外侧缰核介导岛叶皮层控制中缝核释放5-HT
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- 论文作者：王晶华 ; 王敏 ; 刘攀 ; 黄民 ; 李明娴 ; 王绍
- 年：2012
- 作者机构：Department of Physiology Norman Bethune College of Medicine Jilin University;Department of Pneumology the First Affiliated Hospital of Jilin University;
- 论文关键词：睡眠 ; 呼吸暂停 ; 岛叶 ; 缰核 ; 五羟色胺
- 会议召开时间：2012-09-29
- 会议录名称：第二届海峡两岸中医心理学睡眠医学论坛论文汇编
- 英文会议录名称：Proceedings of the 2nd Cross-Straits TCM Psychology & Sleep Medicine Forum
- 语种：中文
- 分类号：R766
- 学会代码：YXSM
- 会议名称：第二届海峡两岸中医心理学睡眠医学论坛
- 会议地点：中国台湾台北
- 主办单位：世界中医药学会联合会中医心理学专业委员会、世界中医药学会联合会睡眠医学专业委员会
- 学会名称：世界中医药学会联合会睡眠医学专业委员会
- 页数：14
- 文件大小：846k
- 原文格式：D
- 会议级别：全国
摘要
目的边缘系统的岛叶皮层和缰核通过控制中缝核5-HT释放参与动物和人类呼吸困难的调节。由于缰核分内外侧两个部分,岛叶信号是通过内侧缰核、还是通过外侧缰核下行传导并不清楚。为了深入探讨在睡眠呼吸暂停综合征(Obstructive sleep apnea syndrome,OSA)发病中缰核及岛叶皮层的作用及功能关系,应用电刺激Wistar大鼠前岛叶皮层(anterior insular cortex,INS),记录呼吸曲线、内、外侧缰核神经元放电情况及动脉血气分析,并将记录结果与对照组(电刺激INS周围组)进行比较分析。结果电刺激INS大鼠出现呼吸紊乱及呼吸暂停;血p H值明显降低,剩余碱(BE)负值明显增大,与对照组比较具有显著差异(P<0.05);电刺激岛叶使大鼠内侧缰核神经元自发放电减弱,使外侧缰核神经元自发放电增加。结论电刺激岛叶皮层可诱发动物出现呼吸暂停,形成类似人类OSA的表现。岛叶皮层与缰核之间存在的功能联系,刺激岛叶皮层分别引起内、外侧缰核的抑制和兴奋。通过外侧缰核对中缝核的抑制加强,而导致OSA症状出现。从理论上阐述刺激岛叶皮层建立OSA动物模型的机制,也推进了对OSA中枢神经系统病因探讨。
引文
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[6]Kou ZY,Li MS,Zhang CX,Wang S.[Habenula participates the vasopressor response by stimulation of the insular cortex,central-,lateral amygdaloid nucleus respectively].Zhongguo Ying Yong Sheng Li Xue Za Zhi.2003 Nov;19(4):334-6.
[7]Li M,Wang J,Huang M,Lin W,Wang M,Yu L,Wang S.Blockage of the habenular nucleus can eliminate dyspnea induced by electrostimulation of the insular cortex.Neural Regeneration Research 2010:5(13):1025-1029。
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[10]Wang S,Fu Q,Fu J.Modulation of preoptic area on discharges of parafascicular pain neurons.Kexue Tongbao.1983;28(3):401-405.
[11]Cao Y,Fujito Y,Matsuyama K,Aoki M(2006).Effects of electrical stimulation of the medullary raphe nuclei on respiratory movement in rats.J Comp Physiol A Neuroethol Sens Neural Behav Physiol.2006;192(5):497-505.
[12]Carley DW,Trbovic S,Radulovacki M.Sleep apnea in normal and REM sleepdeprived normotensive Wistar-Kyoto and spontaneously hypertensive(SHR)rats.[J]Physiol Behav,1996,59:827-831.
[13]Ling L.Serotonin and NMDA receptors in respiratory long-term facilitation.Respir Physiol Neurobiol.2008 Dec 10;164(1-2):233-41.
[14]Grace KP,Liu H,Horner RL.5-HT1A receptor-responsive pedunculopontine tegmental neurons suppress REM sleep and respiratory motor activity.JNeurosci.2012 Feb 1;32(5):1622-33.
[15]Shelton L,Becerra L,Borsook D.Unmasking the mysteries of the habenula in pain and analgesia.Prog Neurobiol.2012 Feb;96(2):208-19.
[16]Wang S.Habenula--a new target for treatment of intractable depression.Sheng Li Ke Xue Jin Zhan.2011 Dec;42(6):407-12.
[17]Pobbe RL,Zangrossi H Jr.The lateral habenula regulates defensive behaviors through changes in 5-HT-mediated neurotransmission in the dorsal periaqueductal gray matter.Neurosci Lett.2010 Jul 26;479(2):87-91.
[18]C.Peyron,J.-M.Petit,C.Rampon,M.Jouvet and P.-H.Luppi,Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods,Neuroscience.1998;82:443-468.
[19]Poller WC,Bernard R,Derst C,et al.Lateral habenular neurons projecting to reward-processing monoaminergic nuclei express hyperpolarization-activated cyclic nucleotid-gated cation channels.Neuroscience.2011 Oct 13;193:205-16.
[20]Roger Luis Henschel Pobbe,Helio Zangrossi Jr.The lateral habenula regulates defensive behaviors through changes in 5-HT-mediated neurotransmission in the dorsal periaqueductal gray matter.Neuroscience Letters,2010;479(2):87-91.
[21]Herkenham M,Nauta W.Efferent connections of the habenular nuclei in the rat.J Comp Neurol,1979;187(1):19-47.
[22]Eckenrode T,Barr G,Battisti W,Murray M.Acetylcholine in the interpeduncular nucleus of the rat:normal distribution and effects of deafferentation.Brain Res,1987;418(2):273-286.
[23]Fasolo A,Virgili M,Panzica G,Contestabile A.Immunohistochemistry and neurochemistry of the habenulo-interpeduncular connection after partial developmental depletion of habenular cholinergic neurons in the rat.Exp Brain Res Bull,1992;90(2):297-301.
[24]Bernard R,Veh RW.Individual neurons in the rat lateral habenular complex project mostly to the dopaminergic ventral tegmental area or to the serotonergic raphe nuclei.J Comp Neurol.2012 Aug 1;520(11):2545-58.
[25]Herbstreit F,Zigrahn D,Ochterbeck C,et al.Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure.Anesthesiology.2010 Dec;113(6):1280-8.
[26]Kubin,RO Davies,AI Pack:Control of upper airway motoneurons during REMsleep.News Physiol Sci.1998;13:91-7.
[27]A Jelev,S Sood,H Liu,et al.Microdialysis perfusion of 5-HT into the hypoglossal motor nucleus differentially modulates genioglossus activity across natural sleep-wake states in rats.J Physiol(Lond).2001;532:467-481.
[28]Veasey SC.Serotonin.Culprit or Promising Therapy for Obstructive Sleep Apnea?Am J Respir Crit Care Med,2001,163(5):1045-1047.
[29]Peng L,Wang J,Zhang L,Liu P,Wang M,Huang M,Liu S,He P,Cui L,Li M,Wang S.Role of 5-hydroxytryptamine expression in cerebellar Purkinje cells in obstructive sleep apnea syndrome.Neural Regeneration Research 2012;7(8):606-610.
[2]Saboisky JP,Stashuk DW,Hamilton-Wright A,Carusona AL,Campana LM,Trinder J,Eckert DJ,Jordan AS,Mc Sharry DG,White DP,Nandedkar S,David WS,Malhotra A.Neurogenic changes in the upper airway of patients with obstructive sleep apnea.Saboisky JP,et al.Show Am J Respir Crit Care Med.2012 Feb1;185(3):322-9.Epub 2011 Oct 20
[3]Mckay LC,Evans KC,Frackowiak RS,Corfield DR.Neural correlates of voluntary breathing in humans.J Appl Physiol.2003;95:1170-8.
[4]Henderson LA,Woo MA,Macey PM,Macey KE,Frysinger RC,Alger JR,Yan-Go F,Harper RM.Neural responses during Valsalva maneuvers in obstructive sleep apnea syndrome.J Appl Physiol 2003:94(3):1063-1074.
[5]Cui L,Wang JH,Wang M,Huang M,Wang CY,Xia H,Xu JG,Li MX,Wang S.Injection of L-glutamate into the insular cortex produces sleep apnea and serotonin reduction in rats.Sleep Breath 2011.2011;Sep 27..
[6]Kou ZY,Li MS,Zhang CX,Wang S.[Habenula participates the vasopressor response by stimulation of the insular cortex,central-,lateral amygdaloid nucleus respectively].Zhongguo Ying Yong Sheng Li Xue Za Zhi.2003 Nov;19(4):334-6.
[7]Li M,Wang J,Huang M,Lin W,Wang M,Yu L,Wang S.Blockage of the habenular nucleus can eliminate dyspnea induced by electrostimulation of the insular cortex.Neural Regeneration Research 2010:5(13):1025-1029。
[8]The Ministry of Science and Technology of the People’s Republic of China(2006).Guidance Suggestions for the Care and Use of Laboratory Animals.2006-09-30.
[9]Fields HL,Bry J,Hentall I,Zorman G(1983).The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat.J Neurosci.1983;3(12):2545-2552.
[10]Wang S,Fu Q,Fu J.Modulation of preoptic area on discharges of parafascicular pain neurons.Kexue Tongbao.1983;28(3):401-405.
[11]Cao Y,Fujito Y,Matsuyama K,Aoki M(2006).Effects of electrical stimulation of the medullary raphe nuclei on respiratory movement in rats.J Comp Physiol A Neuroethol Sens Neural Behav Physiol.2006;192(5):497-505.
[12]Carley DW,Trbovic S,Radulovacki M.Sleep apnea in normal and REM sleepdeprived normotensive Wistar-Kyoto and spontaneously hypertensive(SHR)rats.[J]Physiol Behav,1996,59:827-831.
[13]Ling L.Serotonin and NMDA receptors in respiratory long-term facilitation.Respir Physiol Neurobiol.2008 Dec 10;164(1-2):233-41.
[14]Grace KP,Liu H,Horner RL.5-HT1A receptor-responsive pedunculopontine tegmental neurons suppress REM sleep and respiratory motor activity.JNeurosci.2012 Feb 1;32(5):1622-33.
[15]Shelton L,Becerra L,Borsook D.Unmasking the mysteries of the habenula in pain and analgesia.Prog Neurobiol.2012 Feb;96(2):208-19.
[16]Wang S.Habenula--a new target for treatment of intractable depression.Sheng Li Ke Xue Jin Zhan.2011 Dec;42(6):407-12.
[17]Pobbe RL,Zangrossi H Jr.The lateral habenula regulates defensive behaviors through changes in 5-HT-mediated neurotransmission in the dorsal periaqueductal gray matter.Neurosci Lett.2010 Jul 26;479(2):87-91.
[18]C.Peyron,J.-M.Petit,C.Rampon,M.Jouvet and P.-H.Luppi,Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods,Neuroscience.1998;82:443-468.
[19]Poller WC,Bernard R,Derst C,et al.Lateral habenular neurons projecting to reward-processing monoaminergic nuclei express hyperpolarization-activated cyclic nucleotid-gated cation channels.Neuroscience.2011 Oct 13;193:205-16.
[20]Roger Luis Henschel Pobbe,Helio Zangrossi Jr.The lateral habenula regulates defensive behaviors through changes in 5-HT-mediated neurotransmission in the dorsal periaqueductal gray matter.Neuroscience Letters,2010;479(2):87-91.
[21]Herkenham M,Nauta W.Efferent connections of the habenular nuclei in the rat.J Comp Neurol,1979;187(1):19-47.
[22]Eckenrode T,Barr G,Battisti W,Murray M.Acetylcholine in the interpeduncular nucleus of the rat:normal distribution and effects of deafferentation.Brain Res,1987;418(2):273-286.
[23]Fasolo A,Virgili M,Panzica G,Contestabile A.Immunohistochemistry and neurochemistry of the habenulo-interpeduncular connection after partial developmental depletion of habenular cholinergic neurons in the rat.Exp Brain Res Bull,1992;90(2):297-301.
[24]Bernard R,Veh RW.Individual neurons in the rat lateral habenular complex project mostly to the dopaminergic ventral tegmental area or to the serotonergic raphe nuclei.J Comp Neurol.2012 Aug 1;520(11):2545-58.
[25]Herbstreit F,Zigrahn D,Ochterbeck C,et al.Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure.Anesthesiology.2010 Dec;113(6):1280-8.
[26]Kubin,RO Davies,AI Pack:Control of upper airway motoneurons during REMsleep.News Physiol Sci.1998;13:91-7.
[27]A Jelev,S Sood,H Liu,et al.Microdialysis perfusion of 5-HT into the hypoglossal motor nucleus differentially modulates genioglossus activity across natural sleep-wake states in rats.J Physiol(Lond).2001;532:467-481.
[28]Veasey SC.Serotonin.Culprit or Promising Therapy for Obstructive Sleep Apnea?Am J Respir Crit Care Med,2001,163(5):1045-1047.
[29]Peng L,Wang J,Zhang L,Liu P,Wang M,Huang M,Liu S,He P,Cui L,Li M,Wang S.Role of 5-hydroxytryptamine expression in cerebellar Purkinje cells in obstructive sleep apnea syndrome.Neural Regeneration Research 2012;7(8):606-610.