The health and production traits in bovine are associated with single nucleotide polymorphisms at NOD2 gene
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- 英文论文题名：The health and production traits in bovine are associated with single nucleotide polymorphisms at NOD2 gene
- 论文作者：W.Wang ; L.Chen ; J.Yi ; J.Gan ; H.Tang ; M.Z.Fu ; H.Wang ; S.J.Lai
- 英文论文作者：W.Wang ; L.Chen ; J.Yi ; J.Gan ; H.Tang ; M.Z.Fu ; H.Wang ; S.J.Lai ; College of Animal Science and Technology ; Sichuan Agricultural University ; Sichuan Animal Science Academy ; Sichuan animal husbandry station
- 年：2016
- 作者机构：College of Animal Science and Technology,Sichuan Agricultural University;Sichuan Animal Science Academy;Sichuan animal husbandry station;
- 英文论文关键词：NOD2 gene ; bovine mastitis ; SCS ; bovine mastitis
- 会议召开时间：2016-09-27
- 会议录名称：第十一届(2016)中国牛业发展大会论文集
- 语种：英文
- 分类号：S823
- 学会代码：ZXMY
- 会议名称：第十一届(2016)中国牛业发展大会
- 会议地点：中国四川宣汉
- 主办单位：中国畜牧业协会
- 学会名称：中国畜牧业协会
- 页数：9
- 文件大小：1125k
- 原文格式：D
- 会议级别：全国
摘要
NOD2 gene plays a fundamental role in the initiation of the inflammatory and subsequent immune response. Which have been previously identified as susceptibility loci for inflammatory bowel diseases in human. In this study, we detected two mutations in exon 12(A→T, G→A) among five cattle breeds(n=315) and analyzed their associations with production traits and genetic resistance against bovine mastitis in Chinese Holstein and Chinese Simmental breeds(n=218). The transitions(A→T) at position 114 bp associated with SCS(p<0.01). The G→A at position 1594 bp have been described to play a critical role to increase 305-day milk yields. In Chinese Holstein and Chinese Simmental breeds, BB genotype may contribute to disease susceptibility. When compared to all genotypic combinations, the genotypic combinations simultaneously carried allele A, B, and genotype FF are beneficial not only for reducing SCS but also increasing production.
NOD2 gene plays a fundamental role in the initiation of the inflammatory and subsequent immune response. Which have been previously identified as susceptibility loci for inflammatory bowel diseases in human. In this study, we detected two mutations in exon 12(A→T, G→A) among five cattle breeds(n=315) and analyzed their associations with production traits and genetic resistance against bovine mastitis in Chinese Holstein and Chinese Simmental breeds(n=218). The transitions(A→T) at position 114 bp associated with SCS(p<0.01). The G→A at position 1594 bp have been described to play a critical role to increase 305-day milk yields. In Chinese Holstein and Chinese Simmental breeds, BB genotype may contribute to disease susceptibility. When compared to all genotypic combinations, the genotypic combinations simultaneously carried allele A, B, and genotype FF are beneficial not only for reducing SCS but also increasing production.
NOD2 gene plays a fundamental role in the initiation of the inflammatory and subsequent immune response. Which have been previously identified as susceptibility loci for inflammatory bowel diseases in human. In this study, we detected two mutations in exon 12(A→T, G→A) among five cattle breeds(n=315) and analyzed their associations with production traits and genetic resistance against bovine mastitis in Chinese Holstein and Chinese Simmental breeds(n=218). The transitions(A→T) at position 114 bp associated with SCS(p<0.01). The G→A at position 1594 bp have been described to play a critical role to increase 305-day milk yields. In Chinese Holstein and Chinese Simmental breeds, BB genotype may contribute to disease susceptibility. When compared to all genotypic combinations, the genotypic combinations simultaneously carried allele A, B, and genotype FF are beneficial not only for reducing SCS but also increasing production.
引文
Bramley AJ(1996).Current concepts of bovine mastitis.National Mastitis Council,Madison,Wis.
Bryner(1989).Comparison of four procedures to detect Listeria spp.in foods.J.Food Prot.52:154-157.
Bonen DK,Ogura Y,Nicolae DL,Inohara N,Saab L,Tanabe T,Chen FF,Foster SJ,Duerr RH,Bra nt SR,Cho JH,Nunez G(2003).Crohn’s disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan.Gastroenterology.124:140-147
Cormac J,whelehan,KG Meade,PD Eckersall(2011).Experimental staphylococcus aureus infection of the mammary gland induces region-specific changes in innate immune gene expression.Veterinary immunology and immunopathology.140(15):181-189
Girardin SE,Sansonetti PJ,Philpott DJ(2002).Trends Microbiol.10:193-199
Girardin SE,Tournebize R,Mavris M,Page AL,Li X,Stark GR,Bertin J(2001).EMBO Rep.2:736-742
Hugot JP,Chamaillard M,Zouali H,Lesage S,Cezard JP,Belaiche J,Almer.S(2001).Nature.411:599-603
Heisick JE,FM Harrell,EH Peterson,SM c Laughlin,DE Wagner,IV.Wesley,J
Inohara N,Ogura Y,Nunez G(2002).Curr.Opin.Microbiol.5:76-80
Inohara N,Ogura Y,Chen FF,Muto A,Nunez G(2001).J.Biol.Chem.276:2551-255
International Dairy Federation(IDF)(1985).Laboratory methods for use in mastitis work.IDF.Brussel s,Belgium.132
Mark T,Fikse WF,Emanuelson U(2005).International Genetic Evaluations of Holstein sires for milk somatic cell and clinical mastitis.Journal of Dairy Science.85:2384-2392.
MX Chu(1999).Occurrence and preventive treatment of cattle mastitis.Chinese cattle.(4):39-40.
Nash DL,Rogers GW,Cooper JB(2004).Heritability of clinical mastitis incidence and relationships w ith sire transmitting abilities for simatic cell score,udder type traits,productive life,and protein yield.Journal of Dairy Science.83:2350-2360.
National Mastitis Council.Microbiological(2004).Procedures for the Diagnosis of Bovine Udder Infec tion and Determination of Milk Quality.WI:National Mastitis Council,W.D.Hoard and Sons Co.4thed.Fort Atkinson
Ogura Y,Inohara N,Benito A,Chen FF,Yamaoka S,Nunez G(2001).Nod2,a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappa B.The Journal of biological chemistry.276(7):4812-4818.
Pellegrini O,Aurel MR,Lagriffoul G,Marie C,Remeuf F,Rivemale M,Barillet F(1994).Relations entre les comptages de cellules somatiques,les caractéristiques physico-chimiques et l’aptitudeàla coa gulation par la présure delaits individuels de brebis de race Lacaune,in:Proceedings of the Internation al symposiumon somatic cells and milk of small ruminants,Bella,25-27 September Italy,EAAP Publi cation No.77,pp.253-258.
Ren G,Chen H,Zhang LZ,Lan XY,Wei TB,Li MJ,Jing YJ,Lei CZ,Wang JQ(2009)A coding SNP of LHX4 gene is associated with body weight and body length in bovine.Mol Biol Rep.37(1):417-422
Shimosato T,Kitazawa H,Katoh S,Tohno M,Iliev ID,Nagasawa C,Kimura T,Kawai Y,Saito T(2005 a).Augmentation of T(H)-1 type response by immunoactive AT oligonucleotide from lactic acid ba cteria via Toll-like receptor 9 signaling.Biochem.Biophys.Res.Commun.326:782-787.
Shimosato T,Tohno M,Kitazawa H,Katoh S,Watanabe K,Kawai Y,Aso H,Yamaguchi T,Saito T(2005b).Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer’s patches.Immunol.Lett.98:83-89.
Tohno M,Ueda W,Azuma Y(2008).Molecular cloning and functional characterization of porcine nuc leotide-binding oligomerization domain-2(NOD2).Mol Immunol.Jan.45(1):194-203.
Watts J L(1988).Etiological agents of bovine mastitis.Vet.Microbiol.16:41-66.
Wang J,Li ZJ,Lan XY,Hua LS,Huai YT,Huang YZ,Ma L,Zhao M,Jing YJ,Chen H,Wang JQ(2010).Two novel SNPs in the coding region of the bovine PRDM16 gene and its associations with growth traits.Mol Biol Rep.37(1):571-577
Y Ogura(2001)Nod2,a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappa B,J.Biol.Chem.276:4812-4818.
Bryner(1989).Comparison of four procedures to detect Listeria spp.in foods.J.Food Prot.52:154-157.
Bonen DK,Ogura Y,Nicolae DL,Inohara N,Saab L,Tanabe T,Chen FF,Foster SJ,Duerr RH,Bra nt SR,Cho JH,Nunez G(2003).Crohn’s disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan.Gastroenterology.124:140-147
Cormac J,whelehan,KG Meade,PD Eckersall(2011).Experimental staphylococcus aureus infection of the mammary gland induces region-specific changes in innate immune gene expression.Veterinary immunology and immunopathology.140(15):181-189
Girardin SE,Sansonetti PJ,Philpott DJ(2002).Trends Microbiol.10:193-199
Girardin SE,Tournebize R,Mavris M,Page AL,Li X,Stark GR,Bertin J(2001).EMBO Rep.2:736-742
Hugot JP,Chamaillard M,Zouali H,Lesage S,Cezard JP,Belaiche J,Almer.S(2001).Nature.411:599-603
Heisick JE,FM Harrell,EH Peterson,SM c Laughlin,DE Wagner,IV.Wesley,J
Inohara N,Ogura Y,Nunez G(2002).Curr.Opin.Microbiol.5:76-80
Inohara N,Ogura Y,Chen FF,Muto A,Nunez G(2001).J.Biol.Chem.276:2551-255
International Dairy Federation(IDF)(1985).Laboratory methods for use in mastitis work.IDF.Brussel s,Belgium.132
Mark T,Fikse WF,Emanuelson U(2005).International Genetic Evaluations of Holstein sires for milk somatic cell and clinical mastitis.Journal of Dairy Science.85:2384-2392.
MX Chu(1999).Occurrence and preventive treatment of cattle mastitis.Chinese cattle.(4):39-40.
Nash DL,Rogers GW,Cooper JB(2004).Heritability of clinical mastitis incidence and relationships w ith sire transmitting abilities for simatic cell score,udder type traits,productive life,and protein yield.Journal of Dairy Science.83:2350-2360.
National Mastitis Council.Microbiological(2004).Procedures for the Diagnosis of Bovine Udder Infec tion and Determination of Milk Quality.WI:National Mastitis Council,W.D.Hoard and Sons Co.4thed.Fort Atkinson
Ogura Y,Inohara N,Benito A,Chen FF,Yamaoka S,Nunez G(2001).Nod2,a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappa B.The Journal of biological chemistry.276(7):4812-4818.
Pellegrini O,Aurel MR,Lagriffoul G,Marie C,Remeuf F,Rivemale M,Barillet F(1994).Relations entre les comptages de cellules somatiques,les caractéristiques physico-chimiques et l’aptitudeàla coa gulation par la présure delaits individuels de brebis de race Lacaune,in:Proceedings of the Internation al symposiumon somatic cells and milk of small ruminants,Bella,25-27 September Italy,EAAP Publi cation No.77,pp.253-258.
Ren G,Chen H,Zhang LZ,Lan XY,Wei TB,Li MJ,Jing YJ,Lei CZ,Wang JQ(2009)A coding SNP of LHX4 gene is associated with body weight and body length in bovine.Mol Biol Rep.37(1):417-422
Shimosato T,Kitazawa H,Katoh S,Tohno M,Iliev ID,Nagasawa C,Kimura T,Kawai Y,Saito T(2005 a).Augmentation of T(H)-1 type response by immunoactive AT oligonucleotide from lactic acid ba cteria via Toll-like receptor 9 signaling.Biochem.Biophys.Res.Commun.326:782-787.
Shimosato T,Tohno M,Kitazawa H,Katoh S,Watanabe K,Kawai Y,Aso H,Yamaguchi T,Saito T(2005b).Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer’s patches.Immunol.Lett.98:83-89.
Tohno M,Ueda W,Azuma Y(2008).Molecular cloning and functional characterization of porcine nuc leotide-binding oligomerization domain-2(NOD2).Mol Immunol.Jan.45(1):194-203.
Watts J L(1988).Etiological agents of bovine mastitis.Vet.Microbiol.16:41-66.
Wang J,Li ZJ,Lan XY,Hua LS,Huai YT,Huang YZ,Ma L,Zhao M,Jing YJ,Chen H,Wang JQ(2010).Two novel SNPs in the coding region of the bovine PRDM16 gene and its associations with growth traits.Mol Biol Rep.37(1):571-577
Y Ogura(2001)Nod2,a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappa B,J.Biol.Chem.276:4812-4818.