张仲景方证论治体系研究及其方证数据库
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摘要
方证论治是中医辨证论治的方法之一,它有别于传统的脏腑辨证、八纲辨证、六经辨证等辨证方法,要求“观其脉证,知犯何逆,随证治之”,临床时重在辨认症状,据症选择合适的方剂或对方剂进行适当加减。因而,证候与方剂是方证论治的两大核心问题,证候是确定方剂的依据,又是方剂干预的对象,二者密切相关,不可分割。基于上述认识,要求我们在对方证论治的研究中,研究方剂必然涉及证,研究证又必然与方剂关联。把二者作为整体,重点研究方与证相关的科学规律,对揭示证的科学内涵以及方剂治疗疾病的科学规律意义重大。
1.目的
(1)构建出张仲景方证论治体系;
(2)建立“张仲景方证数据库”;
(3)提炼张仲景方剂的核心药对及其对应的适应症状;
(4)探索张仲景在治疗外感病与杂病方面的处方用药异同,进而探索仲景的组方用药思想及规律。
2.方法
(1)应用文献学及史学考证的方法对方证相关概念进行阐释,在此基础上对张仲景方证的渊源进行详尽的探讨;
(2)运用数据统计的方法,基于“张仲景方证数据库”的统计结果,打破传统的《伤寒论》方、《金匮要略》方割裂的方剂划分方法,将张仲景方剂以类方的形式重新划分归类;从纵向上将张仲景方证体系划分成“方——证”“药对(药组)——主症(症群)”“药——症”三个层面的内容:
①“方——证”层面,从类方的角度将《伤寒论》和《金匮要略》的方证重新划分,为避免给人以重复繁杂之感,在每一方名后只给出该方在原作中出现的条文号。
②“药对——主症”层面,整理经方中的主要药对和药对的主治病症。这是论文的核心内容。
③“药——症”层面,该部将张仲景方证中的单方和加减中典型的药物功效加以整理。
(3)运用统计学的方法对上述划分的结果进行统计;提炼张仲景方剂的核心药对及其对应的适应症状;
(4)运用逻辑学的方法对统计的结果及特殊现象进行分析。
3.结果
通过对张仲景方证体系的划分统计,结果发现:
①张仲景方剂在药物使用方面,如果按照现代的中药功效划分标准,仲景经方中使用最多的药物为补虚药,占26.8%;其次为解表药,占18.3%;清热药占9.8%;化痰止咳平喘药占7.8%;祛湿药和温里药各占7.5%。如果将温里药亦归入补虚药,则补虚药占到了34.3%,占所用药次的1/3强。从绝对数量来看,使用次数在10次以上的24味药物中,解表药仅4味;而补气、补血之品竟达7味之多,如果加上扶阳的附子、干姜,则占到了38%。尽管现代中药功效与仲景之用药功效存在差异,但由于用药频率在一定程度上能反映组方遣药的总体倾向,体现出该类方剂配伍结构的相似性和稳定性,因此有理由认为仲景在外感病与杂病的治疗上,配伍用药主要涉及补虚、解表、清热、化痰止咳平喘、祛湿等方面。而补虚扶正的特点尤为突出。另据统计,在《伤寒论》398条和113方中,虚寒的脉象有100多种。经方用人参的方剂高达37首,用附子的达到34首;从使用的方剂来看,桂枝汤中的甘草、大枣,小柴胡汤中的人参,猪苓汤中的阿胶等扶正之品的使用,这亦说明了仲景重视使用补益扶正的方法。经方中的核心药物除生姜、茯苓外,其余药物在《神农本草经》中均有记载,去除这两味药,从药性看,包括:寒性4味,微寒2味,平性7味,温性9味;一般认为平性药与温性药用则温,与寒性药用则寒,因此可以不计入统计的范围,则经方用药偏温可以显而易见。从药味看,甘味药6味,苦味药9味,辛味药6味,成味药1味。辛甘合化为阳。从侧面说明了经方用药尚温的特点。
②在常用方剂方面,张仲景使用次数≥5次的方剂依次为:大承气汤30次、小柴胡汤23次、桂枝汤22次、四逆汤16次、五苓散11次、麻黄汤10次、小承气汤8次、调胃承气汤8次、栀子豉汤7次、白虎加人参汤7次、小建中汤5次、十枣汤5次、大陷胸汤5次、抵当汤5次、小青龙汤5次。这些方剂在治法上主要侧重于:下法,包括三承气汤、十枣汤;和法,小柴胡汤;汗法,包括桂枝汤、麻黄汤;温法,四逆汤;补法,小建中汤;清法,栀子豉汤、白虎加人参汤等。而攻邪的治法比较突出。
③在常用药对方面,统计发现仲景方剂在药对构成方面,姜、枣、草占用较大比重。从三者的功效来看,主要在于调药、和中,而在顾护脾胃方面的作用较为明显,因而提示经方重视顾护后天之本。
4.结论
综合上述统计结果与分析,笔者认为张仲景方证理论体系在处方用药方面存在以下特点:①治杂病,注重补虚,扶正以驱邪;治外感,注重驱邪,善用汗下之法;②顾护脾胃,重视后天之本,以期“阴阳自和”;③用药偏温,扶助阳气;④治疗八法之中,伤寒以驱邪为主;⑤使用方剂、药物具有明显的核心倾向;张仲景方剂在药物使用方面具有明显的核心倾向,形成以核心药物为主体,以常用药对为纽带,以基本方剂为中心的类方体系;⑥从所用核心药物、常用药对、基本方剂来看,《伤寒》、《金匮》处方用药大体一致;从中我们看出,《伤寒》与《金匮》在方证论治体系方面存在较多相似之处。
Formula—Syndrome diagnosis and treatment is one of TCM diagnosis and treatment methods,it is different from the traditional Internal organs dialectical,Eight principal syndromes dialectical,six by the dialectical method of differentiation,such as calling "Observe whose syndromes,know his disease,follow a certificate prescription",Clinical focus on identifying when symptoms of disease,according to select appropriate prescription or other appropriate addition and subtraction agent.Thus,syndromes and prescription are to rule on two core issues.Identified syndrome are the basis for prescriptions,and prescriptions are the object of intervention,the two are closely related and inseparable.Based on the above understanding,this requires us to permit the study of governance,the study necessarily involves prescription,study Syndrome invariably associated with the prescription.Put the two as a whole,focuses on the side with the laws of relevant scientific evidence,the evidence reveals the scientific connotation,as well as prescription treatment of diseases of the scientific laws of great significance.
1.Objectivs
(1) To construct Zhang Zhongjing Formula—Syndrome to permit construction of a system of governance;
(2) To establish "Zhang zhongjing Formula—Syndrome database";
(3) Zhang refining the core of prescription drugs and the corresponding adaptation of the symptoms;
(4) To explore in the treatment of Zhang zhongjing exopathic disease and miscellaneous diseases similarities and differences between the prescription of the medication,and to explore medication Zhongjing prescription thinking and the rule of parties.
2.Methods
(1)The application of philology and the method of history research evidence relatedto each other to explain the concept,based on this Formula of Zhang Zhongjing detailed evidence of the origin of;
(2) The use of statistical methods,based on the "Zhang Zhongjing database to permit" the statistical results,breaking the traditional "typhoid" side, "Golden" to split the prescription into ways to Zhang's prescription in order to type into the form of re-naturalization category;Zhang from the vertical Formula—Syndrome system will be divided into "Formula—Syndrome,"" Medicine suits(drug group)-the main disease(syndrome)" "drug-disease," the contents of three levels:
①"Formula—Syndrome" level,from the category's point of view of "typhoid fever" and "Essence" to permit the re-division,in order to avoid repeat,in each of the parties were only given the appeared in the provisions of the original number.
②"Medicine suits-the main disease" level,finishing as the main prescription drugs and medicine on the charge of the disease.This is the core content of this papers.
③"Drug-disease" level,that part of the initial decision to permit Zhang side of the unilateral and the addition and subtraction in a typical finishing a drug's efficacy.
(3) The use of statistical methods for the delineation of the results of the above-mentioned statistics;refining the core of Zhang Zhongjing prescription drugs and the corresponding adaptation of the symptoms;
(4) The use of logic in the method of the survey results and analysis of a particular phenomenon.
3.Results
Zhang zhongjing Formula—Syndrome system through the division of statistics,the results were as follows:
①Prescription drug use,if the efficacy of Chinese medicine according to the modern criteria for the classification of Fangzhong Zhongjing's most frequently used by drug Makes up empty drug,accounting for 26.8%; followed by relieving drugs,accounting for 18.3%;Qingre drugs accounted for 9.8%PingchuanReducing phlegm and stopping coughing drugs accounted for 7.8%;Qushi drugs and drug distribution in temperature of 7.5%.If the temperature is also classified as drugs in medicine Makes up empty drug,,the Makes up empty drug,drugs accounted for 34.3 percent,accounting for the drug over the 1/3.In absolute terms,the frequency of use in more than 10 drugs,the drug solution of Table 4 only flavor;and vitality and taste as much blood as many as 7,if the Young's Aconite,Ginger,it accounted for 38%. Although the efficacy of modern medicine and Zhongjing differences in the effectiveness of the medication,but the frequency of administration to some extent,reflect the group sent to the general tendency of drugs shows the compatibility of such prescription is similar to the structure and stability,it has reason to that Zhongjing exopathic disease and miscellaneous in the treatment of disease,mainly related to drug Makes up empty compatibility, solution table,clearing away heat,Reducing phlegm and stopping coughingPingchuan,Qushi and so on.Fuzheng Makes up empty characteristics and is particularly prominent.According to statistics,in the "Treaty of Febrile and miscellaneous",there are 398 and 113 formulas,of which have more than 100 kinds of cold pulse.Ginseng by side with up to 37 prescriptions,the use of Aconite 34 to reach,from the use of the prescription, the Guizhi soup liquorice,jujube,Xiao Chai Hu Tang of ginseng,in Zhu-Ling-Tang Fuzheng Ejiao of goods,etc.use,this also shows that the emphasis on the use of benefit Fuzheng Zhongjing method.By the drug in addition to the core of Fangzhong ginger,Poria,the other drugs in the "after" in both records,the removal of these two drugs flavor,from the properties to see,including:cold 4 kinds,less cold 2,level 7 kinds,smell warm 9;is generally believed that leveling of medicinal drugs and the temperature is warm,and cold medicine is cold,it can not be included in the scope of statistics,the warm side by side can be obvious medication.From Taste,the sweet smell medicine 6,9,taste bitter medicine,medicine 6Pungent taste, salty taste drugs 1.Hop into Xin Gan Yang.From the side by side shows the characteristics of drug use is still warm.
②In the commonly used formulas,Zhang Zhongjing use more than 5 times the number of prescriptions were as follows:Dachengqitang 30 times,23 times of Xiao Chai Hu Tang,Guizhi Tang 22,Sini Tang 16 Powder 11 Mahuangtang 10 times,small chengqitang 8 times Tiaowei chengqitang 8 times 7 times gardenia soy soup,plus Ginseng Decoction Baihu 7 times,small Jianzhong Tang 5 times 5 times 10 Decoction,Da Xianxiong tang 5 times Didangtang 5 times,5 times Xiaoqinglongtang.These Formulas in the law governing the main focus on:diarrhea agents,including three chengqitang ten Decoction;reconciliation agent,including Xiao Chai Hu Tang;Khan agents, including Guizhi soup,Ephedra Decoction;temperature agent,Sini Decoction; supplements,small Jian Zhong Tang;clearance agent gardenia soy soup,such as White Tiger plus Ginseng Decoction.And the evil attack of the more prominent law enforcement.
③In the commonly used drug for the connection,the statistics found on the composition of drug Zhongjing,ginger,jujube,occupy a larger proportion of grass.Judging from the effectiveness of the three,mainly due to drugs and in tune,and in nursing care the role of the spleen and stomach are more obvious, and thus prompted by the spleen and stomach to attach more importance to nursing care.
4.Conclusion
The results of the above statistics and analysis,I believe that the theoretical system of Zhang Zhongjing to permit prescription drug administration in the following characteristics:①Treats various illnesses,pays great attention to make up empty,straightens up exorcises,duplicate from goes evilly;Governs the external disease factors,pays great attention to exorcise,makes good use of under the perspiration the law,goes peacefully evilly from;②Attends to protects the taste,will take foundation of the day after tomorrow,by time "masculine and feminine elements from and";③The medication is warm, assists the Yang spirit;④Treats in eight law,typhus exorcises primarily;⑤The consumer medicinal preparation,the medicine have the obvious core tendency; Zhang Zhongjing prescription has the obvious core tendency in the medicine use aspect,forms take the core medicine as the main body,take often applies drugs to as the link,take the base we medicinal preparation as central kind of side system;⑥Looking from uses the core medicine,often to apply drugs to, the base we medicinal preparation,typhus,the gold bookcase prescription medication are roughly consistent;We see,"Shang han lun" and "Jin kui yao lue" governs the system aspect in Fang Zhenglun to have many similarities.
1.目的
(1)构建出张仲景方证论治体系;
(2)建立“张仲景方证数据库”;
(3)提炼张仲景方剂的核心药对及其对应的适应症状;
(4)探索张仲景在治疗外感病与杂病方面的处方用药异同,进而探索仲景的组方用药思想及规律。
2.方法
(1)应用文献学及史学考证的方法对方证相关概念进行阐释,在此基础上对张仲景方证的渊源进行详尽的探讨;
(2)运用数据统计的方法,基于“张仲景方证数据库”的统计结果,打破传统的《伤寒论》方、《金匮要略》方割裂的方剂划分方法,将张仲景方剂以类方的形式重新划分归类;从纵向上将张仲景方证体系划分成“方——证”“药对(药组)——主症(症群)”“药——症”三个层面的内容:
①“方——证”层面,从类方的角度将《伤寒论》和《金匮要略》的方证重新划分,为避免给人以重复繁杂之感,在每一方名后只给出该方在原作中出现的条文号。
②“药对——主症”层面,整理经方中的主要药对和药对的主治病症。这是论文的核心内容。
③“药——症”层面,该部将张仲景方证中的单方和加减中典型的药物功效加以整理。
(3)运用统计学的方法对上述划分的结果进行统计;提炼张仲景方剂的核心药对及其对应的适应症状;
(4)运用逻辑学的方法对统计的结果及特殊现象进行分析。
3.结果
通过对张仲景方证体系的划分统计,结果发现:
①张仲景方剂在药物使用方面,如果按照现代的中药功效划分标准,仲景经方中使用最多的药物为补虚药,占26.8%;其次为解表药,占18.3%;清热药占9.8%;化痰止咳平喘药占7.8%;祛湿药和温里药各占7.5%。如果将温里药亦归入补虚药,则补虚药占到了34.3%,占所用药次的1/3强。从绝对数量来看,使用次数在10次以上的24味药物中,解表药仅4味;而补气、补血之品竟达7味之多,如果加上扶阳的附子、干姜,则占到了38%。尽管现代中药功效与仲景之用药功效存在差异,但由于用药频率在一定程度上能反映组方遣药的总体倾向,体现出该类方剂配伍结构的相似性和稳定性,因此有理由认为仲景在外感病与杂病的治疗上,配伍用药主要涉及补虚、解表、清热、化痰止咳平喘、祛湿等方面。而补虚扶正的特点尤为突出。另据统计,在《伤寒论》398条和113方中,虚寒的脉象有100多种。经方用人参的方剂高达37首,用附子的达到34首;从使用的方剂来看,桂枝汤中的甘草、大枣,小柴胡汤中的人参,猪苓汤中的阿胶等扶正之品的使用,这亦说明了仲景重视使用补益扶正的方法。经方中的核心药物除生姜、茯苓外,其余药物在《神农本草经》中均有记载,去除这两味药,从药性看,包括:寒性4味,微寒2味,平性7味,温性9味;一般认为平性药与温性药用则温,与寒性药用则寒,因此可以不计入统计的范围,则经方用药偏温可以显而易见。从药味看,甘味药6味,苦味药9味,辛味药6味,成味药1味。辛甘合化为阳。从侧面说明了经方用药尚温的特点。
②在常用方剂方面,张仲景使用次数≥5次的方剂依次为:大承气汤30次、小柴胡汤23次、桂枝汤22次、四逆汤16次、五苓散11次、麻黄汤10次、小承气汤8次、调胃承气汤8次、栀子豉汤7次、白虎加人参汤7次、小建中汤5次、十枣汤5次、大陷胸汤5次、抵当汤5次、小青龙汤5次。这些方剂在治法上主要侧重于:下法,包括三承气汤、十枣汤;和法,小柴胡汤;汗法,包括桂枝汤、麻黄汤;温法,四逆汤;补法,小建中汤;清法,栀子豉汤、白虎加人参汤等。而攻邪的治法比较突出。
③在常用药对方面,统计发现仲景方剂在药对构成方面,姜、枣、草占用较大比重。从三者的功效来看,主要在于调药、和中,而在顾护脾胃方面的作用较为明显,因而提示经方重视顾护后天之本。
4.结论
综合上述统计结果与分析,笔者认为张仲景方证理论体系在处方用药方面存在以下特点:①治杂病,注重补虚,扶正以驱邪;治外感,注重驱邪,善用汗下之法;②顾护脾胃,重视后天之本,以期“阴阳自和”;③用药偏温,扶助阳气;④治疗八法之中,伤寒以驱邪为主;⑤使用方剂、药物具有明显的核心倾向;张仲景方剂在药物使用方面具有明显的核心倾向,形成以核心药物为主体,以常用药对为纽带,以基本方剂为中心的类方体系;⑥从所用核心药物、常用药对、基本方剂来看,《伤寒》、《金匮》处方用药大体一致;从中我们看出,《伤寒》与《金匮》在方证论治体系方面存在较多相似之处。
Formula—Syndrome diagnosis and treatment is one of TCM diagnosis and treatment methods,it is different from the traditional Internal organs dialectical,Eight principal syndromes dialectical,six by the dialectical method of differentiation,such as calling "Observe whose syndromes,know his disease,follow a certificate prescription",Clinical focus on identifying when symptoms of disease,according to select appropriate prescription or other appropriate addition and subtraction agent.Thus,syndromes and prescription are to rule on two core issues.Identified syndrome are the basis for prescriptions,and prescriptions are the object of intervention,the two are closely related and inseparable.Based on the above understanding,this requires us to permit the study of governance,the study necessarily involves prescription,study Syndrome invariably associated with the prescription.Put the two as a whole,focuses on the side with the laws of relevant scientific evidence,the evidence reveals the scientific connotation,as well as prescription treatment of diseases of the scientific laws of great significance.
1.Objectivs
(1) To construct Zhang Zhongjing Formula—Syndrome to permit construction of a system of governance;
(2) To establish "Zhang zhongjing Formula—Syndrome database";
(3) Zhang refining the core of prescription drugs and the corresponding adaptation of the symptoms;
(4) To explore in the treatment of Zhang zhongjing exopathic disease and miscellaneous diseases similarities and differences between the prescription of the medication,and to explore medication Zhongjing prescription thinking and the rule of parties.
2.Methods
(1)The application of philology and the method of history research evidence relatedto each other to explain the concept,based on this Formula of Zhang Zhongjing detailed evidence of the origin of;
(2) The use of statistical methods,based on the "Zhang Zhongjing database to permit" the statistical results,breaking the traditional "typhoid" side, "Golden" to split the prescription into ways to Zhang's prescription in order to type into the form of re-naturalization category;Zhang from the vertical Formula—Syndrome system will be divided into "Formula—Syndrome,"" Medicine suits(drug group)-the main disease(syndrome)" "drug-disease," the contents of three levels:
①"Formula—Syndrome" level,from the category's point of view of "typhoid fever" and "Essence" to permit the re-division,in order to avoid repeat,in each of the parties were only given the appeared in the provisions of the original number.
②"Medicine suits-the main disease" level,finishing as the main prescription drugs and medicine on the charge of the disease.This is the core content of this papers.
③"Drug-disease" level,that part of the initial decision to permit Zhang side of the unilateral and the addition and subtraction in a typical finishing a drug's efficacy.
(3) The use of statistical methods for the delineation of the results of the above-mentioned statistics;refining the core of Zhang Zhongjing prescription drugs and the corresponding adaptation of the symptoms;
(4) The use of logic in the method of the survey results and analysis of a particular phenomenon.
3.Results
Zhang zhongjing Formula—Syndrome system through the division of statistics,the results were as follows:
①Prescription drug use,if the efficacy of Chinese medicine according to the modern criteria for the classification of Fangzhong Zhongjing's most frequently used by drug Makes up empty drug,accounting for 26.8%; followed by relieving drugs,accounting for 18.3%;Qingre drugs accounted for 9.8%PingchuanReducing phlegm and stopping coughing drugs accounted for 7.8%;Qushi drugs and drug distribution in temperature of 7.5%.If the temperature is also classified as drugs in medicine Makes up empty drug,,the Makes up empty drug,drugs accounted for 34.3 percent,accounting for the drug over the 1/3.In absolute terms,the frequency of use in more than 10 drugs,the drug solution of Table 4 only flavor;and vitality and taste as much blood as many as 7,if the Young's Aconite,Ginger,it accounted for 38%. Although the efficacy of modern medicine and Zhongjing differences in the effectiveness of the medication,but the frequency of administration to some extent,reflect the group sent to the general tendency of drugs shows the compatibility of such prescription is similar to the structure and stability,it has reason to that Zhongjing exopathic disease and miscellaneous in the treatment of disease,mainly related to drug Makes up empty compatibility, solution table,clearing away heat,Reducing phlegm and stopping coughingPingchuan,Qushi and so on.Fuzheng Makes up empty characteristics and is particularly prominent.According to statistics,in the "Treaty of Febrile and miscellaneous",there are 398 and 113 formulas,of which have more than 100 kinds of cold pulse.Ginseng by side with up to 37 prescriptions,the use of Aconite 34 to reach,from the use of the prescription, the Guizhi soup liquorice,jujube,Xiao Chai Hu Tang of ginseng,in Zhu-Ling-Tang Fuzheng Ejiao of goods,etc.use,this also shows that the emphasis on the use of benefit Fuzheng Zhongjing method.By the drug in addition to the core of Fangzhong ginger,Poria,the other drugs in the "after" in both records,the removal of these two drugs flavor,from the properties to see,including:cold 4 kinds,less cold 2,level 7 kinds,smell warm 9;is generally believed that leveling of medicinal drugs and the temperature is warm,and cold medicine is cold,it can not be included in the scope of statistics,the warm side by side can be obvious medication.From Taste,the sweet smell medicine 6,9,taste bitter medicine,medicine 6Pungent taste, salty taste drugs 1.Hop into Xin Gan Yang.From the side by side shows the characteristics of drug use is still warm.
②In the commonly used formulas,Zhang Zhongjing use more than 5 times the number of prescriptions were as follows:Dachengqitang 30 times,23 times of Xiao Chai Hu Tang,Guizhi Tang 22,Sini Tang 16 Powder 11 Mahuangtang 10 times,small chengqitang 8 times Tiaowei chengqitang 8 times 7 times gardenia soy soup,plus Ginseng Decoction Baihu 7 times,small Jianzhong Tang 5 times 5 times 10 Decoction,Da Xianxiong tang 5 times Didangtang 5 times,5 times Xiaoqinglongtang.These Formulas in the law governing the main focus on:diarrhea agents,including three chengqitang ten Decoction;reconciliation agent,including Xiao Chai Hu Tang;Khan agents, including Guizhi soup,Ephedra Decoction;temperature agent,Sini Decoction; supplements,small Jian Zhong Tang;clearance agent gardenia soy soup,such as White Tiger plus Ginseng Decoction.And the evil attack of the more prominent law enforcement.
③In the commonly used drug for the connection,the statistics found on the composition of drug Zhongjing,ginger,jujube,occupy a larger proportion of grass.Judging from the effectiveness of the three,mainly due to drugs and in tune,and in nursing care the role of the spleen and stomach are more obvious, and thus prompted by the spleen and stomach to attach more importance to nursing care.
4.Conclusion
The results of the above statistics and analysis,I believe that the theoretical system of Zhang Zhongjing to permit prescription drug administration in the following characteristics:①Treats various illnesses,pays great attention to make up empty,straightens up exorcises,duplicate from goes evilly;Governs the external disease factors,pays great attention to exorcise,makes good use of under the perspiration the law,goes peacefully evilly from;②Attends to protects the taste,will take foundation of the day after tomorrow,by time "masculine and feminine elements from and";③The medication is warm, assists the Yang spirit;④Treats in eight law,typhus exorcises primarily;⑤The consumer medicinal preparation,the medicine have the obvious core tendency; Zhang Zhongjing prescription has the obvious core tendency in the medicine use aspect,forms take the core medicine as the main body,take often applies drugs to as the link,take the base we medicinal preparation as central kind of side system;⑥Looking from uses the core medicine,often to apply drugs to, the base we medicinal preparation,typhus,the gold bookcase prescription medication are roughly consistent;We see,"Shang han lun" and "Jin kui yao lue" governs the system aspect in Fang Zhenglun to have many similarities.
引文
[1]艾华主编。金匮要略辞典[M].北京:学苑出版社.2005。10:60-63
[2]条文数根据全国高等中医院校五版教材《伤寒论讲义》
[3]条文数根据《金匮要略讲义》[M]上海科学技术出版社1985,10
[4]张志民.试论伤寒论六病分证的特点及其意义[J].浙江中医杂志1980:(1):22
[5]柯琴。伤寒来苏集·凡例一[M].上海科学技术出版社.1986.1:1
[6]根据金山词霸2007年版解释.
[7]贾春华,王永炎,黄启福基于命题逻辑的伤寒论方证论治系统构建[J]。北京中医药大学学报.2007,30(6):369-374
[8]贾春华,王永炎,鲁兆麟,等.《伤寒论》方证理论体系框架[J]。河北中医,2006。28(3):224-226.
[9]冯世纶.经方的方证体系[J]。中国医药学报,2002,17(10):629-632
[10]金海浩.中医学的方证相应论[J].黑龙江中医药,2005,1(1):45.
[11]李国臣,王冠民,崔文艺.胡希恕方证辨证说略[J].上海中医药杂志,2003,37(10):39.
[12]邓铁涛。再论辨证论治[J]。新中医,1999,31(4):8.
[13]张兰凤,王阶,王永炎.方证对应研究[J].中华中医药杂志,2005,20(1)8-10.
[14]王玉川.关于“有是证用是方”的反思[J]。北京中医药大学学报,1998,11,21(6)2-5。
[15]谢鸣主编.方剂学[M].北京。人民卫生出版社,2002。9:1
[16]柯琴.伤寒来苏集[M].上海科学技术出版社,1986.1:202
[17]赵金铎主编.中医症状鉴别诊断学[M]。北京。人民卫生出版社,1984.3:1
[18]傅延龄.刘渡舟教授学术思想精华[J].中国农村医学1996,24(5):55-58
[19]Helen Feddema著.张波,张剑青,唐云端译。精通Microsoft Access 2002中文版[M]。第一版,北京:清华大学出版社.2002,41-58
[20]Weinshenker BG.Databasea in MS research:pitfalls and promises.Mult-Scler.1999;5(4):206-211。
[21]Mears G.Omato JP,Dawson DE.Emergency medical services information systems and a future EMS national database.Prehosp-EmergCare,2002;6(1):123-130
[22]骆欢欢,邓高丕.妇科血瘀证治疗的客观化研究[J].中国医药卫生,2005.6(1):64
[23]杨丁友,段学忠.冠心病心虚证不同证型与血小板活化分子cd62P及cd63表达的关系[J].中国中医药科技,2001.8(5):293
[24]徐征,吴承玉.中医肺系证的规范化研究探讨[J].吉林中医药,2004.24 (7):1.
[25]李瀚曼,张六痛,梅家俊,等.“肝肾精血亏虚”大鼠动物模型的建立[J]中国中医基础医学杂志,2001.7(4):51
[26]晋·皇甫谧撰。鲁兆麟等点校.针灸甲乙经·黄帝三部针灸甲乙经序[M].沈阳:辽宁科技出版社.1997.
[27]汉·张仲景著.历畅等点校.伤寒论·伤寒论序[M].北京:中医古籍出版社.1997.
[28]http://www.enweiculture.com/culture/dsptext.asp?lmdm=05020302&wdd m=0057&file=200659050203020057.htm
[29]许国敏,张横柳。仲景伤寒经典著述源流探微[J].浙药人学学报2006.7;30(4):324-326。
[30]任应秋.任应秋论医集[M]。北京:人民卫生出版社1984:413.
[31]刘渡舟.“经方”溯源.北京中医药大学学报[J].1999.1.22(1).7-9
[32]孙思邈.千金冀方[M],北京:人民卫生出版社,1955.5:97。
[33]金礼蒙.医方类聚[M],北京:人民卫生出版社,1981.229-234.
[34]朱肱.类证活人书卷十二[M].广东刻本,1886.
[35]成无己。伤寒明理论·伤寒明理药方论序[M].北京.中国中医药出版社,2007,9
[36]柯琴。伤寒来苏集[M].上海:上海科学技术出版社,1959.3:47-56
[37]柯琴.伤寒来苏集[M].上海:上海科学技术出版社,1959.3:162
[38]柯琴.伤寒来苏集·伤寒论翼[M].上海:上海科学技术出版社,1959,3:158
[39]柯琴.伤寒来苏集[M].上海:上海科学技术出版社,1959.3:182-183
[40]清·陆九芝.世补斋医书.前集上[M].上海:上海千顷堂书局.1950.179
[41]陆渊雷。伤寒论今释·章太炎序[M].北京:人民卫生出版社.1995.1
[42]徐灵胎.伤寒论类方.江苏科学技术出版社.[M]1984.10:3
[43]徐灵胎。伤寒论类方.江苏科学技术出版社.[M]1984.10:3-4
[44]富杭育,姜廷良.1991-1994年中药复方药理研究动态分析[J].中国实脸方剂学杂志,1995。(2):3.
[45]富杭育,李晓芹,郭淑英,等.桂枝汤的药理学研究[J].中药药理与临床,1987。(2):1
[46]初杰,关庆增,吴茱萸汤证治规律的研究[J].河南中医,1991.(6):2.
[47]谷言芳。黄连阿胶汤证治规律的研究[J].实用中医内科杂志,1990.(3):19.
[48]艾华,谭素娟.麻杏石甘汤证治规律研究[J].黑龙江中医药,1991.(1):44
[49]唐建明,简丁山。桃核承气汤证治规律研究[J].国医论坛,1995.(4):1.
[50]吉益东洞.东洞全集[M].日本大正七年(1918)吐凤堂书店.
[51]潘桂娟,樊正伦.日本汉方医学[M].北京:中国中医药出版社,1994.408-414,499.
[52]李赛美,黄仰模,蔡文就.经方临床运用(第二辑)[M]北京:中国中医药出版社2007.7:41
1.陈恭和主编.数据库基础与Access应用教程[M].北京:高等教育出版社.2003,12.
2.Robinson C等著.Access2002.从入门到精通[M].邱仲潘等译.北京:电子工业出版社,2002
3.王珊,陈红。数据库系统原理教程[M].北京:清华大学出版社.2006,10
4.陈恭和主编.计算机程序设计--VB语言[M].北京:中国财政经济出版社,2001
5.张林.计算机辅助古代肝病方剂组方规律的研究及古代肝病方剂数据库初探.北京中医药大学方剂教研室2004届硕士论文.
6.中医现代化科技发展战略研究课题组.现代中医信息技术的应用研究.世界科学技术--中药现代化,2001,3(6):50-52
7 戴水平.中医活血化瘀方数据库及数据挖掘.北京中医药大学方剂教研室2007届博士论文
8 李志敏等.《金匮要略》信息化的研究与实现[J].电脑知识与技术B 2007;9(20):723-725
9.任廷革.中医信息学[M]。北京:科学出版社,2003
10.中医方剂数据库简介.http://www.tcm120.com/1w2k/tcm_recipe.asp
[1]高学敏主编.中药学.北京:中国中医要出版社,2002年.
[2]郑全雄、丁晓刚、贺红莉主编.《张仲景医学全集·张仲景方方族学》[M]北京:中国中医科技出版社.2004,11
[3]刘渡舟.新编伤寒论类方.[M].山西人民出版社,1984,8:3.
[4]条文数根据全国高等中医院校五版教材《伤寒论讲义》
[5]条文数根据《金匮要略讲义》[M]上海科学技术出版社1985,10
[6]谭同来 眭湘宜 张咏梅.中药配伍十法.LM]太原:山西科学技术出版社,2006.4
[7]柯雪帆。张仲景药对选要[J].中国医药学报,1994,9(4):41-43
[8]柯琴.伤寒来苏集[M]上海科学技术出版社.1986,1:17
[9]黄煌.张仲景50味药证.人民卫生出版社.2004年3月第二版7-9.
[10]胡忠智,蔡小玲。芍药甘草汤组方规律的探讨.上海中医药杂志1996年第11期:25-26
[11]孙洽熙.黄元御医学全书·长沙药解,第2版[M].北京:中国中医药出版社,1999:986.
[12]明·缪希雍.本草经疏[M].池阳周氏校刊本,卷六:1891:7.
[13]黄煌.张仲景五十味药证,第1版[M].北京:人民卫生出版社,1998:17,153.
[14]明·贾九如.药品化义[M]。北京郁文书局铅印本,卷十三:1904:2
[15]清·吴谦。医宗金鉴。第1版[M].北京:人民卫生出版社,1997:63.
[1]刘渡舟.“经方”溯源.北京中医药大学学报[J].1999.1.22(1).7-9)
[2]傅延龄.刘渡舟教授学术思想精华[J]56《中国农村医学》1996,24(5):55-58
1.王冰,《黄帝内经素问》[M].王冰注文.北京:人民卫生出版社,1963,6.
2.吴普著。《神农本草经》[M].中医古籍出版社,1982,5.
3.晋·王叔和,《脉经》引自《中国医学大成》(十).上海:上海科学技术出版社,1990年6月第一版
4.李景荣等主编,《备急千金要方校释》[M].北京:人民卫生出版社,1997,12。
5.吴风全等主编,《脏腑标本虚实寒热用药式校释》[M]。北京:中医古籍出版社.1994.
6.徐灵胎撰著.《伤寒论类方》[M].南京:江苏科学技术出版社,1984.
7.尤怡著.《金匮翼》[M]。北京:中国中医药出版社,1996,8.
8.清·柯琴。《伤寒来苏集》[M].北京:中国中医药出版社,1998,3。
9.清·尤怡.《金匮要略心典》[M].北京:中国中医药出版社,1992,6.
10.刘渡舟主编,《伤寒论校注》[M].北京:人民卫生出版社,1996,6.
11.刘渡舟。《新编伤寒论类方》[M].山西:山西人民出版社,1984,8.
12.陈亦人.《伤寒论求是》[M].上海:上海科学技术出版社,2008,9.
13.钱超尘,温长路主编.张仲景研究集成(上下册)[M].第一版,北京中医古籍出版社,2004.
14.王付。《经方药对》[M],北京,学苑出版社,2005.4.
15.吕志杰主编《张仲景方剂学》[M].北京:中国中医药出版社.2005.1。
16 黄煌《张仲景50味药证》[M]北京:人民卫生出版社,2004.3.
17张长恩主编《中国汤液方证续》[M](《金匮要略》方证学)北京:人民军医出版社,2008.3
18 冯世纶,张长恩主编《张仲景用方解析》[M]北京:人民军医出版社,2005。11
19 陈明,张印生主编《伤寒名医验案精选》[M]北京:学苑出版社,1989.9
20 周祯祥,邹忠梅主编《张仲景药物学》[M]北京:中国中医药出版社,2004.10
21 清·吴谦.医宗金鉴.第1版[M].北京:人民卫生出版社,1997
22 傅延龄主编.《张仲景医学源流》[M].北京:中国中医药出版社,2006.8
23 郑全雄,丁晓刚,贺红莉主编《张仲景方方族》[M]北京:中国中医药出版社,2005.2
24 贾春华.基于命题逻辑的《伤寒论》方证理论体系研究。北京中医药大学博士后工作报告2006,5.
25 马继兴.马王堆古医书考释[M].长沙.湖南科技出版社.1992
26 刘渡舟,傅士垣。伤寒论诠解[M]天津科技出版社.1983.
[2]条文数根据全国高等中医院校五版教材《伤寒论讲义》
[3]条文数根据《金匮要略讲义》[M]上海科学技术出版社1985,10
[4]张志民.试论伤寒论六病分证的特点及其意义[J].浙江中医杂志1980:(1):22
[5]柯琴。伤寒来苏集·凡例一[M].上海科学技术出版社.1986.1:1
[6]根据金山词霸2007年版解释.
[7]贾春华,王永炎,黄启福基于命题逻辑的伤寒论方证论治系统构建[J]。北京中医药大学学报.2007,30(6):369-374
[8]贾春华,王永炎,鲁兆麟,等.《伤寒论》方证理论体系框架[J]。河北中医,2006。28(3):224-226.
[9]冯世纶.经方的方证体系[J]。中国医药学报,2002,17(10):629-632
[10]金海浩.中医学的方证相应论[J].黑龙江中医药,2005,1(1):45.
[11]李国臣,王冠民,崔文艺.胡希恕方证辨证说略[J].上海中医药杂志,2003,37(10):39.
[12]邓铁涛。再论辨证论治[J]。新中医,1999,31(4):8.
[13]张兰凤,王阶,王永炎.方证对应研究[J].中华中医药杂志,2005,20(1)8-10.
[14]王玉川.关于“有是证用是方”的反思[J]。北京中医药大学学报,1998,11,21(6)2-5。
[15]谢鸣主编.方剂学[M].北京。人民卫生出版社,2002。9:1
[16]柯琴.伤寒来苏集[M].上海科学技术出版社,1986.1:202
[17]赵金铎主编.中医症状鉴别诊断学[M]。北京。人民卫生出版社,1984.3:1
[18]傅延龄.刘渡舟教授学术思想精华[J].中国农村医学1996,24(5):55-58
[19]Helen Feddema著.张波,张剑青,唐云端译。精通Microsoft Access 2002中文版[M]。第一版,北京:清华大学出版社.2002,41-58
[20]Weinshenker BG.Databasea in MS research:pitfalls and promises.Mult-Scler.1999;5(4):206-211。
[21]Mears G.Omato JP,Dawson DE.Emergency medical services information systems and a future EMS national database.Prehosp-EmergCare,2002;6(1):123-130
[22]骆欢欢,邓高丕.妇科血瘀证治疗的客观化研究[J].中国医药卫生,2005.6(1):64
[23]杨丁友,段学忠.冠心病心虚证不同证型与血小板活化分子cd62P及cd63表达的关系[J].中国中医药科技,2001.8(5):293
[24]徐征,吴承玉.中医肺系证的规范化研究探讨[J].吉林中医药,2004.24 (7):1.
[25]李瀚曼,张六痛,梅家俊,等.“肝肾精血亏虚”大鼠动物模型的建立[J]中国中医基础医学杂志,2001.7(4):51
[26]晋·皇甫谧撰。鲁兆麟等点校.针灸甲乙经·黄帝三部针灸甲乙经序[M].沈阳:辽宁科技出版社.1997.
[27]汉·张仲景著.历畅等点校.伤寒论·伤寒论序[M].北京:中医古籍出版社.1997.
[28]http://www.enweiculture.com/culture/dsptext.asp?lmdm=05020302&wdd m=0057&file=200659050203020057.htm
[29]许国敏,张横柳。仲景伤寒经典著述源流探微[J].浙药人学学报2006.7;30(4):324-326。
[30]任应秋.任应秋论医集[M]。北京:人民卫生出版社1984:413.
[31]刘渡舟.“经方”溯源.北京中医药大学学报[J].1999.1.22(1).7-9
[32]孙思邈.千金冀方[M],北京:人民卫生出版社,1955.5:97。
[33]金礼蒙.医方类聚[M],北京:人民卫生出版社,1981.229-234.
[34]朱肱.类证活人书卷十二[M].广东刻本,1886.
[35]成无己。伤寒明理论·伤寒明理药方论序[M].北京.中国中医药出版社,2007,9
[36]柯琴。伤寒来苏集[M].上海:上海科学技术出版社,1959.3:47-56
[37]柯琴.伤寒来苏集[M].上海:上海科学技术出版社,1959.3:162
[38]柯琴.伤寒来苏集·伤寒论翼[M].上海:上海科学技术出版社,1959,3:158
[39]柯琴.伤寒来苏集[M].上海:上海科学技术出版社,1959.3:182-183
[40]清·陆九芝.世补斋医书.前集上[M].上海:上海千顷堂书局.1950.179
[41]陆渊雷。伤寒论今释·章太炎序[M].北京:人民卫生出版社.1995.1
[42]徐灵胎.伤寒论类方.江苏科学技术出版社.[M]1984.10:3
[43]徐灵胎。伤寒论类方.江苏科学技术出版社.[M]1984.10:3-4
[44]富杭育,姜廷良.1991-1994年中药复方药理研究动态分析[J].中国实脸方剂学杂志,1995。(2):3.
[45]富杭育,李晓芹,郭淑英,等.桂枝汤的药理学研究[J].中药药理与临床,1987。(2):1
[46]初杰,关庆增,吴茱萸汤证治规律的研究[J].河南中医,1991.(6):2.
[47]谷言芳。黄连阿胶汤证治规律的研究[J].实用中医内科杂志,1990.(3):19.
[48]艾华,谭素娟.麻杏石甘汤证治规律研究[J].黑龙江中医药,1991.(1):44
[49]唐建明,简丁山。桃核承气汤证治规律研究[J].国医论坛,1995.(4):1.
[50]吉益东洞.东洞全集[M].日本大正七年(1918)吐凤堂书店.
[51]潘桂娟,樊正伦.日本汉方医学[M].北京:中国中医药出版社,1994.408-414,499.
[52]李赛美,黄仰模,蔡文就.经方临床运用(第二辑)[M]北京:中国中医药出版社2007.7:41
1.陈恭和主编.数据库基础与Access应用教程[M].北京:高等教育出版社.2003,12.
2.Robinson C等著.Access2002.从入门到精通[M].邱仲潘等译.北京:电子工业出版社,2002
3.王珊,陈红。数据库系统原理教程[M].北京:清华大学出版社.2006,10
4.陈恭和主编.计算机程序设计--VB语言[M].北京:中国财政经济出版社,2001
5.张林.计算机辅助古代肝病方剂组方规律的研究及古代肝病方剂数据库初探.北京中医药大学方剂教研室2004届硕士论文.
6.中医现代化科技发展战略研究课题组.现代中医信息技术的应用研究.世界科学技术--中药现代化,2001,3(6):50-52
7 戴水平.中医活血化瘀方数据库及数据挖掘.北京中医药大学方剂教研室2007届博士论文
8 李志敏等.《金匮要略》信息化的研究与实现[J].电脑知识与技术B 2007;9(20):723-725
9.任廷革.中医信息学[M]。北京:科学出版社,2003
10.中医方剂数据库简介.http://www.tcm120.com/1w2k/tcm_recipe.asp
[1]高学敏主编.中药学.北京:中国中医要出版社,2002年.
[2]郑全雄、丁晓刚、贺红莉主编.《张仲景医学全集·张仲景方方族学》[M]北京:中国中医科技出版社.2004,11
[3]刘渡舟.新编伤寒论类方.[M].山西人民出版社,1984,8:3.
[4]条文数根据全国高等中医院校五版教材《伤寒论讲义》
[5]条文数根据《金匮要略讲义》[M]上海科学技术出版社1985,10
[6]谭同来 眭湘宜 张咏梅.中药配伍十法.LM]太原:山西科学技术出版社,2006.4
[7]柯雪帆。张仲景药对选要[J].中国医药学报,1994,9(4):41-43
[8]柯琴.伤寒来苏集[M]上海科学技术出版社.1986,1:17
[9]黄煌.张仲景50味药证.人民卫生出版社.2004年3月第二版7-9.
[10]胡忠智,蔡小玲。芍药甘草汤组方规律的探讨.上海中医药杂志1996年第11期:25-26
[11]孙洽熙.黄元御医学全书·长沙药解,第2版[M].北京:中国中医药出版社,1999:986.
[12]明·缪希雍.本草经疏[M].池阳周氏校刊本,卷六:1891:7.
[13]黄煌.张仲景五十味药证,第1版[M].北京:人民卫生出版社,1998:17,153.
[14]明·贾九如.药品化义[M]。北京郁文书局铅印本,卷十三:1904:2
[15]清·吴谦。医宗金鉴。第1版[M].北京:人民卫生出版社,1997:63.
[1]刘渡舟.“经方”溯源.北京中医药大学学报[J].1999.1.22(1).7-9)
[2]傅延龄.刘渡舟教授学术思想精华[J]56《中国农村医学》1996,24(5):55-58
1.王冰,《黄帝内经素问》[M].王冰注文.北京:人民卫生出版社,1963,6.
2.吴普著。《神农本草经》[M].中医古籍出版社,1982,5.
3.晋·王叔和,《脉经》引自《中国医学大成》(十).上海:上海科学技术出版社,1990年6月第一版
4.李景荣等主编,《备急千金要方校释》[M].北京:人民卫生出版社,1997,12。
5.吴风全等主编,《脏腑标本虚实寒热用药式校释》[M]。北京:中医古籍出版社.1994.
6.徐灵胎撰著.《伤寒论类方》[M].南京:江苏科学技术出版社,1984.
7.尤怡著.《金匮翼》[M]。北京:中国中医药出版社,1996,8.
8.清·柯琴。《伤寒来苏集》[M].北京:中国中医药出版社,1998,3。
9.清·尤怡.《金匮要略心典》[M].北京:中国中医药出版社,1992,6.
10.刘渡舟主编,《伤寒论校注》[M].北京:人民卫生出版社,1996,6.
11.刘渡舟。《新编伤寒论类方》[M].山西:山西人民出版社,1984,8.
12.陈亦人.《伤寒论求是》[M].上海:上海科学技术出版社,2008,9.
13.钱超尘,温长路主编.张仲景研究集成(上下册)[M].第一版,北京中医古籍出版社,2004.
14.王付。《经方药对》[M],北京,学苑出版社,2005.4.
15.吕志杰主编《张仲景方剂学》[M].北京:中国中医药出版社.2005.1。
16 黄煌《张仲景50味药证》[M]北京:人民卫生出版社,2004.3.
17张长恩主编《中国汤液方证续》[M](《金匮要略》方证学)北京:人民军医出版社,2008.3
18 冯世纶,张长恩主编《张仲景用方解析》[M]北京:人民军医出版社,2005。11
19 陈明,张印生主编《伤寒名医验案精选》[M]北京:学苑出版社,1989.9
20 周祯祥,邹忠梅主编《张仲景药物学》[M]北京:中国中医药出版社,2004.10
21 清·吴谦.医宗金鉴.第1版[M].北京:人民卫生出版社,1997
22 傅延龄主编.《张仲景医学源流》[M].北京:中国中医药出版社,2006.8
23 郑全雄,丁晓刚,贺红莉主编《张仲景方方族》[M]北京:中国中医药出版社,2005.2
24 贾春华.基于命题逻辑的《伤寒论》方证理论体系研究。北京中医药大学博士后工作报告2006,5.
25 马继兴.马王堆古医书考释[M].长沙.湖南科技出版社.1992
26 刘渡舟,傅士垣。伤寒论诠解[M]天津科技出版社.1983.