Fermented Yupingfeng Polysaccharides Enhance Immunity by Improving the Foregut Microflora and Intestinal Barrier in Weaning Rex Rabbits
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- 英文论文题名：Fermented Yupingfeng Polysaccharides Enhance Immunity by Improving the Foregut Microflora and Intestinal Barrier in Weaning Rex Rabbits
- 论文作者：Hao Sun ; Xueqin Ni ; Xu Song ; Bin Wen ; Yi Zhou ; Fuqin Zou ; Mingyue Yang ; Zhirong Peng ; Hui Zhu ; Yan Zeng ; Hesong Wang ; Xiangchao Fu ; Yunduo Shi ; Zhongqiong Yin ; Kangcheng Pan ; Bo Jing ; Dong Zeng ; Ping Wang
- 英文论文作者：Hao Sun ; Xueqin Ni ; Xu Song ; Bin Wen ; Yi Zhou ; Fuqin Zou ; Mingyue Yang ; Zhirong Peng ; Hui Zhu ; Yan Zeng ; Hesong Wang ; Xiangchao Fu ; Yunduo Shi ; Zhongqiong Yin ; Kangcheng Pan ; Bo Jing ; Dong Zeng ; Ping Wang ; Animal Microecology Institute ; College of Veterinary Medicine ; Sichuan Agricultural University ; Key Laboratory of Animal Disease and Human Health of Sichuan Province ; Sichuan Academy of Grassland Science ; Sichuan Fishery School
- 年：2016
- 作者机构：Animal Microecology Institute,College of Veterinary Medicine,Sichuan Agricultural University;Key Laboratory of Animal Disease and Human Health of Sichuan Province;Sichuan Academy of Grassland Science;Sichuan Fishery School;
- 英文论文关键词：Yupingfeng polysaccharide ; Rhizopus oligosporus SH ; Immunity ; Intestinal microflora ; Intestinal barrier ; Toll-like receptors
- 会议召开时间：2016-11-04
- 会议录名称：中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会论文集
- 语种：英文
- 分类号：S829.1
- 学会代码：ZGXJ
- 会议名称：中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会
- 会议地点：中国山东青岛
- 主办单位：中国畜牧兽医学会动物微生态学分会
- 学会名称：中国畜牧兽医学会
- 页数：1
- 文件大小：70k
- 原文格式：O
- 会议级别：全国
摘要
Yupingfeng(YPF) is a kind of Astragali Radix-based ancient Chinese herbal supplemented with Atractylodis Macrocephalae Rhizoma and Radix Saposhnikoviae.Increasing evidence has proven the beneficial immunomodulating activity of YPF.However,the action mechanism(s) of it is not known.Here,we explored the immunomodulatory activity of unfermented Yupingfeng polysaccharides(UYP) and fermented Yupingfeng polysaccharides(FYP) obtained using Rhizopus oligosporus SH in weaning rex rabbits.The results showed that both UYP and FYP exhibited notable growth-promoting and immune-enhancing activities,improvement of the intestinal flora homeostasis and maintenance of intestinal barrier integrity and functionality.Notably,compared with UYP,FYP effectively enhanced average daily gain,organ indices,IL-2,IL-4,IL-10,TNF-α,TLR2 and TLR4 mRNA levels in spleen,IL-1,IL-2,IL-4,IL-6,IL-10,IL-12,TNF-a and IFN-γ protein concentrations in serum and TLR2 and TLR4 mRNA expressions in gastrointestinal tract(GIT).Moreover,FYP exhibited greater beneficial effects in improving the intestinal flora,including augment flora diversity and the abundance of cellulolytic bacteria,reduction the abundance of Streptococcus spp.and Enterococcus spp.in GIT,particularly foregut and maintaining the intestinal barrier integrity and functionality by upregulating zonula occludens 1,claudin,polymeric immunoglobulin receptor,trefoil factor and epidermal growth factor mRNA levels in jejunum and ileum.Our results indicated the immunoenhancement effect of FYP is superior over that of UYP,which is probably related with the amelioration of the intestinal microflora and intestinal barrier in foregut.
Yupingfeng(YPF) is a kind of Astragali Radix-based ancient Chinese herbal supplemented with Atractylodis Macrocephalae Rhizoma and Radix Saposhnikoviae.Increasing evidence has proven the beneficial immunomodulating activity of YPF.However,the action mechanism(s) of it is not known.Here,we explored the immunomodulatory activity of unfermented Yupingfeng polysaccharides(UYP) and fermented Yupingfeng polysaccharides(FYP) obtained using Rhizopus oligosporus SH in weaning rex rabbits.The results showed that both UYP and FYP exhibited notable growth-promoting and immune-enhancing activities,improvement of the intestinal flora homeostasis and maintenance of intestinal barrier integrity and functionality.Notably,compared with UYP,FYP effectively enhanced average daily gain,organ indices,IL-2,IL-4,IL-10,TNF-α,TLR2 and TLR4 mRNA levels in spleen,IL-1,IL-2,IL-4,IL-6,IL-10,IL-12,TNF-a and IFN-γ protein concentrations in serum and TLR2 and TLR4 mRNA expressions in gastrointestinal tract(GIT).Moreover,FYP exhibited greater beneficial effects in improving the intestinal flora,including augment flora diversity and the abundance of cellulolytic bacteria,reduction the abundance of Streptococcus spp.and Enterococcus spp.in GIT,particularly foregut and maintaining the intestinal barrier integrity and functionality by upregulating zonula occludens 1,claudin,polymeric immunoglobulin receptor,trefoil factor and epidermal growth factor mRNA levels in jejunum and ileum.Our results indicated the immunoenhancement effect of FYP is superior over that of UYP,which is probably related with the amelioration of the intestinal microflora and intestinal barrier in foregut.
Yupingfeng(YPF) is a kind of Astragali Radix-based ancient Chinese herbal supplemented with Atractylodis Macrocephalae Rhizoma and Radix Saposhnikoviae.Increasing evidence has proven the beneficial immunomodulating activity of YPF.However,the action mechanism(s) of it is not known.Here,we explored the immunomodulatory activity of unfermented Yupingfeng polysaccharides(UYP) and fermented Yupingfeng polysaccharides(FYP) obtained using Rhizopus oligosporus SH in weaning rex rabbits.The results showed that both UYP and FYP exhibited notable growth-promoting and immune-enhancing activities,improvement of the intestinal flora homeostasis and maintenance of intestinal barrier integrity and functionality.Notably,compared with UYP,FYP effectively enhanced average daily gain,organ indices,IL-2,IL-4,IL-10,TNF-α,TLR2 and TLR4 mRNA levels in spleen,IL-1,IL-2,IL-4,IL-6,IL-10,IL-12,TNF-a and IFN-γ protein concentrations in serum and TLR2 and TLR4 mRNA expressions in gastrointestinal tract(GIT).Moreover,FYP exhibited greater beneficial effects in improving the intestinal flora,including augment flora diversity and the abundance of cellulolytic bacteria,reduction the abundance of Streptococcus spp.and Enterococcus spp.in GIT,particularly foregut and maintaining the intestinal barrier integrity and functionality by upregulating zonula occludens 1,claudin,polymeric immunoglobulin receptor,trefoil factor and epidermal growth factor mRNA levels in jejunum and ileum.Our results indicated the immunoenhancement effect of FYP is superior over that of UYP,which is probably related with the amelioration of the intestinal microflora and intestinal barrier in foregut.
引文
Aloisio I,Mazzola G,Corvaglia LT,Tonti G,Faldella G,Biavati B,Gioia DD(2014)Influence of intrapartum antibiotic prophylaxis against group b streptococcus on the early newborn gut composition and evaluation of the antistreptococcus activity of Bifidobacterium strains.Appl Microbiol Biot 98:6051-6060.doi:10.1007/s00253-014-5712-9