痤疮合剂治疗寻常痤疮肺胃湿热证的临床和实验研究
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摘要
1.研究目的:
①通过观察痤疮患者皮损和综合证候的改善情况,比较痤疮合剂与当归苦参丸治疗寻常痤疮的疗效,客观性评价痤疮合剂治疗寻常痤疮的临床疗效。
②寻常痤疮患者皮损内容物经派克墨水染色直接镜检,对糠秕马拉色菌与本病的相关性进行探讨。
③用痤疮合剂对痤疮丙酸杆菌、糠秕马拉色菌进行体外抑菌试验研究,为中医药治疗痤疮提供理论和实验室依据。
2.研究方法:
2.1临床研究:采用随机、对照方法,观察痤疮合剂治疗寻常痤疮的临床疗效。治疗组内服痤疮合剂30ml,每日2次;对照组内服当归苦参丸6g,每日2次。两组患者均局部外用痤疮合剂,每日2次。疗程4周。治疗前后对皮损情况(包括皮损程度、数量、颜色、肿痛情况)和综合证候疗效(包括皮损积分和中医证候)进行评分,评价疗效,同时注意观察不良反应。
2.2实验研究:
2.2.1痤疮患者皮损处糠秕马拉色菌带菌情况研究对痤疮患者皮损内糠秕马拉色菌用派克墨水染色法进行直接镜检检查。
2.2.2痤疮合剂治疗寻常痤疮的体外抑菌试验研究对痤疮丙酸杆菌、糠秕马拉色菌标准菌株传代培养,制成菌悬液,用不同浓度的痤疮合剂进行体外抑菌试验研究。
3.研究结果
3.1临床研究:治疗组34例,对照组28例。两组皮损积分、综合疗效积分在治疗前后有极显著性差异(P<0.01),说明两组均有较好的改善皮损和综合证候的作用。治疗后两组皮损积分有极显著性差异(P<0.01),治疗组皮损消退率为61.31%,高于对照组皮损消退率,说明治疗组在改善皮损方面疗效优于对照组。治疗后两组综合疗效积分有极显著性差异(P<0.01),治疗组综合证候疗效率为62.77%,高于对照组综合证候疗效率,说明治疗组在改善综合证候方面疗效优于对照组。痤疮患者主要为油性、混合性皮肤类型,分别占患者总数48.39%、41.94%;发病部位主要在额(42例,占67.74%)、面颊(59例,占95.16%)、口周(38例,占61.29%);61.29%患者性情急躁,显示精神情绪因素与本病有一定相关性; 71.11%的女性患者皮疹加重与月经周期有关。两组不良反应均较少。
3.2实验研究:
3.2.1痤疮患者皮损处糠秕马拉色菌带菌情况研究共检测117例痤疮患者,糠秕马拉色菌总带菌率为23.08%;其中男性患者30例,7例糠秕马拉色菌阳性,带菌率23.33%;女性患者87例,20例糠秕马拉色菌阳性,带菌率22.99%。与年龄的相关性研究结果显示:16～25岁患者糠秕马拉色菌检出率占患者总数80%以上。与病情严重程度的关系:中度(Ⅱ级)痤疮患者糠秕马拉色菌检出18例,检出率为66.67%。
3.2.2采用试管稀释法进行痤疮合剂对痤疮丙酸杆菌的抑菌实验研究。将痤疮丙酸杆菌标准株转种于厌氧血平皿,取次代培养的杆菌制成菌悬液,中药倍比稀释后进行抑菌试验。结果显示:经72h厌氧培养后,对照管中有细菌生长。中药液自1:2倍比稀释,稀释度至1:128时未见细菌生长,为该药最小抑菌浓度,即MIC为11.41mg/ml。采用琼脂扩散法进行痤疮合剂对糠秕马拉色菌的抑菌实验研究。将糠秕马拉色菌标准株传代培养2次,制备菌悬液,均匀涂于橄榄油固体培养基平皿上;将痤疮合剂用无菌蒸馏水分别稀释成浓度为100%、60%、50%、40%、30%、20%、10%、5%、0%(生长对照)进行抑菌实验。结果显示: 48小时菌落生长及抑菌环出现,在100%药物浓度抑菌环直径为14mm,30%药物浓度抑菌环直径为10mm。痤疮合剂对糠秕马拉色菌有抑菌环生长(直径≥10mm)的最低药物浓度为30%。
4.结论:
4.1痤疮合剂治疗寻常痤疮有较好效果,适用对象为中度痤疮(皮损主要为炎性丘疹、脓疱)肺胃湿热之证。与对照组相比,治疗组在改善皮损情况和综合证候方面疗效优于对照组。
4.2寻常痤疮患者皮损处可检出糠秕马拉色菌;体外抑菌实验证实痤疮合剂对痤疮丙酸杆菌有抑制作用,MIC为11.41mg/ml;对糠秕马拉色菌有抑菌环生长(直径≥10mm)的最低药物浓度为30%。
综上所述,本课题研究证明痤疮合剂治疗寻常痤疮具有较好的临床疗效,值得临床推广使用和进一步深入研究。
1.Objectives:
①The present study was designated to investigate the effects of using Cuochuang mixture and Dangguikushen pill to treat acne,according to the improvement of patients’skin lesions and syndromes.Assessing the curative effect of Cuochuang mixture.
②Using parker ink to dye the material coming from patients’skin lesions,Discussing the relativity of acne and M.furfur.
③Doing external bacteria repressing experiment with Cuochuang mixture ,that was to offer datas of theory and experimentation.
2.Methods:
2.1 Clinical trial: this randomized,controlled,4-week study assessed the efficacy of Cuochuang mixture to treat acne.The samples were collected from 62 cases of acne.amomg which 34 cases were treated with Cuochuang mixture as treatment group,28 cases with Dangguikushen pill as control group.Forming an estimate of scores and syndromes.The side-effects were also evaluated both in the two groups.
2.2 Experimental research:
2.2.1 The study of M.furfur coming from acne patients’skin lesions: Using parker ink to dye the material,then detected it with microscope.
2.2.2 The research of external bacteria repressing experiment:using different concentration of Cuochuang mixture to inhibit P.ance and M.furfur.
3.Results:
3.1 Clinical trial: After 4 weeks’treatment, the scores of skin lesions and symptom in both the treatment group (n=34) and the control group (n=28) reduced obviously.the reducing rate of treatment group was 61.31%,higher than the reducing rate of control group. The scores of syndromes reduced obviously between two groups in the end of the treatment,the reducing rate of treatment group was 62.77%,also higher than the other.The study showed that the skin of many acne patients was greasy and mixed;The central places of skin lesions was forehead,jowl and around the mouth; The character of 61.29 percent patients were impetuously; The change of the period would bring serious result to the skin lesions among many of female patients.
3.2 Experimental research:
3.2.1 The study of M.furfur coming from acne patients’skin lesions:positive rate of M.furfur was 23.08% in 117 cases of acne patients,including 7 cases of male patients and 20 cases of female patients.The outcomes of this research showed that 16～25 aged patients had M.furfur ,more than 80% of total cases.The relationship of disease serious degree showed that the positive rate was 66.67% among mid-term degree acne patients.
3.2.2 The inhibitory experiment of P.acne:inoculate P.acne to the anaerobic blood plate,using the different concentration of Cuochuang mixture to carry out the test.Conclusion:incubating for 72 hours,the MIC of Cuochuang mixture was 11.41mg/ml.Using agar diffused method to put up the inhibitory experiment of M.furfur.The usable concentration of Cuochuang mixture was 100%、60%、50%、40%、30%、20%、10%、5%、0%.As a result:the minimum inhibitory concentration (that the ring of inhibitory bacteria≥10mm)of Cuochuang mixture was 30%.
4.Conclusion
4.1 It could be seen that Cuochuang mixture had better curative effect on acne treatment.Compared with control group,treatment group had better impact on improvement of skin lesions and syndromes.
4.2 M.furfur could be found in the material of ance patients’skin lesions;External bacteria repressing experiment approved that Cuochuang mixture could repress P.acne and M.furfur.
To sum up,this task proved that Cuochuang mixture had better curative effect on acne treatment,it should be deserved clinical generalization usage and further thorough researched.
①通过观察痤疮患者皮损和综合证候的改善情况,比较痤疮合剂与当归苦参丸治疗寻常痤疮的疗效,客观性评价痤疮合剂治疗寻常痤疮的临床疗效。
②寻常痤疮患者皮损内容物经派克墨水染色直接镜检,对糠秕马拉色菌与本病的相关性进行探讨。
③用痤疮合剂对痤疮丙酸杆菌、糠秕马拉色菌进行体外抑菌试验研究,为中医药治疗痤疮提供理论和实验室依据。
2.研究方法:
2.1临床研究:采用随机、对照方法,观察痤疮合剂治疗寻常痤疮的临床疗效。治疗组内服痤疮合剂30ml,每日2次;对照组内服当归苦参丸6g,每日2次。两组患者均局部外用痤疮合剂,每日2次。疗程4周。治疗前后对皮损情况(包括皮损程度、数量、颜色、肿痛情况)和综合证候疗效(包括皮损积分和中医证候)进行评分,评价疗效,同时注意观察不良反应。
2.2实验研究:
2.2.1痤疮患者皮损处糠秕马拉色菌带菌情况研究对痤疮患者皮损内糠秕马拉色菌用派克墨水染色法进行直接镜检检查。
2.2.2痤疮合剂治疗寻常痤疮的体外抑菌试验研究对痤疮丙酸杆菌、糠秕马拉色菌标准菌株传代培养,制成菌悬液,用不同浓度的痤疮合剂进行体外抑菌试验研究。
3.研究结果
3.1临床研究:治疗组34例,对照组28例。两组皮损积分、综合疗效积分在治疗前后有极显著性差异(P<0.01),说明两组均有较好的改善皮损和综合证候的作用。治疗后两组皮损积分有极显著性差异(P<0.01),治疗组皮损消退率为61.31%,高于对照组皮损消退率,说明治疗组在改善皮损方面疗效优于对照组。治疗后两组综合疗效积分有极显著性差异(P<0.01),治疗组综合证候疗效率为62.77%,高于对照组综合证候疗效率,说明治疗组在改善综合证候方面疗效优于对照组。痤疮患者主要为油性、混合性皮肤类型,分别占患者总数48.39%、41.94%;发病部位主要在额(42例,占67.74%)、面颊(59例,占95.16%)、口周(38例,占61.29%);61.29%患者性情急躁,显示精神情绪因素与本病有一定相关性; 71.11%的女性患者皮疹加重与月经周期有关。两组不良反应均较少。
3.2实验研究:
3.2.1痤疮患者皮损处糠秕马拉色菌带菌情况研究共检测117例痤疮患者,糠秕马拉色菌总带菌率为23.08%;其中男性患者30例,7例糠秕马拉色菌阳性,带菌率23.33%;女性患者87例,20例糠秕马拉色菌阳性,带菌率22.99%。与年龄的相关性研究结果显示:16～25岁患者糠秕马拉色菌检出率占患者总数80%以上。与病情严重程度的关系:中度(Ⅱ级)痤疮患者糠秕马拉色菌检出18例,检出率为66.67%。
3.2.2采用试管稀释法进行痤疮合剂对痤疮丙酸杆菌的抑菌实验研究。将痤疮丙酸杆菌标准株转种于厌氧血平皿,取次代培养的杆菌制成菌悬液,中药倍比稀释后进行抑菌试验。结果显示:经72h厌氧培养后,对照管中有细菌生长。中药液自1:2倍比稀释,稀释度至1:128时未见细菌生长,为该药最小抑菌浓度,即MIC为11.41mg/ml。采用琼脂扩散法进行痤疮合剂对糠秕马拉色菌的抑菌实验研究。将糠秕马拉色菌标准株传代培养2次,制备菌悬液,均匀涂于橄榄油固体培养基平皿上;将痤疮合剂用无菌蒸馏水分别稀释成浓度为100%、60%、50%、40%、30%、20%、10%、5%、0%(生长对照)进行抑菌实验。结果显示: 48小时菌落生长及抑菌环出现,在100%药物浓度抑菌环直径为14mm,30%药物浓度抑菌环直径为10mm。痤疮合剂对糠秕马拉色菌有抑菌环生长(直径≥10mm)的最低药物浓度为30%。
4.结论:
4.1痤疮合剂治疗寻常痤疮有较好效果,适用对象为中度痤疮(皮损主要为炎性丘疹、脓疱)肺胃湿热之证。与对照组相比,治疗组在改善皮损情况和综合证候方面疗效优于对照组。
4.2寻常痤疮患者皮损处可检出糠秕马拉色菌;体外抑菌实验证实痤疮合剂对痤疮丙酸杆菌有抑制作用,MIC为11.41mg/ml;对糠秕马拉色菌有抑菌环生长(直径≥10mm)的最低药物浓度为30%。
综上所述,本课题研究证明痤疮合剂治疗寻常痤疮具有较好的临床疗效,值得临床推广使用和进一步深入研究。
1.Objectives:
①The present study was designated to investigate the effects of using Cuochuang mixture and Dangguikushen pill to treat acne,according to the improvement of patients’skin lesions and syndromes.Assessing the curative effect of Cuochuang mixture.
②Using parker ink to dye the material coming from patients’skin lesions,Discussing the relativity of acne and M.furfur.
③Doing external bacteria repressing experiment with Cuochuang mixture ,that was to offer datas of theory and experimentation.
2.Methods:
2.1 Clinical trial: this randomized,controlled,4-week study assessed the efficacy of Cuochuang mixture to treat acne.The samples were collected from 62 cases of acne.amomg which 34 cases were treated with Cuochuang mixture as treatment group,28 cases with Dangguikushen pill as control group.Forming an estimate of scores and syndromes.The side-effects were also evaluated both in the two groups.
2.2 Experimental research:
2.2.1 The study of M.furfur coming from acne patients’skin lesions: Using parker ink to dye the material,then detected it with microscope.
2.2.2 The research of external bacteria repressing experiment:using different concentration of Cuochuang mixture to inhibit P.ance and M.furfur.
3.Results:
3.1 Clinical trial: After 4 weeks’treatment, the scores of skin lesions and symptom in both the treatment group (n=34) and the control group (n=28) reduced obviously.the reducing rate of treatment group was 61.31%,higher than the reducing rate of control group. The scores of syndromes reduced obviously between two groups in the end of the treatment,the reducing rate of treatment group was 62.77%,also higher than the other.The study showed that the skin of many acne patients was greasy and mixed;The central places of skin lesions was forehead,jowl and around the mouth; The character of 61.29 percent patients were impetuously; The change of the period would bring serious result to the skin lesions among many of female patients.
3.2 Experimental research:
3.2.1 The study of M.furfur coming from acne patients’skin lesions:positive rate of M.furfur was 23.08% in 117 cases of acne patients,including 7 cases of male patients and 20 cases of female patients.The outcomes of this research showed that 16～25 aged patients had M.furfur ,more than 80% of total cases.The relationship of disease serious degree showed that the positive rate was 66.67% among mid-term degree acne patients.
3.2.2 The inhibitory experiment of P.acne:inoculate P.acne to the anaerobic blood plate,using the different concentration of Cuochuang mixture to carry out the test.Conclusion:incubating for 72 hours,the MIC of Cuochuang mixture was 11.41mg/ml.Using agar diffused method to put up the inhibitory experiment of M.furfur.The usable concentration of Cuochuang mixture was 100%、60%、50%、40%、30%、20%、10%、5%、0%.As a result:the minimum inhibitory concentration (that the ring of inhibitory bacteria≥10mm)of Cuochuang mixture was 30%.
4.Conclusion
4.1 It could be seen that Cuochuang mixture had better curative effect on acne treatment.Compared with control group,treatment group had better impact on improvement of skin lesions and syndromes.
4.2 M.furfur could be found in the material of ance patients’skin lesions;External bacteria repressing experiment approved that Cuochuang mixture could repress P.acne and M.furfur.
To sum up,this task proved that Cuochuang mixture had better curative effect on acne treatment,it should be deserved clinical generalization usage and further thorough researched.
引文
1.李光宇,王萍.痤疮的中医治疗进展.北京中医,2006,25(l2):756-758.
2.李艳萍,张友堂. 痤疮病因病机探讨.中国中医基础医学杂志,2004,10(11):59-60.
3.吴小红,刘瓦利.痤疮发病机理的中西医研究现状.中国中西医结合皮肤性病学杂志,2003,2(3):193-197.
4.孙艳红,秦竹,张胜,等. 痤疮治疗方剂的历史及现状浅析.云南中医学院学报,2006,29(5):49-51.
5.赵炳南,张志礼.简明中医皮肤病学.北京:中国展望出版社,1983,238.
6.张志礼.皮肤科手册.北京:中医古籍出版社,2004,472-473.
7.中国中医研究院广安门医院.朱仁康临床经验集.北京:人民卫生出版社,1986,197.
8.华华.薛伯寿教授治疗痤疮的中医辨证体会.中医药学报,2005,33(6):37.
9. 陈力.痤疮的中医药辨治概况.江苏中医药,2003,24(10):58-60.
10. 李成义,王德林.痤疮治疗经验初探.甘肃中医学院学报,1998,15(3):23.
11.张晓杰.赵纯修治疗痤疮经验.山东中医杂志,1999,18(9):420.
12.沈冬,刘瓦利.庄国康治疗痤疮经验.中医杂志,2001,42(4):210.
13.何国强,周世印,张和平. 痤疮从瘀毒辨治的体会.浙江中医杂志,2006, 41(2):102-103.
14.陈文曾,刘建新,陈汉章. 陈汉章教授治疗痤疮临床经验撷菁. 中医药学刊,2006,24(2):213-214.
15.傅佩骏,马绍.枇杷清肺饮加减治疗痤疮疗效观察.辽宁中医杂志,2005,32(7):679-680.
16.许新.普济消毒饮加味治疗面部痤疮 50 例.河南中医学院学报,2005,20(119):7.
17.王渝,崔丽.消痤汤治疗寻常型痤疮 166 例临床观察.河北中医,2004,26(6):426.
18.刘得喜,吴沛田,萨仁.痘痘消治疗寻常痤疮60例临床研究.中国热带医学,2005,5(4):740.
19.欧柏生,刘卫兵.龙血竭胶囊治疗寻常型痤疮7O例.中国民间疗法,2005,9(13):9.
20.王松岩.平痤胶囊治疗痤疮(肺胃蕴热型)的临床观察.中医药学报,2002,30(3):28-29.
21.张天灿.加味泻心汤治疗痤疮65例.云南中医中药杂志,2002,23(3):48.
22.周克邦.功劳去火片治疗寻常痤疮58例.新中医,2002,34(6):48-49.
23.杨健芳.148 例痤疮中医辨证分型与临床疗效观察. 湖南医科大学学报,2001,26(3):219-220.
24.扈晓成.辨证治疗寻常型痤疮 86 例临床观察.河北中医,2005,27(8):584.
25.王朝霞,李金祥.中医辨证治疗痤疮115例.河南中医药学刊,2000,15(2):27-28.
26.齐凤琴,韩淑香,富学东,等.五参散治疗寻常性痤疮156例临床研究.时珍国医国药,2005,16(5):409.
27.李灵巧.排毒消痤饮治疗寻常性痤疮135例.河北中医药学报,2002,17(2):9-10.
28.孔瑞龙.清热解毒合剂治疗痤疮的临床观察.辽宁中医杂志,2004,31(5):431.
29.王利民,王庆梅,潘洋.从肝脾论治痤疮 32 例.中医药学报 2000,(4):42 .
30.周德瑛,李元文,张丰川. 柴芩消痤汤治疗寻常痤疮 82 例. 中国中医急症,2004,13(6):346.
31.蒋志洪、甘宁峰.中药外治寻常性痤疮 48 例.广西中医药,2003,26(5):15.
32.蔡绿珍.消痤散外敷治疗寻常痤疮 48 例疗效观察.云南中医中药杂志,2003,24(1):19.
33.李玉和.中西结合治疗寻常型痤疮 50 例.中国民间疗法,2005,13(9):5-6.
34.史萍.中药面膜治疗面部炎症性寻常痤疮.辽宁中医杂志,2003,
30(4):320.
35.于守连.紫外线离子喷雾加中药倒膜治疗痤疮疗效观察.皮肤病与性病,2003,25(3):25.
36.刘毅,崔艳华.中西医结合治疗重度痤疮的临床观察.中国麻风皮肤病杂志,2005,21(3):237.
37.彭晓云,彭建梅,李常兴,等.中药倒膜联合外搽治疗痤疮的疗效观察.中华医学美学美容杂志,2006,12(4):198.
38.苏丽.中药外洗治疗痤疮.中医外治杂志,2000,9(2):48.
39.候慧先.中药内外合治青春期颜面痤疮的临床研究.中医药学报,2002,30(5):11-12.
40.宋宇.耳尖配合大椎点刺放血治疗痤疮 85 例.上海针灸杂志,2002,21(1):29.
41.任幼红,张文平,陈竹碧.火针配合刺络拔罐治疗痤疮 58 例.上海针灸杂志,2005,4(4):16-17.
42.潘纪华.耳穴贴压六神丸治疗痤疮57例.中医外治杂志,1999,8(3):45.
43.杨梅坤.耳针治疗寻常痤疮30例.长春中医学院学报,1999,15(3):37.
44.丁原全,董瑞祥,张信.火针治疗痤疮50例.中国针灸,2000,20(2):84.
45.林宏,陈美华.刮痧放血法治疗痤疮的临床观察.中国医药学,2000,15(1):75.
46.周秀莲. 刺络拔罐法配合西医治疗痤疮50 例临床观察.实用医学杂志,2007,23(5):730.
47.沈冬,许铣. 复方蛇草汤治疗寻常痤疮的临床与实验研究.临床皮肤科杂志,2000,29(4):201-203.
48.顾丽贞,郑荣波.清热暗疮片对痤疮丙酸杆菌等致病菌的体外抗菌作用的实验研究.中国中医药科技,2004,11(3):140-141.
49.童明庆,施瑞华,戴传箴,等. 寻常痤疮致病菌的分离及其药敏结果.临床检验杂志,1996,14(6):291-293.
50.吴剑波,蒋小音,雷鹏程,等.微生物学检查对寻常痤疮治疗的指导意义,中国皮肤性病学杂志,1999,13(3):149.
51.汤红峰,林燕辉,张玉新,等.235 例痤疮患者并糠秕孢子菌感染特点分析.岭南皮肤性病科杂志,2003,10(3):175-176.
52.蒙秉新,苏建英. 面部痤疮皮损内糠秕马拉色菌检测及酮康唑治疗效果观察.中国热带医学,2003,3(4):468-469.
53.杨典秋. 寻常痤疮患者皮损中马拉色菌带菌情况的调查分析.现代医药卫生,2007,23(9):1360.
54.林新瑜,罗旭松,向雪岑,等. 寻常痤疮患者的甲襞微循环及血液流变学研究.中华医学美学美容杂志,2003,9(2):120.
55.杜锡贤,汪五清,赵 颖. 痤疮饮治疗痤疮65例及其对血液流变学的影响.山东中医杂志,2000,19(5):268-269.
56.曾燕,蒋艳霞,郑金锋,等. 痤疮患者外周血白细胞雄激素受体的测定.中华皮肤科杂志,1999,32(2):131.
57.张又仁,徐祖森. 雄激素在痤疮发病机制中的研究进展.实用医学杂志,2004,20(4):463-464.
58.张芃,王萍,张志礼,等.金菊香煎剂治疗女性寻常性痤疮临床观察及血清睾酮检测.中国皮肤性病学杂志,2001,15(1):48-49.
59.范瑞强.痤疮的中西医研究进展.岭南皮肤性病科杂志,2000,7(4):51-53.
60.章明美,杨小明,谢吉民,等. 15 种生药提取物抑制痤疮致病菌的活性筛选. 江苏大学学报(医学版),2006,14(3):188-190.
61.耿东升,刘 发,杨弟存,等. 消痤灵颗粒抗菌及其对丙酸杆菌致大鼠耳廓炎症痤疮的防治作用. 解放军药学学报,1999,15(6):6-8.
62. 程丽芳,陈兴强,刘太华,等.消痤丸防治痤疮药效学实验研究.时珍国医国药,2001,12(1):15-16.
63.张友堂,尹霞,孙丽英,等. 痤疮颗粒治疗寻常痤疮的临床与实验研究.中医药信息,2007,24(2):58-59.
64. 陈红斌,陈钧.大黄对痤疮主要致病菌的体外抑菌作用研究.中药药理与临床,2006,22(3、4):111-112.
65.杜青云,王国胜,张铭穷.姜黄挥发油洗剂对糠秕孢子菌的抑菌实验研究.人民军医药学专刊,1997,13(2):73-75.
66.李向阳,朱宇同,王艳芳,等.青蒿油纳米脂质体制剂对痤疮致病菌的抑制作用.广州中医药大学学报,2004,21(2):122-124.
67.蒋燕萍,曹 煜,李淑芳.珊瑚姜的有效成分对糠秕孢子菌抑制作用的实验研究.贵阳中医学院学报,2006,28(5):57-59.
1.Odom RB , James WD , Berger TG.Andrews Diseases of the skin .9ed.W.B.Saunders Co,Philadelphia 2000:284-306.
2.White GM.Recent findings in the epidemio1ogic evidence,classification,and subtype of the ance vulgaris.J Am Acad Dermatol,l998,39:34-37.
3. Goulden V,Clark SM,Cunliffe WJ.Post-adolescent acne:a review of clinical features.Br J Dermatol l997,136:66-70.
4.Goulden V,Stables GI,Cunliffe WJ.Prevalence of facial acne in adults.J A Am Acad Dermatol l999,41:577-580.
5.杨智,何黎. 痤疮与遗传. 国外医学皮肤性病学分册,2005,31(1):33-34.
6. 耿嘉玮,韩 洪. 补肾药在痤疮治疗中的应用.中国医刊,2001,36(4):55.
7.施伟民,陈德利,朴莫兰,等.痤疮患者血清性激素水平的研究.临床皮肤科杂志,1998,27(1): 15-16.
8.范瑞强,何盛供,张国维.66 例痤疮患者血清睾酮及雌二醇水平研究.临床皮肤科杂志,1998,27(1):17-18.
9. 曾燕,张素芳,李韧,等.13-顺维甲酸对痤疮患者 AR 的影响.中华医学美容杂志, 2001,7(1): 17-18.
10. 胡晓莉,张书梅,赵广碧,等.女性迟发性痤疮与性激素关系的研究.中华皮肤科杂志,2000,33(6): 419.
11. Goulden V, Clark SM,Cunliffe WJ. Postadolescent acne: a review of clinical features. Br J Dermatol 1997,136: 66-70.
12.靳培英.痤疮的分型论治.中华皮肤科杂志,2002,35(1): 67-69.
13. Nishijima S, Kurokawal, Katoh N,et al. The bacteriology of acne vulgaris antimicrobial susceptibility of Propionibacterium acnes and Staphylococcus epidermidis isolated from acne lesions. J Dermatol 2000, 27(5): 318-323.
14.党倩丽,罗秀荣,马小萍.幽门螺杆菌感染与酒渣鼻的相关性.临床皮肤科杂志,2000,29(1):9.
15. Sagi E. The combination formulation of 2% erythromycin plus 1% bi- fonazole once a day versus formulations of topical 2% erythromycin alone twice a day in the treatment of acne vulgaris. A random and blind study. J Dermatol Treat,2000,11(4): 247-251.
16.陈人义.美满霉素与四环素治疗寻常痤疮的疗效比较.中国皮肤性病学杂志,1996,10:52.
17.杨福勤.灭滴灵治疗痤疮 58 例疗效观察.临床皮肤科杂志,1995,24:327.
18.谭升顺,等.抗雄激素对寻常痤疮的临床疗效观察.中华皮肤科杂志,1984,17:27.
19.毛玲娥,等.复方醋酸环丙孕酮治疗女性痤疮 80 例疗效评估.上海第二医科大学学报,1995,15:69.
20.徐晖,等.达因-35 治疗女性痤疮 50 例.浙江医学,1992,14:37.
21.王希,等.寻常型痤疮患者血清和头发锌含量及补锌疗法分析.中华皮肤科杂志,1995,28:321.
22.周展超,等.外用 2.5%丹参酮霜治疗寻常痤疮的临床及实验研究.临床皮肤科杂志,1996,25:376.
23.冯信忠.必麦森凝胶治疗寻常型痤疮临床疗效观察.临床皮肤科杂志,1996,25:35.
24.涂平,等.必麦森凝胶治疗寻常型痤疮疗效观察.中华皮肤科杂志,1996,29:301.
25.罗燕,等.外用特丽仙液治疗寻常痤疮 60 例疗效评价.临床皮肤科杂志,1994,23:266.
26.姜辉,等.复方灭滴灵霜治疗寻常性痤疮 50 例.中国皮肤性病学杂志,1995,9:51.
27.穆艳蕾,杨蓉娅,王文岭,等. 蓝光治疗痤疮 120 例临床疗效观察.美容医学,2007,16(1):80-82.
28.钟建桥,先德海,陈德宇. 窄谱蓝光治疗寻常痤疮临床疗效观察.临床皮肤科杂志,2007,36(2):115-116.
29.Lehmann HP,Robinson KA,Andrews JS,et al.Acne therapy: ameth odologic review. J Am Acad Dermatol 2002,47(2): 231.
30.Pochi PE,Shalita AR,Strauss JS,etal.Report of the consensus conference on acne classification.J Am Acad Dermatol 1991,24(3):495.
31.Doshi A,Zaheer A,Stiller MJ.A comparison of current acne grading systems and proposal of a novel system.Int J Dermatol,1997,36(6):416-418.
1. 赵辨.临床皮肤病学.江苏科学技术出版社,2001:935-938.
2. Odom RB , James WD , Berger TG. Andrews Diseases of the skin .9ed.W.B.Saunders Co,Philadelphia 2000:284-306.
3.李光宇,王萍.痤疮的中医治疗进展.北京中医,2006,25(l2):756-758.
4.孙凤琴.许连霈教授治疗痤疮经验介绍.北京中医药大学学报,1999,22(5):48.
5.凌一揆.中药学(第五版).上海科学技术出版社,1994.
1. 熊琳.马拉色菌的命名和分类进展.临床皮肤科杂志,2000,29 (5):310-312.
2. 冉玉平.检测糠秕马拉色菌的几种取材染色和培养方法介绍.中国皮肤性病学杂志,1999,13(3):181-182.
3. 蒙秉新,苏建英. 面部痤疮皮损内糠秕马拉色菌检测及酮康唑治疗效果观察.中国热带医学,2003,3(4):468-469.
4. 汤红峰,林燕辉,张玉新,等.235 例痤疮患者并糠秕孢子菌感染特点分析.岭南皮肤性病科杂志,2003,10(3):175-176.
5. 杨典秋. 寻常痤疮患者皮损中马拉色菌带菌情况的调查分析.现代医药卫生,2007,23(9):1360.
6. 高峰,胡素泉,李智华,等.176 例寻常痤疮患者马拉色菌带菌率的调查分析.中华皮肤科杂志,2004,37(8):492.
1.Gollnick HPM, Zouboulis CC,Akamatsu H etal;Pathogenesis and pathogenesis related treatment of acne. J Dermatollgy 1991,18:489.
2. 朱忠勇.实用医学检验学.人民军医出版社,1992,第1版:549-550.
3.戴自英,刘裕昆,汪复,等.实用抗菌药物学.上海∶上海科技出版社,1992,12-13.
4.曲剑华,姚卫海,王萍,等.痤疮中医证型与面部菌群关系临床和实验研究.医学研究杂志,2006,35(10):100-101.
5.程丽芳,陈兴强,刘太华,等.消痤丸防治痤疮药效学实验研究.时珍国医国药,2001,12(1):15-16.
6.张友堂,尹霞,孙丽英,等. 痤疮颗粒治疗寻常痤疮的临床与实验研究.中医药信息,2007,24(2):58-59.
7.黄畋等.48种中药对痤疮丙酸杆菌的抑制作用.中华皮肤科杂志,1992,25( 2 ):307-308.
8.汤红峰,林燕辉,张玉新,等.235例痤疮患者并糠秕孢子菌感染特点分析.岭南皮肤性病科杂志,2003,10(3):175-176.
9.关学琛,杨健.糠秕孢子菌在寻常型痤疮中致病性的探讨.新医学,1998,29(增刊2):76-77.
10.宫毓静,安汝国,虞慧,等.164种中药乙醇提取物抗真菌作用研究.中草药,2002,33(1):42-47.
11.王理达,胡迎庆,果德安,等.13种生药提取物及化学成分的抗真菌活性筛选.中草药,2001,32(3):241-244.
12.尹秀芝,蒲卓,王冰梅,等.中药苍术抗真菌作用的研究及临床观察.北 华大学学报(自然科学版),2000,1(6):492-494.
13.郑晓晖,高进,郑义,等.9种中药对马拉色菌分离株的抑菌实验研究.中国中西医结合皮肤性病学杂志,2003,2(1):16-18.
2.李艳萍,张友堂. 痤疮病因病机探讨.中国中医基础医学杂志,2004,10(11):59-60.
3.吴小红,刘瓦利.痤疮发病机理的中西医研究现状.中国中西医结合皮肤性病学杂志,2003,2(3):193-197.
4.孙艳红,秦竹,张胜,等. 痤疮治疗方剂的历史及现状浅析.云南中医学院学报,2006,29(5):49-51.
5.赵炳南,张志礼.简明中医皮肤病学.北京:中国展望出版社,1983,238.
6.张志礼.皮肤科手册.北京:中医古籍出版社,2004,472-473.
7.中国中医研究院广安门医院.朱仁康临床经验集.北京:人民卫生出版社,1986,197.
8.华华.薛伯寿教授治疗痤疮的中医辨证体会.中医药学报,2005,33(6):37.
9. 陈力.痤疮的中医药辨治概况.江苏中医药,2003,24(10):58-60.
10. 李成义,王德林.痤疮治疗经验初探.甘肃中医学院学报,1998,15(3):23.
11.张晓杰.赵纯修治疗痤疮经验.山东中医杂志,1999,18(9):420.
12.沈冬,刘瓦利.庄国康治疗痤疮经验.中医杂志,2001,42(4):210.
13.何国强,周世印,张和平. 痤疮从瘀毒辨治的体会.浙江中医杂志,2006, 41(2):102-103.
14.陈文曾,刘建新,陈汉章. 陈汉章教授治疗痤疮临床经验撷菁. 中医药学刊,2006,24(2):213-214.
15.傅佩骏,马绍.枇杷清肺饮加减治疗痤疮疗效观察.辽宁中医杂志,2005,32(7):679-680.
16.许新.普济消毒饮加味治疗面部痤疮 50 例.河南中医学院学报,2005,20(119):7.
17.王渝,崔丽.消痤汤治疗寻常型痤疮 166 例临床观察.河北中医,2004,26(6):426.
18.刘得喜,吴沛田,萨仁.痘痘消治疗寻常痤疮60例临床研究.中国热带医学,2005,5(4):740.
19.欧柏生,刘卫兵.龙血竭胶囊治疗寻常型痤疮7O例.中国民间疗法,2005,9(13):9.
20.王松岩.平痤胶囊治疗痤疮(肺胃蕴热型)的临床观察.中医药学报,2002,30(3):28-29.
21.张天灿.加味泻心汤治疗痤疮65例.云南中医中药杂志,2002,23(3):48.
22.周克邦.功劳去火片治疗寻常痤疮58例.新中医,2002,34(6):48-49.
23.杨健芳.148 例痤疮中医辨证分型与临床疗效观察. 湖南医科大学学报,2001,26(3):219-220.
24.扈晓成.辨证治疗寻常型痤疮 86 例临床观察.河北中医,2005,27(8):584.
25.王朝霞,李金祥.中医辨证治疗痤疮115例.河南中医药学刊,2000,15(2):27-28.
26.齐凤琴,韩淑香,富学东,等.五参散治疗寻常性痤疮156例临床研究.时珍国医国药,2005,16(5):409.
27.李灵巧.排毒消痤饮治疗寻常性痤疮135例.河北中医药学报,2002,17(2):9-10.
28.孔瑞龙.清热解毒合剂治疗痤疮的临床观察.辽宁中医杂志,2004,31(5):431.
29.王利民,王庆梅,潘洋.从肝脾论治痤疮 32 例.中医药学报 2000,(4):42 .
30.周德瑛,李元文,张丰川. 柴芩消痤汤治疗寻常痤疮 82 例. 中国中医急症,2004,13(6):346.
31.蒋志洪、甘宁峰.中药外治寻常性痤疮 48 例.广西中医药,2003,26(5):15.
32.蔡绿珍.消痤散外敷治疗寻常痤疮 48 例疗效观察.云南中医中药杂志,2003,24(1):19.
33.李玉和.中西结合治疗寻常型痤疮 50 例.中国民间疗法,2005,13(9):5-6.
34.史萍.中药面膜治疗面部炎症性寻常痤疮.辽宁中医杂志,2003,
30(4):320.
35.于守连.紫外线离子喷雾加中药倒膜治疗痤疮疗效观察.皮肤病与性病,2003,25(3):25.
36.刘毅,崔艳华.中西医结合治疗重度痤疮的临床观察.中国麻风皮肤病杂志,2005,21(3):237.
37.彭晓云,彭建梅,李常兴,等.中药倒膜联合外搽治疗痤疮的疗效观察.中华医学美学美容杂志,2006,12(4):198.
38.苏丽.中药外洗治疗痤疮.中医外治杂志,2000,9(2):48.
39.候慧先.中药内外合治青春期颜面痤疮的临床研究.中医药学报,2002,30(5):11-12.
40.宋宇.耳尖配合大椎点刺放血治疗痤疮 85 例.上海针灸杂志,2002,21(1):29.
41.任幼红,张文平,陈竹碧.火针配合刺络拔罐治疗痤疮 58 例.上海针灸杂志,2005,4(4):16-17.
42.潘纪华.耳穴贴压六神丸治疗痤疮57例.中医外治杂志,1999,8(3):45.
43.杨梅坤.耳针治疗寻常痤疮30例.长春中医学院学报,1999,15(3):37.
44.丁原全,董瑞祥,张信.火针治疗痤疮50例.中国针灸,2000,20(2):84.
45.林宏,陈美华.刮痧放血法治疗痤疮的临床观察.中国医药学,2000,15(1):75.
46.周秀莲. 刺络拔罐法配合西医治疗痤疮50 例临床观察.实用医学杂志,2007,23(5):730.
47.沈冬,许铣. 复方蛇草汤治疗寻常痤疮的临床与实验研究.临床皮肤科杂志,2000,29(4):201-203.
48.顾丽贞,郑荣波.清热暗疮片对痤疮丙酸杆菌等致病菌的体外抗菌作用的实验研究.中国中医药科技,2004,11(3):140-141.
49.童明庆,施瑞华,戴传箴,等. 寻常痤疮致病菌的分离及其药敏结果.临床检验杂志,1996,14(6):291-293.
50.吴剑波,蒋小音,雷鹏程,等.微生物学检查对寻常痤疮治疗的指导意义,中国皮肤性病学杂志,1999,13(3):149.
51.汤红峰,林燕辉,张玉新,等.235 例痤疮患者并糠秕孢子菌感染特点分析.岭南皮肤性病科杂志,2003,10(3):175-176.
52.蒙秉新,苏建英. 面部痤疮皮损内糠秕马拉色菌检测及酮康唑治疗效果观察.中国热带医学,2003,3(4):468-469.
53.杨典秋. 寻常痤疮患者皮损中马拉色菌带菌情况的调查分析.现代医药卫生,2007,23(9):1360.
54.林新瑜,罗旭松,向雪岑,等. 寻常痤疮患者的甲襞微循环及血液流变学研究.中华医学美学美容杂志,2003,9(2):120.
55.杜锡贤,汪五清,赵 颖. 痤疮饮治疗痤疮65例及其对血液流变学的影响.山东中医杂志,2000,19(5):268-269.
56.曾燕,蒋艳霞,郑金锋,等. 痤疮患者外周血白细胞雄激素受体的测定.中华皮肤科杂志,1999,32(2):131.
57.张又仁,徐祖森. 雄激素在痤疮发病机制中的研究进展.实用医学杂志,2004,20(4):463-464.
58.张芃,王萍,张志礼,等.金菊香煎剂治疗女性寻常性痤疮临床观察及血清睾酮检测.中国皮肤性病学杂志,2001,15(1):48-49.
59.范瑞强.痤疮的中西医研究进展.岭南皮肤性病科杂志,2000,7(4):51-53.
60.章明美,杨小明,谢吉民,等. 15 种生药提取物抑制痤疮致病菌的活性筛选. 江苏大学学报(医学版),2006,14(3):188-190.
61.耿东升,刘 发,杨弟存,等. 消痤灵颗粒抗菌及其对丙酸杆菌致大鼠耳廓炎症痤疮的防治作用. 解放军药学学报,1999,15(6):6-8.
62. 程丽芳,陈兴强,刘太华,等.消痤丸防治痤疮药效学实验研究.时珍国医国药,2001,12(1):15-16.
63.张友堂,尹霞,孙丽英,等. 痤疮颗粒治疗寻常痤疮的临床与实验研究.中医药信息,2007,24(2):58-59.
64. 陈红斌,陈钧.大黄对痤疮主要致病菌的体外抑菌作用研究.中药药理与临床,2006,22(3、4):111-112.
65.杜青云,王国胜,张铭穷.姜黄挥发油洗剂对糠秕孢子菌的抑菌实验研究.人民军医药学专刊,1997,13(2):73-75.
66.李向阳,朱宇同,王艳芳,等.青蒿油纳米脂质体制剂对痤疮致病菌的抑制作用.广州中医药大学学报,2004,21(2):122-124.
67.蒋燕萍,曹 煜,李淑芳.珊瑚姜的有效成分对糠秕孢子菌抑制作用的实验研究.贵阳中医学院学报,2006,28(5):57-59.
1.Odom RB , James WD , Berger TG.Andrews Diseases of the skin .9ed.W.B.Saunders Co,Philadelphia 2000:284-306.
2.White GM.Recent findings in the epidemio1ogic evidence,classification,and subtype of the ance vulgaris.J Am Acad Dermatol,l998,39:34-37.
3. Goulden V,Clark SM,Cunliffe WJ.Post-adolescent acne:a review of clinical features.Br J Dermatol l997,136:66-70.
4.Goulden V,Stables GI,Cunliffe WJ.Prevalence of facial acne in adults.J A Am Acad Dermatol l999,41:577-580.
5.杨智,何黎. 痤疮与遗传. 国外医学皮肤性病学分册,2005,31(1):33-34.
6. 耿嘉玮,韩 洪. 补肾药在痤疮治疗中的应用.中国医刊,2001,36(4):55.
7.施伟民,陈德利,朴莫兰,等.痤疮患者血清性激素水平的研究.临床皮肤科杂志,1998,27(1): 15-16.
8.范瑞强,何盛供,张国维.66 例痤疮患者血清睾酮及雌二醇水平研究.临床皮肤科杂志,1998,27(1):17-18.
9. 曾燕,张素芳,李韧,等.13-顺维甲酸对痤疮患者 AR 的影响.中华医学美容杂志, 2001,7(1): 17-18.
10. 胡晓莉,张书梅,赵广碧,等.女性迟发性痤疮与性激素关系的研究.中华皮肤科杂志,2000,33(6): 419.
11. Goulden V, Clark SM,Cunliffe WJ. Postadolescent acne: a review of clinical features. Br J Dermatol 1997,136: 66-70.
12.靳培英.痤疮的分型论治.中华皮肤科杂志,2002,35(1): 67-69.
13. Nishijima S, Kurokawal, Katoh N,et al. The bacteriology of acne vulgaris antimicrobial susceptibility of Propionibacterium acnes and Staphylococcus epidermidis isolated from acne lesions. J Dermatol 2000, 27(5): 318-323.
14.党倩丽,罗秀荣,马小萍.幽门螺杆菌感染与酒渣鼻的相关性.临床皮肤科杂志,2000,29(1):9.
15. Sagi E. The combination formulation of 2% erythromycin plus 1% bi- fonazole once a day versus formulations of topical 2% erythromycin alone twice a day in the treatment of acne vulgaris. A random and blind study. J Dermatol Treat,2000,11(4): 247-251.
16.陈人义.美满霉素与四环素治疗寻常痤疮的疗效比较.中国皮肤性病学杂志,1996,10:52.
17.杨福勤.灭滴灵治疗痤疮 58 例疗效观察.临床皮肤科杂志,1995,24:327.
18.谭升顺,等.抗雄激素对寻常痤疮的临床疗效观察.中华皮肤科杂志,1984,17:27.
19.毛玲娥,等.复方醋酸环丙孕酮治疗女性痤疮 80 例疗效评估.上海第二医科大学学报,1995,15:69.
20.徐晖,等.达因-35 治疗女性痤疮 50 例.浙江医学,1992,14:37.
21.王希,等.寻常型痤疮患者血清和头发锌含量及补锌疗法分析.中华皮肤科杂志,1995,28:321.
22.周展超,等.外用 2.5%丹参酮霜治疗寻常痤疮的临床及实验研究.临床皮肤科杂志,1996,25:376.
23.冯信忠.必麦森凝胶治疗寻常型痤疮临床疗效观察.临床皮肤科杂志,1996,25:35.
24.涂平,等.必麦森凝胶治疗寻常型痤疮疗效观察.中华皮肤科杂志,1996,29:301.
25.罗燕,等.外用特丽仙液治疗寻常痤疮 60 例疗效评价.临床皮肤科杂志,1994,23:266.
26.姜辉,等.复方灭滴灵霜治疗寻常性痤疮 50 例.中国皮肤性病学杂志,1995,9:51.
27.穆艳蕾,杨蓉娅,王文岭,等. 蓝光治疗痤疮 120 例临床疗效观察.美容医学,2007,16(1):80-82.
28.钟建桥,先德海,陈德宇. 窄谱蓝光治疗寻常痤疮临床疗效观察.临床皮肤科杂志,2007,36(2):115-116.
29.Lehmann HP,Robinson KA,Andrews JS,et al.Acne therapy: ameth odologic review. J Am Acad Dermatol 2002,47(2): 231.
30.Pochi PE,Shalita AR,Strauss JS,etal.Report of the consensus conference on acne classification.J Am Acad Dermatol 1991,24(3):495.
31.Doshi A,Zaheer A,Stiller MJ.A comparison of current acne grading systems and proposal of a novel system.Int J Dermatol,1997,36(6):416-418.
1. 赵辨.临床皮肤病学.江苏科学技术出版社,2001:935-938.
2. Odom RB , James WD , Berger TG. Andrews Diseases of the skin .9ed.W.B.Saunders Co,Philadelphia 2000:284-306.
3.李光宇,王萍.痤疮的中医治疗进展.北京中医,2006,25(l2):756-758.
4.孙凤琴.许连霈教授治疗痤疮经验介绍.北京中医药大学学报,1999,22(5):48.
5.凌一揆.中药学(第五版).上海科学技术出版社,1994.
1. 熊琳.马拉色菌的命名和分类进展.临床皮肤科杂志,2000,29 (5):310-312.
2. 冉玉平.检测糠秕马拉色菌的几种取材染色和培养方法介绍.中国皮肤性病学杂志,1999,13(3):181-182.
3. 蒙秉新,苏建英. 面部痤疮皮损内糠秕马拉色菌检测及酮康唑治疗效果观察.中国热带医学,2003,3(4):468-469.
4. 汤红峰,林燕辉,张玉新,等.235 例痤疮患者并糠秕孢子菌感染特点分析.岭南皮肤性病科杂志,2003,10(3):175-176.
5. 杨典秋. 寻常痤疮患者皮损中马拉色菌带菌情况的调查分析.现代医药卫生,2007,23(9):1360.
6. 高峰,胡素泉,李智华,等.176 例寻常痤疮患者马拉色菌带菌率的调查分析.中华皮肤科杂志,2004,37(8):492.
1.Gollnick HPM, Zouboulis CC,Akamatsu H etal;Pathogenesis and pathogenesis related treatment of acne. J Dermatollgy 1991,18:489.
2. 朱忠勇.实用医学检验学.人民军医出版社,1992,第1版:549-550.
3.戴自英,刘裕昆,汪复,等.实用抗菌药物学.上海∶上海科技出版社,1992,12-13.
4.曲剑华,姚卫海,王萍,等.痤疮中医证型与面部菌群关系临床和实验研究.医学研究杂志,2006,35(10):100-101.
5.程丽芳,陈兴强,刘太华,等.消痤丸防治痤疮药效学实验研究.时珍国医国药,2001,12(1):15-16.
6.张友堂,尹霞,孙丽英,等. 痤疮颗粒治疗寻常痤疮的临床与实验研究.中医药信息,2007,24(2):58-59.
7.黄畋等.48种中药对痤疮丙酸杆菌的抑制作用.中华皮肤科杂志,1992,25( 2 ):307-308.
8.汤红峰,林燕辉,张玉新,等.235例痤疮患者并糠秕孢子菌感染特点分析.岭南皮肤性病科杂志,2003,10(3):175-176.
9.关学琛,杨健.糠秕孢子菌在寻常型痤疮中致病性的探讨.新医学,1998,29(增刊2):76-77.
10.宫毓静,安汝国,虞慧,等.164种中药乙醇提取物抗真菌作用研究.中草药,2002,33(1):42-47.
11.王理达,胡迎庆,果德安,等.13种生药提取物及化学成分的抗真菌活性筛选.中草药,2001,32(3):241-244.
12.尹秀芝,蒲卓,王冰梅,等.中药苍术抗真菌作用的研究及临床观察.北 华大学学报(自然科学版),2000,1(6):492-494.
13.郑晓晖,高进,郑义,等.9种中药对马拉色菌分离株的抑菌实验研究.中国中西医结合皮肤性病学杂志,2003,2(1):16-18.