增殖细胞核抗原表达的影响。中国骨伤,2005,18(5):278-281.
476.卢思俭,姜全心,王成。益肾为主对兔膝骨关节炎模型软骨细胞凋亡的影响。山东中医杂志,2006,25(10):696-698.
477.国家中医药管理局5中华本草6编委会.中华本草.上海:上海科学技术出版社,1999:6191-6194.
478.沈霖,沈耀,杨述华。丹参注射液对维甲酸诱导的软骨细胞凋亡的影响。中国中医骨伤科杂志,2002,10(5):1-8.
479.杨腊芝,张琴,张红星。丹参酮对人软骨细胞增殖及其抗氧化作用的影响。中国康复,2008,23(2):83-84.
480.龚权,程传国。肌松Ⅱ号胶囊对兔膝骨性关节炎软骨细胞凋亡的影响。颈腰痛杂志,2007,28(2):101-103.
481.谭杨,陈廖斌,汪晖等。黄芪多糖对体外培养大鼠软骨细胞内糖胺多糖合成的影响及其机制。武汉大学学报(医学版),2008,29(2):153-156.
482.梁伯进,唐兴荣。丹芪注射液关节腔注射改善创伤后关节退行性病变的实验研究。中国临床康复,2004,8(11):2088-2090.
483.李正华,詹奇,梁笃。补骨方治疗膝骨性关节炎的疗效观察。现代医院,2004,4(11):32-33.
484.孟庆莉,赵生文。补肾祛瘀法治疗骨关节炎139例。河南中医,2002,22(5):51.
485.吴永昕,肖泓,吴生元.补中桂枝汤治疗退行性骨关节病83例.四川中医,2002,20(2):63-64
486.王敖明,邱德华等.石氏调中保元汤治疗老年性膝关节病.上海中医药杂志,2001,7:34-35
487.陈广祯,李心沁,梁安明。从瘀血痰湿论治膝关节骨性关节炎58例。山东中医药 大学学报,1998,22(1):30-31
488.李志敏,周文雄。归元散方治疗膝骨性关节炎的疗效观察。海南医学,2005,16(10):159-160.
489.杜天信,韩新峰,高书图.寒湿痹颗粒治疗寒湿痹阻型风湿病的临床观察.中医正骨,2002,14(3):10-12
490.韩新峰,杜天信,李无阴.湿热痹颗粒治疗湿热痹阻型风湿病的临床观察.中医正骨,2002,14(4):9-11
491.刘金文,冯立科,许少健。金桂外洗方对膝骨关节炎患者生存质量的改善作用。中医药临床杂志,2004,16(1):47-48.
492.顾凯平,张飞飞。中药熏蒸治膝骨关节炎临床疗效观察.江西中医药,2003,34(12):25.
493.张密香,左艳,董博.针刺配合中药热敷治疗膝骨性关节炎45例.现代中医药,2006,26(3):40.
494.王莉。三色敷热敷治疗膝骨性关节炎60例。陕西中医,2004,25(10):890-891.
495.莴兴国.通督针法治疗膝骨关节炎.上海针灸杂志,2006,25(3):23.
496.葛鸿庆,陈文治,余宇峰,等.腹针治疗膝关节骨性关节炎患者生存质量的影响.新中医,2007,39(2):41.
497.裘敏蕾,戴琪萍,车涛,等.电针膝眼穴治疗膝骨关节炎的临床研究.中医正骨,2006,18(3):15.
498.李常度,黄信勇,杨旭光等.温针殆疗虚寒型膝骨关节炎疗效观察.中国针灸,2006,26(3):189.
499.付勇,康明非,陈日新等。无痛化脓灸治疗膝关节骨性关节炎疗效观察.中国针灸,2007,27(7):513.
500.旷秋和.火针治疗膝骨性关节炎50例疗效观察.针灸临床杂志,2006,22(5):19.
501.蒋生云。推拿治疗膝关节骨关节炎50例体会。按摩与导引,2003,19(1):36
502.杨宏。推拿治疗膝关节增生性骨关节炎156例。中国中医药信息杂志,2001,8(11):80,83.
503.雷西凤,徐鹏刚,常江。中药离子导入法治疗膝骨关节炎65例。陕西中医,2002,23(9):808-809.
504.陈利新,马少云,莫卫海.中药离子导入治疗膝关节骨性关节炎400例临床报告。医学理论与实践,2003,16(5):557.
505.谢进,孟凯,王式鲁。自制小针刀治疗膝骨关节炎124例疗效观察。山东医药,2008,48(5):103-104.
506.王学普。温针刮痧治疗膝关节骨性关节炎48例。华北煤炭医学院学报,2005,7(2):199.
507.郑昱新,詹红生,张琥,等.奇正青鹏膏剂治疗膝骨关节炎的随机对照临床研究.中国骨伤,2006,19(5):316.
508.雷明,陈红明.综合疗法治疗膝关节骨性关节炎46例.新中医,2005,37(6):71.
509.孙素艳.电针配合药物离子导入及超短波治疗膝骨关节炎53例。针灸临床杂志,2006,22(4):31.
510.邱彩信,陈一凡。穴位注射治疗膝关节退行性变及护理.国际医药卫生导报,2006,12(2):83.
511.陈礼坤。小针刀、手法加中药治疗膝关节骨性关节炎68例疗效观察。颈腰痛杂志,2007,28(6):511-512.
512.韩村显,宁静,张小卫,等.中药离子导入并玻璃酸钠治疗膝骨关节炎80例.陕西中医,2006,27(11):1363.
513.李卫宁,刘向前,卢敏等.复方温通散外敷加关节腔内注射透明质酸钠治疗膝关节骨关节炎临床观察.湖南中医学院学报,2004,24(1):50.
514.马红炜,李文银,杨明庭。针刀加膝眼注射施佩特治疗膝骨性关节炎71例。陕西中医,2008,29(5):594-595.
515.刘云鹏,刘沂。骨与关节损伤和疾病的诊断分类及功能评定标准。北京:清华大学出版社,2002:230.
516.郑筱萸,任德权。中药新药临床研究指导原则。北京:中国医药科技出版社,2002:349-353
517.梁晓春,郭赛珊。肾虚、衰老与自由基的关系以及补肾药对自由基的影响。中西医结合杂志,1990,10(8):51.
518.褚立希,周恩元,赵敏辉。关节1号方治疗骨关节炎的实验研究。上海中医药大学学报,2001,15(1):47.
519.汪青春,董蕙芳,沈培芝等。中药对膝骨关节炎黑鼠血清SOD、HA、NO水平的影响。中医正骨,1999,11(5):6-8
520.王文瑞,刘宏泽,卫小春等。川芎嗪防治膝关节软骨退变的实验研究。中国骨伤,2004,17(2),80-82.
521.王辉。部分中草药生物反应调节剂的研究现状。实用中医药结合杂志,1992,5(2):90.
522.BOBINACD,SPANJOL,ZORICICS,et al.Changes in articularcartilage and sub-chondral bone histomorphometry in osteoarthritic knee joints in humans.Bone,2003,32(3):284-290.
523.BRADLEYJD.Joint irrigetion as treatment for osteoarthritis.Curr Rheuma- tol Rep,2003,5(1):20-26.
524.程鹏。关节镜下清理术治疗老年人膝关节骨关节炎。中国骨伤,2003,16(3):144。
525.张利恒,桑平,宋成,等。关节镜微创清理术治疗老年膝关节骨性关节炎,中国老年学杂志,2006,26(7):989-990.
526.凌沛学。透明质酸。北京:中国轻工业出版社,2000:137-151.
2.Felson DT,Zhang Y,Hannan MT,et al.The incidence and natural history of knee osteoarthritis in the elderly:the Framingham osteoarthritis study.Arthritis Rheum 1995,38:1500-1505.
3.Cooper C,Egger P,Coggon D,et al.Generalized osteoarthritis in women:pattern of joint involvement and approaches to definition for epidemiological studies.J Rheumatol 1996,23:1938-1942.
4.Spector TD,Hart DJ,Doyle DV.Incidence and progression of osteoarthritis in women with unilateral knee disease in the general population:the effect of obesity.Ann Rheum Dis 1994,53:565-568.
5.Spector TD,Dacre JE,Harris RA,et al.Radiological progression of osteoarthritis:an 11 year follow up study of the knee.Ann Rheum Dis 1992,51:1107-1110.
6.McAlindon T,Zhang Y,Hannan M,et al.Are risk factors for patellofemoral and tibiofemoral knee osteoarthritis different?J Rheumatol 1996,23:332-337.
7.McAlindon TE,Snow S,Cooper C,et al.Radiographic patterns of osteoarthritis of the knee joint in the community:the importance of the patellofemoral joint.Ann Rheum Dis 1992,51:844-849.
8.Neame R,Zhang W,Deighton C,et al.Distribution of Radiographic osteoarthritis between the right and left hands,hips and knees.Arthritis Rheum 2004,50:1487-1490.
9.Schouten JSAG.A 12-year follow-up study on osteoarthritis of the knee in the general population.An epidemiological study of classification criteria,risk factors and prognostic factors.Dissertation,Erasmus University Medical School,Rotterdam,1991.
10.林锦洪,李敏健,许智源等。广州市社区18个居委会45岁以上人群退行性膝关节病的流行病学调查。中国临床康复,2005;9(47):8-9.
11.Van Saase JL,Van Romunde LK,Cats A,et al.Epidemiology of osteoarthritis:Zoetermeer survey.Comparison of radiographical osteoarthritis in a Dutch population with that in 10 other populations.Ann Rheum Dis 1989,48:271-280.
12.Lawrence JS,Bremner JM,Bier E.Osteoarthrosis,prevalence in the popula- tion and relationship between symptoms and x-ray changes.Ann Rheum Dis 1966,25:1-23.
13.Felson DT,Naimark A,Anderson J,et al.The prevalence of knee osteoar-thritis in the elderly.Arthritis Rheum 1987,30:914-918.
14.Anderson JJ,Felson DT.Factors associated with osteoarthritis of the knee in the first National Health and Nutrition Examination Survey(HANES Ⅰ),evidence for an association with overweight,race,and physical demands of work.Am J Epidemiol 1988,128:179-189.
15.Zhang Y,Xu L,Nevitt MC,et al.Comparison of the prevalence of knee osteo-arthritis between elderly Chinese population in Beijing and whites in the United States:The Beijing Osteoarthritis Study.Arthritis Rheum 2001,44:2065-2071.
16.余卫,徐苓,秦明伟。北京市城区老年人膝关节骨关节炎流行病学调查——与美国白种人膝关节骨关节炎的临床和x线比较分析。中华放射学杂志,2005;39(1):67-71.
17.Felson DT,Zhang Y,Hannan MT,et al.Risk factors for incident radiographic knee osteoarthritis in the elderly.Arthritis Rheum 1997,40:728-733.
18.颜贻站,曾云记,谢作完等。农村50岁以上5016人退行性膝关节病流行病学调查。浙江中西医结合杂志,2007;17(7):422,456.
19.Hart DJ,Doyle DV,Spector TD.Incidence and risk factors for radiographic knee osteoarthritis in middleaged women,the Chingford Study.Arthritis Rheum 1999,42:17-24.
20.Sharma L,Lou C,Felson DT,et al.Laxity in health and osteoarthritis knees.Arthritis Rheum,in press.
21.Slemenda C,Heilman DK,Brandt KD,et al.Reduced quadriceps strength relative to body weight:a risk factor for knee osteoarthritis in women?Arthritis Rheum 1998,41:1951-1959.
22.Kivimakj J,Riihimaki H,Hanninen K.Knee disorders in carpet and floor layers and painters.Scand J Work Environ Health 18:310-316,1992.
23.Cooper C,McAlindon T,Coggon D,et al.Occupational activity and osteoarthritis of the knee.Ann Rheum Dis 1994,53:90-93.
24.Kujala UM,Kettunen J,Paananen H,et al.Knee osteoarthritis in former runners,soccer players,weight lifters and shooters.Arthritis Rheum 1995,38:539-546.
25.Panush RS,Schmidt C,Caldwell JR,et al.Is running associated with degenerative joint disease?JAMA.1986,255:1152-1154.
26.Hannan MT,Felson DT,Anderson JJ,et al.Habitual physical activity is not associated with knee osteoarthritis:the Framingham Study.J Rheumatol 1993,20:704-709.
27.Bagge E,Bjelle A,Eden S,et al.Factors associated with radiographic osteoarthritis:results from the population study 70-year-old people in Goteborg.J Rheumatol 1991,18:1218-1222.
28.Hart DJ,Mootoosamy I,Doyle DV,et al.The relationship between osteoarthritis and osteoporosis in the general population:the Chingford Study.Ann Rheum Dis 1994,53:158-162.
29.Hannan MT,Anderson JJ,Zhang Y,et al.Bone mineral density and knee osteoarthritis in elderly men and women,the Framingham Study.Arthritis Rheum, 1993,36:1671-1680.
30.Wluka AE,Davis SR,Bailey M,et al.Users of oestrogen replacement therapy have more knee cartilage than non-users.Ann Rheum Dis 2001,60:332—336.
31.Spector TD,Cicuttini F,Baker J,et al.Genetic influences on osteoarthritis in women:a twin study.BMJ 1996,312:940-943.
32.Felson DT,Couropmitree NN,Chaisson CE,et al.Evidence for a mendelian gene in a segregation analysis of generalized radiographic osteoarthritis.Arthritis Rheum 1998,41:1064-1071.
33.Keen RW,Hart DJ,Lanchbury JS,et al.Association of early osteoarthritis of the knee with a Taq I polymorphism of the vitamin D receptor gene.Arthritis Rheum 1997,40:1444-1449.
34.Uitterlinden AG,Burger H,Huang Q,et al.Vitamin D receptor genotype is associated with radiographic osteoarthritis at the knee.J Clin Invest 1997,100:259-263.
35.Loughlin J,Polymorphism in signal transduction is a major route through which osteoarthritis susceptibility is acting.Curr Opin Rheumatol 2005,17:629-633.
36.Loughlin J,Dowling B,Chapman K,et al.Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.Proc Natl Acad Sci USA 2004,101:9757-9762.
37.Min JL,Meulenbelt I.Riyazi N,et al.Association of the frizzled-related protein gene with symptomatic osteoarthritis at multiple sites.Arthritis Rheum 2005,52:1077-1080.
38.Kizawa H,Kou I,Iida A,et al.An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis.Nat Genet 2005,37:138-144.
39.Mustafa Z,Dowling B,Chapman K,et al.Investigating the aspartic acid(D) repeat of asporin as a risk factor for osteoarthritis in a U.K.Caucasian population.Arthritis Rheum 2005,52:3502-3506.
40.Cooper C.McAlindon T,Snow S,et al.Mechanical and constitutional risk factors for symptomatic knee osteoarthritis:differences between medial tibiofemoral and patellofemoral disease.J Rheumatol 1994,21:307-313.
41.Englund M,Lohmander LS.Risk factors for symptomatic knee osteoarthritis fifteen to twenty-two years after meniscectomy.Arthritis Rheum 2004,50:2811-2819.
42.Sharma L,Song J,Felson DT,et al.The role of knee alignment in disease progression and functional decline in knee osteoarthritis.JAMA 2001,286:188-195.
43.Miyazaki T,Wada M,Kawahara H,et al.Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis.Ann Rheum Dis 2002,61:617-622.
44.Cahue S,Dunlop D,Hayes K,et al.Varus-valgus alignment in the pro-gression of patellofemoral osteoarthritis.Arthritis Rheum 2004,50:2184-2190.
45.Felson DT,Goggins J,Niu J,et al.The effect of body weight on progression of knee osteoarthritis is dependent on alignment.Arthritis Rheum 2004,50:3904-3909.
46.McAlindon TE,Felson DT,Zhang Y,et al.Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among partici-pants in the Framingham study.Ann Intern Med 1996,125:353-359.
47.Brandt KD,Heilman DK,Slemenda C,et al.Quadriceps strength in women with radiographically progressive osteoarthritis of the knee and those with stable radiographic changes.J Rheumatol 1999,2.6:2431-2437.
48.Sharma L,Dunlop DD,Cahue S,et al.Quadreceps strength and osteoarthritis progression in malaligned and lax knees.Ann Int Med 2003,138:613-619.
49.Dieppe P.Subchondral bone should be the main target for the treatment of pain and disease progression in osteoarthritis.Osteoarthritis Cartilage 1999,7:325-326.
50.Zhang Y,Hannan MT,Chaisson CE,et al.Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women:the Framing-ham Study.J Rheumatol 2000,27:1032-1039.
51.Felson D.McLahughlin S,Goggins J,et al.Bone marrow edema and its relation to progression of knee osteoarthritis.Ann Intern Med 2003,139:330-336.
52．Roland W,Roy D,Mare C,Joseph A,Victor M．骨关节炎诊断与治疗。第4版。谢利民主译。北京：人民卫生出版社,2008．16．
53.Berhiaume MJ,Raynauld JP,Martel-Pelletier,et al.Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging.Ann Rheum Dis 64:556-563,2005.Epub 2004 Sep 16.
54.Chang A,Hayes K,Dunlop D,et al.Hip abduction moment and protection against medial tibiofemoral osteoarthritis progression.Arthritis Rheum 2005,52:3515-3519.
55.Davis MA,Ettinger WH,Neuhaus JM,et al.Correlates of knee pain among U.S.adults with and without radiographic knee osteoarthritis.J Rheumatol 1992,19:1943-1949.
56.Hill CL,Gale DG,Chaisson CE,et al.Knee effusions,popliteal cysts,and synovial thickening:association with knee pain in osteoarthritis.J Rheumatol 2001,28:1330-1337.
57.Sowers MF,Hayes C,Jamadar D,et al.Magnetic resonance detected subchondral bone marrow and cartilage defect characteristics associated with pain and x-ray defined knee osteoarthritis.Osteoarthritis Cartilage 2003,11:387-393.
58.Hochberg MC,Lawrence RC,Evefett DF,et al.Epidemiologic associations of pain in osteoarthritis of the knee:data from the National Health and Nutrition Examination Survey and the National Health and Nutrition Examination-1 Epidemiologic Followup Survey.Semin Arthritis Rheum 1989,18:4—9.
59.Summers MN,Haley WE,Reveille JD,et al.Radiographic assessment and psychologic variables as predictors of pain and functional impairment in osteoarthritis of the knee or hip.Arthritis Rheum 31:204-209,1988.
60.Lunghi ME,Miller PM,McQuillan WM.Psychological factors in osteoa rthritis of the hip.J Psychosom Res 1978,22:57-63.
61.O'Reilly SC,Jones A,Muir KR,et al.Quadriceps weakness in knee osteoarthritis:the effect on pain and disability.Ann Rheum Dis 199-8,57:588—594.
62.Lichtenberg PA,Skehan MW,Swensen CH.The role of personality,recent life stress and arthritic severity in predicting pain.J Psychosom Res 1984,28:231-236.
63.Lankhorst GJ,van de Stadt,vari der Korst.The relationships of functional capacity of the knee.Scand J Rehabil Med 1985,17:167-172.
64.Miller ME,Rejeski WJ,Messier SP,et al.Modifiers of change in physical functioning in older adults with knee pain:the Observational Arthritis Study in Seniors(OASIS).Arthritis Care Res 2001;45:331-339.
65.Sharma L,Cahue S,Song J,et al.Physical functioning over 3 years in knee osteoarthritis.Arthritis Rheum 2003,48:3359-3370.
66.Rejeski WJ,Miller ME,Foy C,et al.Self-efficacy and the progression of functional limitations and self-reported disability in adults with knee pain.J Gerontol 2001,56B:S261-265.
67．叶永平,蒋垚,曾炳芳。膝骨关节炎病因、X线片及临床表现分析。临床骨科杂志,2000,3(3)：169-173．
68.Evans CH,Brown TD.Role of physical and mechanical agents in degrading the matrix.In:Woessner JFJ,Howell DS,eds.Joint Cartilage Degradation;Basic and Clinical Aspects.New York:Marcel Dekker;1993:187-208.
69.Redin EL,Burr DB,Caterson B,et al.Mechanical determinants of oste oarthritis.Semin Arthritis Rheum 1991,21:12-21.
70.Buckwalter JA.Osteoarthritis and articular cartilage use,disuse,and abuse:experimental studies.J Rheumatol Suppl 1995,43:13-15.
71.Palmoski MJ,Brandt KD.Running inhibits the reversal of atrophic changes in canine knee,cartilage after removal of a leg cast.Arthritis Rheum 1981,24:1329—1337.
72.Setton LA,Elliott DM.Mow VC.Altered mechanics of cartilage with osteoarthritis:human osteoarthritis and an experimental model of joint degeneration.Osteoarthritis Cartilage 1999,7:2-14.
73.Setton LA,Mow VC,Muller FJ,et al.Mechanical properties of canine articular cartilage are significantly altered following transection of the anterior cruciate ligament.J Orthop Res 1994,12:451-463.
74.Setton LA,Mow VC,Muller FJ,et al.Mechanical behavior and biochemical composition of canine knee cartilage following periods of joint disuse and disuse with remobilization.Osteoarthritis Cartilage 1997,5:1-16.
75.Grumbles RM,Howell DS,Howard GA,et al.Cartilage metalloproteases in disuse atrophy.J Rheumatol Suppl 1995,43:146-148.
76.Lammi MJ,Hakkinen TP,Parkkinen JJ,et al.Effects of long-term running exercise on canine femoral head articular cartilage.Agents& Actions-Supplements 1993,39:95-99.
77.Lane NE,Buckwalter JA.Exercise:a cause of osteoarthritis?Rheum Dis Clin North Am 1993,19:617-633.
78.Kraus VB.Pathogenesis and treatment of osteoarthritis.Med Clin North Am 1997,81:85-112.
79.Griffin TM,Guilak F.The role of mechanical loading in the onset and progression of osteoarthritis.Exerc Sport Sci Rev 2005,33:195—200.
80.Lane JM,Chisena E,Black J.Experimental knee instability:Early mechanical property changes in articular cartilage in a rabbit model.Clin Orthop Rel Res 1979,140:262-265.
81.Howell DS,Treadwell BV.Trippel SB.Etiopathogenesis of osteoarthritis.In:Moskowitz RW,Howell DS,Goldberg VM,et al.,eds.Osteoarthri tis,Diagnosis and Medical/Surgical Management.2~(nd) ed.Philadelphia:W.B.Saunders;pp 1992,233-252.
82.Pond MJ,Nuki G.Experimentally induced osteoarthritis in the dog.Ann Rheum Dis 1973,32:387-388.
83.Moskowitz RW,Davis W,Sammarco J.Experimentally induced degenerative joint lesions following partial meniscectomy in the rabbit.Arthritis Rheum 1973,16:397-405.
84.McDevitt C,Gilbertson E,Muir H.An experimental model of osteoar thritis;early morphological and biochemical changes.J Bone Joint Surg 1977,59B:24-35.
85.Eyre DR,McDevitt CA,Billingham ME,et al.Biosynthesis of collagen and other matrix proteins by articular cartilage in experimental osteoarthritis.Biochem J 1980,188:823-837.
86.Altman RD,Tenenbaum J,Latta L,et al.Biomechanical and biochemical properties of dog cartilage in experimentally induced osteoarthritis.Ann Rheum Dis 1984,43:83-90.
87.Sandy JD,Adams ME,Billingham ME,et al.In vivo and in vitro stimulation of chondrocyte biosynthetic activity in early experimental osteoarthritis.Arthritis Rheum 1984,27:388-397.
88.Guilak F,Ratcliffe A,Lane N,et al.Mechanical and biochemical changes in the superficial zone of articular cartilage in canine experimental osteoarthritis.J Orthop Res 1994,12:474-484.
89.Messier SP.Osteoarthritis of the knee and associated factors of age and obesity:effects on gait.Med Sci Sports Exerc 1994,26:1446-1452.
90.Das UN.Obesity,metabolic syndrome X,and inflammation.Nutrition 2002,18:430-432.
91.O'Connor BL,Palmoski MJ,Brandt KD.Neurogenic acceleration of degenerative joint lesions.J Bone Joint Surg Am 1985,67:562—572.
92.Yang KH,Riegger CL,Rodgers MM.Diminished lower limb deceleration as a factor in early stage osteoarthritis.Trans Orthop Res Soc 1989,14:52.
93.O'Reilly SC,Jones A,Muir KR,et al.Quadriceps weakness in knee osteoarthritis:the effect on pain and disability.Ann Rheum Dis 1998,57:588-594.
94.McAlindon T,Felson DT.Nutrition:risk factors for osteoarthritis.Ann Rheum Dis 1997,56:397-400.
95.Aurich M,Squires GR,Reiner A,et al.Differential matrix degradation and turnover in early cartilagr lesions of human knee and ankle joints.Arthritis Rheum 2005,52:112-119.
96.Hardingham TE,Fosang AJ,Dudhia J.The structure,function and turnover of aggrecan,the large aggregating proteoglycan from cartilage.Eur J Clin Chem Clin Biochem 1994,32:249-257.
97.Maroudas A.Physicochemical properties of articular cartilage.In:Freeman M,ed.Adult Articular Cartilage.Tunbridge Wells:Pitman Medical;1979,pp 215-290.
98.Mow VC,Kuer SC,Lai WM,et al.Biphasic creep and stress relaxation of articular cartilage in compression:Theory and experiments.J Biomech Eng 1980,102:73-84.
99.Kempson GE,Muir H,Pollard C,et al.The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans.Biochim Biophys Acta 1973,297:456-472.
100.Roth V.Mow VC.The intrinsic tensile behavior of the matrix of bovine articular cartilage and its variation with age.J Bone Joint Surg 1980,62:1102—1117.
101.Chen AC,Temple MM,Ng DM,et al.Induction of advanced glycation end products and alterations of the tensile properties of articular cartilage.Arthritis Rheum 2002,46:3212-3217.
102.Poole AR.Cartilage in health and disease.In:Koopman WJ.Moreland LW,eds.Arthritis and Allied Conditions.A Textbook of Rheumatology.15th ed.Baltimore:Williams&Williams;2005,pp 223-269.
103.Setton LA,Tohyama H,Mow VC.Swelling and curling behaviors of articular cartilage.J Biomech Eng,1998,120:355-361.
104.Narmoneva DA,Wang JY,Set ton LA.Nonuniform swelling induced residual strains in articular cartilage.J Biomech 1999,32:401-408.
105.Flahiff CM,Kraus VB,Huebner JL,et al.Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic loading method.Osteoarthritis Cartilage 2004,12:383-388.
106.Alexopoulos LG,Setton LA,Guilak F.The biomechanical role of the chondrocyte pericellular matrix in articular cartilage.Acta Biomater 2005,1:317-325.
107.Mow VC,Ateshian GA.Lubrication and wear of diarthrodial joints.In:Mow VC,Hayes WC,eds.Basic Orthopaedic Biomechanics,2~(nd) Ed.Philadelphia:Lippincott-Raven;1997,pp 275-315.
108.Malcom LL.An experimental investigation of the frictional and deformational responses of articular cartilage interfaces to static and dynamic loading[dissertation].San Diego,University of California,San Diego,1976.
109.Park S,Krishnan R,Nicoll SB,et al.Cartilage interstitial fluid load support in unconfined compression.J Biomech 2003,36:1785-1796.
110.McCutchen CW.Joint lubrication.Bull Hosp Jt Dis Orthop Inst 1983,43:118-129.
111.Hou JS,Mow VC,Lai WM,et al.An analysis of the squeezefilm lubrication mechanism for articular cartilage.J Biomech 1992,25:247-259.
112.Helminen HJ,Jurvelin J,Kiviranta I,et al.Joint loading effects on articular cartilage:A historical review.In:Helminen HJ,Kiviranta I,Tammi M,et al.,eds.Joint Loading:Biology and Health of Articular Structures.Bristol:Wright and Sons;1987,1-46.
113.Guilak F,Sah RL,Setton LA.Physical regulation of cartilage metabolism.In:Mow VC,Hayes WC,eds.Basic Orthopaedic Biomechanics.2~(nd)ed.Philadelphia:Lippincott-Raven,1997,179-207.
114.Gray ML,Pizzanelli AM,Grodzinsky AJ,et al.Mechanical and physiochemical determinants of the chondrocyte biosynthetic response.J Orthop Res 1988,6:777-92.
115.Sah RL,Doong JY,Grodzinsky AJ,et al.Effects of compression on the loss of newly synthesized proteoglycans and proteins from cartilage explants.Arch Biochem Biophys 1991,286:20-29.
116.Guilak E,Meyer BC,Ratcliffe A,et al.The effects of matrix compression on proteoglycan metabolism in articular cartilage explants.Osteoarthritis Cartilage 1994,2:91-101.
117.Torzilli PA,Grigiene R,Huang C,et al.Characterization of cartilage metabolic response to static and dynamic stress using a mechanical explant test system.J Biomech 1997,30:1-9.
118.Farquhar T,Xia Y,Mann K,et al.Swelling and fibronectin accumulation in articular cartilage explants after cyclical impact.J Orthop Res 1996,14:417-423.
119.Chen C-T,Burton-Wurster N,Borden C,et al.Chondrocyte necrosis and apoptosis in impact damaged articular cartilage.J Orthop Res 2001,19:703-711.
120.Loening AM,James IE,Levenston ME,et al.Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis.Arch Biochem Biophys 2000,381:205-212.
121.Nishida Y,Shinomura T,Iwata H,et al.Abnormal occurrence of a large chondroitin sulfate proteoglycan,PG-M/versican in osteoarthritis cartilage.Osteoarthritis Cartilage 1994,2:43-49.
122.Brandt K.Paracetamol in the treatment of osteOArthritis pain.Drugs,2003;63:23-41.
123.Nelaon E,Billinghurst RC,Pidoux I,et al.Early posttraumatic osteoarthr-itis-like changes in human articular cartilage following rupture of the anterior cruciate ligament.Osteoarthritis Cartilage 2006,14:114-119.
124.Adams ME,Brandt KD.Hyperteophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection.J Rheumatol 1991,18:428-435.
125.Brandt KD,Braunstein EM,Visco DM,et al.Anterior(cranial)of osteoarthritis,not merely of cartilage injury and repair.J Rheumatol 1991,18:436-446.
126.张超,王旭等。NNP-1、-13mRNA和DDR2表达与关节软骨退变的关系。复旦学报(医学粕,2007,34(1):126-128.
127.Krzeski P,Buckland-Wright C,Bá lint G,et al.Development of musculo-skeletal toxicity without clear benefit after administration of PG-116800,a matrix metalloproteinase inhibitor,to patients with knee osteoarthritis:a randomized,12-month,double-blind,placebocontrolled study.Arthritis Res Ther 2007;9(5):R109.
128.BlomAB,van Lent PL,Libregts S,et al.Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis:involvement of matrix metalloproteinase 3.Arthritis Rheum.2007;56(1):147-157.
129.Lohmander LS,Brandt KD,Mazzuca SA,et al.Use of the plasma stromelysin (matrix metalloproteinase 3) concentration to predict joint space narrowing in knee osteoarthritis.Arthritis Rheum.2005;52(10):3160-3167.
130.闫训友,薛冲,刘志敏等。基质金属蛋白酶及其组织抑制剂研究进展。生物技术通讯,2004,15(3):302-305.
131.孙永生,娄思权。骨性关节炎发病分子机制研究进展。中国骨与关节损伤杂志,2005,20(8):571-573.
132.Mitchell PG,Magna HA,Reeves LM,et al.Cloning expression,and type Ⅱcollagenolytic activity of matrix metal loproteinase-13 from human osteoarthritis cartilage.J Clin Invest 1996,97:761-768.
133.Billinghurst.RC,Dahlbert L,Ionescu M,et al.Enhanced cleavage of type Ⅱcollagen by collagenases in osteoarthritis articular cartilage.J Clin Invest 1997,99:1534-1545.
134.Dahlberg L,Billinghurst RC,Manner P,et al.Selective enhancement of coll-agenasemediated cleavage of resident type Ⅱ collagen in cultured osteoarthritis cartilage and arrest with a synthetic inhibitor that spares collagenasa 1(matrix metalloproteinase 1).Arthritis Rheum 2000,43:673-682.
135.管剑龙,施桂英,韩星海等。骨关节炎关节软骨和滑膜MMP-1、-3表达。中华内科杂志,2000,39(9):62-631.
136.吴宏斌,杜靖远,胡勇等。兔前交叉韧带切断骨关节炎模型中MMP-1、-13及TIMP-1的表达研究。中华风湿病学杂志,2002,6(3):169-173.
137.王爱民,王宝恩.基质金属蛋白酶.国外医学:临床生化与检验学分册,1995,16(6):246.
138.Sondergaard BC,Henriksen K,Wulf H,et al.Relative contribution of matrix metalloprotease and cysteine protease activities to cytokinestimulated articular cartilage degradation.Osteoarthritis Cartilage 2006;14(8):738-748.
139.Zhao HB,Du JY.Guowai Yixue:Chuangshang yu Waike Jiben Wenti Fence 1996;17(1):27赵海波,杜靖远.基质金属蛋白酶及其中骨吸收中的作用.国外医学:创伤与外科基本问题分册,1996,17(1):27.
140.Kafienah W,BrommeD,Buttle DJ,et al.Human cathepsin K cleaves native type Ⅰ and Ⅱ col lagens at the N-terminal end of the triple helix.Biochem J 1998,331(Pt 3):727-732.
141.Konttinen YT,Mandelin J,Li TF,et al.Acidic cysteine endoprotei- nase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis.Arthritis Rheum 2002,46:953-960.
142.Kevorkian L,Young DA,Darrah C,et al.Expression profiling of metallo-proteinases and their inhibiors in cartilage.Arthritis Rheum 2004,50:131-141.
143.Bau B,Gebhard PM,Haag J,et al.Relative messenger RNA expression profi- ling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro.Arthritis Rheum 2002,46:2648-2657.
144.Wu CW,Tchetina EV,Mwale F,et al.Proteolysis involving matrix metalloproteinase 13(collagenase-3)is required for chondrocyte differentiation that is associated with matrix mineralization.J Bone Miner Res 2002,17:639-651.
145.Tchetina EV,Squires G,Poole AR.Increased type Ⅱ collagen degradation and very early focal cartilage degegeration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.J Rheumatol 2005,32:876-886.
146.Martel-Pelletier J,Faure MP,McCollum R,et al.Plasminogen activators and inhibitor in human osteoarthritic cartilage.J Rheumatol 1991,18:1863-1871.
147.Baici A,Horler D,Lang A,et al.Cathepsin B in osteoarthritis:zonal variation of enzyme activity in human femoral head cartilage.Ann Rheum Dis 1995,54:281-288.
148.Mehraban F,Tindal MH,Proffitt MM,et al.Temporal pattern of cysteine endopeptidase(cathepsin B)expression in cartilage and synovium from rabbit knees with experimental osteoarthritis:gene expression in chondrocytes in response to interleukin-1 and matrix depletion.Ann Rheum Dis 1997,56:108-115.
149.Hollander AP,Healthfield TE,Webber C,et al.Increased damage to type Ⅱ collagen in osteoarthritic articular cartilage detected by a new immunoassay.J Clin Invest 1994,93:1722-1732.
150.Hollander AP,Pidoux Ⅰ,Reiner A,et al.Damage to type Ⅱ collagen in aging and osteoarthtitis starts at the articular surface,originates around chondrocytes,and extends into the cartilage with progressive degeneration.J Clin Invest 1995,96:2859-2869.
151.Squires GR,Okouneff S,Ionescu M,et al.The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes charcateristic of osteoarthritis.Arthritis Rheum 2003,48:1261-1270.
152.Poole AR.Biochemical/immunochemical biomarkers of osteoarthritis:utility for prediction of incident or progressive osteoarthritis.Rheum Dis Clin North Am 2003,29:803-818.
153.Price JS,Till SH,Bickerstaff DR,et al.Degradation of cartilage type Ⅱ collagen precedes the onset of osteoarthritis following anterior cruciate ligament rupture.Arthritis Rheum 1999,42:2390-2398.
154.Aigner T,Bertling W,Stoss H,et al.Independent expression of f ibrilfor-ming collagens Ⅰ、Ⅱ and Ⅲ in chondrocytes of human osteoarthritis cartilage.J Clin Invest 1993,91:829-837.
155.Matyas JR,Adams ME,Huang D,et al.Major role of collagen ⅡB in the elevation of type II procollagen messenger RNA in the hypertrophic phase of experimental osteoarthritis.Arthritis Rheum 1997,40:1046-1049.
156.Nelson F,Dahlberg L,Laverty S,et al.Evidence for altered synthesis of type II collagen in patients with osteoarthritis.J Clin Invest 1998,102:2115-2125.
157.Rizkalla G,Reiner A.Bogoch E,et al.Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis.Evidence for molecular heterogeneity and extensive molecular changes in disease.J Clin Invest 1992,90: 2268-2277.
158.Tortorella MD,Burn TC,Pratta MA,et al.Purification and cloning of aggrecanase-1:a member of the ADAMTS family of proteins.Science 1999,284:1664-1666.
159.Poole AR,Alini M.Hollander AP.Cellular biology of cartilage degradation.In:Henderson B.Edwards JCW,Pettipher ER,eds.Mechanisms and Models in Rheumatoid Arthritis.London:Academic Press,1995,pp 163-204.
160.Lark MW,Bayne EK,Flanagan J,et al.Aggrecan degradarion in human cartilage.Evidence for both matrix metalloproteinase and aggrecanase activity in normal,osteoarthritic,and rheumatoid joints.J Clin Invest 1997,100:93-106.
161.Glasson SS,Askew R,Sheppard B,et al.Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.Nature 2005,434:644-648.
162.Stanton H,Rogerson FM,East CJ,et al.ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.Nature 2005,434:648-652.
163.Gao G,Plaas A,Thomopson VP,et al.ADAMTS4(aggrecanase-1)activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositola-nchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.J Biol Chem 2004,279:10042-10051.
164.Hollander AP,Heathfied TF,Webber C,et al.Increased damage to type Ⅱcollagen in osteoarthritic cartilage detected by a new immunoassay.J Clin Invest 1998;93(4):1722-1732.
165.Krzeski P,Buckland-Wright C,Bá lint G,et al.Development of musculo-skeletal toxicity without clear benefit after administration of PG-116800,a matrix metalloproteinase inhibitor,to patients with knee osteoarthritis:a randomized,12-month,double-blind,placebo-controlled study.Arthritis Res Ther 2007;9(5):R109。
166.Diab M.The role of type IX collagen in osteoarthritis and rheumatoid arthritis.Orthop Rev 1998;222(2):165-170.
167.Kobayashi A,Naito S,Enomoto H,et al.Serum levels of matrix metalloproteinase 3(stromelysin 1) for monitoring synovitis in rheumatoid arthritis.Arch Pathol Lab Med 2007;131(4):563-570.
168.邓廉夫,柴本甫.正常关节软骨的胶原表型与骨关节炎关节软骨的表型异常.国外医学:创伤与外科基本问题分册,1996,17(3):152-155.
169.Homandberg GA,Meyers R,Xie DL.Fibronection fragments cause chondrolysis of bovine articular cartilage slices in culture.J Biol Chem 1992,267:3597-3604.
170.Yasuda T,Poole AR.A fibronectin fragment induces type Ⅱ collagen degradation by collagenase through an interleukin-1-mediated pathway.Arthritis Rheum 2002,46:138-148.
171.Yasuda T,Poole AR,Shimizu M,et al.Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparinbinding fragment of fibrone- ction in human articular cartilage in culture.Arthritis Rheum 2003,48:1271-1280.
172.Chevalier X,Claudepierre P,Groult N,et al.Presence of ED-A contaning fibronectin in human articular cartilage from patients with osteoarthritis and rheumatoid arthritis.J.Rheumatol 1996,23:1022-1030.
173.Arner EC,Tortorella MD.Signal transduction through chondrocyte integrin receptors induces matrix metallopfoteinase synthesis and synergizes with interleukin-1.Arthritis Rheum 1995,38:1304-1314.
174.孙廓,张键。细胞因子在骨关节炎中的作用研究进展。中国临床医学,2007,14(5):690-692.
175.Yasuda T,Tchetina E,Ohsawa K,et al.Peptides of type II collagen can induce the cleavage of type Ⅱ collagen and aggrecan in articular cartilage.Matrix Biol,In press,2006.
176.Fichter M,Korner U,Schomburg J,et al.Collagen degradation products modulate matrix metallopteinase expression in cultured articular chondrocytes.J Orthop Res 2006,24:63-70.
177.Martel-Pelletier J,McCollum R,DiBattista J,et al.The interleukin-1receptor in normal and osteoarthritis human articular chondrocytes.Identifica-tion as the type I receptor and anaysis of binding kinetics and biologic function.Arthritis Rheum 1992,35:530-540.
178.Webb GR,Westacott CJ,Elson CJ.Chondrocyte tumor necrosis factor recep-tors and focal loss of cartilage in osteoarthritis.Osteoarthritis Cartilage 1997,5:427-437.
179.Shlopov BV,Gumanovskaya ML,Hasty KA.Autocrine regulation of collagenase 3(matrix metalloproteinase 13) during osteoarthritis.Arthritis Rheum 2000,43:195-205.
180.Sandra K,Leo ABJ,Alison MB,et al.Different roles of tumour necrosis factor a and interleukin-1 in murine streptococcal cell wall arthritis.Cytokine,1998,10:690-702.
181.Murakami S,Lefebvre V,de Crombrugge B.Potent inhibition of the master chondrogenic factor Sox9 gene by inteleukin-1 and tumor necrosis factor-alpha.Biol Chem,2000,275(5):3687-3692.
182.王晶,肖德明。性激素与骨关节炎。中华骨科杂志,2001,21(1):50-52.
183.乔礼芬,刘晓晴。前列腺素2对人成骨样细胞白介素IL-6、骨保护素配体/骨保护素mRNA表达的影响。中国老年学杂志,2005,25:1468-1471.
184.Cawston TE,Curry VA,Summers CA,et al.The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint.Arthritis Rheum 1998,41:1760-1771.
185.Kobayashi M,Squires GR,Mousa A,et al.Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarth- ritic cartilage.Arthritis Rheum 2005,52:128-135.
186.Amin AR,Di Cesare PE,Vyas P,et al.The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes:evidence for up-regulated neuronal nitric oxide synthase.J Exp Med 1995,182:2097-2102.
187.Palmer RM,Hickery MS,Charles IG,et al.Induction of nitric oxide synthase in human chondrocytes.Biochem Biophys Res Commun 1993,193:398-405.
188.Attur MG,Dave MN,Stuchin S,et al.Osteopontin:an intrinsic inhibitor of inflammation in cartilage.Arthritis Rheum 2001,44:578-584.
189.Nakamura S,Kamihagj K,Satakeda H,et al.Enhancement of SPARC(osteonectin)synthesis in arthritic cartilage.Increased levels in synovial fluids from patients with rheumatoid arthritis and regulation by growth factors and cytokines in chondrocyte cultures.Arthritis Rheum 1996,39:539-551.
190.Melchiorri C,Meliconi R,Frizziero L,et al.Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocy- tes from patients with osteoarthritis.Arthritis Rheum 1998,41:2165-2174.
191.Taskiran D,Stefanovic-Racic M,Georgescu H,et al.Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1.Biochem Biophys Res Commun 1994,200:142-148.
192.Stefanovic-Racic M,Morales TI,Taskiran D,et al.The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures.J Immunol 1996,156:1213-1220.
193.Clements KM,Price JS,Chambers MG,et al.Gene deletion of either interleukin-lbeta,interleukin-lbeta-converting enzyme,inducible nitric oxide synthase,or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy.Arthritis Rheum 2003,48:3452-3463.
194.张辉,田学忠,梁茂华等。诱导型一氧化氮合酶在关节软骨缺血再灌注损伤及软骨细胞凋亡中的作用。中国临床康复,2006,10(5):102-104.
195.赵程,王成琪,王继芳等。肢体缺血再灌注后关节软骨细胞凋亡的规律。中国临床康复,2005,9(2):106-108.
196.Rowan AD,Young DA.Collagenase gene regulation by proinflammatory cytokines in cartilage.Front Biosci 2007;12:536-550.
197.Pelletier JP,Jovanovic DV,Lascau-Coman V,et al.Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoar- thritis in vivo:possible link with the reduction in chondrocyte apoptosis and caspase 3 level.Arthritis Rheum 2000,43:1290-1299.
198.孙炜,王吉兴,金大地等。软骨修复组织蛋白多糖代谢与一氧化氮合酶抑制剂的影响。中国组织工程研究与临床康复,2007,11(45):9063-9066.
199.Gulilak F,Fermor B,Keefe FJ,et al.The role of biomechanics and inflammation in cartilage injury and repair.Clin Orthop Relat Res 2004,17-26.
200.Fermor B,Weinberg JB,Pisetsky DS,et al.The influence of oxygen tension on the induction of nitric oxide and prostaglandin E_2 by mechanical stress in articular cartilage.Osteoarthritis Cartilage 2005,.13:935-941.
201.Fermor B,Weinberg JB,Pisetsky DS,et al.Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway.Osteoarthritis Cartilage 2002,10:792-798.
202.Dean DD,Martel-Pelletier J,Pelletier JP,et al.Evidence for mentallopro-teinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage.J Clin Invest 1989,84:678-685.
203.Yamada H,Nakagawa T,Stephens RW,et al.Proteinases and their inhibitors in normal and osteoarthritic articular cartilage.Biomed Res 1987,8:289-300.
204.Gendron C,Kashiwagi M,Hughes C,et al.TIMP-3 inhibits aggrecanasemediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors.FEBS Lett 2003,555:431-436.
205.Moulharat N,LesurC,Thomas M,et al.Effects of transforming growth factor-beta on aggrecanase production and proteoglycan degradation by human chondrocytes in vitro.Osteoarthritis Cartilage 2004,12:296-305.
206.Tchetina EV,Antoniou J,Tanzer M,et al.Transforming growth factor-beta2suppresses collagen cleavage in cultured human osteoarthritic cartilage,reduces expression of genes associated with chondrocyte hypertrophy and degradarion,and increases prostaglandin E(2) production.Am J Pathol 2006,168:131-140.
207.Ling H,Recklies AD.The Chitinase 3-1ike protein human cartilage glycopr-otein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1and tummour necrosis factor-alpha.Biochem J 2004,380:651-659.
208.Poole AR,Rosenberg LC,Reiner A,et al.Contents and distributions of the proteoglycans decor in and biglycan in normal and osreoarthritic human articular cartilage.J Orthop Res 1996,14:681-689.
209.Lefkoe TP,Nalin AM,Clark JM,et al.Gene expression of collagen types ⅡA and IX correlates wi th ultrastructural events in early osteoarthrosis:new applications of the rabbit meniscectomy model.J Rheumatol 1997,24:1155-1163.
210.Aigner T,Zhu T,Chansky,HH,et al.Reexpression of type ⅡA procollagen by adult articular chondrocytes in osteoarthritic cartilage.Arthritis Rheum 1999,42: 1443-1450.
211.Sandel1 LJ,Morris N,Robbins JR,et al.Alternatively spliced type Ⅱ procollagen mRNAs define distinct populations of cells during vertebral development:differential expression of the aminopropeptide.J Cell Biol 1991,114:1307—1319.
212.McDevitt CA,Pahl JA,Ayad S,et al.Expermental osteoarthritic articular cartilage is enriched in guanidine soluble type Ⅵ collagen.Biochem Biophys Res Commun 1988,157:250-255.
213.Ronziere MC,Ricard-Blum S,Tiollier J,et al.Commparative analysis of collagens solubilized from human foetal,and normal and osteoarthritic adult articular cartilage,wrth emphasis on type Ⅵ collagen.Bioclim Biophys Acta.1990,1038:222-230.
214.Hambach L,Neureiter D,Zeiler G,et al.Severe disturbance of the distribution and expression of type Ⅵ collagen chains in osteoarthritic articular cartilage.Arthritis Rheum 1998,41:986-996.
215.Soder S,Hambach L,Lissner R,et al.Ultrastructural localization of type Ⅵ collagen in normal adult and osteoarthritic human articular cartilage.Osteoarthritis Cartilage 2002,10:464-470.
216.Lee CM,Paul TA,Slabaugh M,et al.The pericellular matrix is enlarged in osteoarthritic cartilage.Trans Orthop Res Soc 1997,22:495.
217.Alexopoulos LG,Williams GM,Upton ML,et al.Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrixinarti-cular cartilage.J Biomech 2005,38:509-517.
218.Alexopoulos LG,Haider MA,Vail TP,et al.Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis.J Biomech Eng 2003,125:323-333.
219.Cs-Szabo G,Roughley,PJ,Plaas AH,et al.Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage.Arthritis Rheum 1995,38:660-668.
220.Cs-Szabo G,Melching LI,Roughley,et al.Changes in messenger RNA and pro-tein levels of proteoglycans and link protein in human osteoarthritic cartilage samples.Arthritis Rheum 1997,40:1037-1045.
221.Nishida Y,Shinomura T,Iwata H,et al.Abnormal occurrence of a large chondroitin sulfate proteoglycan,PG-M/versican in osteoarthritic cartilage.Osteoarthritis Cartilage 1994,2:43-49.
222.Schneiderman R,Rosenberg N,Hiss J,et al.Concentration and size distribution of insulin-like growth factor-1 in human normal and osteoarthritic synovial fluid and cartilage.Arch Biochem Biophys 324:1995,173-188.
223.Dore S,Pelletier JP,DiBattista JA,et al.Human osteoarthritic chondrocy-tes possess an increased number of insulin-like growth factor 1 binding sites but are unresponsive to its stimulation.Possible role of IGF-1-blinding proteins.Arthritis Rheum 1994,37:253-263.
224.田华,Carrie Fang,Paul E。骨形态发生蛋白-2对软骨寡聚基质蛋白在软骨细胞内表达的影响。北京大学学报(医学片反),2003,35(3):317.
225.Chen AL,Fang G,Liu C,et al.Expression of bone morphogeneric proteins,receptors,and tissue inhibitors in human fetal,adult,and osteoarthritic articular cartilage.J Orthop Res 2004,22:1188-1192.
226.Di Cesare PE,Carlson CS,Stolerman ES,et al.Increased degradation and altered tissue distribution of cartilage oligoneric matrix protein in human rheumatoid and osteoarthritic cartilage.J Orthop Res 1996,14:946-955.
227.Okimura A,Okada Y,Makihira S,et al.Enhancement of cartilage matrix protein synthesis in arthritic cartilage.Arthritis Rheum 1997,40:1029-1036.
228.Chevalier X,Groult N,Larget-Piet B,et al.Tenascin distribution in articular cartilage from normal subjects and from patients with osteoarthritis and rheumatoid arthritis.Arthritis Rheum 1994,37:1013-1022.
229.Recklies AD,White C,Ling H.The Chitinase 3-like protein human cartilage glycoprotein 39(HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase and protein kinase B-mediated signalling pathways.Biochem J 2002,365:119-126.
230.Marshall KW,Zhang H,Yager TD,et al.Blood-based biomarkers for detecting mild osteoarthritis in the human knee.Osteoarthritis Cartilage 2005,13:861-871.
231.van den Berg WB,van der Kraan PM,van Beuningen HM.Synovial mediators of cartilage damage and repair in OA.In:Brandt KD,Doherty M,Lohmander LS,eds.Osteoarthritis.Oxford:Oxford University Press,1998.
232.Goldring MB.Osteoarthritis and cartilage:the role of cytokines.Curr Rheumatol Rep 2000,2:459-465.
233.Morales T,I.The role of signaling factors in articular cartilage homeos-tasis and osteoarthritis.In:Osteoarthritic Disorders.Rosemont,IL:American Academy of Orthopaedic Surgeons,1995,pp 261-270.
234.Middleton JF,Tyler JA.Upregulation of insulin-like growth factor 1 gene expression in the lesions of osteoarthritic human articular cartilage.Ann Rheum Dis 1992,51:440-447.
235.Tyler JA.Insulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines.Biochem J 1989,260:543-548.
236.Trippel SB,Corvol MT,Dumontier ME,et al.Effect of somatomedin-C/ insulin- like growth factor 1 and growth hormone on cultured growth plate and articular chondrocytes.Pediatr Res 1989,25:76-82.
237.Im HJ,Pacione C,Chubinskaya S,et al.Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment and interleukin-1 stimulated matrix metalloproteinase-13 expression in human chondrocytes.Biol Chem,2003,278(28):25386-25394.
238.Sachs BL,Goldberg VM,Moskowitz RW,et al.Response of articular chondrocytes to pituitary fibroblast growth factor(FGF).J Cell Physiol 1982,112:51-59.
239.Kato Y,Gospodarowicz D.Sulfated proteoglycan synthesis by confluent cultures of rabbit costal chondrocytes grown in the presence of fibroblast growth factor.J Cell Biol 1985,100:477-485.
240.郑召民,董天华,刘纪思。骨性关节炎病人肿瘤坏死因子和白细胞介素-6的测定及意义。中国矫形外科杂志,1998,5(6):544-545.
241.Xiao YT,Xiang LX,Shao JZ.Bone morphogenetic protein.Biochem Biophys,Res Commun,2007;362(3):550-553.
242.Campbell IK,Wojta J,Novak U,et al.Cytokine modulation of plasminogen activator inhibitor-1(PAI-1)production by human articular cartilage and chondrocytes.Down-regulation by tumor necrosis factor alpha and up-regulation by transforming growth factor-B basic fibro- blast growth factor.Biochin Biophs Acta 1994,1226:277-285.
243.王卫国,娄思权,余华等。TGF-β2转染关节软骨细胞的实验研究。中华骨科杂志,2003,23(2):434.
244.von der Mark K,Kirsch T,Nerlich A,et al.Type Xcollagen synthesis in human osteoarthritic cartilage.Indication of chondrocytes hypertrophy.Arthri- tis Rheum 1992,35:806-811.
245.Hashimoto S,Ochs RL,Komiya S,et al.Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis.Arthritis Rheum 1998,41:1632-1638.
246.Blanco FJ,Guitian R,Vazquez-Martul E,et al.Osteoarthritis chondroeytes die by apoptosis.A possible pathway for osteoarthritis pathology.Arthritis Rheum 1998,41:284-289.
247.Sharif M,Whitehouse A,Sharman P,et al.Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3.Arthritis Rheum 2004,50:507-515.
248.Mollenhauer J,Mok MT,King KB,et al.Expression of anchorin C Ⅱ(cartilage annexin Ⅴ)in human young,normal adult,and osteoarthritic cartilage.J Histochem Cytochem 1999,47:209- 220.
249.邓廉夫,柴本甫,杨庆铭。肿瘤坏死因子α对骨关节炎滑膜细胞增殖和表达的影响。中国药理学通报,1998,14(6):506-508.
250.Wu W,Billinghurst RC^Pidoux I,et al.Sites of collagenase cleavage and denaturat'ion of type Ⅱ collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13.Arthritis Rheum 2002,46:2087-2094.
251.Shlopov RV,Lie WR,Mainardi CL,et al.Osteoarthritic lesions:involvement of three different collagenases.Arthritis Rheum 1997,40:2065-2074.
252.Reboul P,Pelletier JP,Tardif G,et al.The new collagenase,collagenase-3,is expressed and synthesized by human chondrocytes but not by synoviocytes.A role in osteoarthritis.J Clin Invest 1996,97:2011-2019.
253.Wang FL,Connor JR,Dodds RA,et al.Differential expression of egr-1 in osteoarthritic compared to normal adult human articular cartilage.Osteoarthri-tis Cartilage 2000,8:161-169.
254.Gordon GV,Villanueva T,Schumacher HR,et al.Autopsy study correlating degree of osteoarthritis,synovitis and evidence of articular calcification.J Rheumatol 1984,11:681-686.
255.Ali SY,Rees JA,Scotchford CA.Microcrystal deposition in cartilage and in osteoarthritis.Bone Miner 1992,17:115-118.
256.Swan A,Chapman B,Heap P,et al.Submicroscopic crystals in osteoarthritic synovial fluids.Ann Rheum Dis 1994,53:467-470.
257.Derfus B,Steinberg M,Mandel N,et al.Characterization of an additional articular cartilage vesicle fraction that generates calcium pyrophosphate dihydrate crystals in vitro.J Rheumatol 1995,22:1514-1519.
258.Hashimoto S,Ochs RL,Rosen F,et al.Chondrocyte-derived apoptotic bodies and calcification of articular cartilage.Proc Natl Acad Sci USA 1998,95:3094-3099.
259.Terkeltaub RA.What does cartilage calcification tell us about osteoarthritis?J Rheumatol 2002,29:411-415.
260.Johnson K,Terkeltaub R.Upregulated ank expression in osteoarthritis can promote both chondrocyte MMP-13 expression and calcification via chondrocyte extracellular Ppi excess.Osteoarthritis Cartilage 2004,12:321-335.
261.Hart DJ,Cronin C,Daniels M,et al.The relationship of bone density and fracture to incident and progessive radiographic osteoarthritis of the knee:the Chingford Study.Arthritis Rheum 2002,46:92-99.
262.Dieppe P,Cushnaghan J,Young P,et al.Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy.Ann Rheum Dis 1993,52:557-563.
263.Huebner JL,Hannes MA,Beekman B,et al.A compatative analysis of bone and cartilage metabolism in two strains of guineapig with varying degrees of naturally occutting osteoarthritis.Osteoarthritis Cartilage 2002,10:758-767.
264.Matsui H,Shimizu M,Tsuji H.Cartilage and subchondral bone interaction in osteoarthrosis of human knee joint:a histological and histomorphometric study.Microsc Res Tech 1997,37:333-342.
265.Burr DB,Schaffler MB.The involvement of subchondral mineralized tissues in osteoarthrosis:quantitative microscopic evidence.Microsc Res Tech 1997,37:343-357.
266.Watson PJ,Hall LD,Malcolm A,et al.Degenerative joint disease in the guinea pig.Use of magnetic resonance imaging to monitor progression of bone pathology.Arthritis Rheum 1996,39:1327-1337.
267.van Osch GJ,van der Kraan PM,van Valburg AA,et al.The relation between cartilage damage and osteophyte size in a murine model for osteoarthritis in the knee.Rheumatol Int 1996,16:115-119.
268.Garnero P.Mazieres B,Gueguen A,at al.Cross-sectional association of 10 molecular markers of bone,cartilage,and synovium with hip osteoarthritis:the ECHODIAH cohort.J Rheumatol 2005,32:697-703.
269.Behets C,Williams JM,Chappard D,et al.Effects of calcitonin on subchondral trabecular bone changes and on osteoarthritis cartilage lesions after acute acterior cruciate ligament defiviency.J Bone Miner Res 2004,19:1821—1826.
270.Hayami T.Pickarski M,Wesolowski GA,et al.The role of subchondral bone remodeling in osteoarthritis:reduction of cartilage degeneration and prevention of osteophyte formation by alensronate in the rat anterior cruciate ligament transection model.Arthritis Rheum 2004,50:1193-1206.
271.Smith MD,Triantaf illou S,Parker A,et al.Synovial membrane inflammation and cytokine production in patients with early osteoarthritis.J Rheumatol 1997,24:365-371.
272.Pelletier JP,Martel-Pelletier J.Abramson SB.Osteoarthritis,an inflammatory disease:potential implication for the selection of new therapeutic targets.Arthritis Rheum 2001,44:1237-1247.
273.Lindblad S,Hedfors E.Arthroscopic and immunohistologic characterization of knee joint synovitis in osteoarthritis.Arthritis Rheum 1987,30:1081-1088.
274.Ayral X,Pickering EH,Woodworth TG,et al.Synovitis:a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis—results of al year longitudinal arthroscopic study in 422 patients.Osteoar-thritis Cartilage 2005,13:361-367.
275．邓廉夫,柴本甫,杨庆铭。骨关节炎滑膜细胞分泌肿瘤坏死因子的生物学特征研究。中华骨科杂志,1999,19(12)：726-729．
276.Hedbom E,Hauselmann HJ.Molecular aspects of pathogenesis in osteoarthritis:the role of inflammation.Cell Mol Life Sci,2002,59(1):45-53.
277.Oliver JC,Bland LA,Oettinger CW,et al.Cytokine kinetics in an in vitro whole blood model following an endotoxin challenge.Lymphokine Cytokine Res,1993,12(2):115-120.
278.Martel-Pelletier J,Alaaeddine N,Pelletier JP.Cytokines and their role in the pathophysiology of osteoarthritis.Front Biosci 1999,4:D694703.
279.Alaaeddine N,Di Battisa JA,Pelletier JP,et al.Inhibition of humor necrosis factor alpha-induced prostaglandin E2 production by the antiinflamma-tory cytokines interleukin-4,interleukin-10,and inter-leukin-13 in osteoarthri-tic synovial fibroblasts:distinct targeting in the signaling pathways.Arthritis Rheum 1999,42:710-718.
280.Recklies AD,Baillargeon L,White C.Regulation of cartilage oligoneric matrix protein synthesis in human synovial cells and articular chondrocytes.Arthritis Rheum 1998,41:997-1.006.
281.Sharif M,Saxne T,Shepstone L,et al.Relationship between serum cartilage oligomeric matrix protein levels and disease progression in osteoarthritis of the knee joint.Br J Rheumatol 1995,34:306-310.
282.Petersson IF,Boegard T,Svensson B,et al.Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint.Br,Rheumatol 1998,37:46-50.
283.Conrozier T,Saxne T,Fan CS,et al.Serum concentrations of cartilage oligomeric matrix protein and bone sialoprotein in hip osteoarthritis:a one year prospective study.Ann Rheum Dis 1998,57:527-535.
284.Vilim V,Olejarova M,Machacek S,et al.Serum levels of cartilage oligom-ericl matrix protein(COMP)correlate with radiographic progression of knee osteoarthritis.Osteoarthritis Cartilage 2002,10:707-713.
285.Jordan KM,Syddall HE,Garnero P,et al.Urinary CTX-Ⅱ and glucosyl-galactosyl-pytidinoline are associated with the presence and severity of radiographic knee osteoarthritis in men.Ann Rheum Dis 2006,65:871—877.
286.Koch AE,Kunkel SL,Shah MR,et al.Macrophage inflammatory protein-1 beta:a C-C chemokine in osteoarthritis.Clin Immunol Immunopa-thol 1995,77:307-314.
287.Hsu YH,Hsieh MS,Liang YC,et al.Production of the chemokine eotaxin-1 in osteoarthritis and its role in cartilage degradarion.J Cell Biochem 2004,93:929-939.
288.Hashimoto H,Tanaka M,Suda T,et al.Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis.Arthritis Rheum 1998,41:657-662.
289.Torres L,Dunlop DD,Peterfy C,et al.The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis.Osteoar-thritis Cartilage 2006.
290.Garabedian BV,Lemaigre-Dubreuil Y,Mariani J.Central origin of IL-lbeta produced during peripheral inflammation:role of meninges.Brain Res Mol Brain Res 2000,75:259-263.
291.Dieppe PA,Lohmander LS.Pathogenesis and management of pain in osteoarthritis.Lancet 2005,365:965-973.
292.Woolf CJ,Chong MS.Preemptive analgesia:treating postoperative pain by preventing the establishment of central sensitization.Anesth Analg 1993,77:362-379.
293.Lotz M,Carson DA,Vaughan JH.Substance P activation of rheumatoid synoviocytes:neural in pathogenesis of arthritis.Science 1987,235:893-895.
294.Kimball ES.Substance P,cytokines,and arthritis.Ann N Y Acad Sci 1990,594:293-308.
295.Takeba T,Suzuki N,Kaneko A,et al.Evidence for neural regulation of inflammatory synovial cell functions by secreting calcitonin generelated peptide and vasoactive intestinal peptide in patients with rheu-matoid arthritis.Arthritis Rheum 1999,42:2418-2429.
296.Takeba Y,Suzuki N,Takeno M,et al.Modulation of synovial cell functions by somatostatin in patients with rheumatoid arthritis.Arthritis Rheum 1997,40:2128-2138.
297.Wang H,Yu M,Ochani M,et al.Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammtion.Nature 2003,421:384-388.
298.Kondo H,Nifuji A,Takeda S,et al.Unloading induces osteoblastic cell suppression osteoclastic cell activation to lead to bone loss via sympathetic nervous system.J Biol Chem 2005,280:30192-30200.
299.Elef teriou F,Ann JD,Takeda S,et al.Leptin regulation of bone resorption by the sympathetic nervous system and CART.Nature 2005,434:514-520.
300.Persson E,Lerner UH.The neuropeptide VIP potentiates IL-6 production induced by proinflammatory osteotropic cytokines in calvarial osteoblasts and the osteoblastic cell line MC3T3-E1.Biochem Biophys Res Commum 2005,335:705-711.
301.Matayoshi T,Goto T,Fukuhara E,et al.Neuropeptide substance P stimulates the formation of osteoclasts via synovial fibroblastic cells.Biochem Biophys Res Commun 2005,327:756-764.
302.Elvenes J,Andjelkov N,Figenschau Y,et al.Expression of functional mu-opioid receptors in human osteoarthritic cartilage and chondrocytes.Biochem Biophys Res Commun 2003,311:202-207.
303.Andjelkow N,Elvenes J,Martin J,et al.Opiate regulation of IL-lbeta and TNF-alpha in cultured human articular chondrocytes.Biochem Biophys Res Commun 2005,333:1295-1299.
304.Fieisch H,Russell RGG,Straumann F.Effect of pyrophosphate on hydroxyapa-tite and its complications in calcium homeostasis.Nature,1966,212:901-903.
305.赵文国,张柳,梁春雨等。降钙素对膝前交叉韧带切断大鼠股骨远段骨组织结构的影响。山东医药,2008,48(6):9-11.
306.刘志翔,张柳,张楠。降钙素对兔骨关节炎软骨基质金属蛋白酶1的影响。中国矫形外科杂志,2006,14(22):1741-1743.
307.陆圣君,杨述华。降钙素对大鼠骨关节炎关节软骨和软骨下骨的影响。中国骨质疏松杂志,2008,14(3):182-186.
308.Roland W,Roy D.Mare C,Joseph A,Victor M.骨关节炎诊断与治疗。第4版。谢利民主译。北京:人民卫生出版社,2008.47-50.
309.Burr DB,Radin EL.Microfractures and mircocracks in subchondral bone:are they relevant to osteoarthrosis?Rheum Dis Clin North Am 2003,29:675-685.
310.Rosai J.Bone and joints In Rosai I ed.Ackeman' s surgical pathology.9~(th) ed Philadelphia:Mosby,2004,2137-2208.
311.Neuman P,Hulth A,Linden B,et al.The role of osteophytic growth in hip osteoarthritis.Int Orthop 27:262-266,2003.
312.Hameman D.The biology of osteoarthritis N Engl J Med,1989,320:1322-1330.
313.Sokoloff L.Pathology and pathogenesis of osteoarthritis.In McCarty DJ.Arthritis and applied conditions 9th ed.Philadelphia:lea & Febiger,1979,1135-1153.
314.Goldenberg DL,Egan MS,Cohen AS,Inflammatory synovitis in degenerative joint disease.J Rheumatol 1982,9:204-209.
315.Dijkgraaf LC,Liem RS,de Bont LG.Ultrastructural characterstics of the synovial membrane in osteoarthritic temporomandibular joints.J Oral Maxillofac Surg 1997,55:1269-1279.
316.Resnik D,Vint V.The "tunnel" view in assessment of cartilage loss in osteoarthritis of the knee.Radiology 1980,137:547-548.
317.Roland W,Roy D,Mare C,Joseph A,Victor M.骨关节炎诊断与治疗。第4版。谢利民主译。北京:人民卫生出版社,2008.331.
318.李焯洪,MRI在膝关节退行性骨关节病诊断中的价值。临床和实验医学杂志,2008,7(4).127-128.
319.王运昌,张米荣。高频超声对膝骨性关节炎的诊断价值。中医正骨,2007,19(5).
320.Passariello R,Trecco F,De Paulis F,et al.Computed tomography of the knee joint:clinical results.J Comput Assist Tomogr 1983,7(6):1043-1049.
321.Dye S,Chew M.The use of scintigraphy to detect increased osseous meta- bolic activity about the knee.J Bone Joint Surg Am 1993,75:1388-1406.
322.Wolfe F.The C-reactive protein but not erythrocyte sedimentation rate is associated with clinical severity in patients with osteoarthritis of the knee or hip.J Rheumatol 1997,24:1486-1488.
323.Schouten JS,Van den Ouweland FA,Valkenburg HA,et al.Insulin-like growth factor-l:a prognostic factor of knee osteoarthritis.Br Rheumatol 1993,32:274-280.
324.Sharif M,Kirwan JR,Elson CJ,et al.Suggestion of nonliner or phasic progression of knee osteoarthritis based on measurements of serum cartilage oligomeric matrix protein levels over five years.Arthritis Rheum 2004,50:2479-2488.
325.Elliott AL,Kraus VB,Luta G,et al.Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project.Arthritis Rheum 2005,52:105-111.
326.Petersson IF,Sandqvist L,Svensson B,et al.Cartilage markers in synovial fluid in symptomatic knee osteoarthritis.Ann Rheum Dis 1997,56:64-67.
327.Hasegawa M,Hirata H,Sudo A,et al.Tenascin-C concentration in synovial fluid correlates with radiographic progression of knee osteoarthriris.J Rheumatol 2004,31:2021-2026.
328.Fuchs S,Rolauffs B,Arndt S,et al.CD44H and the isoforms CD44v6 and CD44v6in the synovial fluid of osteoarthritic human knee joint.Osteoarthritis Cartilage 2003,11:839-844.
329.Saito S,Kondo S,Mishima S,et al.Analysis of cartilage-derived retinoic-acid-sensitive protein(CD-RAP) in synovial fluid from patients with osteoarthritis and rheumatoid arthritis.J Bone Joint Surg Br 2002,84:1066-1069.
330.彭成忠,曹建民,肖涛等。骨关节炎关节滑液中IL-18与PGE_2含量的测定及意义。中南大学学报(医学版),2006,31(6):862-865.
331:中华医学会骨科分会。骨关节炎诊治指南(2007版)。中华骨科杂志,2007,27(10):793-796.
332.施桂英。关节炎概要。第1版。北京:中国医药科技出版社,2000,327-340.
333.倪家骧,樊碧发,薛富善。临床疼痛治疗技术。北京:科学技术文献出版社,2003:170。
334.周迎光,夏建龙。膝关节骨性关节炎的治疗进展。辽宁中医药大学学报,2006,8(6):156.
335.徐桂莲。膝关节骨性关节炎的治疗进展。贵州医药,2006,30(12):1142-1143.
336.张英泽,冯和林,李增炎.膝关节周围骨折术后综合康复训练的临床疗效.中国康复医学杂志,2006,21(2):154-155.
337.杨丹丹,徐琳峰,陈丽娜。以运动疗法为主治疗膝关节骨关节炎的疗效观察。中国康复医学杂志,2008,23(5):428-430.
338.杜杰,张福金。膝关节骨性关节炎治疗进展。临床军医杂志,2008,36(2):301-304.
339.Phan T,Maillefert JF,Hudry C,et al.Laterally elevated wedged insoles in the treatment of medial knee osteoarthritis:a two-year prospective randomized controlled study.Osteoarthritis Cartilage 2004,12:46-55.
340.Chan AT,Manson JE,Albert CM,et al.Nonsteroidal antiliflammatory drugs,acetaminophen and the risk of cardiovascular events.Circula- tion 2006,113:1578-1587.
341.Roland W,Roy D,Mare C,Joseph A,Victor M.骨关节炎诊断与治疗。第4版。谢利民主译。北京:人民卫生出版社,2008.223-233.
342.Ghosh S,Paul S,Das N,et al.A study on the effects of diclofenac sodium and etoricoxib in the treatment of osteoarthritis.J Indian Med Assoc,2007,105(5):260.
343.Roland W,Roy D,Mare C,Joseph A,Victor M.骨关节炎诊断与治疗。第4版。谢利民主译。北京:人民卫生出版社,2008.233.
344.Turajane T,Tanavaree A,Labpiboonpong V,et al.Outcomes of intraarticular injection of sodium hyaluronate for the treatment of osteoarthritis of the knee.J Med Assoc Thai,2007,90(9):1845-52.
345.饶余波,王元利,闫志刚等。透明质酸钠对膝关节炎患者生存质量的影响(附220例报告)。北京医学,2007,29(11):675-677.
346.陈磊,凌沛学,张天民。硫酸软骨素在骨关节炎防治中的作用。中国生化药物杂志,2008,29(2):137-139.
347.王虹蕾。硫酸氨基葡萄糖治疗骨关节炎。医药论坛杂志,2006,27(8):46-47.
348.江相保,高李侠。盐酸氨基葡萄糖治疗膝退行性骨性关节炎的临床观察。中国修复重建外科杂志,2008,22(1):29-31.
349.施宇翔,熊利泽,董海龙等。玻璃酸钠与得宝松关节腔内注射治疗膝骨关节炎的临床应用观察。中国综合临床,2007,23(6):551-552.
350.黄乔东,何雁冰,陈金生等。生长抑素关节腔内注射治疗膝关节骨性关节炎的疗效观察[J]。广东医学,2006,27(1):8-9.
351.王君,何炳书,李笑萍。四环素对骨关节炎模型的作用观察。山东医药,2008,48(3):33-34.
352.沈彦,袁建迪,朱少兵。膝骨关节炎治疗进展。光明中医,2008,23(5):700-702.
353.陈述祥。关节镜下清理术治疗骨性关节炎。中国内镜杂志,2003,9(12):156.
354.郭磊,白希壮,张世亮等。关节镜下关节灌洗清理术对老年性膝关节骨关节炎的疗效分析。中国医科大学学报,2007,36(5):584-586.
355.王卫国,岳德波,郭万首等。关节镜清理术治疗Kellgren-LawrenceⅢ级以上膝关节骨关节炎。中国内镜杂志,2008,14(2):185-187,190.
356.Day B.The indications for arthroscopic debridement for osteoarthritis of the knee.Orthop Clin North Am,2005,36(4):413-417.
357.Arnoldi CC,Lemperg K,Linderholm H.Intraosseous hypertension and pain in the knee.J Bone Joint Surg(Br),1975,57(3):360-363.
358.Phillips Rs.Phlebographies in osteoarthritis of the hip.J Bone Joint Surg,1996,482B:280.
359.陈学明,卢森桂,唐焕章。钻孔减压治疗早期退行性膝关节炎。中国矫形外科杂志,2000,7(2):115-116.
360.朱建军,刘自建,宗兆凯。钻孔减压后冲洗治疗膝关节骨性关节炎62例报告。山东医药,2001,41(2):49.
361.Bae DK,Yoon KH,Song SJ.Cartilage healing after micro fracture in osteoarthritic knees.Arthroscopy,2006,.22(4):367-374.
362.Kreuz PC,Erggelet C,Steinwachs MR,et al.Is microfracture of chondral defects in the knee associated with different results in patients aged 40 years or younger.Arthroscopy,2006,22(11):1180-1186.
363.Miller BS,Steadman,Briggs KK,et al.Patient satisfaction and outcome after microfracture of the degenerative knee.J Knee Surg,2004,17(1):13-17.
364.李海鹏,刘玉杰,王志刚。关节镜下微骨折术治疗膝关节软骨损伤。中国矫形外科杂志,2007,15(10):731-733.
365.王彦明,余家阔,于长隆等。关节镜下微骨折术修复膝关节软骨全层缺损的临床疗效观察。中国运动医学杂志,2006,25(6):651-654,724.
366.Miller BS,Steadman,Briggs KK,et al.Patient satisfaction and outcome after microfracture of the degenerative knee.J Knee Surg,2004,17(1):13-17.
367.Steadman,Rodkey WG,Briggs KK.Microfracture to treat fullthickness chondral defects:surgical technique,rehabilitation,and outcomes.J Knee Surg,2002,15(3):170-176.
368.陈意磊,程飚。膝骨关节炎的关节镜治疗进展。复旦学报(医学版),2008,35(1):148-151,160.
369.Peterson L,Minas T,BrittbergM,et al.Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation:results at twp to ten years.J Bone Joint Sutg Am 2003;85-A Suppl 2:17-24.
370.刘尚礼,李卫平,宋卫东。软骨细胞移植治疗关节软骨缺损。广州医药,2000,31:1-4.
371.Marlovits S,Striessnig G,Kutscha-Lissberg F,et al.Early postoperative adherence of matrix-induced autologous chondrocyte implantation for the treatment of full-thickness cartilage defects of the femoral condyle.Knee Surg Sports Traumatol Arthrosa 2005;13(6):451-457.
372.杨造成,张仲文,侯世科等。移植基质诱导的自体软骨细胞修复关节软骨缺损临床研究。武警医学,2007,18(4).249-253.
373.Bartlett W,Skinner JA,Gooding CR,et al.Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee:a prospective,randomised study.J Bone Joint Surg Br 2005,879(5):640-645.
374.Hangody L,Kish G,Karpati Z,et al.Arthroscopic autogenous osteochondral mosaicplasty for the treatment of femoral condylararticular defects.A prelinary report.Knee Surg Sports Traumatol Arthrosc 1997,5(4),262-267.
375.Barber FA,Chow JC.Arthroscopic osteochondral transplantation:histolo- gic results.Arthroscopy 2001,17(8):832-835.
376.徐东潭,臧洪敏,徐光辉。自体骨软骨移植修复股骨髁关节软骨缺损:应用关节镜治疗的可行性。中国组织工程研究与临床康复,2007,11(47):9532-9534.
377.钟建明,王丹,杨文龙等。关节镜下自体镶嵌式骨软骨移植治疗膝关节软骨缺损。浙江临床医学,2008,1(3):299-300.
378.SHASHA N,KRYWULAK S,BACKSTEIN D,et al.Long-term follow-up of fresh tibial osteochondral allografts for failed tibial plateau fractures.J Bone Joint Surg Am,2003,85(Suppl2):33-39.
379.王洪,周游,李宝兴等。冷冻同种异体骨软骨移植修复大面积关节软骨缺损的可行性研究。华中科技大学学报(医学版),2007,36(4):485-488.
380.余家阔,于长隆,敖英芳。关节镜辅助下的同种异体半月板移植(附4例术后20个月以上随访报告)。中国运动医学杂志,2007,26(3):261-265.
381于至悌,张雪华,张书永等。自体软骨膜、骨膜游离移植修复软骨缺损治疗骨性关节炎[J]。临床骨科杂志,1998,1(1):13-16.
382.吕厚山。髋、膝关节骨性关节炎的研究现状和进展。实用老年医学,2001,15(5):229-233.
383.曹立峰,裴宪武,李延明等。改良胫骨高位截骨术治疗膝骨性关节炎32例报告。北京医学,2008,30(3):187-188.
384.张功林,章鸣,蔡国荣等。胫骨高位截骨治疗膝关节骨性关节炎。中国骨伤,2008,21(3):211-212.
385.武东升,李玉民,刘铁战等。胫骨高位球形截骨术治疗膝骨关节炎。实用骨科杂志,2008,14(5):305-306.
386.Finkelstein A,Gross A,Davis A.Varus osteotomy of the distal part of the femur:a survivorship analysis.J Bone Joint Surg Am 78:1348-1352,1996.
387.韩一生。慢性关节炎的外科治疗。中国临床康复,2002,6(5):629.
388.于德刚,董纪元,王岩。人工膝关节单髁置换术36例临床应用特点:1年随访影像学及膝关节功能评估。中国组织工程研究与临床康复,11(51):10246-10250.
389.Berger RA,Meneghini RM,Jacobs JJ,et al.Results of unicompartmental knee arthroplasty at a minimum of ten years of followup.J Bone Joint Surg AM 2005,87(5):999-1006.
390.陈云苏,Andrew A Freiber。膝关节单髁置换术23例分析。中国临床医学,2004,11(5):787-788.
391.黄霄汉,于海峰。膝关节表面置换术治疗膝关节骨关节炎31例近期疗效观察。中国矫形外科杂志,2008,16(7):548-550.
392.王英振,王湘达,吕成昱等。人工全膝关节置换术治疗膝关节骨关节炎。中国矫形外科杂志,2006,14(23).1784-1786.
393.Hass SB,Cook S,Beksac B.Minimally invasive total knee replacement through a minimidvastus a pproach:a comparative study.Clinorthop Relat Res,2004,(428):68-73.
394.Laskin RS,Beksac.B,Phong junakom A,et al.Minimally invasive total knee replacement through a mini-midvastus incision:an out-come study.Clin Orthop Relat Res,2004,(428):74-81.
395.何森,曹文,李刚等。QS微创全膝关节置换术的早期疗效观察。第三军医大学学报。2007,29(23):2283-2285.
396.Wakitani S,Imoto K,Yamamoto T,et al.Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees.Osteoarthritis Cartilage,2002,10(3):199-206.
397.林智军,王万明,刘航涛。组织工程化关节软骨的研究进展。实用医学杂志,2007,23(19):2963-2965.
398.赵钟岳,李世民,娄思权,等。关节外科学[M]。天津:天津科学技术出版社,2002:1283-1284.
399.高益民。膝关节骨关节炎Ⅱ期临床试验方案。中药新药与临床药理,1998,9(1):16.
400.李平,韩明向,孔秀媞。肾虚络阻是骨关节炎的病机特点。中医药临床杂志,2006,18(1):89.
401.贺宪,魏春山,蔡智刚。膝骨性关节炎的病机和防治机制探讨。山东中医杂志,2005,24(2):73.
402.徐传毅,樊粤光,宁显明。肾虚血瘀与膝骨性关节炎关系初探。新中医,2002,34(3):7.
403.陈龙全,郝双阶。方竹节参片配合穴位注射治疗膝骨性关节炎82例。陕西中医,2004,25(8):716.
404.章建华,童培建,陈俊杰等。膝关节骨性关节炎的综合治疗。中医正骨,2005,17(7):25-26.
405.胡敏,杨军平,邱丽瑛。中药调节兔膝骨关节软骨代谢作用的研究。北京中医药大学学报。2006,29(12):830-832.
406.陈述祥,司徒坚,杨运东等。自制复方中药对膝骨性关节炎家兔血液流变及病理形态的影响。中国临床康复,2005,9(30):147-149.
407.石关桐,韩大鹏,郑昱新等。补肾和柔肝中药对C57黑鼠膝骨关节炎滑膜中COMP 基因表达的影响。上海中医药大学学报,2007,21(3):55-58.
408.汪青春,沈培芝,徐宇,等。不同方药治疗膝骨关节炎的组织形态学对比研究。中国中医骨伤科杂志,1998,6(2):1-3.
409.冯伟,石印玉,沈培芝,等.中药对软骨细胞代谢的影响.中国中医骨伤科杂志,2000,8(2):9-11.
410.祁传才,于宝云,王伟卓。附桂骨痛胶囊对膝关节骨性关节炎NO及iNOS影响的实 验研究。陕西中医学院学报,2007,30(4):65-67.
411.韩大鹏,郑昱新,石关桐。化痰中药对C57黑鼠膝骨关节炎滑膜中COMP表达的影响。中国中医骨伤科杂志,2007,15(8):9-12.
412.毕荣修,殷惠芬,王式鲁。关节止痛胶囊对兔膝骨性关节炎模型血清和关节液中自由基水平的影响。中医正骨,2004,16(11):3-4.
413.熊鹏程,寿折星,熊昌源。伤科薰洗方对实验性兔膝骨性关节炎软骨组织形态学的影响。中国中医骨伤科杂志,2008,16(5):19-21.
414.郭颖杰。鹿茸多肽对骨、软骨细胞增殖的实验研究。中国生化药物杂志,1998,19(2):74-75.
415.王文瑞,刘宏泽,卫小春等。川芎嗪防治膝关节软骨退变的实验研究。中国骨伤,2004,17(2):80-82.
416.郑召民,许振华。骨内高压与活血化瘀。中国中医骨伤科,1994,2(3):43-47.
417.周尊谦,谢林,孙达武。丹柴康膝冲剂治疗膝关节退行性骨关节病的临床研究。中国骨伤,1999,12(2):49-50.
418.吴驶,高翔,王拥军等。益气化瘀利水方对骨关节炎兔前列腺素代谢的影响。老年医学与保健,2004,10(1):24-26.
419.童敏,王静,向大雄等。骨康合剂对兔实验性膝骨关节炎血液流变性的影响。中南药学,2007,5(3):227-230.
420.李巍,吴国志,陈德喜等。熏蒸一、二号方治疗膝骨性关节炎的药效学研究。中医外治杂志,2007,16(2):5-7.
421.黄涛,徐传毅,邹季等。活血止痛汤治疗早期骨性关节炎的实验研究[J]。中医正骨,1999,11(5):3-5.
422.毛小兵,邹季。风湿骨痛药酒药槌外治法防治关节软骨退变的实验研究[J]。中医骨伤,2002,15(4):220-221.
423.徐卫东,侯铁胜,张春才等。FGF对关节软骨细胞基质及其TGF-β1表达的作用[J]。第二军医大学学报,1999,20(10):773-774.
424.王本祥。现代中药药理与临床。天津:天津科技翻译出版公司,2004:322-325.
425.李珍娟,黄红英。羌活的药理作用及临床新用概述。实用中医药杂志,2004,20(2):108-109.
426.于慧敏,聂英坤,王璟璐。白芍总苷对膝骨性关节炎患者血清一氧化氮和白细胞介素-1β水平的影响。2007,41(5):455-456,459.
427.宁显明,樊粤光,徐传毅。补肾中药对膝骨关节炎软骨TGF-β1表达的影响。中国中医骨伤科杂志,2004,12(1):36-38.
428.唐勇,姜杰,孟辉等。补肾益气活血方含药血清对兔软骨细胞增殖和bFGF-mRNA表达的影响。时珍国医国药,2006,17(5):686-687.
429.张炳冉。补肾壮筋汤对膝骨关节炎患者血清肿瘤坏死因子-α与白细胞介素-6水平的影响。中草药,2006,37(9):1389-1390.
430.安莉萍,卫荣,魏晓丽等。益肾通痹方对膝关节骨性关节炎兔血清和膝关节腔液 中炎性细胞因子和一氧化氮含量的影响。中国临床康复,2006,10(15):79-81.
431.卢思俭,邵璟,梁梅荣。益肾方对兔膝骨关节炎模型关节滑液中TNF-α、IL-1β水平的影响。浙江中医杂志,2006,41(5):292-293.
432.汪青春,石印玉,沈培芝等。中药对膝骨关节炎小鼠关节软骨IL-1、iNOS基因表达的影响。山西医药杂志,1999,28(5):381-383.
433.苏友新,陈顺有,林清坚等。壮骨健膝方对膝骨性关节炎患者关节滑液细胞因子、NO的影响。福建中医学院学报,2006,16(2):38-40.
434.高翔,吴驶,王拥军等。益气化瘀利水方干预兔膝骨关节炎软骨中胰岛素样生长因子1的变化。中国临床康复,2006,10(39):95-97.
435.吴弢,高翔,王拥军等。益气化瘀利水方干预后兔膝骨关节炎软骨中转化生长因子β1的变化。中国临床康复,2006,10(3):118-119.
436.孟祥奇,惠礽华,姜宏等。化痰祛湿剂对兔膝骨性关节炎细胞因子IL-1、IL-6、TNF-α的影响。中国骨伤,2007,20(8):575-576.
437.刘英杰,马利杰,王相利。独活寄生汤对兔膝骨性关节炎关节液白细胞介素-1和肿瘤坏死因子的影响。河北中医,2007,29(8):748-750.
438.钟玉,李荣亨,周小莉等。复元胶囊对实验性兔骨关节炎白介素1及转化生长因子β2的调节作用。重庆医科大学学报,2007,32(8):856-861.
439.郭礼跃,胡慧华,米健国。古方豨莶丸对膝骨性关节炎模型家兔关节液中IL-1β、TNF-α含量及关节软骨细胞形态学的影响。中国骨伤,2006,19(6):377-378.
440.陈朝蔚,陈永强。阳和汤干预兔骨关节炎软骨细胞中血管内皮生长因子变化。中西医结合学报,2008,6(4):372-375.
441.陈朝蔚,陈永强。阳和汤治疗兔膝骨性关节炎的作用机制。中医正骨,2008,20(4):11-12.
442.杨惠琴,陈礼荣。青藤碱注射液对兔膝骨性关节炎关节液及血清IL-6水平的影响。中医药导报,2007,13(10):62-63.
443.曲俊才。膝骨关节炎模型兔关节液中细胞因子白细胞介素1水平及复方归芪液的干预效应。中国组织工程研究与临床康复,2008,12(20):3845-3848.
444.廖八根,徐勇,高鹏吉。中医外治法干预运动创伤性膝关节炎模型兔膝关节滑膜中碱性成纤维细胞生长因子的表达。中国组织工程研究与临床康复,2008,12(11):2047-2050.
445.郑曙光,陈波,马四补等。艾灸治疗对兔膝关节骨性关节炎调节作用的实验研究。北京中医药大学学报,2008,31(5):358-360.
446.田丰玮,宋军,杨金蓉。艾叶油乳膏剂对兔膝骨性关节炎关节冲洗液中细胞因子含量的影响。中医正骨,2005,17(12):15-16.
447.包飞,王道海,王凤琴等。电针对实验性膝骨关节炎大鼠软骨转化生长因子β1表达的影响。中国康复理论与实践,2008,14(4):345-346.
448.黄剑,卓廉士,王永渝等。电针对膝骨关节炎家兔关节液中自由基的影响。针刺研究,2007,4(32):115-118.
449.吴洪,徐华洲,韦哲。十一方酒对兔膝骨性关节炎TGF-β1以及病理形态学的影响。 中国医药导报,2007,4(20):134-135.
450.俞杰,明顺培,张秀芬。针刀疗法对兔膝骨关节炎关节液中IL-1β、IL-6和TNF-α水平的影响。中国中医骨伤科杂志,2002,10(4):15-18.
451.关建军,张智慧,姬军风等。地黄膝龙颗粒对家兔骨性关节炎的实验研究。陕西中医,2007,28(7):922-923.
452.姬军风,关建军,张智慧等。地黄膝龙颗粒治疗兔实验性膝骨关节炎的实验研究。辽宁中医杂志,2008,35(2):296-298.
453.关建军,张智慧,姬军风等。地黄膝龙颗粒对家兔骨性关节炎的实验研究。陕西中医,2007,28(7):922-923.
454.刘春芳,林娜,陈卫衡等。骨痹散防治小鼠膝骨关节炎的实验研究。中国实验方剂学杂志,2008,14(1):55-58.
455.周尊谦,谢林,孙达武。丹柴康膝冲剂治疗膝关节退行性骨关节病的临床研究。中国骨伤,1999,12(2):49-50.
456.任芳,邹季。丹紫康膝冲剂对家兔实验性膝骨关节炎氧自由基代谢的影响。中国中医骨伤科杂志,2008,16(3):39-41.
457.周达岸,蔡玉文。骨痹消对兔实验性膝关节骨性关节炎氧自由基代谢的影响。数理医药学杂志,2008,21(2):179-180.
458.孟祥奇,惠礽华,姜宏等。化痰祛湿剂对兔膝骨性关节炎血清中SOD、NO的影响。中医药学报,2007,35(2):21-23.
459.程传国,龚权,程龙等。肌松Ⅱ号胶囊对实验性骨关节炎氧自由基代谢的影响。颈腰痛杂志,2005,26(1):19-21.
460.姚啸生,李洪久,宋雅梅等。加味补肾壮筋汤对膝骨关节炎氧自由基代谢的影响。中医正骨,2005,17(9):5-6.
461.任芳,李勇光。雪莲注射液对兔膝关节骨性关节炎模型动物血清NO和滑膜组织SOD、MDA的影响。中国中医骨伤科杂志,2008,16(5):22-24.
462.马建兵,刘德玉,李堪印等。中药对家兔实验性膝关节骨性关节炎氧自由基代谢的影响。中医正骨,2000,12(1):8-9.
463.Nakazawa T,Xui N,Hesong Z,et al.Danshen inhibits oxysterol-induced endothelial cell apoptosis in vivo.J Atheroscler Thromb,2005,12(3):132.
464.戴七一,刘靖,王大伟。手法对兔膝骨性关节炎软骨细胞DNA氧化性损伤的防治作用。中医正骨,2006,18(3):6-7.
465.黄剑,卓廉士,王永渝等。电针对膝骨关节炎家兔关节液中自由基的影响。针刺研究,2008,33(2):116-119.
466.韩崑,熊昌源。“三联疗法”对兔膝关节骨关节炎氧自由基代谢的影响。湖北中医杂志,2006,28(3):9-10.
467.张劫,张闻生,邹季。风湿骨痛药酒药槌外治法治疗兔膝关节骨关节炎的实验研究。中医正骨,2001,13(7):9-10.
468.唐勇,姜杰,孟辉等。补肾益气活血方对兔软骨细胞凋亡和bcl-2mRNA表达的影响。 中国中医基础医学杂志,2006,12(3):174-175.
469.唐勇,姜杰,孟辉等。骨炎定对兔实验性膝骨关节炎关节软骨细胞中bcl-2mRNA表达的影响。山东中医杂志,2004,23(3):169-171.
470.Kim HA,Lee YJ,Seong SC,et al.Apoptotic chondrocyte death in human osteoarthritis[J].J Rheumatol,2000,27(2):455.
471.Pan H,Li X F.Bian H G.Effect of Bu Shen Zhuang Jin Tang Decoctioin on chondrocyte apoptosis and NO of experimental osteoarthritis.Chin J Surg Integrat Tradit Chin West Med,2005,11(3):238-242.
472.赵瑜,陈华燕,刘日光。补肾康膝方对家兔软骨细胞增殖与凋亡的影响。时珍国医国药,2008,19(5):1133-1134.
473.赵瑜,冯齐凤,朱祝生。中药补肾方对体外培养软骨细胞影响。时珍国医国药,2008,19(4):960-961.
474.饶咏梅,杜建时,赵晴等。白芍总苷对骨关节炎血清及关节液中一氧化氮及诱生型一氧化氮合酶的影响。中国实验诊断学,2006,10(12):1444-1445.
475.潘浩,胡庆丰,李雄峰等。补肾壮筋汤对兔早期实验性膝骨关节炎软骨细胞凋亡及增殖细胞核抗原表达的影响。中国骨伤,2005,18(5):278-281.
476.卢思俭,姜全心,王成。益肾为主对兔膝骨关节炎模型软骨细胞凋亡的影响。山东中医杂志,2006,25(10):696-698.
477.国家中医药管理局5中华本草6编委会.中华本草.上海:上海科学技术出版社,1999:6191-6194.
478.沈霖,沈耀,杨述华。丹参注射液对维甲酸诱导的软骨细胞凋亡的影响。中国中医骨伤科杂志,2002,10(5):1-8.
479.杨腊芝,张琴,张红星。丹参酮对人软骨细胞增殖及其抗氧化作用的影响。中国康复,2008,23(2):83-84.
480.龚权,程传国。肌松Ⅱ号胶囊对兔膝骨性关节炎软骨细胞凋亡的影响。颈腰痛杂志,2007,28(2):101-103.
481.谭杨,陈廖斌,汪晖等。黄芪多糖对体外培养大鼠软骨细胞内糖胺多糖合成的影响及其机制。武汉大学学报(医学版),2008,29(2):153-156.
482.梁伯进,唐兴荣。丹芪注射液关节腔注射改善创伤后关节退行性病变的实验研究。中国临床康复,2004,8(11):2088-2090.
483.李正华,詹奇,梁笃。补骨方治疗膝骨性关节炎的疗效观察。现代医院,2004,4(11):32-33.
484.孟庆莉,赵生文。补肾祛瘀法治疗骨关节炎139例。河南中医,2002,22(5):51.
485.吴永昕,肖泓,吴生元.补中桂枝汤治疗退行性骨关节病83例.四川中医,2002,20(2):63-64
486.王敖明,邱德华等.石氏调中保元汤治疗老年性膝关节病.上海中医药杂志,2001,7:34-35
487.陈广祯,李心沁,梁安明。从瘀血痰湿论治膝关节骨性关节炎58例。山东中医药 大学学报,1998,22(1):30-31
488.李志敏,周文雄。归元散方治疗膝骨性关节炎的疗效观察。海南医学,2005,16(10):159-160.
489.杜天信,韩新峰,高书图.寒湿痹颗粒治疗寒湿痹阻型风湿病的临床观察.中医正骨,2002,14(3):10-12
490.韩新峰,杜天信,李无阴.湿热痹颗粒治疗湿热痹阻型风湿病的临床观察.中医正骨,2002,14(4):9-11
491.刘金文,冯立科,许少健。金桂外洗方对膝骨关节炎患者生存质量的改善作用。中医药临床杂志,2004,16(1):47-48.
492.顾凯平,张飞飞。中药熏蒸治膝骨关节炎临床疗效观察.江西中医药,2003,34(12):25.
493.张密香,左艳,董博.针刺配合中药热敷治疗膝骨性关节炎45例.现代中医药,2006,26(3):40.
494.王莉。三色敷热敷治疗膝骨性关节炎60例。陕西中医,2004,25(10):890-891.
495.莴兴国.通督针法治疗膝骨关节炎.上海针灸杂志,2006,25(3):23.
496.葛鸿庆,陈文治,余宇峰,等.腹针治疗膝关节骨性关节炎患者生存质量的影响.新中医,2007,39(2):41.
497.裘敏蕾,戴琪萍,车涛,等.电针膝眼穴治疗膝骨关节炎的临床研究.中医正骨,2006,18(3):15.
498.李常度,黄信勇,杨旭光等.温针殆疗虚寒型膝骨关节炎疗效观察.中国针灸,2006,26(3):189.
499.付勇,康明非,陈日新等。无痛化脓灸治疗膝关节骨性关节炎疗效观察.中国针灸,2007,27(7):513.
500.旷秋和.火针治疗膝骨性关节炎50例疗效观察.针灸临床杂志,2006,22(5):19.
501.蒋生云。推拿治疗膝关节骨关节炎50例体会。按摩与导引,2003,19(1):36
502.杨宏。推拿治疗膝关节增生性骨关节炎156例。中国中医药信息杂志,2001,8(11):80,83.
503.雷西凤,徐鹏刚,常江。中药离子导入法治疗膝骨关节炎65例。陕西中医,2002,23(9):808-809.
504.陈利新,马少云,莫卫海.中药离子导入治疗膝关节骨性关节炎400例临床报告。医学理论与实践,2003,16(5):557.
505.谢进,孟凯,王式鲁。自制小针刀治疗膝骨关节炎124例疗效观察。山东医药,2008,48(5):103-104.
506.王学普。温针刮痧治疗膝关节骨性关节炎48例。华北煤炭医学院学报,2005,7(2):199.
507.郑昱新,詹红生,张琥,等.奇正青鹏膏剂治疗膝骨关节炎的随机对照临床研究.中国骨伤,2006,19(5):316.
508.雷明,陈红明.综合疗法治疗膝关节骨性关节炎46例.新中医,2005,37(6):71.
509.孙素艳.电针配合药物离子导入及超短波治疗膝骨关节炎53例。针灸临床杂志,2006,22(4):31.
510.邱彩信,陈一凡。穴位注射治疗膝关节退行性变及护理.国际医药卫生导报,2006,12(2):83.
511.陈礼坤。小针刀、手法加中药治疗膝关节骨性关节炎68例疗效观察。颈腰痛杂志,2007,28(6):511-512.
512.韩村显,宁静,张小卫,等.中药离子导入并玻璃酸钠治疗膝骨关节炎80例.陕西中医,2006,27(11):1363.
513.李卫宁,刘向前,卢敏等.复方温通散外敷加关节腔内注射透明质酸钠治疗膝关节骨关节炎临床观察.湖南中医学院学报,2004,24(1):50.
514.马红炜,李文银,杨明庭。针刀加膝眼注射施佩特治疗膝骨性关节炎71例。陕西中医,2008,29(5):594-595.
515.刘云鹏,刘沂。骨与关节损伤和疾病的诊断分类及功能评定标准。北京:清华大学出版社,2002:230.
516.郑筱萸,任德权。中药新药临床研究指导原则。北京:中国医药科技出版社,2002:349-353
517.梁晓春,郭赛珊。肾虚、衰老与自由基的关系以及补肾药对自由基的影响。中西医结合杂志,1990,10(8):51.
518.褚立希,周恩元,赵敏辉。关节1号方治疗骨关节炎的实验研究。上海中医药大学学报,2001,15(1):47.
519.汪青春,董蕙芳,沈培芝等。中药对膝骨关节炎黑鼠血清SOD、HA、NO水平的影响。中医正骨,1999,11(5):6-8
520.王文瑞,刘宏泽,卫小春等。川芎嗪防治膝关节软骨退变的实验研究。中国骨伤,2004,17(2),80-82.
521.王辉。部分中草药生物反应调节剂的研究现状。实用中医药结合杂志,1992,5(2):90.
522.BOBINACD,SPANJOL,ZORICICS,et al.Changes in articularcartilage and sub-chondral bone histomorphometry in osteoarthritic knee joints in humans.Bone,2003,32(3):284-290.
523.BRADLEYJD.Joint irrigetion as treatment for osteoarthritis.Curr Rheuma- tol Rep,2003,5(1):20-26.
524.程鹏。关节镜下清理术治疗老年人膝关节骨关节炎。中国骨伤,2003,16(3):144。
525.张利恒,桑平,宋成,等。关节镜微创清理术治疗老年膝关节骨性关节炎,中国老年学杂志,2006,26(7):989-990.
526.凌沛学。透明质酸。北京:中国轻工业出版社,2000:137-151.