Anti-tumor and anti-virus activity of polysaccharides extracted from Sipunculus nudus(SNP) on Hepg2.2.15
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- 英文论文题名：Anti-tumor and anti-virus activity of polysaccharides extracted from Sipunculus nudus(SNP) on Hepg2.2.15
- 论文作者：Jie Su ; Linlin Jiang ; Jingna Wu ; Zhiyu Liu ; Yuping Wu
- 英文论文作者：Jie Su ; Linlin Jiang ; Jingna Wu ; Zhiyu Liu ; Yuping Wu ; South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center ; School of Life Sciences ; Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering ; Zhuhai Key Laboratory of Marine Bioresources and Environment ; School of Marine Sciences ; Sun Yat-Sen University ; Key Laboratory of Cultivation and High-value Utilization of Marine Organisms in Fujian Province ; Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources ; Fisheries Research Institute of Fujian
- 年：2016
- 作者机构：South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center,School of Life Sciences,Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering,Zhuhai Key Laboratory of Marine Bioresources and Environment,School of Marine Sciences,Sun Yat-Sen University;Key Laboratory of Cultivation and High-value Utilization of Marine Organisms in Fujian Province,Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources,Fisheries Research Institute of Fujian;
- 英文论文关键词：Polysaccharide ; Sipunculus nudus ; Anti-tumor activity ; Anti-virus activity
- 会议召开时间：2016-11-11
- 会议录名称：福建省海洋学会2016年学术年会论文摘要集
- 语种：英文
- 分类号：R285;R284
- 学会代码：FJHY
- 会议名称：福建省海洋学会2016年学术年会
- 会议地点：中国福建厦门
- 主办单位：福建省海洋学会、福建省水产研究所
- 学会名称：福建省海洋学会
- 页数：1
- 文件大小：28k
- 原文格式：O
- 会议级别：地方
摘要
Many polysaccharides have biological activities and have been investigated for their antitumor effects.In this study,we investigated the anti-tumor activity and anti-virus activity of SNP—the water-soluble polysaccharides extracted from Sipunculus nudus on Hepg2.2.15.Flow cytometry analysis demonstrated that SNP induced dose-dependent cell apoptosis on Hepg2.2.15.Real-time PCR and Western Blot analysis showed that SNP down-regulated the synthesis of HBsAg,HBV-DNA and enhanced the expression of pro-apoptosis proteins TNF-ci,caspase-3,and Bax,while decreasing the expression of the antiapoptosis proteins survivin.Bcl-2.and VECF.These results suggested that SNP suppressed cell viability of Hepg2.2.15 and that could be a novel anti-tumor and anti-HBV agent.
Many polysaccharides have biological activities and have been investigated for their antitumor effects.In this study,we investigated the anti-tumor activity and anti-virus activity of SNP—the water-soluble polysaccharides extracted from Sipunculus nudus on Hepg2.2.15.Flow cytometry analysis demonstrated that SNP induced dose-dependent cell apoptosis on Hepg2.2.15.Real-time PCR and Western Blot analysis showed that SNP down-regulated the synthesis of HBsAg,HBV-DNA and enhanced the expression of pro-apoptosis proteins TNF-ci,caspase-3,and Bax,while decreasing the expression of the antiapoptosis proteins survivin.Bcl-2.and VECF.These results suggested that SNP suppressed cell viability of Hepg2.2.15 and that could be a novel anti-tumor and anti-HBV agent.
Many polysaccharides have biological activities and have been investigated for their antitumor effects.In this study,we investigated the anti-tumor activity and anti-virus activity of SNP—the water-soluble polysaccharides extracted from Sipunculus nudus on Hepg2.2.15.Flow cytometry analysis demonstrated that SNP induced dose-dependent cell apoptosis on Hepg2.2.15.Real-time PCR and Western Blot analysis showed that SNP down-regulated the synthesis of HBsAg,HBV-DNA and enhanced the expression of pro-apoptosis proteins TNF-ci,caspase-3,and Bax,while decreasing the expression of the antiapoptosis proteins survivin.Bcl-2.and VECF.These results suggested that SNP suppressed cell viability of Hepg2.2.15 and that could be a novel anti-tumor and anti-HBV agent.
引文