Structural Insights into Transamination Mechanism of the Aminotransferase CrmG in Caerulomycin Biosynthesis
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- 英文论文题名：Structural Insights into Transamination Mechanism of the Aminotransferase CrmG in Caerulomycin Biosynthesis
- 论文作者：Jinxin Xu ; Yiguang Zhu ; Zhan Feng ; Changsheng Zhang ; Jinsong Liu
- 英文论文作者：Jinxin Xu ; Yiguang Zhu ; Zhan Feng ; Changsheng Zhang ; Jinsong Liu ; Guangzhou Institutes of Biomedicine and Health ; Chinese Academy of Sciences ; South China Sea Institutes of Oceanology ; Chinese Academy of Sciences
- 年：2016
- 作者机构：Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences;South China Sea Institutes of Oceanology,Chinese Academy of Sciences;
- 会议召开时间：2016-12-19
- 会议录名称：中国晶体学会第六届学术年会暨会员代表大会（大分子晶体学分会）论文摘要集
- 英文会议录名称：Abstracts of the 6th Annual Conference of Chinese Crystallographic Society
- 语种：英文
- 分类号：O629.8
- 学会代码：ZGJY
- 会议名称：中国晶体学会第六届学术年会暨会员代表大会（大分子晶体学分会）
- 会议地点：中国广东广州
- 主办单位：中国晶体学会
- 学会名称：中国晶体学会
- 页数：1
- 文件大小：191k
- 原文格式：D
- 会议级别：全国
摘要
<正>Caerulomycin A(CRM A)belongs to a family of natural products containing a 2,2'-bipyridyl ring core structure,and is currently under development as a potent novel immunosuppressive agent.The aminotransferase Crm G was confirmed to catalyze a key transamination reaction to convert an aldehyde group to an amino group in CRM A biosynthetic pathway,preferring L-glutamate and
引文
[1]Zhu,Yiguang,et al.Biochemical and Structural Insights into the Aminotransferase Crm G in Caerulomycin Biosynthesis.ACSchemical biology,2016,11,943-952