不同配穴法针刺对大鼠急性胃黏膜损伤保护作用的研究
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摘要
目的：采用“本经配穴法”,“表里经配穴法”,“同名经配穴法”,“他经配穴法”选穴观察针刺对急性胃黏膜损伤大鼠的保护效应,从胃黏膜的组织形态学、前列腺素E2(PGE2)、生长抑素(SS)、胃动素(MTL)、肿瘤坏死因子(TNF-α)和表皮生长因子(EGF)、转化生长因子α(TGF-α)的表达比较不同配穴法针刺对大鼠胃黏膜损伤的保护差异。为经脉(穴)脏腑的内在联系及不同配穴法的针灸临床处方提供实验依据。
方法：将SD大鼠60只随机分为6组,每组10只。即：空白组(A组),模型组(B组),本经配穴组(C组针刺足三里、冲阳穴),表里经配穴组(D组针刺足三里、太白穴),同名经配穴组(E组针刺足三里、合谷穴),他经配穴组(F组针刺承筋、京骨穴)。采用无水乙醇灌胃法制作急性胃黏膜损伤模型,按Guth法记录大鼠胃黏膜损伤指数,光镜下观察胃黏膜组织形态学变化；放射免疫法测定PGE2、SS.MTL、TNF-α；免疫组化法检测胃黏膜EGF和TGF-α的表达。
结果：①模型组及各针刺组大鼠与空白组比较胃黏膜损伤指数升高,其中模型组、表里经配穴组、他经配穴组升高更明显(P<0.01或P<0.05)；本经配穴组、表里经配穴组、同名经配穴组与模型组比较胃黏膜损伤指数显著降低(P<0.05),他经配穴组回降不明显；同名经配穴组与他经配穴组比较,胃黏膜损伤指数降低更明显(P<0.05)。
②肉眼及显微镜观察大鼠胃黏膜,结果显示：本经配穴组、表里经配穴组、同名经配穴组胃黏膜色泽红润,略有少数点状出血,上皮基本完整,腺体排列较整齐,少量炎细胞浸润,胃黏膜无充血或充血较轻微。模型组及他经配穴组大鼠胃黏膜充血、水肿,可见点状出血和糜烂,上皮不完整,腺体受损,结构紊乱,细胞排列无序,胞核胞质模糊,毛细血管增生及出血,可见大量炎性细胞浸润。
③模型组、各针刺组大鼠与空白组比较胃黏膜及血浆PGE2含量无明显差异；各针刺组与模型组比较,仅见本经配穴组胃黏膜及血浆PGE2含量升高(P<0.05)；本经配穴组与他经配穴组比较血浆PGE2含量升高明显(P<0.05),其他针刺组之间比较未见明显差异。
模型组、表里经配穴组、同名经配穴组、他经配穴组大鼠与空白组比较胃黏膜SS含量显著降低(P<0.01)；本经配穴组、表里经配穴组、同名经配穴组大鼠与模型组比较胃黏膜及血浆SS含量均显著升高(P<0.05或P<0.01),其中本经配穴组血浆SS含量升高明显强于表里经配穴组、同名经配穴组及他经配穴组(P<0.01)。
模型组、各针刺组大鼠与空白组比较胃黏膜及血浆TNF-α含量明显升高(P<0.05或P<0.01),本经配穴组、表里经配穴组、同名经配穴组大鼠与模型组、他经配穴组比较胃黏膜及血浆TNF-α含量均显著降低(P<0.01),其中本经配穴组、表里经配穴组血浆TNF-α含量与同名经配穴组比较降低更为明显(P<0.05或P<0.01)。
各组胃黏膜及血浆MTL含量未见明显差异。
④各组大鼠均可检测到胃黏膜EGF、TGF-α的表达,阳性表达主要集中在胃腺部。本经配穴组、表里经配穴组均能上调EGF的表达,与空白组、模型组、同名经配穴组、他经配穴组比较差异均具有显著性意义(P<0.05或P<0.01)。本经配穴组能上调TGF-α的表达,与空白组、模型组、同名经配穴组、他经配穴组比较差异具有显著性意义(P<0.05或P<0.01)。
结论：①大鼠急性胃黏膜损伤7d后,胃黏膜损伤指数升高,胃黏膜SS含量显著降低,胃黏膜及血浆TNF-α含量明显升高,提示上述物质的异常变化与酒精性胃黏膜损伤的病理机制有关。
②本经配穴组、表里经配穴组、同名经配穴组均能降低胃黏膜损伤大鼠胃黏膜损伤指数,改善胃黏膜组织形态学的病理变化,他经配穴组大鼠组织形态学变化不明显,说明三种相关经脉配穴针刺均可促进大鼠胃黏膜损伤的修复,而他经配穴针刺作用不明显。
③“本经配穴法”,“表里经配穴法”,“同名经配穴法”选穴针刺对大鼠急性胃黏膜损伤修复的作用机制可能与抑制炎性介质TNF-α释放,促进内源性保护物质PGE2、SS合成、促进EGF和TGF-α在胃黏膜的表达有关且存在差异,他经配穴组的对上述调整作用不明显。本经配穴法的保护效应与这三个方面均相关,表里经配穴法可能更侧重于调整TNF-α、SS的合成、释放及促进EGF的表达,同名经配穴法可能更侧重于调整TNF-α、SS的合成、释放。其作用差异机理有待继续研究。
Objective:To observe the effect on PGE2, SS, MTL, TNF-a, EGF, TGF-a, and histological changes of acute gastric mucosal lesion rats treated by different acupoint combination groups, and to analyze the protective effect of them.
Method:60 SD rats were divided randomly into 6 groups,10 rats each group. Group A was blank control group. Group B was model group. Rats in group C (combining points on the same meridians) was electroacupunctured in Zusanli and Chongyang. Rats in group D (combining points on the exteriorly-interiorly related meridians) was electroacupunctured in Zusanli and Taibai. Rats in group E (combining points on the meridians sharing the same name) was electroacupunctured in Zusanli and Hegu. Rats in group F (combining points on the unrelated meridians) was electroacupunctured in Chengjin and Jinggu. Acute gastric mucosal lesion rat model was built by ethanol ingestion. Gastric mucosal lesion index was recorded and histological changes of gastric mucosal tissues were observed under microscope. Radioimmunoassay was used to determine contents of PGE2、SS、MTL、TNF-α, and Immunohistochemistry for expression of EGF and TGF-α.
Results:①Compared with blank control group, UI was increased in other 5 groups, especially in group B, D, and F (P<0.05 or P<0.01). Compared with model group, UI was decreased in group C, D, E (P<0.05), no significant decrease in group F. Compared with group F, UI was decreased in group E (P<0.05).
②In group C, D, and E, gastric mucosa looked bloom, few punctuate hemorrhage, epithelium tissue was integrated, glandular organs was regular, few inflammatory cell infiltration, gastric mucosa was lightly congestive. In model group, and group F, gastric mucosa was congestive, dropsied, punctuate hemorrhage and erosion, epithelium tissue was incomplete, glandular organs was damaged and disorder, nucleocytoplasmic was fuzzy, capillary proliferation, Substantial inflammatory cell infiltration.
③Compared with group A, content of PGE2 were similar in each group. Compared with group B and F, content of PGE2 increased in group C (P<0.05).
Content of SS was decreased in group B, D, E, F, compared with group A (P<0.01). compared with group B, content of SS was obviously increased in group C, D, E (P<0.05 or P<0.01), and that in group C was obviously higher than group D, E, F (P<0.01)
Compared with group A, content of TNF-αwas increased in group B, C, D, E, F (P<0.05 or P<0.01). Compared with group B and F, that was decreased in group C, D, E (P<0.01), and that in group C, D was obviously lower than group E (P<0.05 or P<0.01)
No significant difference showed in content of MTL in each group.④EGF, TGF-αexpressed in gastric mucosa of every group, located mainly in gastric gland. Compared with other groups, EGF expression was increased obviously in group C, D (P<0.01 or P<0.05). Compared with other 5 groups, TGF-a expression was increased obviously in group C (P<0.01 or P<0.05)。
Conclusion:
①7 days after acute gastric mucosal lesion, UI was increased, content of GM rats SS was descended, and TNF-αof gastric mucosa and plasma was increased. There might be some relationship between abnormity of SS and TNF-αwith GM pathomechanism.
②Reparation effect on GM showed in 3 kind of point combination:acupoints of same Meridians, acupoints of Exteriorly-Interiorly Related Meridians, acupoints of Meridians Sharing the Same Name. But no significant effect showed in unrelated points.
③The reparation effect of acupoints of the Same Meridians might be to inhibit TNF-αrelease, promote PGE2, SS synthesis, and promote expression of EGF and TNF-αin gastric mucosa. The reparation effect of acupoints of the Exteriorly-Interiorly Related Meridians might be to regulate TNF-αand SS synthesis, promote expression of EGF. The reparation effect of acupoints of the Meridians Sharing the Same Name might be to regulate TNF-αand SS synthesis and release.
方法：将SD大鼠60只随机分为6组,每组10只。即：空白组(A组),模型组(B组),本经配穴组(C组针刺足三里、冲阳穴),表里经配穴组(D组针刺足三里、太白穴),同名经配穴组(E组针刺足三里、合谷穴),他经配穴组(F组针刺承筋、京骨穴)。采用无水乙醇灌胃法制作急性胃黏膜损伤模型,按Guth法记录大鼠胃黏膜损伤指数,光镜下观察胃黏膜组织形态学变化；放射免疫法测定PGE2、SS.MTL、TNF-α；免疫组化法检测胃黏膜EGF和TGF-α的表达。
结果：①模型组及各针刺组大鼠与空白组比较胃黏膜损伤指数升高,其中模型组、表里经配穴组、他经配穴组升高更明显(P<0.01或P<0.05)；本经配穴组、表里经配穴组、同名经配穴组与模型组比较胃黏膜损伤指数显著降低(P<0.05),他经配穴组回降不明显；同名经配穴组与他经配穴组比较,胃黏膜损伤指数降低更明显(P<0.05)。
②肉眼及显微镜观察大鼠胃黏膜,结果显示：本经配穴组、表里经配穴组、同名经配穴组胃黏膜色泽红润,略有少数点状出血,上皮基本完整,腺体排列较整齐,少量炎细胞浸润,胃黏膜无充血或充血较轻微。模型组及他经配穴组大鼠胃黏膜充血、水肿,可见点状出血和糜烂,上皮不完整,腺体受损,结构紊乱,细胞排列无序,胞核胞质模糊,毛细血管增生及出血,可见大量炎性细胞浸润。
③模型组、各针刺组大鼠与空白组比较胃黏膜及血浆PGE2含量无明显差异；各针刺组与模型组比较,仅见本经配穴组胃黏膜及血浆PGE2含量升高(P<0.05)；本经配穴组与他经配穴组比较血浆PGE2含量升高明显(P<0.05),其他针刺组之间比较未见明显差异。
模型组、表里经配穴组、同名经配穴组、他经配穴组大鼠与空白组比较胃黏膜SS含量显著降低(P<0.01)；本经配穴组、表里经配穴组、同名经配穴组大鼠与模型组比较胃黏膜及血浆SS含量均显著升高(P<0.05或P<0.01),其中本经配穴组血浆SS含量升高明显强于表里经配穴组、同名经配穴组及他经配穴组(P<0.01)。
模型组、各针刺组大鼠与空白组比较胃黏膜及血浆TNF-α含量明显升高(P<0.05或P<0.01),本经配穴组、表里经配穴组、同名经配穴组大鼠与模型组、他经配穴组比较胃黏膜及血浆TNF-α含量均显著降低(P<0.01),其中本经配穴组、表里经配穴组血浆TNF-α含量与同名经配穴组比较降低更为明显(P<0.05或P<0.01)。
各组胃黏膜及血浆MTL含量未见明显差异。
④各组大鼠均可检测到胃黏膜EGF、TGF-α的表达,阳性表达主要集中在胃腺部。本经配穴组、表里经配穴组均能上调EGF的表达,与空白组、模型组、同名经配穴组、他经配穴组比较差异均具有显著性意义(P<0.05或P<0.01)。本经配穴组能上调TGF-α的表达,与空白组、模型组、同名经配穴组、他经配穴组比较差异具有显著性意义(P<0.05或P<0.01)。
结论：①大鼠急性胃黏膜损伤7d后,胃黏膜损伤指数升高,胃黏膜SS含量显著降低,胃黏膜及血浆TNF-α含量明显升高,提示上述物质的异常变化与酒精性胃黏膜损伤的病理机制有关。
②本经配穴组、表里经配穴组、同名经配穴组均能降低胃黏膜损伤大鼠胃黏膜损伤指数,改善胃黏膜组织形态学的病理变化,他经配穴组大鼠组织形态学变化不明显,说明三种相关经脉配穴针刺均可促进大鼠胃黏膜损伤的修复,而他经配穴针刺作用不明显。
③“本经配穴法”,“表里经配穴法”,“同名经配穴法”选穴针刺对大鼠急性胃黏膜损伤修复的作用机制可能与抑制炎性介质TNF-α释放,促进内源性保护物质PGE2、SS合成、促进EGF和TGF-α在胃黏膜的表达有关且存在差异,他经配穴组的对上述调整作用不明显。本经配穴法的保护效应与这三个方面均相关,表里经配穴法可能更侧重于调整TNF-α、SS的合成、释放及促进EGF的表达,同名经配穴法可能更侧重于调整TNF-α、SS的合成、释放。其作用差异机理有待继续研究。
Objective:To observe the effect on PGE2, SS, MTL, TNF-a, EGF, TGF-a, and histological changes of acute gastric mucosal lesion rats treated by different acupoint combination groups, and to analyze the protective effect of them.
Method:60 SD rats were divided randomly into 6 groups,10 rats each group. Group A was blank control group. Group B was model group. Rats in group C (combining points on the same meridians) was electroacupunctured in Zusanli and Chongyang. Rats in group D (combining points on the exteriorly-interiorly related meridians) was electroacupunctured in Zusanli and Taibai. Rats in group E (combining points on the meridians sharing the same name) was electroacupunctured in Zusanli and Hegu. Rats in group F (combining points on the unrelated meridians) was electroacupunctured in Chengjin and Jinggu. Acute gastric mucosal lesion rat model was built by ethanol ingestion. Gastric mucosal lesion index was recorded and histological changes of gastric mucosal tissues were observed under microscope. Radioimmunoassay was used to determine contents of PGE2、SS、MTL、TNF-α, and Immunohistochemistry for expression of EGF and TGF-α.
Results:①Compared with blank control group, UI was increased in other 5 groups, especially in group B, D, and F (P<0.05 or P<0.01). Compared with model group, UI was decreased in group C, D, E (P<0.05), no significant decrease in group F. Compared with group F, UI was decreased in group E (P<0.05).
②In group C, D, and E, gastric mucosa looked bloom, few punctuate hemorrhage, epithelium tissue was integrated, glandular organs was regular, few inflammatory cell infiltration, gastric mucosa was lightly congestive. In model group, and group F, gastric mucosa was congestive, dropsied, punctuate hemorrhage and erosion, epithelium tissue was incomplete, glandular organs was damaged and disorder, nucleocytoplasmic was fuzzy, capillary proliferation, Substantial inflammatory cell infiltration.
③Compared with group A, content of PGE2 were similar in each group. Compared with group B and F, content of PGE2 increased in group C (P<0.05).
Content of SS was decreased in group B, D, E, F, compared with group A (P<0.01). compared with group B, content of SS was obviously increased in group C, D, E (P<0.05 or P<0.01), and that in group C was obviously higher than group D, E, F (P<0.01)
Compared with group A, content of TNF-αwas increased in group B, C, D, E, F (P<0.05 or P<0.01). Compared with group B and F, that was decreased in group C, D, E (P<0.01), and that in group C, D was obviously lower than group E (P<0.05 or P<0.01)
No significant difference showed in content of MTL in each group.④EGF, TGF-αexpressed in gastric mucosa of every group, located mainly in gastric gland. Compared with other groups, EGF expression was increased obviously in group C, D (P<0.01 or P<0.05). Compared with other 5 groups, TGF-a expression was increased obviously in group C (P<0.01 or P<0.05)。
Conclusion:
①7 days after acute gastric mucosal lesion, UI was increased, content of GM rats SS was descended, and TNF-αof gastric mucosa and plasma was increased. There might be some relationship between abnormity of SS and TNF-αwith GM pathomechanism.
②Reparation effect on GM showed in 3 kind of point combination:acupoints of same Meridians, acupoints of Exteriorly-Interiorly Related Meridians, acupoints of Meridians Sharing the Same Name. But no significant effect showed in unrelated points.
③The reparation effect of acupoints of the Same Meridians might be to inhibit TNF-αrelease, promote PGE2, SS synthesis, and promote expression of EGF and TNF-αin gastric mucosa. The reparation effect of acupoints of the Exteriorly-Interiorly Related Meridians might be to regulate TNF-αand SS synthesis, promote expression of EGF. The reparation effect of acupoints of the Meridians Sharing the Same Name might be to regulate TNF-αand SS synthesis and release.
引文
[1]刘俊岭,陈振荣.“九五”国家攀登计划预选项目“经络的研究”进展.针刺研究.2002；27(3)：230-237
[2]周美启,周逸平,汪克明,等.基因芯片技术在经脉脏腑相关研究中的应用思考.中国针灸.2005；25(3)：197-200)
[3]Junfeng He,jie Yan,Xiaorong Chang, et al. Neurons in the NTS of Rat Response to Gastric Distention Stimalation and Acupuncture at Body Surface Points.AJCM.2006;34(3):427-433
[4]严洁,黎喜平,易受乡,等.电针对应激性胃黏膜损伤大鼠胃黏膜肠三叶因子基因表达的影响.中国针灸.2006；26(1)：66-68
[5]林亚平,易受乡,严洁,等.电针四白、天枢、足三里穴对胃黏膜损伤大鼠的胃黏膜血流量及生长抑素的影响.中国中西结合消化杂志.2003；11(2)：75-77
[6]张泓,易受乡,严洁,等.电针足三阳经穴对家兔脑肠肽类物质影响的比较研究.中国临床康复.2004；(12)：2290-2291)
[7]电针大鼠胃经后血清对其胃黏膜细胞表皮生长因子受体表达的影响及浓度效应。中国临床康复.2006；10(35)：87-89
[8]电针胃经(穴)血清对胃黏膜损伤大鼠胃黏膜细胞PLC γ-1、PKC和c-myc基因表达的影响.中西医结合学报.2007；5(3)：338-342
[9]石学敏.针灸学[M].第2版.北京：中国中医药出版社.2002,196
[10]Takano H, Satoh M, Shimada A,et al. Cytoprotection by metallothionein against gastroduodenal mucosal injury caused by ethanol in mice.Leb Invest,2000,80(3):371-377
[11]李忠仁.实验针灸学[M].北京：中国中医药出版社.2003,154,231
[12]Guth PH, Aures D, Paulson G, et al. Topical aspirin plus Hcl gastric lesions in the rat[J]. Gastroenterology,1979,76(1):89-93
[13]李铁,张席锦.巯基参与胃黏膜防御机制.生理学报[J],1990,42(6)：571-577
[14]陆震宇,刘菲,王莉,陆伟,陈光明,杨若才,杨富强.胃安素对胃黏膜保护作用的动物实验及临床研究.新消化病学杂志1996；4：185-188
[15]夏敏,陶嘉泳.乙醇对小鼠胃黏膜的损伤机制.新消化病学杂志1997；5：211-212
[16]Sibilia V, Rindi G, Pagani F, Rapetti D, Locatelli V, Torsello A, Campanini N, Deghenghi
R, Netti C. Ghrelin protects against ethanol-induced gastric ulcers in rats:studies on the mechanisms of action. Endocrinology 2003; 144:353-359
[17]Knoll MR, Kolbel CB, Teyssen S, Singer MV. Action of pure ethanol and some alcoholic beverages on the gastric mucosa in healthy humans:a descriptive endoscopic study. Endoscopy 1998; 30:293-301
[18]李兆申,湛先保,许国铭.胃黏膜损伤与保护-基础与临床.第1版.上海：上海科学技术出版社,2004：498-502
[19]Bienia A, Sodolski W, Luchowska E. The effect of chronic alcohol abuse on gastric and duodenal mucosa. Ann Univ Mariae Curie Sklodowska 2002; 57:570-582
[20]Ko JK, Cho CH. Alcohol drinking and cigarette smoking:a "partner" for gastric ulceration. Zhonghua YiXue ZaZhi 2000; 63:845-854
[21]Brzozowski T, Konturek PC, Konturek SJ, Kwiecien S, Sliwowski Z, Pajdo R, Duda A, Ptak A, Hahn EG. Implications of reactive oxygen species and cytokines in gastroprotection against stress-induced gastric damage by nitric oxide releasing aspirin. Int J Colorectal Dis 2003; 18:320-329
[22]Kwiecien S, Brzozowski T, Konturek SJ. Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury. J Physiol Pharmacol 2002; 53:39-50)
[23]Repetto M, Maria A, Guzman J, Giordano O, Llesuy S. Protective effect of Artemisia douglasiana Besser extracts in gastric mucosal injury. J Pharm Pharmacol 2003; 55: 551-557
[24]苏红,曹之宪,林兆鑫.乙醇对大鼠胃黏膜的影响.世界华人消化杂志2000；8：355-356)
[25]Stermer E. Alcohol consumption and the gastrointestinal tract. Isr Med Assoc J 2002; 4: 200-202
[26]Chari S, Teyssen S, Singer MV. Alcohol and gastric acid secretion in humans. Gut 1993; 34: 843-847)
[27]Lenz HJ, Ferrari-Taylor J, Isenberg JI. Wine and five percent ethanol are potent stimulants of gastric acid secretion in humans. Gastroenterology 1983; 85:1082-1087
[28]Matsuno K, Tomita K, Okabe S. Wine stimulates gastric acid secretion in isolated rabbit gastric glands via two different pathways. Aliment Pharmacol Ther 2002; 16 Suppl 2: 107-114
[29]杨春敏,毛高平,朱明,张秀荣,张映辉.乙醇对清醒兔Oddi括约肌运动功能的影响.世界华人消化杂志2001；9：653-657
[30]Iino T, Nakahara K, Miki W, Kiso Y, Ogawa Y, Kato S, Takeuchi K. Less damaging effect of whisky in rat stomachs in comparison with pure ethanol. Role of ellagic acid, the nonalcoholic component. Digestion 2001; 64:214-221
[31]Bilici D, Suleyman H, Banoglu ZN, Kiziltunc A, Avci B, Ciftcioglu A, Bilici S. Melatonin prevents ethanol-induced gastric mucosal damage possibly due to its antioxidant effect. Dig Dis Sci 2002; 47:856-861
[32]La Casa C, Villegas I, Alarcon de la Lastra C, Motilva V, Martin Calero MJ. Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J Ethnopharmacol 2000; 71:45-53
[33]Ajaikumar KB, Asheef M, Babu BH, Padikkala J. The inhibition of gastric mucosal injury by Punicagranatum L. (pomegranate) methanolic extract. J Ethnopharmacol 2005; 96: 171-176
[34]Arafa HM, Sayed-Ahmed MM. Protective role of carnitine esters against alcohol-induced gastric lesions in rats. Pharmacol Res 2003; 48:285-290
[35]Raphael KR, Kuttan R. Inhibition of experimental gastric lesion and inflammation by Phyllanthus amarus extract. J Ethnopharmacol 2003; 87:193-197)
[36]Liu ES, Wong BC, Cho CH. Influence of gender difference and gastritis on gastric ulcer formation in rats. J Gastroenterol Hepatol 2001; 16:740-747
[37]Saeki T, Ohno T, Kamata K, Arai K, Mizuguchi S, Katori M, Saigenji K, Majima M. Mild irritant prevents ethanol-induced gastric mucosal microcirculatory disturbances through actions of calcitonin gene-related peptide and PGI2 in rats. Am J Physiol Gastrointest Liver Physiol 2004; 286:G68-G75)
[38]Kawabata A, Nishikawa H, Saitoh H, Nakaya Y, Hiramatsu K, Kubo S, Nishida M, Kawao N, Kuroda R, Sekiguchi F, Kinoshita M, Kakehi K, Arizono N, Yamagishi H, Kawai K. A protective role of protease-activated receptor 1 in rat gastric mucosa. Gastroenterology 2004; 126:208-219
[39]Brzozowski T, Konturek PC, Konturek SJ, Kwiecien S, Drozdowicz D, Bielanski W,
Pajdo R, Ptak A, Nikiforuk A, Pawlik WW, Hahn EG. Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage. Regul Pept 2004; 120: 39-51
[40]Komori M, Tsuji S, Sun WH, Tsujii M, Kawai N, Yasumaru M, Kakiuchi Y, Kimura A, Sasaki Y, Higashiyama S, Kawano S, Hori M. Gastrin enhances gastric mucosal integrity through cyclooxygenase-2 upregulation in rats. Am J Physiol Gastrointest Liver Physiol 2002; 283:G1368-G1378
[41]Miyake K, Tsukui T, Wada K, Tatsuguchi A, Futagami S, Hiratsuka T, Shinoki K, Iizumi T, Akamatsu T, Sakamoto C, Kobayashi M. Irritant-induced cyclooxygenase-2 is involved in the defense mechanism of the gastric mucosa in mice. J Gastroenterol 2002; 37: 164-171
[42]Kawano S, Tsuji S. Role of mucosal blood flow:a conceptional review in gastric mucosal injury and protection. J Gastroenterol Hepatol 2000; 15 Suppl:D1-D6
[43]Ohta M, Nguyen TH, Tarnawski AS, Pai R, Kratzberg YP, Sugimachi K, Sarfeh IJ. Overexpression of endothelin-1 mRNA and protein in portal hypertensive gastric mucosa of rats:a key to increased susceptibility to damage? Surgery 1997; 122:936-942
[44]Masuda E, Kawano S, Nagano K, Tsuji S, Takei Y, Hayashi N, Tsujii M, Oshita M, Michida T, Kobayashi I, et al. Role of endogenous endothelin in pathogenesis of ethanol-induced gastric mucosal injury in rats. Am J Physiol 1993; 265:G474-G481
[45]Masuda E, Kawano S, Nagano K, Tsuji S, Ishigami Y, Tsujii M, Hayashi N, Fusamoto H, Kamada T. Effect of intravascular ethanol on modulation of gastric mucosal integrity: possible role of endothelin-1. Am J Physiol 1992; 262:G785-G790
[46]Morales RE, Johnson BR, Szabo S. Endothelin induces vascular and mucosal lesions, enhances the injury by HCl/ethanol, and the antibody exerts gastroprotection. Faseb J 1992; 6:2354-2360
[47]Zayachkivska OS, Konturek SJ, Drozdowicz D, Konturek PC, Brzozowski T, Ghegotsky MR. Gastroprotective effects of flavonoids in plant extracts. J Physiol Pharmacol 2005; 56 Suppl 1:219-231
[48]Pan LR, Tang Q, Fu Q, Hu BR, Xiang JZ, Qian JQ. Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice. Acta Pharmacol Sin 2005; 26: 1334-1338
[49]Zayachkivska OS, Konturek SJ, Drozdowicz D, Brzozowski T, Gzhegotsky MR. Influence of plant-originated gastroproteciive and antiulcer substances on gastric mucosal repair. Fiziol Zh 2004; 50:118-127
[50]Sibilia V, Torsello A, Pagani F, Rapetti D, Lattuada N, Locatelli V, Bulgarelli I, Guidobono F, Netti C. Effects of hexarelin against acid-independent and acid-dependent ulcerogens in the rat. Peptides 2004; 25:2163-2170
[51]Li YH, Li J, Huang Y, Lu XW, Jin Y. Gastroprotective effect and mechanism of amtolmetin guacyl in mice. World J Gastroenterol 2004; 10:3616-3620
[52]Iaquinto G, Giardullo N, Taccone W, Leandro G, Pasquale L, De Luca L, Szabo S. Role of endogenous endothelin-1 in ethanol-induced gastric mucosal damage in humans. Dig Dis Sci 2003; 48:663-669
[53]Kalia N, Bardhan KD, Reed MW, Jacob S, Brown NJ. Mast cell stabilization prevents ethanol-induced rat gastric mucosal injury:mechanisms of protection. J Gastroenterol Hepatol 2000; 15:133-141
[54]Ishizuka Y, Kamisaki T, Sato M. Anti-gastric acid secretory mechanism of 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylic acid. Effect on mucosal mast cell. Arzneimittelforschung 1996; 46:919-922
[55]Erkasap S, Erkasap N, Aral E, Koken T, Kahraman A, Aydin Y, Yilmaz S, Ates E. Mast cell stabilizator and antioxidant effects of epidermal growth factor (EGF) on gastric mucosal injury induced by ethanol in rats. Chin J Physiol 2005; 48:1-6
[56]Kahraman A, Erkasap N, Koken T, Serteser M, Aktepe F, Erkasap S. The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions. Toxicology 2003; 183:133-142
[57]Ko JK, Cho CH, Lam SK. Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis. World J Gastroenterol 2004; 10:2503-2508
[58]Karmeli F, Eliakim R, Okon E, Rachmilewitz D. Role of vasoactive intestinal peptide (VIP) in pathogenesis of ethanol-induced gastric mucosal damage in rats. Dig Dis Sci 1993; 38:1210-1219)
[59]Asai K, Buurman WA, Reutelingsperger CP, Schutte B, Kaminishi M. Modular effects of estradiol on ethanol-induced apoptosis in human intestinal epithelial cells. Scand J Gastroenterol 2005; 40:326-335
[60]Tsutsumi S, Tomisato W, Takano T, Rokutan K, Tsuchiya T, Mizushima T. Gastric irritant-induced apoptosis in guinea pig gastric mucosal cells in primary culture. Biochim Biophys Acta 2002; 1589:168-180
[61]Mustonen H, Kiviluoto T, Paimela H, Puolakkainen P, Kivilaakso E. Calcium signaling is involved in ethanol-induced volume decrease and gap junction closure in cultured rat gastric mucosal cells. Dig Dis Sci 2005; 50:103-110
[62]Koko V, Todorovic V, Varagic J, Micev M, Korac A, Bajcetic M, Cakic-Milosevic M, Nedeljkovic M, Drndarevic N. Gastrin producing G-cells after chronic ethanol and low protein nutrition. Indian J Exp Biol 1998; 36:1093-1101
[63]Ancha H, Ojeas H, Tedesco D, Ward A, Harty RF. Somatostatin-induced gastric protection against ethanol:involvement of nitric oxide and effects on gastric mucosal blood flow. Regul Pept 2003; 110:107-113
[64]Karmeli F, Eliakim R, Okon E, Rachmilewitz D. Somatostatin effectively prevents ethanol-and NSAID-induced gastric mucosal damage in rats. Dig Dis Sci 1994; 39: 617-625)
[65]Sekiguchi F, Saito S, Takaoka K,et al.Mechanisms for prostaglandin E2 formation caused by proteinase-activated receptor-1 activation in rat gastric mucosal epithelial cells.Biochem Pharmacol.2007;73(1):103-14
[66]周国平,严洁,常小荣,等.电针足三里对胃黏膜损伤家兔前列腺素E2胃泌素水平的影响.中国中医药科技.2004；11(1)：1-2
[67]孙勇,许冠荪.一氧化氮／内皮素在大鼠胃黏膜损伤中的作用及电针的调整效应[J].生理学报.1999；51(2)：206
[68]高巍,黄裕新,陈洪,等.电针对胃经-脑肠肽-免疫网络的调节机制.世界华人消化杂志；2001；9(3)：279-281.
[69]易受乡,林亚平,严洁,等.电针对大鼠胃运动、P物质和胃动素的影响.世界华人消化杂志.2001；9(3)：284
[70]申国明,江安宏,徐颖,等.电针对胃黏膜损伤大鼠血管活性肠肽影响的实验研究.中国中医药科技.2002；9(6)：321-322
[71]易受乡,严洁,林亚平,等.针刺胃经穴对M受体阻断大鼠胃电及脑肠肽的影响.中国中西医结合消化杂志.2002；10(4)：203-205
[72]Hunyady B,Palkovits M,Mozsik G,et al.Susceptibility of dopamine D5 receptor targeted mice to cysteamine.J Physiol Paris.2001;95:147-151
[73]刘希元.针灸治疗上消化道溃疡52例疗效观察.时珍国医国药,2001,12(3)：250-250
[74]肖凡.针刺配合中药治疗胃十二指肠溃疡穿孔23例.湖南中医学院学报,1999,19(1)：56-57
[75]田丙周,段浩.艾条灸治疗胃溃疡54例.实用中西医结合杂志,1994,7(10)：623-623
[76]李德益,胡银柱,邓春蕾,等.穴位埋线治疗十二指肠球部溃疡488例.针灸学报,1990,6(4)：3-5
[77]苗春达.穴注、口服甲氰眯胍对胃、十二指肠溃疡疗效比较.中国针灸.1990,10(5)：39-40
[78]董蕴,刘广林,赵淑敏.胃及十二指肠球部溃疡患者耳穴压痛阈的变化.中国针灸,1996,16(8)：39-40
[79]方理桃,王大云.贴敷膏药治疗胃及十二指肠溃疡118例临床观察.湖南中医杂志,1991,5(6)：12
[80]裴文芬,许冠荪,孙勇,等.大鼠迷走神经背核在保护胃黏膜损伤中的作用.中国中西医结合脾胃杂志,1997,5(2)：92-94,97
[81]严洁,常小荣,邓元江,等.电针足阳明经穴对家兔胃黏膜损伤细胞保护作用的研究.针刺研究,2001,26(4)：264-267
[82]潘朝宠,金文秀,沈德凯.针刺对大鼠胃黏膜保护作用及其相关的神经递质组化的观察.针刺研究,1990,15(1)：48-54
[83]沈德凯,刘冰怀,韦多,等。电针对大鼠应激性胃溃疡保护过程中中枢及外周单胺类神经递质的影响.针刺研究,1994,19(1)：51-54
[84]朱舜丽,许冠荪,陈全珠,等.电针足三里穴对应激性胃溃疡大鼠一氧化氮和儿茶酚胺的影响.中国中西医结合脾胃杂志,1996,4(1)：39-41
[85]周吕,柳力公,谢益宽,等.针刺对狗胃运动的影响及其作用机制的研究.中华消化杂志,1988,8(1)：30-32
[86]周吕,柳力公,张荣,等.针刺治疗胃病的疗效机制研究.基础医学与临床,1993,13(5)：470
[87]苏薇薇,范尚廉,郭荣斌,等.针刺对血浆胃肠激素和胃分泌机能的影响.中华消化杂志,1989,9(3)：148-150
[88]孙大勇.黄裕新,褚自宏,等.电针对狗胃黏膜血流量的影响及与血浆胃肠激素的关系.世界华人消化杂志,1998,6(11)：936-938
[89]艾炳蔚,郭诚杰,段克敬.针刺对大鼠实验性胃溃疡胃黏膜组织前列腺素含量的影响.上海针灸杂志,1995,14(5)：235-238
[90]许冠荪,陈日新,沈德凯.针刺对大鼠胃黏膜损伤的保护作用.针刺研究,1987,12(3)：214-216
[91]杨丹红,江庆淇,许文波,等.神阙穴隔药灸对荷瘤化疗大鼠胃黏膜保护作用的研究.中国针灸,1999,9(8)：484-485
[92]李怡凡，许冠荪,刘维洲,等.电针对大鼠胃缺血再灌注损伤后胃局部血流量的影响.安徽中医学院学报,1991,10(2)：51-54
[93]魏庆兴,菊地一博,郑义弘,等.针灸预防大鼠应激性胃溃疡作用的实验研究.中国针灸,1997,17(10)：608-610
[94]王月芳,刘元亮,许冠荪,等.L-Arg-NO通路在针灸对胃黏膜损伤保护中的作用.中国中医药科技,1999,6(5)：281-283
[95]孙勇,许冠荪.一氧化氮／内皮素在大鼠胃黏膜损伤中的保护作用及电针的调整效应.生理学报,1999,51(2)：206-210
[96]Xu GS, Sun Y, Wang ZJ, et al. Effects of electroacupuncture on gastric mucosal blood flow and transmucosal potential difference in stress rats. World Chin J Digestol,1998, 6(1):4
[97]李铁,张席锦.氧自由基在应激性溃疡中的发病学意义.生理学报,1993,45(3)：286-291
[98]赵百孝,邓诚杰,段克敬.针刺对大鼠刀性胃黏膜损伤氧自由基及胃黏膜超微结构的影响.上海针灸杂志,1995,14(5)：235-237
[99]李英,冯明秀,黄喜梅.电针对化疗大鼠胃肠功能影响的实验研究.中国针灸,1996,16(3)：31-32
[100]沈德凯,潘朝宏,金文秀.电针对大鼠应激性溃疡的保护机制初步研究.针灸学报,1992,8(3)：34-36
[101]易受乡,彭艳,常小荣,等.艾灸足三里、梁门对应激性溃疡大鼠胃黏膜细胞凋 亡的干预作用.世界华人消化杂志,2006,14(33)：3163-3168
[102]易受乡,彭艳,常小荣,等.艾灸对应激性胃溃疡大鼠胃黏膜细胞增值和凋亡的影响及其与热休克蛋白表达关系的研究.针刺研究,2006,31(5)：259-263
[103]周国平,严洁,李江山,等.电针足三里对胃黏膜损伤大鼠细胞凋亡及其调控基因l-2、 Fas蛋白表达的影响.新中医,2005,37(4)：92-94
[104]周国平,严洁,李江山,等.电针“足三里”对胃黏膜损伤大鼠Bcl-2、 Fas蛋白表达的影响.针刺研究,2004,29(1)：31-34
[105]严洁,阳仁达,易受乡,等.从针刺不同经穴对家兔胃黏膜保护作用探讨多经司控同一脏腑的规律[J].中国针灸,2004,24(8)：579-582
[106]Peng CX, Wang L, Zhou GP, Deng CQ. Comparative study on different point combinations of Zusanli (ST 36) for improving acute gastric mucosa injury[J]. Zhongguo Zhen jiu.2007,27(1):44-7
[107]刘建华.足阳明经与胃相关的延脑初级中枢(孤束核)机制的研究.湖南中医学院1999级博士生学术论文
[108]张海蒙,沈雪勇,王彩虹.公孙、足三皇等穴伏安特性的研究.上海针灸杂志1999,18(1)：1
[109]查炜,王茵萍,吴旭,项晓人,朱苗花.穴位注射疗法对MNNG致慢性萎缩胃炎大鼠肝组织病理及SOD影响.上海针灸杂志.2004,23(9)：39
[110]李韶山.中药方剂胃肠复原汤加减治疗腹部手术后胃瘫,中华现代中西医杂志,2005.23(3)：226-227
[111]石丸圭莊.电针刺激全身的镇痛效果与经络的关系.国外医学中医中药分册,2003,25(1)：56
[112]邵乐文,俞小玲.择时选穴按摩对胃肠道术后肠蠕动恢复的影响.中华护理杂志2006,41(8)：752
[113]商军科,杨志光,薛丽.针刺对62例硬膜外阻滞下行腹部手术后胃肠功能恢复的影响.陕西中医,2001,22(7)：416
[114]刘文全,王健,郝志友.针刺对功能性消化不良胃肠动力影响的临床研究.中国针灸.2001,21(5)：267
[115]陈永斌,陆青,兰爱珍,苏荣,黄海华.针刺干预胃镜检查反应临床观察.中国针灸.2007,27(9)：685
[116]常小荣,严洁,林亚平,等.电针足三里对家兔胃黏膜损伤细胞保护作用的观察.中国中医药信息杂志,2002,9(7)：26-27
[117]金伯泉.细胞和分子免疫学,第1版.西安：世界囝书出版公司.1995：95-175
[118]lshii S, Shimizu T. Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice[J]. Prog Lipid Res,2000,39-41
[119]李东复,段亚清.细胞因子在胃十二指肠疾病中的作用机理.白求恩医科大学学报,1999,25(4)：437-438
[120]Saeki T, Ohno T, Kamata K, Arai K, Mizuguchi S, Katori M, Saigenji K, Majima M. Mild irritant prevents ethanol-induced gastric mucosal microcirculatory disturbances through actions of calcitonin gene-related peptide and PGI2 in rats. Am J Physiol Gastrointest Liver Physiol2004; 286:G68-G75
[121]Kay Y. Efect of16.16-dmPGE2 on lipidic organelles of rat gastric suface mucous cells[J]. Gastroenterol,1993,104:103
[122]Kawabata A, Nishikawa H, Saitoh H, Nakaya Y, Hiramatsu K, Kubo S, Nishida M, Kawao N, Kuroda R, Sekiguchi F, Kinoshita M, Kakehi K, Arizono N, Yamagishi H, Kawai K. A protective role of protease-activated receptor 1 in rat gastric mucosa. Gastroenterology 2004; 126:208-219
[123]Brzozowski T, Konturek PC, Konturek SJ, Kwiecien S, Drozdowicz D, Bielanski W, Pajdo R, Ptak A, Nikiforuk A, Pawlik WW, Hahn EG. Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage. Regul Pept 2004; 120: 39-51
[124]Komori M, Tsuji S, Sun WH, Tsujii M, Kawai N, Yasumaru M, Kakiuchi Y, Kimura A, Sasaki Y, Higashiyama S, Kawano S, Hori M. Gastrin enhances gastric mucosal integrity through cyclooxygenase-2 upregulation in rats. Am JPhysiol Gastrointest Liver Physiol 2002; 283:G1368-G1378
[125]Miyake K, Tsukui T, Wada K, Tatsuguchi A, Futagami S, Hiratsuka T, Shinoki K, Iizumi T, Akamatsu T, Sakamoto C, Kobayashi M. Irritant-induced cyclooxygenase-2 is involved in the defense mechanism of the gastric mucosa in mice. J Gastroenterol 2002; 37:164-171
[126]徐军全,李秋萍,魏利惠,等.消化性溃疡、胃癌患者胃窦黏膜中胃肠激素含量变 化及其意义.临床消化杂志,1996,8(1)：8-10
[127]李平,许国铭,王成海.生长抑素对急性胃黏膜损伤保护作用的实验研究[J].第二军医大学学报,1997,18(1)：50
[128]Kontrurek PC, Brzozowski T, Konturek SJ et al. Scand J Gastroenterol,1997; 32(1): 6-15
[129]Ma L, Wang WP, Chow JY et al. Am J Physiol Gastrointest Liver Physiol,2000; 278(1): 10-17
[130]Yanaka A, Suzuki H, Shibahara T, et al. EGF promotes gastric mucoal restitution by activating Na(+)/H (+) exchange of epithelial cells. Am J Physiol Gastrointest Liver Physiol,2002,282:866-876
[131]Romano M, Polk WH, Awad JA, et al. Transformation growth factor alpha protection agjnst drug-induced injury to the rat gastric mucosa invo[J]. J Clin Invest,1992,90: 2409
[132]Niki S, Matsubayashi H, Mizoue T et al. Nippon Shokibyo Gakkai Zasshi,1999; 96(4):385-391
[133]Louw JA, Modlin IM, Tang L et al. J Int Med Res,1998; 26(2):82-86
[134]Wong BC, Wang WP, So WH et al. Aliment Pharmacol Ther,2001; 15(9):1459-1465
[135]阳仁达,严洁，易受乡,等.针刺胃经穴对家兔胃黏膜损伤的细胞保护作用及机理研究.中国医学研究与临床.2004；2(16)：8-11
[136]周国平,严洁,常小荣,等.电针足三里对胃黏膜损伤家兔EGF、 NO的影响.中国中医药信息杂志.2005；12(7)：39-40
[137]易受乡,阳仁达,严洁,等.针刺对胃黏膜损伤家兔表皮生长因子、生长抑素及生长抑素受体基因表达的影响世界华人消化杂志.2004；12(7)：1721-1723
[1]Mendelsohn J. Targeting the epidermal growth factor receptor for cancer therapy [J]. J Clin Oncol,2002, 20 (18 Suppl):1S-13S.
[2]Xiao z-Q. MajumdarAPN. Increasedin vitro activ oll OfEGFR by-branc-bound TGF from gastric and colonicmucoal Of pd rats[J]. Am J Physiol Gastrolntest Liver Physio,2001,281:G111-G116
[3]李兆申,诺先保,许国铭.胃黏膜损伤与保护-基础与临床.上海：上海科学技术出版社,2004：271
[4]Wells-A. EGF receptor[J]. Int-J-Biochem-Cell-Biol.1999 Jun; 31(6):637-43
[5]Olayioye MA, Neve R M, Lane HA, et al. The erb-B signaling networks:receptor heterodimerization in development and cancer[J].EMBO J,2000;19(13):3159-3167.
[6]Bowers G, Reardon D, Hewitt T, et al. The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells.2001,20(11):1388-97.
[7]Raymond E, Faivre S, Armand JP, et al. Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy.Drugs.2000;60(suppl 1):15-23
[8]Newman L, Xia W, Yang HY,et al. Correlation of p27 protein expression with HER-2/neu expression in breast cancer. Mol Carcinog.2001,30(3):169-75.
[9]黄文林,朱孝峰.信号转导.北京：人民卫生出版社.2005.
[10]Hognason T, Chatterjee S, Vartanian T,et al.Epidermal growrth factor receptor induced apoptosis:potentiation of ras signaling. FEBS Lett.2001;491(1-2):9-15.
[11]Carpenter G. Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways. Journal of cell biology.1999;146(4):697-702.
[12]于燕妮,方艺,车筑萍等.胃溃疡病活检标本中表皮生长因子受体的表达.贵州医药.2000.24(6)323-324
[13]He J H. Role of growth factor in the peptic ulcer healing. Foreign Med (Section of Digestive Disease) 2003;23(1):12-15.
[14]Xiao Z-Q. MajumdarAPN. Increased in vitro activation of EGFR by Membrane-bound TGF-a from gastric and colonic mucosa of aged rats[J].Am J Physiol Gastrolntest Liver Physio.2001,281:G111-G116
[15]刘建平,卜涛,白建乐等.EGF、TGF2α及EGFR在大鼠胃溃疡自愈过程中的表达及意义.中国药理学通报.2003,19(10)：1185～1188
[16]Tarmaw sk TA, Stachura J, Durbin T.Sarteh H, Gryoly H. Increased expression of epidermal growth factor receptor during gastric ulcer healing in rats [J]. Gastroenterology,1992;102:695-698;
[17]Hayashi M, Tapping, RI, ChaoTH et al. BMK1 mediates growth factor induced cell proliferation through direct cellular activation of serum and glucocorticoid inducible kinase.J Biol Chem,2001;276 (12):8631-4
[18]Konturek PC, Brzozowski T, Konturek SJ et al. Expression of epidermal growth factor and transforming growth factor alpha during ulcer healing. Time sequence study. Scand J Gast roenterol,1997;32(1):6-15
[19]Konturek PC, Brzozowski T, Konturek SJ et al. Expression of epidermal growth factor and transforming growth factor alpha during ulcer healing. Time sequence study. Scand J Gast roenterol,1997;32(1):6-15
[20]李兆申,崔忠敏,湛先保等.应激状态下胃黏膜耐受性细胞保护中表皮生长因子及其受体的免疫组化研究.解放军医学杂志.1999.24(6)：397-400
[21]邓兰琼.柴胡桂枝汤对大鼠乙酸胃溃疡黏膜表皮生长因子受体的影响.中国中西医结合消化杂志.2005.13(3)：141-145
[22]Zhao BM.Huang YX.W ang QL.Chu ZH.Zhao NX. Effects of electroacupuncture on gastric acid secretion and its relationship w ith gastric and epidermal growth factor in rats Q]. Shijie Huaren Zazhi (World Chin J Digestol),2000;8(3):271-278
[23]Hirofumi Kawanaka, Morimasa Tomikawa,Dolgor Baatar.Despite activation of EGF-receptor-ERK signaling pathway, epithelial proliferation is impairedin portal hypertensive gastric mucosa Relevance of MKP-l,c-fos,c-myc and cyclin D1 expression. Life Sciences 69 (2001) 3019-3033
[24]李建玲,易红,冯雪萍等大鼠胃黏膜细胞EGFR通过ERK-1／2信号传导通路激活AP-1.中国医师杂志.2003.5(9)：1170-1172
[2]周美启,周逸平,汪克明,等.基因芯片技术在经脉脏腑相关研究中的应用思考.中国针灸.2005；25(3)：197-200)
[3]Junfeng He,jie Yan,Xiaorong Chang, et al. Neurons in the NTS of Rat Response to Gastric Distention Stimalation and Acupuncture at Body Surface Points.AJCM.2006;34(3):427-433
[4]严洁,黎喜平,易受乡,等.电针对应激性胃黏膜损伤大鼠胃黏膜肠三叶因子基因表达的影响.中国针灸.2006；26(1)：66-68
[5]林亚平,易受乡,严洁,等.电针四白、天枢、足三里穴对胃黏膜损伤大鼠的胃黏膜血流量及生长抑素的影响.中国中西结合消化杂志.2003；11(2)：75-77
[6]张泓,易受乡,严洁,等.电针足三阳经穴对家兔脑肠肽类物质影响的比较研究.中国临床康复.2004；(12)：2290-2291)
[7]电针大鼠胃经后血清对其胃黏膜细胞表皮生长因子受体表达的影响及浓度效应。中国临床康复.2006；10(35)：87-89
[8]电针胃经(穴)血清对胃黏膜损伤大鼠胃黏膜细胞PLC γ-1、PKC和c-myc基因表达的影响.中西医结合学报.2007；5(3)：338-342
[9]石学敏.针灸学[M].第2版.北京：中国中医药出版社.2002,196
[10]Takano H, Satoh M, Shimada A,et al. Cytoprotection by metallothionein against gastroduodenal mucosal injury caused by ethanol in mice.Leb Invest,2000,80(3):371-377
[11]李忠仁.实验针灸学[M].北京：中国中医药出版社.2003,154,231
[12]Guth PH, Aures D, Paulson G, et al. Topical aspirin plus Hcl gastric lesions in the rat[J]. Gastroenterology,1979,76(1):89-93
[13]李铁,张席锦.巯基参与胃黏膜防御机制.生理学报[J],1990,42(6)：571-577
[14]陆震宇,刘菲,王莉,陆伟,陈光明,杨若才,杨富强.胃安素对胃黏膜保护作用的动物实验及临床研究.新消化病学杂志1996；4：185-188
[15]夏敏,陶嘉泳.乙醇对小鼠胃黏膜的损伤机制.新消化病学杂志1997；5：211-212
[16]Sibilia V, Rindi G, Pagani F, Rapetti D, Locatelli V, Torsello A, Campanini N, Deghenghi
R, Netti C. Ghrelin protects against ethanol-induced gastric ulcers in rats:studies on the mechanisms of action. Endocrinology 2003; 144:353-359
[17]Knoll MR, Kolbel CB, Teyssen S, Singer MV. Action of pure ethanol and some alcoholic beverages on the gastric mucosa in healthy humans:a descriptive endoscopic study. Endoscopy 1998; 30:293-301
[18]李兆申,湛先保,许国铭.胃黏膜损伤与保护-基础与临床.第1版.上海：上海科学技术出版社,2004：498-502
[19]Bienia A, Sodolski W, Luchowska E. The effect of chronic alcohol abuse on gastric and duodenal mucosa. Ann Univ Mariae Curie Sklodowska 2002; 57:570-582
[20]Ko JK, Cho CH. Alcohol drinking and cigarette smoking:a "partner" for gastric ulceration. Zhonghua YiXue ZaZhi 2000; 63:845-854
[21]Brzozowski T, Konturek PC, Konturek SJ, Kwiecien S, Sliwowski Z, Pajdo R, Duda A, Ptak A, Hahn EG. Implications of reactive oxygen species and cytokines in gastroprotection against stress-induced gastric damage by nitric oxide releasing aspirin. Int J Colorectal Dis 2003; 18:320-329
[22]Kwiecien S, Brzozowski T, Konturek SJ. Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury. J Physiol Pharmacol 2002; 53:39-50)
[23]Repetto M, Maria A, Guzman J, Giordano O, Llesuy S. Protective effect of Artemisia douglasiana Besser extracts in gastric mucosal injury. J Pharm Pharmacol 2003; 55: 551-557
[24]苏红,曹之宪,林兆鑫.乙醇对大鼠胃黏膜的影响.世界华人消化杂志2000；8：355-356)
[25]Stermer E. Alcohol consumption and the gastrointestinal tract. Isr Med Assoc J 2002; 4: 200-202
[26]Chari S, Teyssen S, Singer MV. Alcohol and gastric acid secretion in humans. Gut 1993; 34: 843-847)
[27]Lenz HJ, Ferrari-Taylor J, Isenberg JI. Wine and five percent ethanol are potent stimulants of gastric acid secretion in humans. Gastroenterology 1983; 85:1082-1087
[28]Matsuno K, Tomita K, Okabe S. Wine stimulates gastric acid secretion in isolated rabbit gastric glands via two different pathways. Aliment Pharmacol Ther 2002; 16 Suppl 2: 107-114
[29]杨春敏,毛高平,朱明,张秀荣,张映辉.乙醇对清醒兔Oddi括约肌运动功能的影响.世界华人消化杂志2001；9：653-657
[30]Iino T, Nakahara K, Miki W, Kiso Y, Ogawa Y, Kato S, Takeuchi K. Less damaging effect of whisky in rat stomachs in comparison with pure ethanol. Role of ellagic acid, the nonalcoholic component. Digestion 2001; 64:214-221
[31]Bilici D, Suleyman H, Banoglu ZN, Kiziltunc A, Avci B, Ciftcioglu A, Bilici S. Melatonin prevents ethanol-induced gastric mucosal damage possibly due to its antioxidant effect. Dig Dis Sci 2002; 47:856-861
[32]La Casa C, Villegas I, Alarcon de la Lastra C, Motilva V, Martin Calero MJ. Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J Ethnopharmacol 2000; 71:45-53
[33]Ajaikumar KB, Asheef M, Babu BH, Padikkala J. The inhibition of gastric mucosal injury by Punicagranatum L. (pomegranate) methanolic extract. J Ethnopharmacol 2005; 96: 171-176
[34]Arafa HM, Sayed-Ahmed MM. Protective role of carnitine esters against alcohol-induced gastric lesions in rats. Pharmacol Res 2003; 48:285-290
[35]Raphael KR, Kuttan R. Inhibition of experimental gastric lesion and inflammation by Phyllanthus amarus extract. J Ethnopharmacol 2003; 87:193-197)
[36]Liu ES, Wong BC, Cho CH. Influence of gender difference and gastritis on gastric ulcer formation in rats. J Gastroenterol Hepatol 2001; 16:740-747
[37]Saeki T, Ohno T, Kamata K, Arai K, Mizuguchi S, Katori M, Saigenji K, Majima M. Mild irritant prevents ethanol-induced gastric mucosal microcirculatory disturbances through actions of calcitonin gene-related peptide and PGI2 in rats. Am J Physiol Gastrointest Liver Physiol 2004; 286:G68-G75)
[38]Kawabata A, Nishikawa H, Saitoh H, Nakaya Y, Hiramatsu K, Kubo S, Nishida M, Kawao N, Kuroda R, Sekiguchi F, Kinoshita M, Kakehi K, Arizono N, Yamagishi H, Kawai K. A protective role of protease-activated receptor 1 in rat gastric mucosa. Gastroenterology 2004; 126:208-219
[39]Brzozowski T, Konturek PC, Konturek SJ, Kwiecien S, Drozdowicz D, Bielanski W,
Pajdo R, Ptak A, Nikiforuk A, Pawlik WW, Hahn EG. Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage. Regul Pept 2004; 120: 39-51
[40]Komori M, Tsuji S, Sun WH, Tsujii M, Kawai N, Yasumaru M, Kakiuchi Y, Kimura A, Sasaki Y, Higashiyama S, Kawano S, Hori M. Gastrin enhances gastric mucosal integrity through cyclooxygenase-2 upregulation in rats. Am J Physiol Gastrointest Liver Physiol 2002; 283:G1368-G1378
[41]Miyake K, Tsukui T, Wada K, Tatsuguchi A, Futagami S, Hiratsuka T, Shinoki K, Iizumi T, Akamatsu T, Sakamoto C, Kobayashi M. Irritant-induced cyclooxygenase-2 is involved in the defense mechanism of the gastric mucosa in mice. J Gastroenterol 2002; 37: 164-171
[42]Kawano S, Tsuji S. Role of mucosal blood flow:a conceptional review in gastric mucosal injury and protection. J Gastroenterol Hepatol 2000; 15 Suppl:D1-D6
[43]Ohta M, Nguyen TH, Tarnawski AS, Pai R, Kratzberg YP, Sugimachi K, Sarfeh IJ. Overexpression of endothelin-1 mRNA and protein in portal hypertensive gastric mucosa of rats:a key to increased susceptibility to damage? Surgery 1997; 122:936-942
[44]Masuda E, Kawano S, Nagano K, Tsuji S, Takei Y, Hayashi N, Tsujii M, Oshita M, Michida T, Kobayashi I, et al. Role of endogenous endothelin in pathogenesis of ethanol-induced gastric mucosal injury in rats. Am J Physiol 1993; 265:G474-G481
[45]Masuda E, Kawano S, Nagano K, Tsuji S, Ishigami Y, Tsujii M, Hayashi N, Fusamoto H, Kamada T. Effect of intravascular ethanol on modulation of gastric mucosal integrity: possible role of endothelin-1. Am J Physiol 1992; 262:G785-G790
[46]Morales RE, Johnson BR, Szabo S. Endothelin induces vascular and mucosal lesions, enhances the injury by HCl/ethanol, and the antibody exerts gastroprotection. Faseb J 1992; 6:2354-2360
[47]Zayachkivska OS, Konturek SJ, Drozdowicz D, Konturek PC, Brzozowski T, Ghegotsky MR. Gastroprotective effects of flavonoids in plant extracts. J Physiol Pharmacol 2005; 56 Suppl 1:219-231
[48]Pan LR, Tang Q, Fu Q, Hu BR, Xiang JZ, Qian JQ. Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice. Acta Pharmacol Sin 2005; 26: 1334-1338
[49]Zayachkivska OS, Konturek SJ, Drozdowicz D, Brzozowski T, Gzhegotsky MR. Influence of plant-originated gastroproteciive and antiulcer substances on gastric mucosal repair. Fiziol Zh 2004; 50:118-127
[50]Sibilia V, Torsello A, Pagani F, Rapetti D, Lattuada N, Locatelli V, Bulgarelli I, Guidobono F, Netti C. Effects of hexarelin against acid-independent and acid-dependent ulcerogens in the rat. Peptides 2004; 25:2163-2170
[51]Li YH, Li J, Huang Y, Lu XW, Jin Y. Gastroprotective effect and mechanism of amtolmetin guacyl in mice. World J Gastroenterol 2004; 10:3616-3620
[52]Iaquinto G, Giardullo N, Taccone W, Leandro G, Pasquale L, De Luca L, Szabo S. Role of endogenous endothelin-1 in ethanol-induced gastric mucosal damage in humans. Dig Dis Sci 2003; 48:663-669
[53]Kalia N, Bardhan KD, Reed MW, Jacob S, Brown NJ. Mast cell stabilization prevents ethanol-induced rat gastric mucosal injury:mechanisms of protection. J Gastroenterol Hepatol 2000; 15:133-141
[54]Ishizuka Y, Kamisaki T, Sato M. Anti-gastric acid secretory mechanism of 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylic acid. Effect on mucosal mast cell. Arzneimittelforschung 1996; 46:919-922
[55]Erkasap S, Erkasap N, Aral E, Koken T, Kahraman A, Aydin Y, Yilmaz S, Ates E. Mast cell stabilizator and antioxidant effects of epidermal growth factor (EGF) on gastric mucosal injury induced by ethanol in rats. Chin J Physiol 2005; 48:1-6
[56]Kahraman A, Erkasap N, Koken T, Serteser M, Aktepe F, Erkasap S. The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions. Toxicology 2003; 183:133-142
[57]Ko JK, Cho CH, Lam SK. Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis. World J Gastroenterol 2004; 10:2503-2508
[58]Karmeli F, Eliakim R, Okon E, Rachmilewitz D. Role of vasoactive intestinal peptide (VIP) in pathogenesis of ethanol-induced gastric mucosal damage in rats. Dig Dis Sci 1993; 38:1210-1219)
[59]Asai K, Buurman WA, Reutelingsperger CP, Schutte B, Kaminishi M. Modular effects of estradiol on ethanol-induced apoptosis in human intestinal epithelial cells. Scand J Gastroenterol 2005; 40:326-335
[60]Tsutsumi S, Tomisato W, Takano T, Rokutan K, Tsuchiya T, Mizushima T. Gastric irritant-induced apoptosis in guinea pig gastric mucosal cells in primary culture. Biochim Biophys Acta 2002; 1589:168-180
[61]Mustonen H, Kiviluoto T, Paimela H, Puolakkainen P, Kivilaakso E. Calcium signaling is involved in ethanol-induced volume decrease and gap junction closure in cultured rat gastric mucosal cells. Dig Dis Sci 2005; 50:103-110
[62]Koko V, Todorovic V, Varagic J, Micev M, Korac A, Bajcetic M, Cakic-Milosevic M, Nedeljkovic M, Drndarevic N. Gastrin producing G-cells after chronic ethanol and low protein nutrition. Indian J Exp Biol 1998; 36:1093-1101
[63]Ancha H, Ojeas H, Tedesco D, Ward A, Harty RF. Somatostatin-induced gastric protection against ethanol:involvement of nitric oxide and effects on gastric mucosal blood flow. Regul Pept 2003; 110:107-113
[64]Karmeli F, Eliakim R, Okon E, Rachmilewitz D. Somatostatin effectively prevents ethanol-and NSAID-induced gastric mucosal damage in rats. Dig Dis Sci 1994; 39: 617-625)
[65]Sekiguchi F, Saito S, Takaoka K,et al.Mechanisms for prostaglandin E2 formation caused by proteinase-activated receptor-1 activation in rat gastric mucosal epithelial cells.Biochem Pharmacol.2007;73(1):103-14
[66]周国平,严洁,常小荣,等.电针足三里对胃黏膜损伤家兔前列腺素E2胃泌素水平的影响.中国中医药科技.2004；11(1)：1-2
[67]孙勇,许冠荪.一氧化氮／内皮素在大鼠胃黏膜损伤中的作用及电针的调整效应[J].生理学报.1999；51(2)：206
[68]高巍,黄裕新,陈洪,等.电针对胃经-脑肠肽-免疫网络的调节机制.世界华人消化杂志；2001；9(3)：279-281.
[69]易受乡,林亚平,严洁,等.电针对大鼠胃运动、P物质和胃动素的影响.世界华人消化杂志.2001；9(3)：284
[70]申国明,江安宏,徐颖,等.电针对胃黏膜损伤大鼠血管活性肠肽影响的实验研究.中国中医药科技.2002；9(6)：321-322
[71]易受乡,严洁,林亚平,等.针刺胃经穴对M受体阻断大鼠胃电及脑肠肽的影响.中国中西医结合消化杂志.2002；10(4)：203-205
[72]Hunyady B,Palkovits M,Mozsik G,et al.Susceptibility of dopamine D5 receptor targeted mice to cysteamine.J Physiol Paris.2001;95:147-151
[73]刘希元.针灸治疗上消化道溃疡52例疗效观察.时珍国医国药,2001,12(3)：250-250
[74]肖凡.针刺配合中药治疗胃十二指肠溃疡穿孔23例.湖南中医学院学报,1999,19(1)：56-57
[75]田丙周,段浩.艾条灸治疗胃溃疡54例.实用中西医结合杂志,1994,7(10)：623-623
[76]李德益,胡银柱,邓春蕾,等.穴位埋线治疗十二指肠球部溃疡488例.针灸学报,1990,6(4)：3-5
[77]苗春达.穴注、口服甲氰眯胍对胃、十二指肠溃疡疗效比较.中国针灸.1990,10(5)：39-40
[78]董蕴,刘广林,赵淑敏.胃及十二指肠球部溃疡患者耳穴压痛阈的变化.中国针灸,1996,16(8)：39-40
[79]方理桃,王大云.贴敷膏药治疗胃及十二指肠溃疡118例临床观察.湖南中医杂志,1991,5(6)：12
[80]裴文芬,许冠荪,孙勇,等.大鼠迷走神经背核在保护胃黏膜损伤中的作用.中国中西医结合脾胃杂志,1997,5(2)：92-94,97
[81]严洁,常小荣,邓元江,等.电针足阳明经穴对家兔胃黏膜损伤细胞保护作用的研究.针刺研究,2001,26(4)：264-267
[82]潘朝宠,金文秀,沈德凯.针刺对大鼠胃黏膜保护作用及其相关的神经递质组化的观察.针刺研究,1990,15(1)：48-54
[83]沈德凯,刘冰怀,韦多,等。电针对大鼠应激性胃溃疡保护过程中中枢及外周单胺类神经递质的影响.针刺研究,1994,19(1)：51-54
[84]朱舜丽,许冠荪,陈全珠,等.电针足三里穴对应激性胃溃疡大鼠一氧化氮和儿茶酚胺的影响.中国中西医结合脾胃杂志,1996,4(1)：39-41
[85]周吕,柳力公,谢益宽,等.针刺对狗胃运动的影响及其作用机制的研究.中华消化杂志,1988,8(1)：30-32
[86]周吕,柳力公,张荣,等.针刺治疗胃病的疗效机制研究.基础医学与临床,1993,13(5)：470
[87]苏薇薇,范尚廉,郭荣斌,等.针刺对血浆胃肠激素和胃分泌机能的影响.中华消化杂志,1989,9(3)：148-150
[88]孙大勇.黄裕新,褚自宏,等.电针对狗胃黏膜血流量的影响及与血浆胃肠激素的关系.世界华人消化杂志,1998,6(11)：936-938
[89]艾炳蔚,郭诚杰,段克敬.针刺对大鼠实验性胃溃疡胃黏膜组织前列腺素含量的影响.上海针灸杂志,1995,14(5)：235-238
[90]许冠荪,陈日新,沈德凯.针刺对大鼠胃黏膜损伤的保护作用.针刺研究,1987,12(3)：214-216
[91]杨丹红,江庆淇,许文波,等.神阙穴隔药灸对荷瘤化疗大鼠胃黏膜保护作用的研究.中国针灸,1999,9(8)：484-485
[92]李怡凡，许冠荪,刘维洲,等.电针对大鼠胃缺血再灌注损伤后胃局部血流量的影响.安徽中医学院学报,1991,10(2)：51-54
[93]魏庆兴,菊地一博,郑义弘,等.针灸预防大鼠应激性胃溃疡作用的实验研究.中国针灸,1997,17(10)：608-610
[94]王月芳,刘元亮,许冠荪,等.L-Arg-NO通路在针灸对胃黏膜损伤保护中的作用.中国中医药科技,1999,6(5)：281-283
[95]孙勇,许冠荪.一氧化氮／内皮素在大鼠胃黏膜损伤中的保护作用及电针的调整效应.生理学报,1999,51(2)：206-210
[96]Xu GS, Sun Y, Wang ZJ, et al. Effects of electroacupuncture on gastric mucosal blood flow and transmucosal potential difference in stress rats. World Chin J Digestol,1998, 6(1):4
[97]李铁,张席锦.氧自由基在应激性溃疡中的发病学意义.生理学报,1993,45(3)：286-291
[98]赵百孝,邓诚杰,段克敬.针刺对大鼠刀性胃黏膜损伤氧自由基及胃黏膜超微结构的影响.上海针灸杂志,1995,14(5)：235-237
[99]李英,冯明秀,黄喜梅.电针对化疗大鼠胃肠功能影响的实验研究.中国针灸,1996,16(3)：31-32
[100]沈德凯,潘朝宏,金文秀.电针对大鼠应激性溃疡的保护机制初步研究.针灸学报,1992,8(3)：34-36
[101]易受乡,彭艳,常小荣,等.艾灸足三里、梁门对应激性溃疡大鼠胃黏膜细胞凋 亡的干预作用.世界华人消化杂志,2006,14(33)：3163-3168
[102]易受乡,彭艳,常小荣,等.艾灸对应激性胃溃疡大鼠胃黏膜细胞增值和凋亡的影响及其与热休克蛋白表达关系的研究.针刺研究,2006,31(5)：259-263
[103]周国平,严洁,李江山,等.电针足三里对胃黏膜损伤大鼠细胞凋亡及其调控基因l-2、 Fas蛋白表达的影响.新中医,2005,37(4)：92-94
[104]周国平,严洁,李江山,等.电针“足三里”对胃黏膜损伤大鼠Bcl-2、 Fas蛋白表达的影响.针刺研究,2004,29(1)：31-34
[105]严洁,阳仁达,易受乡,等.从针刺不同经穴对家兔胃黏膜保护作用探讨多经司控同一脏腑的规律[J].中国针灸,2004,24(8)：579-582
[106]Peng CX, Wang L, Zhou GP, Deng CQ. Comparative study on different point combinations of Zusanli (ST 36) for improving acute gastric mucosa injury[J]. Zhongguo Zhen jiu.2007,27(1):44-7
[107]刘建华.足阳明经与胃相关的延脑初级中枢(孤束核)机制的研究.湖南中医学院1999级博士生学术论文
[108]张海蒙,沈雪勇,王彩虹.公孙、足三皇等穴伏安特性的研究.上海针灸杂志1999,18(1)：1
[109]查炜,王茵萍,吴旭,项晓人,朱苗花.穴位注射疗法对MNNG致慢性萎缩胃炎大鼠肝组织病理及SOD影响.上海针灸杂志.2004,23(9)：39
[110]李韶山.中药方剂胃肠复原汤加减治疗腹部手术后胃瘫,中华现代中西医杂志,2005.23(3)：226-227
[111]石丸圭莊.电针刺激全身的镇痛效果与经络的关系.国外医学中医中药分册,2003,25(1)：56
[112]邵乐文,俞小玲.择时选穴按摩对胃肠道术后肠蠕动恢复的影响.中华护理杂志2006,41(8)：752
[113]商军科,杨志光,薛丽.针刺对62例硬膜外阻滞下行腹部手术后胃肠功能恢复的影响.陕西中医,2001,22(7)：416
[114]刘文全,王健,郝志友.针刺对功能性消化不良胃肠动力影响的临床研究.中国针灸.2001,21(5)：267
[115]陈永斌,陆青,兰爱珍,苏荣,黄海华.针刺干预胃镜检查反应临床观察.中国针灸.2007,27(9)：685
[116]常小荣,严洁,林亚平,等.电针足三里对家兔胃黏膜损伤细胞保护作用的观察.中国中医药信息杂志,2002,9(7)：26-27
[117]金伯泉.细胞和分子免疫学,第1版.西安：世界囝书出版公司.1995：95-175
[118]lshii S, Shimizu T. Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice[J]. Prog Lipid Res,2000,39-41
[119]李东复,段亚清.细胞因子在胃十二指肠疾病中的作用机理.白求恩医科大学学报,1999,25(4)：437-438
[120]Saeki T, Ohno T, Kamata K, Arai K, Mizuguchi S, Katori M, Saigenji K, Majima M. Mild irritant prevents ethanol-induced gastric mucosal microcirculatory disturbances through actions of calcitonin gene-related peptide and PGI2 in rats. Am J Physiol Gastrointest Liver Physiol2004; 286:G68-G75
[121]Kay Y. Efect of16.16-dmPGE2 on lipidic organelles of rat gastric suface mucous cells[J]. Gastroenterol,1993,104:103
[122]Kawabata A, Nishikawa H, Saitoh H, Nakaya Y, Hiramatsu K, Kubo S, Nishida M, Kawao N, Kuroda R, Sekiguchi F, Kinoshita M, Kakehi K, Arizono N, Yamagishi H, Kawai K. A protective role of protease-activated receptor 1 in rat gastric mucosa. Gastroenterology 2004; 126:208-219
[123]Brzozowski T, Konturek PC, Konturek SJ, Kwiecien S, Drozdowicz D, Bielanski W, Pajdo R, Ptak A, Nikiforuk A, Pawlik WW, Hahn EG. Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage. Regul Pept 2004; 120: 39-51
[124]Komori M, Tsuji S, Sun WH, Tsujii M, Kawai N, Yasumaru M, Kakiuchi Y, Kimura A, Sasaki Y, Higashiyama S, Kawano S, Hori M. Gastrin enhances gastric mucosal integrity through cyclooxygenase-2 upregulation in rats. Am JPhysiol Gastrointest Liver Physiol 2002; 283:G1368-G1378
[125]Miyake K, Tsukui T, Wada K, Tatsuguchi A, Futagami S, Hiratsuka T, Shinoki K, Iizumi T, Akamatsu T, Sakamoto C, Kobayashi M. Irritant-induced cyclooxygenase-2 is involved in the defense mechanism of the gastric mucosa in mice. J Gastroenterol 2002; 37:164-171
[126]徐军全,李秋萍,魏利惠,等.消化性溃疡、胃癌患者胃窦黏膜中胃肠激素含量变 化及其意义.临床消化杂志,1996,8(1)：8-10
[127]李平,许国铭,王成海.生长抑素对急性胃黏膜损伤保护作用的实验研究[J].第二军医大学学报,1997,18(1)：50
[128]Kontrurek PC, Brzozowski T, Konturek SJ et al. Scand J Gastroenterol,1997; 32(1): 6-15
[129]Ma L, Wang WP, Chow JY et al. Am J Physiol Gastrointest Liver Physiol,2000; 278(1): 10-17
[130]Yanaka A, Suzuki H, Shibahara T, et al. EGF promotes gastric mucoal restitution by activating Na(+)/H (+) exchange of epithelial cells. Am J Physiol Gastrointest Liver Physiol,2002,282:866-876
[131]Romano M, Polk WH, Awad JA, et al. Transformation growth factor alpha protection agjnst drug-induced injury to the rat gastric mucosa invo[J]. J Clin Invest,1992,90: 2409
[132]Niki S, Matsubayashi H, Mizoue T et al. Nippon Shokibyo Gakkai Zasshi,1999; 96(4):385-391
[133]Louw JA, Modlin IM, Tang L et al. J Int Med Res,1998; 26(2):82-86
[134]Wong BC, Wang WP, So WH et al. Aliment Pharmacol Ther,2001; 15(9):1459-1465
[135]阳仁达,严洁，易受乡,等.针刺胃经穴对家兔胃黏膜损伤的细胞保护作用及机理研究.中国医学研究与临床.2004；2(16)：8-11
[136]周国平,严洁,常小荣,等.电针足三里对胃黏膜损伤家兔EGF、 NO的影响.中国中医药信息杂志.2005；12(7)：39-40
[137]易受乡,阳仁达,严洁,等.针刺对胃黏膜损伤家兔表皮生长因子、生长抑素及生长抑素受体基因表达的影响世界华人消化杂志.2004；12(7)：1721-1723
[1]Mendelsohn J. Targeting the epidermal growth factor receptor for cancer therapy [J]. J Clin Oncol,2002, 20 (18 Suppl):1S-13S.
[2]Xiao z-Q. MajumdarAPN. Increasedin vitro activ oll OfEGFR by-branc-bound TGF from gastric and colonicmucoal Of pd rats[J]. Am J Physiol Gastrolntest Liver Physio,2001,281:G111-G116
[3]李兆申,诺先保,许国铭.胃黏膜损伤与保护-基础与临床.上海：上海科学技术出版社,2004：271
[4]Wells-A. EGF receptor[J]. Int-J-Biochem-Cell-Biol.1999 Jun; 31(6):637-43
[5]Olayioye MA, Neve R M, Lane HA, et al. The erb-B signaling networks:receptor heterodimerization in development and cancer[J].EMBO J,2000;19(13):3159-3167.
[6]Bowers G, Reardon D, Hewitt T, et al. The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells.2001,20(11):1388-97.
[7]Raymond E, Faivre S, Armand JP, et al. Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy.Drugs.2000;60(suppl 1):15-23
[8]Newman L, Xia W, Yang HY,et al. Correlation of p27 protein expression with HER-2/neu expression in breast cancer. Mol Carcinog.2001,30(3):169-75.
[9]黄文林,朱孝峰.信号转导.北京：人民卫生出版社.2005.
[10]Hognason T, Chatterjee S, Vartanian T,et al.Epidermal growrth factor receptor induced apoptosis:potentiation of ras signaling. FEBS Lett.2001;491(1-2):9-15.
[11]Carpenter G. Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways. Journal of cell biology.1999;146(4):697-702.
[12]于燕妮,方艺,车筑萍等.胃溃疡病活检标本中表皮生长因子受体的表达.贵州医药.2000.24(6)323-324
[13]He J H. Role of growth factor in the peptic ulcer healing. Foreign Med (Section of Digestive Disease) 2003;23(1):12-15.
[14]Xiao Z-Q. MajumdarAPN. Increased in vitro activation of EGFR by Membrane-bound TGF-a from gastric and colonic mucosa of aged rats[J].Am J Physiol Gastrolntest Liver Physio.2001,281:G111-G116
[15]刘建平,卜涛,白建乐等.EGF、TGF2α及EGFR在大鼠胃溃疡自愈过程中的表达及意义.中国药理学通报.2003,19(10)：1185～1188
[16]Tarmaw sk TA, Stachura J, Durbin T.Sarteh H, Gryoly H. Increased expression of epidermal growth factor receptor during gastric ulcer healing in rats [J]. Gastroenterology,1992;102:695-698;
[17]Hayashi M, Tapping, RI, ChaoTH et al. BMK1 mediates growth factor induced cell proliferation through direct cellular activation of serum and glucocorticoid inducible kinase.J Biol Chem,2001;276 (12):8631-4
[18]Konturek PC, Brzozowski T, Konturek SJ et al. Expression of epidermal growth factor and transforming growth factor alpha during ulcer healing. Time sequence study. Scand J Gast roenterol,1997;32(1):6-15
[19]Konturek PC, Brzozowski T, Konturek SJ et al. Expression of epidermal growth factor and transforming growth factor alpha during ulcer healing. Time sequence study. Scand J Gast roenterol,1997;32(1):6-15
[20]李兆申,崔忠敏,湛先保等.应激状态下胃黏膜耐受性细胞保护中表皮生长因子及其受体的免疫组化研究.解放军医学杂志.1999.24(6)：397-400
[21]邓兰琼.柴胡桂枝汤对大鼠乙酸胃溃疡黏膜表皮生长因子受体的影响.中国中西医结合消化杂志.2005.13(3)：141-145
[22]Zhao BM.Huang YX.W ang QL.Chu ZH.Zhao NX. Effects of electroacupuncture on gastric acid secretion and its relationship w ith gastric and epidermal growth factor in rats Q]. Shijie Huaren Zazhi (World Chin J Digestol),2000;8(3):271-278
[23]Hirofumi Kawanaka, Morimasa Tomikawa,Dolgor Baatar.Despite activation of EGF-receptor-ERK signaling pathway, epithelial proliferation is impairedin portal hypertensive gastric mucosa Relevance of MKP-l,c-fos,c-myc and cyclin D1 expression. Life Sciences 69 (2001) 3019-3033
[24]李建玲,易红,冯雪萍等大鼠胃黏膜细胞EGFR通过ERK-1／2信号传导通路激活AP-1.中国医师杂志.2003.5(9)：1170-1172