加味麻杏石甘汤治疗肺热病疗效观察及其对炎性指标的影响
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摘要
目的:
观察中药制剂加味麻杏石甘汤联合西药常规治疗肺热病痰热壅肺型与单纯西药治疗的效果,比较二者疗效,及其对炎性指标(白细胞、中性粒细胞、C-反应蛋白、肿瘤坏死因子-α)的影响,探讨中西医结合治疗的抗炎作用优势。
资料和方法:
1、选择符合西医诊断为CAP,按肺热病中医辨证标准分型为痰热壅肺型患者60例,随机分为中西医结合治疗组和西药治疗对照组各30例。
2、两组均予呼吸喹诺酮药物抗感染,治疗组在使用西药的基础上,加用加味麻杏石甘汤;进行临床疗效对比并检测两组治疗前后WBC、GR%、GR#、CRP、TNF-α的变化。
3、用SPSS12.0软件对结果进行统计学处理。
结果:
1、临床疗效观察:综合疗效及中医症候疗效比较均于治疗7天后差异显著(P＜0.05);两者于治疗10天后差异不显著;但中医证候积分比较,治疗7天、10天后两组均有显著差异(P＜0.05)。
2、加味麻杏石甘汤对炎性指标的干预:①血常规相关指标:白细胞计数、中性粒细胞百分比及中性粒细胞计数的复常率,两组无显著差异;但是白细胞实际测量值及差值比较,治疗组明显优于对照组(P＜0.05)。②C-反应蛋白复常率两组无显著性差异;但实际值比较,两组治疗后及治疗前后差值比较有差异,治疗组优于对照组(P＜0.05)。③肿瘤坏死因子-α下降率及治疗后测定值两组无显著性差异;但治疗前后差值比较有显著差异(P＜0.05)。
3、两组治疗过程未发现明显毒副作用,试验期间0例受试者退出。
结论:
1.通过非盲随机对照临床研究,表明以加味麻杏石甘汤方配合西药可以显著改善中医辨证为肺热病痰热壅肺型(西医诊断为社区获得性肺炎)患者的临床症状,具有清热化痰肃肺之功效,一定程度上降低血WBC、CRP、TNF-α水平,优于单纯西药治疗。
2.抑制炎症反应,对抗生素治疗感染性疾病具有协同作用,可能是清热化痰中药的作用机制之一。
3.加味麻杏石甘汤安全有效,可在临床推广应用。
Objective:
To observe the clinical curative effect of treating Wind-warm Lung-heat disease in stagnation of phlegm-heat with Chinese drugs preparation Add taste ma xing shi gan t -ang and antibiotic only,compare their curative effect,and contribution to indicatrix o -f phlegmonosis.And to approach the predominance of conbined treatment of traditional Chinese medicine and western medicine therapeutic on cooperation of anti-inflammatory effect.
Materias and Methods:
1.60 patients with CAP were differentiated by adopting the standard of TCM Syn -drome Differentiation for Wind-warm Lung-heat disease.The patients were randomlydi -vided into treatment group and control group.
2.Both groups were treated by Quinolone-kind drug of breathing to anti-infection. Treatment group added to Add taste ma xing shi gan tang.Compare their curative effe -ct and test WBC、GR%、GR#、CRP、TNF-αbefore and after therapy.
3.Statietical analysis were carried out by SPSS 12.0 software.
Results:
1.Observation of curative effect:There was significant curative effect of disease an -d traditional Chinese medicine symptoms in the treatment group after 7 days(P＜0.05). Comparison of integral in traditional Chinese medicine symptoms:treatment group got better obviously effect both after 7 and 10 days(P＜0.05).
2.Intervention of Add taste ma xing shi gan tang recipe to indicatrix of phlegmon -osis:①Indexes related to blood routine detetion:there is no statistically significant dif -ference between the two groups' normalization rate of leukocyte count,neutrophlls perc entage and neutrophil count.But the comparative analysis of the actual measure value and their difference of leukocyte,the effect of the treatment group was superior to the control group significantly(P＜0.05).②There was no singnificant difference of C-react -ive protein's normalization rate between two groups,but there were differences after t -reatment and difference value of pre and post treatment in comparison of actual value. The effect of treatment group was significantly superior to that of control group(P＜ 0.05).③There was no singnificant difference in the decrease rate of Tumor Necrosis Factor-αand its measure value of post treatment,but there were differences in the val -ue of pre and post treatment(P＜0.05).
3.Obvious side effects or adverse reaction were not found during the therapeutic process in the two groups.No patients exit during the experiment.
Conclusion:
1.By non-blind randomized controlled clinical study,it indicated that compound Add taste ma xing shi gan tang recipe with Western medicine can significantly improve the clinical symptoms of Wind-warm Lung-heat disease(Community Acquired Pneumonia), have efficiency of eliminating phlegm by cooling,and reduce level of WBC、CRP and TNF-α,which was superior to using Western medicine only in some degree.
2.Controling inflammation reaction,reducing the level.Having synergistic effect to antibiotic in treating infectious diseases,is one of the possible mechanism of Chinese drug in clearing away heat and dispersing phlegm.
3.Add taste ma xing shi gan tang recipe has obvious effect and scurity on Comm -unity-acquired Pneumonia.
观察中药制剂加味麻杏石甘汤联合西药常规治疗肺热病痰热壅肺型与单纯西药治疗的效果,比较二者疗效,及其对炎性指标(白细胞、中性粒细胞、C-反应蛋白、肿瘤坏死因子-α)的影响,探讨中西医结合治疗的抗炎作用优势。
资料和方法:
1、选择符合西医诊断为CAP,按肺热病中医辨证标准分型为痰热壅肺型患者60例,随机分为中西医结合治疗组和西药治疗对照组各30例。
2、两组均予呼吸喹诺酮药物抗感染,治疗组在使用西药的基础上,加用加味麻杏石甘汤;进行临床疗效对比并检测两组治疗前后WBC、GR%、GR#、CRP、TNF-α的变化。
3、用SPSS12.0软件对结果进行统计学处理。
结果:
1、临床疗效观察:综合疗效及中医症候疗效比较均于治疗7天后差异显著(P＜0.05);两者于治疗10天后差异不显著;但中医证候积分比较,治疗7天、10天后两组均有显著差异(P＜0.05)。
2、加味麻杏石甘汤对炎性指标的干预:①血常规相关指标:白细胞计数、中性粒细胞百分比及中性粒细胞计数的复常率,两组无显著差异;但是白细胞实际测量值及差值比较,治疗组明显优于对照组(P＜0.05)。②C-反应蛋白复常率两组无显著性差异;但实际值比较,两组治疗后及治疗前后差值比较有差异,治疗组优于对照组(P＜0.05)。③肿瘤坏死因子-α下降率及治疗后测定值两组无显著性差异;但治疗前后差值比较有显著差异(P＜0.05)。
3、两组治疗过程未发现明显毒副作用,试验期间0例受试者退出。
结论:
1.通过非盲随机对照临床研究,表明以加味麻杏石甘汤方配合西药可以显著改善中医辨证为肺热病痰热壅肺型(西医诊断为社区获得性肺炎)患者的临床症状,具有清热化痰肃肺之功效,一定程度上降低血WBC、CRP、TNF-α水平,优于单纯西药治疗。
2.抑制炎症反应,对抗生素治疗感染性疾病具有协同作用,可能是清热化痰中药的作用机制之一。
3.加味麻杏石甘汤安全有效,可在临床推广应用。
Objective:
To observe the clinical curative effect of treating Wind-warm Lung-heat disease in stagnation of phlegm-heat with Chinese drugs preparation Add taste ma xing shi gan t -ang and antibiotic only,compare their curative effect,and contribution to indicatrix o -f phlegmonosis.And to approach the predominance of conbined treatment of traditional Chinese medicine and western medicine therapeutic on cooperation of anti-inflammatory effect.
Materias and Methods:
1.60 patients with CAP were differentiated by adopting the standard of TCM Syn -drome Differentiation for Wind-warm Lung-heat disease.The patients were randomlydi -vided into treatment group and control group.
2.Both groups were treated by Quinolone-kind drug of breathing to anti-infection. Treatment group added to Add taste ma xing shi gan tang.Compare their curative effe -ct and test WBC、GR%、GR#、CRP、TNF-αbefore and after therapy.
3.Statietical analysis were carried out by SPSS 12.0 software.
Results:
1.Observation of curative effect:There was significant curative effect of disease an -d traditional Chinese medicine symptoms in the treatment group after 7 days(P＜0.05). Comparison of integral in traditional Chinese medicine symptoms:treatment group got better obviously effect both after 7 and 10 days(P＜0.05).
2.Intervention of Add taste ma xing shi gan tang recipe to indicatrix of phlegmon -osis:①Indexes related to blood routine detetion:there is no statistically significant dif -ference between the two groups' normalization rate of leukocyte count,neutrophlls perc entage and neutrophil count.But the comparative analysis of the actual measure value and their difference of leukocyte,the effect of the treatment group was superior to the control group significantly(P＜0.05).②There was no singnificant difference of C-react -ive protein's normalization rate between two groups,but there were differences after t -reatment and difference value of pre and post treatment in comparison of actual value. The effect of treatment group was significantly superior to that of control group(P＜ 0.05).③There was no singnificant difference in the decrease rate of Tumor Necrosis Factor-αand its measure value of post treatment,but there were differences in the val -ue of pre and post treatment(P＜0.05).
3.Obvious side effects or adverse reaction were not found during the therapeutic process in the two groups.No patients exit during the experiment.
Conclusion:
1.By non-blind randomized controlled clinical study,it indicated that compound Add taste ma xing shi gan tang recipe with Western medicine can significantly improve the clinical symptoms of Wind-warm Lung-heat disease(Community Acquired Pneumonia), have efficiency of eliminating phlegm by cooling,and reduce level of WBC、CRP and TNF-α,which was superior to using Western medicine only in some degree.
2.Controling inflammation reaction,reducing the level.Having synergistic effect to antibiotic in treating infectious diseases,is one of the possible mechanism of Chinese drug in clearing away heat and dispersing phlegm.
3.Add taste ma xing shi gan tang recipe has obvious effect and scurity on Comm -unity-acquired Pneumonia.
引文
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