纤维素衍生物的合成及吸附性能的研究
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摘要
慢性肾功能衰竭是一种以临床中毒症状为特征的严重疾病,病因主要是体内积蓄了大量的毒素—尿素、肌酐和尿酸。研制高效、广谱、副作用小的口服吸附剂用于延缓发病进程具有重要意义。本文以纤维素为载体,开发了一系列纤维素衍生物:氧化纤维素(DAC)、包醛氧纤维素(CDAC)、环氧化纤维素(EC)、交联纤维素(CLC)、硝基纤维素(NC)和纤维素接枝环糊精(CDGC),用于清除体内三种毒素。
采用正交实验等方法,以α-纤维素为原料,高碘酸钠为氧化剂,合成氧化纤维素。在反应温度45℃, pH=2,纤维素与高碘酸钠质量比为1/2,反应时间为4h时得到醛基含量84%的氧化纤维素。氧化纤维素经过明胶和壳聚糖包覆处理得到包醛氧纤维素。通过吸附动力学曲线、一级吸附速率方程和二级吸附速率方程详细研究了各种条件下氧化纤维素和包醛氧纤维素对尿素的吸附能力,结果表明吸附过程可分为两个阶段:8 h以前符合一级吸附速率方程,8 h以后符合二级吸附速率方程,最大吸附容量可达59.22 mg/g。
用环氧氯丙烷和乙二醇二缩水甘油醚作为交联剂制备环氧化纤维素和交联纤维素。通过条件筛选,确定了环氧基含量达到最大的反应条件:纤维素/环氧氯丙烷/30%NaOH(g/mL/mL)=1/6/8,反应温度40℃,反应时间2.5h。研究了环氧化纤维素和交联纤维素对肌酐的吸附作用,结果表明环氧化基含量2.53mmol/g的环氧化纤维素对肌酐的吸附容量为1.1mg/g,交联纤维素的吸附容量为5.12mg/g。
以环氧化纤维素为载体,接枝上3,5-二硝基苯甲酰氯、β-环糊精和甲基β-环糊精,合成了硝基纤维素、纤维素接枝β-环糊精和纤维素接枝甲基β-环糊精三种聚合物,分别利用硝基苯环与肌酐形成络合物,环糊精对尿酸的包合作用,分别达到吸附肌酐和尿酸的目的。
模拟人体环境,将合成的系列纤维素衍生物放入成纤维细胞中,通过MTT实验,观察到纤维素衍生物对细胞具有一定程度的刺激性。
建立慢性肾功能衰竭模型,将包醛氧纤维素通过灌胃方式给药,发现包醛氧化纤维可显著降低大鼠的肌酐和尿酸浓度,起到较好的治疗效果。
Chronic renal failture(CRF) is a serious disease with clinical poisonous symptom,The pathogeny is that many toxins such as urea, creatinine and uric acid are saved inhuman body. The development of novel oral adsorbents with high adsorption capacity,broad spectrum and less side effect is significant for delaying disease progress. In thispaper a series of cellulose derivatives were developed with cellulose as carrier toremove three toxins. These derivatives are 2,3-dialdehyde cellulose(DAC), coated2,3-dialdehyde cellulose(CDAC), epoxycellulose(EC), cross-linked cellulose(CLC),nitrocellulose(NC) and cyclodextrin grafted cellulose (CDGC).
The orthogonal experiments study on oxidizing α-cellulose to DAC with sodiumperiodate (NaIO4) was carried out. The principal factors influencing the aldehydegroup content of DAC were found out and the better oxidation conditions were as thefollowing: The pH was 2. The reaction temperature was 45℃. The weight ratio ofcellulose to NaIO4 was 1:2. The reaction time was 4h. The high aldehyde groupcontent was obtained under above condition. The CDAC was prepared by coatingwith gelatin and chitosan. The kinetic curves of adsorption, the first-order and thesecond-order kinetic models were used to describe the adsorption ability of DAC andCDAC for urea under various conditions. The adsorption for urea has two steps. Oneis first-order kinetic model before 8h, Another is second-order kinetic model after 8h.The most high adsorption capability is 59.22 mg/g.
The synthesis of epoxycellulose and cross-linked cellulose from epoxychloropropane (ECH) and ethanodiol diglycidyl ether ( EGDE ) in the presence ofalkali medium were described. The principal factors affecting the epoxy group contentwere found out and the best conditions were as the following: the weight ratio ofcellulose, epoxy chloropropane and 30%NaOH(g/mL/mL) was1:6:8, The reactiontemperature was 40℃. The reaction time was 2.5h. The adsorption capacity forcreatinine was observed with epoxycellulose and cross-linked cellulose. Theadsorption capabilities are 1.1mg/g and 5.12mg/g, respectively.
NC, β-cyclodextrin(β-CD) grafted cellulose, and methyl-β-cyclodextrin graftedcellulose were synthesized from EC carrier by grafting with 3,5-dinitrobenzoicchloride(DNBC-Cl), β-CD and methyl-β-CD. Nitrobenzene ring and creatinine
formed complex. The CDs had inclusion for uric acid. Thus creatinine and uric acidwere adsorpted.The cellulose derivatives were put into fibroblast for the cytotoxicity experimentto imitate the human body environment. The MTT method assay showed that abovederivatives had hormesis.The rats were treated with CDAC by input-stomach after the chronic renal failurerat model was established. The creatinine and uric acid were obviously reduced in thetreatment rats model with CDAC. The CDAC had good curing effect.
采用正交实验等方法,以α-纤维素为原料,高碘酸钠为氧化剂,合成氧化纤维素。在反应温度45℃, pH=2,纤维素与高碘酸钠质量比为1/2,反应时间为4h时得到醛基含量84%的氧化纤维素。氧化纤维素经过明胶和壳聚糖包覆处理得到包醛氧纤维素。通过吸附动力学曲线、一级吸附速率方程和二级吸附速率方程详细研究了各种条件下氧化纤维素和包醛氧纤维素对尿素的吸附能力,结果表明吸附过程可分为两个阶段:8 h以前符合一级吸附速率方程,8 h以后符合二级吸附速率方程,最大吸附容量可达59.22 mg/g。
用环氧氯丙烷和乙二醇二缩水甘油醚作为交联剂制备环氧化纤维素和交联纤维素。通过条件筛选,确定了环氧基含量达到最大的反应条件:纤维素/环氧氯丙烷/30%NaOH(g/mL/mL)=1/6/8,反应温度40℃,反应时间2.5h。研究了环氧化纤维素和交联纤维素对肌酐的吸附作用,结果表明环氧化基含量2.53mmol/g的环氧化纤维素对肌酐的吸附容量为1.1mg/g,交联纤维素的吸附容量为5.12mg/g。
以环氧化纤维素为载体,接枝上3,5-二硝基苯甲酰氯、β-环糊精和甲基β-环糊精,合成了硝基纤维素、纤维素接枝β-环糊精和纤维素接枝甲基β-环糊精三种聚合物,分别利用硝基苯环与肌酐形成络合物,环糊精对尿酸的包合作用,分别达到吸附肌酐和尿酸的目的。
模拟人体环境,将合成的系列纤维素衍生物放入成纤维细胞中,通过MTT实验,观察到纤维素衍生物对细胞具有一定程度的刺激性。
建立慢性肾功能衰竭模型,将包醛氧纤维素通过灌胃方式给药,发现包醛氧化纤维可显著降低大鼠的肌酐和尿酸浓度,起到较好的治疗效果。
Chronic renal failture(CRF) is a serious disease with clinical poisonous symptom,The pathogeny is that many toxins such as urea, creatinine and uric acid are saved inhuman body. The development of novel oral adsorbents with high adsorption capacity,broad spectrum and less side effect is significant for delaying disease progress. In thispaper a series of cellulose derivatives were developed with cellulose as carrier toremove three toxins. These derivatives are 2,3-dialdehyde cellulose(DAC), coated2,3-dialdehyde cellulose(CDAC), epoxycellulose(EC), cross-linked cellulose(CLC),nitrocellulose(NC) and cyclodextrin grafted cellulose (CDGC).
The orthogonal experiments study on oxidizing α-cellulose to DAC with sodiumperiodate (NaIO4) was carried out. The principal factors influencing the aldehydegroup content of DAC were found out and the better oxidation conditions were as thefollowing: The pH was 2. The reaction temperature was 45℃. The weight ratio ofcellulose to NaIO4 was 1:2. The reaction time was 4h. The high aldehyde groupcontent was obtained under above condition. The CDAC was prepared by coatingwith gelatin and chitosan. The kinetic curves of adsorption, the first-order and thesecond-order kinetic models were used to describe the adsorption ability of DAC andCDAC for urea under various conditions. The adsorption for urea has two steps. Oneis first-order kinetic model before 8h, Another is second-order kinetic model after 8h.The most high adsorption capability is 59.22 mg/g.
The synthesis of epoxycellulose and cross-linked cellulose from epoxychloropropane (ECH) and ethanodiol diglycidyl ether ( EGDE ) in the presence ofalkali medium were described. The principal factors affecting the epoxy group contentwere found out and the best conditions were as the following: the weight ratio ofcellulose, epoxy chloropropane and 30%NaOH(g/mL/mL) was1:6:8, The reactiontemperature was 40℃. The reaction time was 2.5h. The adsorption capacity forcreatinine was observed with epoxycellulose and cross-linked cellulose. Theadsorption capabilities are 1.1mg/g and 5.12mg/g, respectively.
NC, β-cyclodextrin(β-CD) grafted cellulose, and methyl-β-cyclodextrin graftedcellulose were synthesized from EC carrier by grafting with 3,5-dinitrobenzoicchloride(DNBC-Cl), β-CD and methyl-β-CD. Nitrobenzene ring and creatinine
formed complex. The CDs had inclusion for uric acid. Thus creatinine and uric acidwere adsorpted.The cellulose derivatives were put into fibroblast for the cytotoxicity experimentto imitate the human body environment. The MTT method assay showed that abovederivatives had hormesis.The rats were treated with CDAC by input-stomach after the chronic renal failurerat model was established. The creatinine and uric acid were obviously reduced in thetreatment rats model with CDAC. The CDAC had good curing effect.
引文
[1]Rahn K., Heinze C., Celllulosic polymers by subsequent modification of 2,3-dialdehyde cellulose, Cellul. Chem. Technol., 1998,32(3～4):173～183
[2]许冬生编,纤维素衍生物,北京:化学工业出版社,2001,3～4
[3]Kennedy,John F., Melo, Bioconversions of cellulose A major source of material for the biochemical industry, British Polymer Journal, 1990, 23(3):193～198
[4]Lai Y. Z., Reactivity and accessibility of cellulose,hemicellulose, and lignins. In: Hon DN-S, editor. Chemical modification of lignocellulosic materials. New York, Basel, Hong Kong: Marcel Dekker,Inc,1996, 35～39
[5]Hoenich N. A., Woffindin C., Stamp S., et al., Synthetically modified cellulose: an alternative to Synthetic membranes for use in haemodialysis, Biomaterials,1997,18:1299～1303
[6]伊秀丽,生物可降解高聚物, 化学与粘合, 1985,3:184～187
[7]Galgut P. N., Oxidized cellulose mesh , Biomaterials, 1990,11(10): 561～567
[8]Depu C., Baoquan S., New tissue engineering material copolymers of derivatives of cellulose and lactide: their synthesis and characterization, Materials Sciences and engineering C,2000,11: 57～60
[9]Okuyama T., Nakaya M., Kobayashi A., et al., Direct extracorporeal blood purification apparatus packed with adsorbent particles, Jpn. Kokai Tokkyo Koho JP 2001204816, 2001, 7
[10]Hata H., Todokoro M., Heparin adsorbents containing polylysine and removal of heparin from blood using them, Jpn, Kokai Tokkyo Koho JP 2001218839,2001,8
[11]Ogino E., Furuyoshi S., Hirai F., et al., Adsorbents for antibodies, adsorption process and apparatus for treatment of dilated cardiomyopathy, Jpn, Kokai Tokkyo Koho JP 2001286554, 2001,10
[12]Gilchrist G.R., Burns M.T., Lyddiatt A., Solid phases for protein adsorption in liquid fluidized beds. In: Pyle D L. eds. Separations for biotechnology, London: Royal society chemistry, 1994,186～192
[13]牟晓红,金京花,庄殷友,羟丙基甲基纤维素酞酸酯假胶乳的制备及应用于消炎痛肠溶包衣片的质量评价,沈阳葑科大学学报,1996,13(3):157～162
[14]Rojas J.A., Rosell C.M., Benedito C., Pasting properties of different wheat flour-hydrocolloid systems, Food Hydrocolloids, 1999,13: 27～33
[15]Kevin C., Michael H., Davidson, et al., Cholesterol lowering with high-viscosity hydroxypropylmethyl cellulose, Am. J. Cardiol .,1999,84:1198～1203
[16]Zhou D., Zhang L., Zhou J., et al., Cellulose/Chitin beads for adsorption of heavy metals in aqueous solution. Water Research, 2004,38(11):2643～2650
[17]Minghua L., Yun D., Huaiyu Z., et al., Adsorption and desorption of copper(Ⅱ)from solutions on new spherical cellulose adsorbent, J. Appl. Polym. Sci., 2002,84(3):478～485
[18]Tsebrenko M.V., Rezanove N. M.,Tsebrenko I.A., Study on properties of high oil absorption resin, Polymer,1999,39:23～25
[19]Bustanante P., Navarro-Lupion J., Escalers B., A new method to determine the partial solubility parameters of polymers from intrinsic viscosity, Eur. J. pharm. Sci., 2005,24(2-3):229～237
[20]Lokhande H.T., Varadarajan P.V., New approach in the production of non-wood-based cellulose superadsorbent through the PAN grafting method, Bioresource Technology: Biomass, Bioenergy, Biowastes, Conversion Technologies, Biotransformations, Production Technologies, 1993,45(3):161～165
[21]Gong R., Sun Y., Chen J., et al., Effect of chemical modification on dye adsorption capacity of peanut hull, Dyes and Pigments, 2005,67(3):175～181
[22]Werbowyj, Rita S., Derek G.., Liquid crystalline structure in aqueous hydroxypropyl cellulose solutions, Mol. Cryst. Liq. cryst., 1976,34(4):97～103
[23]Flory P.J. ,Theory of liquid crystallinity in polymers American Chemical Society, Polymer preprints, Divis. Polym.Chem. ,1983, 24(2):245～250
[24]Atsuko I., Shigenori K., Takeshi D., Determination of parameters in mechanical model for celluloseⅢ fibre, Polymer, 1998,39(10):1878～1895
[25]Rivera-Armenta J.L., Heinza Th.,. Mendoza-Martinez A.M., New polyurethane foams modified with cellulose derivatives, Eur. Polym.J. 2004(40):2803～2812
[26]Hanada, T., Li Y., Nakaya T., Synthesis and hemocompatibilities of cellulose-containing segmented polyurethanes, Macromol. Chem. Phys., 2001,202: 97～104
[27]陈力田, 慢性肾衰竭, 哈尔滨:黑龙江人民出版社,1981,7～103
[28]李士梅主编,临床肾脏病学,上海:上海科学技术出版社,1986,598～650
[29]石妤澍,马腾骧,临床肾脏病学,天津:天津科学技术出版社,1982,26～64
[30]陈灏珠,实用内科学,北京:人民卫生出版社,1997,1755～1765
[31]Vanholder R., De Sment R., Lameire N., Kinetics of HAS adsorption on to activated carbon fibers, Kidney Int.,2001,59(Suppl78):266～270
[32]Depner T.A., A study of oral adsorbent in chronic renal failure, Kidney Int.,1981,20:511～518
[33]Yang J.B., Ling L.C., et al., Preparation and properties of phenolic rensin-based activated carbon spheres with controlled pro size distribution, Carbon, 2002,40:911～916
[34]Perna A.F., Ingrosso D., De Santo N.G., et al., Acute disease of internal medicine, Kidney Int.,1995,47:247～253
[35]Kushner D., Beckman B., Nguyen L., Clinical application progress of serum creatinine concentration, Kidney Int.,1991,39:725～732
[36]Spustova V., Cemay P., Golier I., Artifical kidney,artificial liver and artificial cell, J .Chromatogr.,1989,490:186～192
[37]Cendoroglo M., Jaber B.L., Balakrishnan V., et al.,Adsorption surface area and porosity, J .Am. Soc. Nephrol.,1999,10:93～100
[38]Cumin F., Baurn H.B., Levens N., Leptin is cleared from the circulation primarily by the kidney, Int. J. Obes. 1996,20:1120～1126
[39]Nordfors L., Lonnqvist P., Heiburgur O., et al., Low leptin gene expression and hyperleptinemia in chronic renal failure, Kidney Int. 1998, 54(4):1267～1275
[40]Vokes E.E.,内科学, 北京:人民卫生出版社,1999,879～880
[41]Kerr I.L., Potentials in the delivery of dental care, Annals of Dentistry, 1971,30(4):89～95
[42]余微明, 祁国荣, 代谢, 北京:北京科技出版社,1988,127～128
[43]张彦, 肾脏病治疗实例 49, 世界医学杂志,2002,9(2):31～33
[44]渠源江, 中西医结合治疗尿毒症 76 例分析,实用中医药杂志, 1999,14(4):59～62
[45]Kolff K. J.,Kidney transplant or homedialysis, Postgraduate Medicine,1968, 44(2):93～99
[46]陈可骥,实用中西医结合内科学, 北京:北京医科大学出版社,2000,952～962
[47]杨文友,腹膜透析管阻塞的原因探讨,现代中西医结合杂志,2005,14(2):218～218
[48]汪涛, 腹膜透析的治疗与研究,世界医学杂志,2003,7(9):44～47
[49]Gordon A., Lewin A., Maranta L.B., Sorbent regeneration of dialysate, Kidney International, 1976,10:227～283
[50]Yatzidis H., A convenient hemoperfution microapparatus over charcoal in the treatment of endogenous and exogenous intoxications, Proc. Eur. Dial. Transpl Assoc.,1964,1:83～84
[51]Wagenen V., Steggall M., Lentz DJ., et al., Activated carbons for medical applications, In vitro micropartille characterization and solute adsorption, Biomaterials, Medical, Devices, and Artificial Organs,1975,3(3):319～364
[52]Materazzi S., Gentili A., Curinieral R., The synthesize of ACAC, Thermochimic Acta,1999, 329: 147～156
[53]Thomas M.S.C., Microcapsule artificial kidney: in cluding updated preparative procedures and properties, Kidney Int., 1976,10: 214～218
[54]Kawano, Kurita H., Iwasaki K., et al., Blood compatibility of cellulose hemodialysis membrane grafted with various polymers, Jpn. J. Polym. Sci. Tech., 1998,55(6):334～343
[55]Chandy T., Sharma C.P., Preparation and performance of Chitosan encapsulated activated charcoal adsorbents for small molecules, J. Microencapsulation,1993, 10(4): 475～486
[56]汤先觉,马育,杨晓兰等,血液净化用吸附剂研究-交联琼脂包嵌凸凹棒微囊的制备和性能,生物医学工程学杂志,2000,17(2):235～237
[57]Noro S.I., Ishii F., Saegusa K., The influence of cross-linking time on the adsorption characteristics of microcapsules containing activated charcoal prepared by gelatine-acacia coacervation. Chem. Pharm.Bull.,1985, 33(11):4649～4653
[58]吴肇光,人工肝肾解毒器Ⅰ型的临床应用,上海第一医学院学报,1980,7(5):321～325
[59]黄蔚农,郑文徽, 新型活性炭膜的合成及其吸附性能的研究, 中国生物医学工程学报,1986,5(3):189～194
[60]Chandy T., Sharma C.P., Preparation and performance of Chinosan encapsulated activated charcoal(ACCB)adsorbents for small molecules, Microenapsulation,1993,10(4):475～479
[61]宋燕,凌立成, 沥青基球状活性炭对肌酐吸附行为的研究, 离于交换与吸附1998,13(4):19～20
[62]Yatzidis H., Oreopoulos D., Early Clinical trials with sorbents, Kidney Int.,1976,10:120～125
[63]Sceenivasan K.,Sivakumar R., Interaction of molecularly imprinted polymers with creatinine, J. Appl. Polym. Sci.,1997,66:2539～2542
[64]何炳林,马建标,血液净化高分子吸附材料,高等学校化学学报,1997,18(7):1212～1218
[65]郭贤权,何炳林, 医用活性高分子吸附材料在血液灌流临床应用的进展,离子交换与吸附,1995,11(4):377～382
[66]王秀玲,刘健,桑小红等, HA 型大孔树脂血液灌流治疗慢性肾功能衰竭的临床观察,中华肾脏病杂志,2000,16(2):97～101
[67]Kolff W. J., Modern therapy of uremia by means of artificial kidney, Genoesk gids, 1948, 26:25～35
[68]Bronnima, et al., The studied of a new adsorbent ability, Microenapsulation, 1964, 9(2):68～72
[69]Rosenahum J. L., Biocompatibility of vesin hemoperfusion, Trans. Amer. Soc. Artif .Intern. Organs.,1956,16:134～136
[70]藤田良之,冈崎进, 具有磺酸基的磺化 P-乙烯基苯酚/二乙烯基苯共聚物对尿素的吸附性能的研究,日本化学会志,1987,(8):1530～1534
[71]Tazaki S., Gap series light emitting device substrate and manufacture thereof, 日本专利,6120561,1994, 4
[72]何炳林,宗芳,以交联聚丙稀酸甲酯为载体的多乙烯多胺/铜(Ⅱ)络合物的合成及其对尿素的吸附研究,功能高分于学报,1994,7(1):35～40
[73]袁直,魏斌, 固载 β-环糊精吸附剂的探讨, 高等学校化学学报,2000,21(5):218～224
[74]赵焱,李莉,刘育,多胺修饰β-环糊精及其铜配合物对几种模型底物的分子识别, 高等学校化学学报,2002,23(12):2272～2277
[75]吴文娟,梁月迎,关玉群,β-环糊精聚合物与药物包和作用的研究, 西北药学杂志,2002,17(2):71～72
[76]何炳林,宗芳,马建标,交联聚丙烯酸固载化氧化β-环糊精的合成及其对尿素的吸附性能,中国科学(B辑),1993,239(3):225～229
[77]王红军,马建标,王亦农等, 交联聚丙烯酰胺负载的氧化β-环糊精的合成及其对尿素的吸附性能,离于交换与吸附,1996,12(5):438～442
[78]史林启,赵芬芝,微多相聚氨酯大孔树脂吸附胆红素的研究,离子交换与吸附,1997,13(4):367～372
[79]Shimizu T., Tanaza Y., Yamazaki Y., Sem analysis of surface-treated dialdehydestarch, Biomed. Mater. Res., 1986, 20(2):247～259
[80]Elcin Y. M., Encapsulation of urease enzyme in xanthan-alginate spheres, Biomaterials, 1995,16(15):1157～1161
[81]张建龙,苏良保,肠道吸附剂对中毒性急性肾衰的作用,新疆医学院学报,1994,17(2):75～78
[82]Giordano C., Esposito R., Pluvio M., The effects of oxidized starch on blood and faecal nitrogen uremia, Proc. Eur. Dial. Traspl. Assoc.,1973,10(0):136～142
[83]Giordano C., Esposito R., Pluvio M., Further studies with oxystarch, Kidney Int., 1976, 10(7):266～268
[84]Friedman E.A., Laungani G. B., Beyer, M.M., Life prolongation of anephric rats treated with oxidized starch (OXY) and charcoal, Kidney Int.,1974,6(6): 43A～50 A
[85]Friedman E.A., Laungani G. B., Beyer M.M., Potassium and nitrogen binding in the human gut by ingested oxidized starch(OS), Trans. Am. Soc. Artif., Intern. Organs, 1974, 20:161～167
[86]史启林,余艺华,孙彦,交联壳聚糖树脂的活化及其对 β-环糊精的固载化研究,离子交换与吸收,1999,15(6):531～537
[87]孔阿克 郭长德, 思密达吸附小分子尿毒素物质的实验与临床观察,中华综合医学杂志,2004,6(4):2～4
[88]张晓东,龙世农,刘景林,包醛酶淀粉吸附性能的研究,化学工业与工程,1996,13(3):11～14
[89]Giordano C., Esposito R., Pluvio M.,Oxycellulose and ammonia treated oxystarch as insoluble polyaldehydes in uremia, Kidney Int. 1975,7(3):380～382
[90]Rahn K., Heinze, Cellulosic polymers by subsequent modification of 2,3-dialdehyde cellulose, Cellul. Chem. Technol., 1998,32(3～4):163～173
[91]Browning B.L., Methods of Wood Chemistry, Interscience, London, NewYork,1967, 2: 476～477
[92]Nishiike H., Koo K., Wakida T., Surface characteristics of aramial fibres by sputter etching and oxygen low temperature plasma treatment, Chem. Expres.,1990,5(5):313～316
[93]Shimizu T., Yamazaki Y., Isa I., et al., 口服球型多孔炭微粒吸附剂AST-120 临床研究, 日本化学会志,1985,6:1278～1284
[94]Aoyama I.,Miyazaki T.,Niwa T., Preventive effects of an oral sorbent on nephropathy in rats, Miner. Electrolyte Metab.,1999,25(4-6):365～372
[95]Yamakado M. , Ise M., Mechanism of oral absorbent AST-120 in lipid abnormalities in experimental uremic rats, Kidney Int.,1999,56:190～192
[96]Sanaka T.,Sugino N.,Teraoka S., et al., Therapentic effects of oral sorbent in undialyzed uremia, Am. J. Kidney Dis.,1988,12 (2):97～103
[97]任青,李祖卿,范宏海等, 爱西特片联合心肝宝对慢性肾衰的疗效观察,中国医科大学学报,1996,25(5):530～532
[98]于九皋,杨冬芝,3,5—二硝基苯甲酸淀粉酯的合成及应用, 应用化学, 2002,19(9):858～861
[99] 于 九 皋 , 王 少 敏 , 硝 化 纤 维 素 对 肌 酐 吸 附 机 理 的 研 究 , 有 机 化学,2003,23(9):1033～1035
[100]高英堂,宋继昌,微囊化转基因修饰细胞的研究进展,国外医学生物医学工程分册,1999,22(3):144～148
[101]刘强,慢性肾衰动物实验的评价,国外医学·泌尿系统分册,1994,14(2):69～74
[102]包玉生,慢性肾功能衰竭动物模型,国外医学·泌尿系统分册,1994,14(2):66～69
[103]Platt R., Roscoe M.H., Smith F.W., et.al., Experimental renal failure, Clin. Sci., 1952,11:217～219
[104]Ormord D., Mlltter T., Experimental uremia description of a model producing varying degrees of stable uremia, Nephron, 1980, 26:249～252
[105]Yokozawa T., Zheng P.,Oura H., et al., Animal model of adetine-induce chronic renal failure in rats, Nephron, 1986, 44:230～234
[106]刘燕,冯亚青,李熙风等,氧化纤维素的制备研究,化学工程, 2002,30(6):54～58
[107]Maekawa E., Koshijima T., Properties of 2,3-dicarboxyl cellulose combined with various metalic ions, J. Appl. Polym. Sci., 1984, (29): 2289～2297
[108]孔德领,贾永会,俞耀庭等,固定化血红蛋白氧载体的研究,高等化学化学学报,1998,19(10):1584～1588
[109]Feng Y.Q., Liu Y., Zhang X.D., Preparation of dialdehyde cellulose and its absorption property. Journal of Tianjin University, 2002, 35(6):766～768.
[110]孟舒献,冯亚青,梁足培等,正交试验研究α-纤维素的氧化工艺,化学工业与工程,2004,21(6):5～7
[111] Fan, Q. G., Lewis, D. M., Tapley, K. N., Characterization of cellulose aldehyde using Fourier transform infrared spectroscopy, J. Appl. Polym. Sci., 2001, 82: 1 195～1 202.
[112]Ho Y. S. , Mckay G ., The sorption of lead (Ⅱ) ions on peat, Wat. Res., 1999 , 33 ( 2 ): 578～584
[113]Aksu Z . , Biosorption of reactive dyes by dried activated sludge : equi1ibrium and kinetic modeling, Biochem. Eng .J. , 2001 , 7 : 79 ～84
[114]陶宗普,现代化学试剂手册(第 3 分册),生化试剂(一),北京:化工工业出版社,1998,130～131
[115]李润涛主编,有机官能团的测定,科技出版社,1990,234～234
[116]王连永,类风湿关节炎免疫吸附剂制备及吸附机制研究,南开大学博士论文,南开大学,2002
[117]Gencheva G.., Ivanova I.., Dimeric nickel creatinine complex foemed in anhydrous organic medium, J. Prakt. Chem.,1991,333(4):669～673
[118]Parekh A.C., A new method for the determination of serum creatinine based on reaction with 3,5-dinitrobenzoyl chioride in an orgnanic medium, Clinica Chimica, 1976,73:221～223
[119]Kohashi K., Tsuruta Y., Yamaguchi M., et al., Mechanism of the color reaction of active methylene compounds with 1,3,5,-trinitrobenzene derivatives Ⅺ the Jaffe reaction, Chem. Pharm. Bull, 1979, 27:2122～2129
[120]Bulter A.R., The Jaffe reaction, Identification of the colored species, Clinica Chimica Acta,1975,59(2):227～232
[121]Vasiliades J., Reaction of alkaline sodium picrate with creatinine: 1. kinetics and mechanism of formation of the mono-creatinine picric acid complex, Clin. Chem.,1976,22(10):1664～1671
[122]Blass K.G., The entire Jaffe reaction mechanism, Clin. Biochem., 2000, 33(3): 225～226
[123]阎建辉,唐课文,易健民,非水溶性β-环糊精聚合物气相色谱固定相对异构体的分离研究,化学试剂,2001,23(2):86～88;106
[124]刘育,尤长城,张衡益,超分子化学,天津:南开大学出版社,2001,188～193
[125]赵焱,李莉,刘育,多胺修饰β-环糊精及其铜配合物对几种模型底物的分子识别,高等学校化学学报,2002,23(12):2272～2277
[126]高子伟,赵晓鹏,水溶性β-环糊精聚合物的交联度对 3-羟基-2-萘甲酸荧光性质及电流变性能的影响,化学学报,2004,62(4):418～423
[127]童林荟,环糊精化学—基础与应用,北京:科学出版社,2001,83～84
[128]王永健,张政朴,何炳林,环糊精聚合物的高分子效应,化学进展,2000,12(3):318～324
[129]邢其毅,徐瑞秋,周政编,基础有机化学,北京:高等教育出版社,1983,1081～1082
[130].Liang M.H., Socher S.A., Larson M.G., et al., Reliability and vialidity of six systems for the clinical assessment of disease activity in systemic lupus erythemmal. Arthritis Rheumatism, 1989, 32(9):1107～1115
[131]王顺宝,孙燕,汪良骏等, MTT测定预测人肺癌细胞对化疗药物的敏感性, 实用肿瘤学杂志, 1992, 2:8～12
[132]司徒镇强,吴军正主编,细胞培养, 北京:世界图书出版公司,1996,186～187
[133]徐元钊,蔡幼德,林善谈,实用内科学,北京:人民卫生出版社, l994, 1521～1532
[134]陈香梅,徐启何,王梅等,现代慢性肾衰治疗学, 北京:人民军医出版社,2001,14～19
[135]李 均,何立群,李屹,侯卫国抗纤灵2号对慢性肾衰竭大鼠模型脂质代谢的影响, 中华国际医学杂志, 2003, 3(3):204～206
[136]奚念朱,顾学裘主编,药剂学,北京:人民卫生出版社,1992,271～271
[137]崔极贵,田 莉, 肾康福液对大鼠慢性肾功能衰竭的预防、治疗作用和Ⅱ期临床试验,中国新药与临床杂志,2001, 20(6):437～439
[2]许冬生编,纤维素衍生物,北京:化学工业出版社,2001,3～4
[3]Kennedy,John F., Melo, Bioconversions of cellulose A major source of material for the biochemical industry, British Polymer Journal, 1990, 23(3):193～198
[4]Lai Y. Z., Reactivity and accessibility of cellulose,hemicellulose, and lignins. In: Hon DN-S, editor. Chemical modification of lignocellulosic materials. New York, Basel, Hong Kong: Marcel Dekker,Inc,1996, 35～39
[5]Hoenich N. A., Woffindin C., Stamp S., et al., Synthetically modified cellulose: an alternative to Synthetic membranes for use in haemodialysis, Biomaterials,1997,18:1299～1303
[6]伊秀丽,生物可降解高聚物, 化学与粘合, 1985,3:184～187
[7]Galgut P. N., Oxidized cellulose mesh , Biomaterials, 1990,11(10): 561～567
[8]Depu C., Baoquan S., New tissue engineering material copolymers of derivatives of cellulose and lactide: their synthesis and characterization, Materials Sciences and engineering C,2000,11: 57～60
[9]Okuyama T., Nakaya M., Kobayashi A., et al., Direct extracorporeal blood purification apparatus packed with adsorbent particles, Jpn. Kokai Tokkyo Koho JP 2001204816, 2001, 7
[10]Hata H., Todokoro M., Heparin adsorbents containing polylysine and removal of heparin from blood using them, Jpn, Kokai Tokkyo Koho JP 2001218839,2001,8
[11]Ogino E., Furuyoshi S., Hirai F., et al., Adsorbents for antibodies, adsorption process and apparatus for treatment of dilated cardiomyopathy, Jpn, Kokai Tokkyo Koho JP 2001286554, 2001,10
[12]Gilchrist G.R., Burns M.T., Lyddiatt A., Solid phases for protein adsorption in liquid fluidized beds. In: Pyle D L. eds. Separations for biotechnology, London: Royal society chemistry, 1994,186～192
[13]牟晓红,金京花,庄殷友,羟丙基甲基纤维素酞酸酯假胶乳的制备及应用于消炎痛肠溶包衣片的质量评价,沈阳葑科大学学报,1996,13(3):157～162
[14]Rojas J.A., Rosell C.M., Benedito C., Pasting properties of different wheat flour-hydrocolloid systems, Food Hydrocolloids, 1999,13: 27～33
[15]Kevin C., Michael H., Davidson, et al., Cholesterol lowering with high-viscosity hydroxypropylmethyl cellulose, Am. J. Cardiol .,1999,84:1198～1203
[16]Zhou D., Zhang L., Zhou J., et al., Cellulose/Chitin beads for adsorption of heavy metals in aqueous solution. Water Research, 2004,38(11):2643～2650
[17]Minghua L., Yun D., Huaiyu Z., et al., Adsorption and desorption of copper(Ⅱ)from solutions on new spherical cellulose adsorbent, J. Appl. Polym. Sci., 2002,84(3):478～485
[18]Tsebrenko M.V., Rezanove N. M.,Tsebrenko I.A., Study on properties of high oil absorption resin, Polymer,1999,39:23～25
[19]Bustanante P., Navarro-Lupion J., Escalers B., A new method to determine the partial solubility parameters of polymers from intrinsic viscosity, Eur. J. pharm. Sci., 2005,24(2-3):229～237
[20]Lokhande H.T., Varadarajan P.V., New approach in the production of non-wood-based cellulose superadsorbent through the PAN grafting method, Bioresource Technology: Biomass, Bioenergy, Biowastes, Conversion Technologies, Biotransformations, Production Technologies, 1993,45(3):161～165
[21]Gong R., Sun Y., Chen J., et al., Effect of chemical modification on dye adsorption capacity of peanut hull, Dyes and Pigments, 2005,67(3):175～181
[22]Werbowyj, Rita S., Derek G.., Liquid crystalline structure in aqueous hydroxypropyl cellulose solutions, Mol. Cryst. Liq. cryst., 1976,34(4):97～103
[23]Flory P.J. ,Theory of liquid crystallinity in polymers American Chemical Society, Polymer preprints, Divis. Polym.Chem. ,1983, 24(2):245～250
[24]Atsuko I., Shigenori K., Takeshi D., Determination of parameters in mechanical model for celluloseⅢ fibre, Polymer, 1998,39(10):1878～1895
[25]Rivera-Armenta J.L., Heinza Th.,. Mendoza-Martinez A.M., New polyurethane foams modified with cellulose derivatives, Eur. Polym.J. 2004(40):2803～2812
[26]Hanada, T., Li Y., Nakaya T., Synthesis and hemocompatibilities of cellulose-containing segmented polyurethanes, Macromol. Chem. Phys., 2001,202: 97～104
[27]陈力田, 慢性肾衰竭, 哈尔滨:黑龙江人民出版社,1981,7～103
[28]李士梅主编,临床肾脏病学,上海:上海科学技术出版社,1986,598～650
[29]石妤澍,马腾骧,临床肾脏病学,天津:天津科学技术出版社,1982,26～64
[30]陈灏珠,实用内科学,北京:人民卫生出版社,1997,1755～1765
[31]Vanholder R., De Sment R., Lameire N., Kinetics of HAS adsorption on to activated carbon fibers, Kidney Int.,2001,59(Suppl78):266～270
[32]Depner T.A., A study of oral adsorbent in chronic renal failure, Kidney Int.,1981,20:511～518
[33]Yang J.B., Ling L.C., et al., Preparation and properties of phenolic rensin-based activated carbon spheres with controlled pro size distribution, Carbon, 2002,40:911～916
[34]Perna A.F., Ingrosso D., De Santo N.G., et al., Acute disease of internal medicine, Kidney Int.,1995,47:247～253
[35]Kushner D., Beckman B., Nguyen L., Clinical application progress of serum creatinine concentration, Kidney Int.,1991,39:725～732
[36]Spustova V., Cemay P., Golier I., Artifical kidney,artificial liver and artificial cell, J .Chromatogr.,1989,490:186～192
[37]Cendoroglo M., Jaber B.L., Balakrishnan V., et al.,Adsorption surface area and porosity, J .Am. Soc. Nephrol.,1999,10:93～100
[38]Cumin F., Baurn H.B., Levens N., Leptin is cleared from the circulation primarily by the kidney, Int. J. Obes. 1996,20:1120～1126
[39]Nordfors L., Lonnqvist P., Heiburgur O., et al., Low leptin gene expression and hyperleptinemia in chronic renal failure, Kidney Int. 1998, 54(4):1267～1275
[40]Vokes E.E.,内科学, 北京:人民卫生出版社,1999,879～880
[41]Kerr I.L., Potentials in the delivery of dental care, Annals of Dentistry, 1971,30(4):89～95
[42]余微明, 祁国荣, 代谢, 北京:北京科技出版社,1988,127～128
[43]张彦, 肾脏病治疗实例 49, 世界医学杂志,2002,9(2):31～33
[44]渠源江, 中西医结合治疗尿毒症 76 例分析,实用中医药杂志, 1999,14(4):59～62
[45]Kolff K. J.,Kidney transplant or homedialysis, Postgraduate Medicine,1968, 44(2):93～99
[46]陈可骥,实用中西医结合内科学, 北京:北京医科大学出版社,2000,952～962
[47]杨文友,腹膜透析管阻塞的原因探讨,现代中西医结合杂志,2005,14(2):218～218
[48]汪涛, 腹膜透析的治疗与研究,世界医学杂志,2003,7(9):44～47
[49]Gordon A., Lewin A., Maranta L.B., Sorbent regeneration of dialysate, Kidney International, 1976,10:227～283
[50]Yatzidis H., A convenient hemoperfution microapparatus over charcoal in the treatment of endogenous and exogenous intoxications, Proc. Eur. Dial. Transpl Assoc.,1964,1:83～84
[51]Wagenen V., Steggall M., Lentz DJ., et al., Activated carbons for medical applications, In vitro micropartille characterization and solute adsorption, Biomaterials, Medical, Devices, and Artificial Organs,1975,3(3):319～364
[52]Materazzi S., Gentili A., Curinieral R., The synthesize of ACAC, Thermochimic Acta,1999, 329: 147～156
[53]Thomas M.S.C., Microcapsule artificial kidney: in cluding updated preparative procedures and properties, Kidney Int., 1976,10: 214～218
[54]Kawano, Kurita H., Iwasaki K., et al., Blood compatibility of cellulose hemodialysis membrane grafted with various polymers, Jpn. J. Polym. Sci. Tech., 1998,55(6):334～343
[55]Chandy T., Sharma C.P., Preparation and performance of Chitosan encapsulated activated charcoal adsorbents for small molecules, J. Microencapsulation,1993, 10(4): 475～486
[56]汤先觉,马育,杨晓兰等,血液净化用吸附剂研究-交联琼脂包嵌凸凹棒微囊的制备和性能,生物医学工程学杂志,2000,17(2):235～237
[57]Noro S.I., Ishii F., Saegusa K., The influence of cross-linking time on the adsorption characteristics of microcapsules containing activated charcoal prepared by gelatine-acacia coacervation. Chem. Pharm.Bull.,1985, 33(11):4649～4653
[58]吴肇光,人工肝肾解毒器Ⅰ型的临床应用,上海第一医学院学报,1980,7(5):321～325
[59]黄蔚农,郑文徽, 新型活性炭膜的合成及其吸附性能的研究, 中国生物医学工程学报,1986,5(3):189～194
[60]Chandy T., Sharma C.P., Preparation and performance of Chinosan encapsulated activated charcoal(ACCB)adsorbents for small molecules, Microenapsulation,1993,10(4):475～479
[61]宋燕,凌立成, 沥青基球状活性炭对肌酐吸附行为的研究, 离于交换与吸附1998,13(4):19～20
[62]Yatzidis H., Oreopoulos D., Early Clinical trials with sorbents, Kidney Int.,1976,10:120～125
[63]Sceenivasan K.,Sivakumar R., Interaction of molecularly imprinted polymers with creatinine, J. Appl. Polym. Sci.,1997,66:2539～2542
[64]何炳林,马建标,血液净化高分子吸附材料,高等学校化学学报,1997,18(7):1212～1218
[65]郭贤权,何炳林, 医用活性高分子吸附材料在血液灌流临床应用的进展,离子交换与吸附,1995,11(4):377～382
[66]王秀玲,刘健,桑小红等, HA 型大孔树脂血液灌流治疗慢性肾功能衰竭的临床观察,中华肾脏病杂志,2000,16(2):97～101
[67]Kolff W. J., Modern therapy of uremia by means of artificial kidney, Genoesk gids, 1948, 26:25～35
[68]Bronnima, et al., The studied of a new adsorbent ability, Microenapsulation, 1964, 9(2):68～72
[69]Rosenahum J. L., Biocompatibility of vesin hemoperfusion, Trans. Amer. Soc. Artif .Intern. Organs.,1956,16:134～136
[70]藤田良之,冈崎进, 具有磺酸基的磺化 P-乙烯基苯酚/二乙烯基苯共聚物对尿素的吸附性能的研究,日本化学会志,1987,(8):1530～1534
[71]Tazaki S., Gap series light emitting device substrate and manufacture thereof, 日本专利,6120561,1994, 4
[72]何炳林,宗芳,以交联聚丙稀酸甲酯为载体的多乙烯多胺/铜(Ⅱ)络合物的合成及其对尿素的吸附研究,功能高分于学报,1994,7(1):35～40
[73]袁直,魏斌, 固载 β-环糊精吸附剂的探讨, 高等学校化学学报,2000,21(5):218～224
[74]赵焱,李莉,刘育,多胺修饰β-环糊精及其铜配合物对几种模型底物的分子识别, 高等学校化学学报,2002,23(12):2272～2277
[75]吴文娟,梁月迎,关玉群,β-环糊精聚合物与药物包和作用的研究, 西北药学杂志,2002,17(2):71～72
[76]何炳林,宗芳,马建标,交联聚丙烯酸固载化氧化β-环糊精的合成及其对尿素的吸附性能,中国科学(B辑),1993,239(3):225～229
[77]王红军,马建标,王亦农等, 交联聚丙烯酰胺负载的氧化β-环糊精的合成及其对尿素的吸附性能,离于交换与吸附,1996,12(5):438～442
[78]史林启,赵芬芝,微多相聚氨酯大孔树脂吸附胆红素的研究,离子交换与吸附,1997,13(4):367～372
[79]Shimizu T., Tanaza Y., Yamazaki Y., Sem analysis of surface-treated dialdehydestarch, Biomed. Mater. Res., 1986, 20(2):247～259
[80]Elcin Y. M., Encapsulation of urease enzyme in xanthan-alginate spheres, Biomaterials, 1995,16(15):1157～1161
[81]张建龙,苏良保,肠道吸附剂对中毒性急性肾衰的作用,新疆医学院学报,1994,17(2):75～78
[82]Giordano C., Esposito R., Pluvio M., The effects of oxidized starch on blood and faecal nitrogen uremia, Proc. Eur. Dial. Traspl. Assoc.,1973,10(0):136～142
[83]Giordano C., Esposito R., Pluvio M., Further studies with oxystarch, Kidney Int., 1976, 10(7):266～268
[84]Friedman E.A., Laungani G. B., Beyer, M.M., Life prolongation of anephric rats treated with oxidized starch (OXY) and charcoal, Kidney Int.,1974,6(6): 43A～50 A
[85]Friedman E.A., Laungani G. B., Beyer M.M., Potassium and nitrogen binding in the human gut by ingested oxidized starch(OS), Trans. Am. Soc. Artif., Intern. Organs, 1974, 20:161～167
[86]史启林,余艺华,孙彦,交联壳聚糖树脂的活化及其对 β-环糊精的固载化研究,离子交换与吸收,1999,15(6):531～537
[87]孔阿克 郭长德, 思密达吸附小分子尿毒素物质的实验与临床观察,中华综合医学杂志,2004,6(4):2～4
[88]张晓东,龙世农,刘景林,包醛酶淀粉吸附性能的研究,化学工业与工程,1996,13(3):11～14
[89]Giordano C., Esposito R., Pluvio M.,Oxycellulose and ammonia treated oxystarch as insoluble polyaldehydes in uremia, Kidney Int. 1975,7(3):380～382
[90]Rahn K., Heinze, Cellulosic polymers by subsequent modification of 2,3-dialdehyde cellulose, Cellul. Chem. Technol., 1998,32(3～4):163～173
[91]Browning B.L., Methods of Wood Chemistry, Interscience, London, NewYork,1967, 2: 476～477
[92]Nishiike H., Koo K., Wakida T., Surface characteristics of aramial fibres by sputter etching and oxygen low temperature plasma treatment, Chem. Expres.,1990,5(5):313～316
[93]Shimizu T., Yamazaki Y., Isa I., et al., 口服球型多孔炭微粒吸附剂AST-120 临床研究, 日本化学会志,1985,6:1278～1284
[94]Aoyama I.,Miyazaki T.,Niwa T., Preventive effects of an oral sorbent on nephropathy in rats, Miner. Electrolyte Metab.,1999,25(4-6):365～372
[95]Yamakado M. , Ise M., Mechanism of oral absorbent AST-120 in lipid abnormalities in experimental uremic rats, Kidney Int.,1999,56:190～192
[96]Sanaka T.,Sugino N.,Teraoka S., et al., Therapentic effects of oral sorbent in undialyzed uremia, Am. J. Kidney Dis.,1988,12 (2):97～103
[97]任青,李祖卿,范宏海等, 爱西特片联合心肝宝对慢性肾衰的疗效观察,中国医科大学学报,1996,25(5):530～532
[98]于九皋,杨冬芝,3,5—二硝基苯甲酸淀粉酯的合成及应用, 应用化学, 2002,19(9):858～861
[99] 于 九 皋 , 王 少 敏 , 硝 化 纤 维 素 对 肌 酐 吸 附 机 理 的 研 究 , 有 机 化学,2003,23(9):1033～1035
[100]高英堂,宋继昌,微囊化转基因修饰细胞的研究进展,国外医学生物医学工程分册,1999,22(3):144～148
[101]刘强,慢性肾衰动物实验的评价,国外医学·泌尿系统分册,1994,14(2):69～74
[102]包玉生,慢性肾功能衰竭动物模型,国外医学·泌尿系统分册,1994,14(2):66～69
[103]Platt R., Roscoe M.H., Smith F.W., et.al., Experimental renal failure, Clin. Sci., 1952,11:217～219
[104]Ormord D., Mlltter T., Experimental uremia description of a model producing varying degrees of stable uremia, Nephron, 1980, 26:249～252
[105]Yokozawa T., Zheng P.,Oura H., et al., Animal model of adetine-induce chronic renal failure in rats, Nephron, 1986, 44:230～234
[106]刘燕,冯亚青,李熙风等,氧化纤维素的制备研究,化学工程, 2002,30(6):54～58
[107]Maekawa E., Koshijima T., Properties of 2,3-dicarboxyl cellulose combined with various metalic ions, J. Appl. Polym. Sci., 1984, (29): 2289～2297
[108]孔德领,贾永会,俞耀庭等,固定化血红蛋白氧载体的研究,高等化学化学学报,1998,19(10):1584～1588
[109]Feng Y.Q., Liu Y., Zhang X.D., Preparation of dialdehyde cellulose and its absorption property. Journal of Tianjin University, 2002, 35(6):766～768.
[110]孟舒献,冯亚青,梁足培等,正交试验研究α-纤维素的氧化工艺,化学工业与工程,2004,21(6):5～7
[111] Fan, Q. G., Lewis, D. M., Tapley, K. N., Characterization of cellulose aldehyde using Fourier transform infrared spectroscopy, J. Appl. Polym. Sci., 2001, 82: 1 195～1 202.
[112]Ho Y. S. , Mckay G ., The sorption of lead (Ⅱ) ions on peat, Wat. Res., 1999 , 33 ( 2 ): 578～584
[113]Aksu Z . , Biosorption of reactive dyes by dried activated sludge : equi1ibrium and kinetic modeling, Biochem. Eng .J. , 2001 , 7 : 79 ～84
[114]陶宗普,现代化学试剂手册(第 3 分册),生化试剂(一),北京:化工工业出版社,1998,130～131
[115]李润涛主编,有机官能团的测定,科技出版社,1990,234～234
[116]王连永,类风湿关节炎免疫吸附剂制备及吸附机制研究,南开大学博士论文,南开大学,2002
[117]Gencheva G.., Ivanova I.., Dimeric nickel creatinine complex foemed in anhydrous organic medium, J. Prakt. Chem.,1991,333(4):669～673
[118]Parekh A.C., A new method for the determination of serum creatinine based on reaction with 3,5-dinitrobenzoyl chioride in an orgnanic medium, Clinica Chimica, 1976,73:221～223
[119]Kohashi K., Tsuruta Y., Yamaguchi M., et al., Mechanism of the color reaction of active methylene compounds with 1,3,5,-trinitrobenzene derivatives Ⅺ the Jaffe reaction, Chem. Pharm. Bull, 1979, 27:2122～2129
[120]Bulter A.R., The Jaffe reaction, Identification of the colored species, Clinica Chimica Acta,1975,59(2):227～232
[121]Vasiliades J., Reaction of alkaline sodium picrate with creatinine: 1. kinetics and mechanism of formation of the mono-creatinine picric acid complex, Clin. Chem.,1976,22(10):1664～1671
[122]Blass K.G., The entire Jaffe reaction mechanism, Clin. Biochem., 2000, 33(3): 225～226
[123]阎建辉,唐课文,易健民,非水溶性β-环糊精聚合物气相色谱固定相对异构体的分离研究,化学试剂,2001,23(2):86～88;106
[124]刘育,尤长城,张衡益,超分子化学,天津:南开大学出版社,2001,188～193
[125]赵焱,李莉,刘育,多胺修饰β-环糊精及其铜配合物对几种模型底物的分子识别,高等学校化学学报,2002,23(12):2272～2277
[126]高子伟,赵晓鹏,水溶性β-环糊精聚合物的交联度对 3-羟基-2-萘甲酸荧光性质及电流变性能的影响,化学学报,2004,62(4):418～423
[127]童林荟,环糊精化学—基础与应用,北京:科学出版社,2001,83～84
[128]王永健,张政朴,何炳林,环糊精聚合物的高分子效应,化学进展,2000,12(3):318～324
[129]邢其毅,徐瑞秋,周政编,基础有机化学,北京:高等教育出版社,1983,1081～1082
[130].Liang M.H., Socher S.A., Larson M.G., et al., Reliability and vialidity of six systems for the clinical assessment of disease activity in systemic lupus erythemmal. Arthritis Rheumatism, 1989, 32(9):1107～1115
[131]王顺宝,孙燕,汪良骏等, MTT测定预测人肺癌细胞对化疗药物的敏感性, 实用肿瘤学杂志, 1992, 2:8～12
[132]司徒镇强,吴军正主编,细胞培养, 北京:世界图书出版公司,1996,186～187
[133]徐元钊,蔡幼德,林善谈,实用内科学,北京:人民卫生出版社, l994, 1521～1532
[134]陈香梅,徐启何,王梅等,现代慢性肾衰治疗学, 北京:人民军医出版社,2001,14～19
[135]李 均,何立群,李屹,侯卫国抗纤灵2号对慢性肾衰竭大鼠模型脂质代谢的影响, 中华国际医学杂志, 2003, 3(3):204～206
[136]奚念朱,顾学裘主编,药剂学,北京:人民卫生出版社,1992,271～271
[137]崔极贵,田 莉, 肾康福液对大鼠慢性肾功能衰竭的预防、治疗作用和Ⅱ期临床试验,中国新药与临床杂志,2001, 20(6):437～439