光敏高分子自组装材料的构建与功能
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- 英文论文题名：Photosensitive Polymeric Self-Assemblies: Fabrication and Application
- 论文作者：王国杰
- 英文论文作者：Guojie Wang ; School of Materials Science and Engineering ; University of Science and Technology Beijing
- 年：2016
- 作者机构：北京科技大学,材料科学与工程学院;
- 论文关键词：光响应 ; 高分子 ; 自组装 ; 荧光检测 ; 控制释放
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十七分会：光化学
- 语种：中文
- 分类号：O631;O657.3
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十七分会 ; 光化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：140k
- 原文格式：D
- 会议级别：全国
摘要
荧光聚电解质与核酸分子静电组装形成复合荧光探针,基于荧光基团芘嵌入核酸复链致使荧光淬灭、苝功能化聚合物聚集诱导发光、芘激基复合物或上转换纳米粒子与插入染料SG能量转移等机制,构建了系列新型无标记荧光探针,为简便、高效、特异性识别核酸分子提供了新途径;基于两亲性高分子自组装,构建了含光响应芘甲酯、苝甲酯、硝基苯甲酯、偶氮苯、螺吡喃等基元的多重响应性聚合物胶束纳米载体材料,揭示了光控高分子纳米载体结构变化对释放性能的影响机制,实现了紫外光、可见光、近红外光调控药物释放,并将光与温度、pH、氧化还原等外场协同实现了装载物质在温和环境下的高效控制释放。
The fluorescent detection of nucleic acids hybridization using complex probe electrostatically self-assembled from fluorescent polycations with high selectivity and sensitivity through the fluorescence quenching of pyrene for the interaction effect, aggregation-induced emission of perylene-functionalized polymer, and fluorescence resonance energy transfer from pyrene excimers/upconversion nanoparticles to intercalation dye SG is presented. Photoresponsive polymeric micellar nanoparticles self-assembled from amphiphilic polymers containing pyrene-acrylate, perylene-acrylate, nitrobenzene-acrylate, or spiropyran for drug delivery are also presented here. It is noted that the synergistic response to the multiple stimuli such as light, pH, temperature and reducing agent could facilitate the cargo release efficiently under mild stimulation.
The fluorescent detection of nucleic acids hybridization using complex probe electrostatically self-assembled from fluorescent polycations with high selectivity and sensitivity through the fluorescence quenching of pyrene for the interaction effect, aggregation-induced emission of perylene-functionalized polymer, and fluorescence resonance energy transfer from pyrene excimers/upconversion nanoparticles to intercalation dye SG is presented. Photoresponsive polymeric micellar nanoparticles self-assembled from amphiphilic polymers containing pyrene-acrylate, perylene-acrylate, nitrobenzene-acrylate, or spiropyran for drug delivery are also presented here. It is noted that the synergistic response to the multiple stimuli such as light, pH, temperature and reducing agent could facilitate the cargo release efficiently under mild stimulation.
引文
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[2]Cao,Z.Q.;Wang,G.J.;Chen,Y.;Liang,F.X.;Yang,Z.Z.Macromolecules 2015,48:7256.
[3]Zhou,R.Y.;Xu,C.;Dong,J.;Wang,G.J.Biosens.Bioelectron.2015,65:103.
[4]Chen,S.;Jiang,F.J.;Cao,Z.Q.;Wang,G.J.;Dang,Z.M.Chem.Commun.2015,51:12633.
[5]Cao,Z.Q.;Wu,H.;Dong,J.;Wang,G.J.Macromolecules 2014,47:8777.
[6]Xu,C.;Zhou,R.Y.;Zhang,R.C.;Yang,L.Y.;Wang,G.J.ACS Macro Lett.2014,3:845.
[7]Wang,G.J.;Zhang,R.C.;Xu,C.;Zhou,R.Y.;Dong,J.;Bai,H.T.;Zhan,X.W.ACS Appl.Mater.Interfaces2014,6:11136.
[8]Wu,H.;Dong,J.;Li,C.C.;Liu,Y.B.;Feng,N.;Xu,L.P.;Zhan,X.W.;Yang,H.;Wang,G.J.Chem.Commun.2013,49:3516.
[9]Dong,J.;Wang,Y.N.;Zhang,J.;Zhan,X.W.;Zhu,S.Q.;Yang,H.;Wang,G.J.Soft Matter 2013,9:370.
[10]Wang,G.J.;Zhang,J.J.Photochem.Photobiol.C:Photochem.Rev.2012,13:299.