鹿茸化学成分及提取方法研究进展
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- 英文论文题名：Research Progress on Chemical Constituents of Antler and its Extraction Technology
- 论文作者：侯召华 ; 张宇 ; 金春爱 ; 赵昌德 ; 孙晓东 ; 崔松焕
- 英文论文作者：Hou Zhaohua ; Zhang Yu ; Jin Chunai ; Zhao Changde ; Sun Xiaodong ; Cui SongHuan ; Institute of Special Economic Animal and Plant Science ; Chinese Academy of Agricultural Sciences
- 年：2016
- 作者机构：中国农业科学院特产研究所;
- 论文关键词：鹿茸 ; 化学成分 ; 提取方法
- 英文论文关键词：Antler ; chemical constituents ; extraction technology
- 会议召开时间：2016-06-01
- 会议录名称：“十二五” 鹿科学研究进展
- 语种：中文
- 分类号：R284
- 学会代码：ZXMY
- 学会名称：中国畜牧业协会
- 页数：6
- 文件大小：301k
- 原文格式：O
摘要
目的:为鹿茸的研究开发利用提供参考。方法:经数据库检索,查阅国内外公开发表的文章,从鹿茸的化学成分及功效成分提取两方面进行综述。结果:鹿茸含有多种化学成分,主要有氨基酸类、蛋白质类、脂类、糖类、甾类、性激素、无机成分等。鹿茸功效成分的提取近年来取得了巨大的进展,从传统的溶剂粗提,发展为超临界萃取,分子筛纯化等技术。结论:鹿茸具有多种化学成分,化学成分与鹿茸药理活性有密切关系,化学成分有效的提取可以为进一步研究鹿茸的生物学活性及其有效利用提供了基础。
To provide the reference for study on the chemical constituents of antler and its extraction method.Methods;Based on the literature about Antler at home and abroad through various databases,the constituents and extraction method were reviewed,respectively.Results:Antler contained many kinds of chemical constituents,primarily including amino acids,fatty acids,lipids,nitrogenous compounds,and polysaccharides,mineral etc.The extraction technology of chemical constituents made great progress.Conclusions:Antler contains various chemical constituents and extraction method,the further chemical and pharmacological research on antler will play an important role for the utilization of Antler reasonably.
To provide the reference for study on the chemical constituents of antler and its extraction method.Methods;Based on the literature about Antler at home and abroad through various databases,the constituents and extraction method were reviewed,respectively.Results:Antler contained many kinds of chemical constituents,primarily including amino acids,fatty acids,lipids,nitrogenous compounds,and polysaccharides,mineral etc.The extraction technology of chemical constituents made great progress.Conclusions:Antler contains various chemical constituents and extraction method,the further chemical and pharmacological research on antler will play an important role for the utilization of Antler reasonably.
引文
[1]Zhou R,Li S F.In vitro antioxidant analysis and characterisation of antler velvet extract[J].Food Chemistry,2009,114,1 321-1 327.
[2]WenH,JeonB,Moon SH,Song YH,Kang S,Yang HJ,Song YM,and Park S.Differentiation of Antlers from Deer on Different Feeds using an NMR-based Metabolomics Approach[J].Archives Pharmacal Research,2010,33(8):1 227-1 234.
[3]Jeon B,Kim S,Lee S,Park P,Sung S,Kim J,Moon S.Effect of antler growth period on the chemical composition of velvet antler in sika deer(Cervus nippon)[J].Mammalian biology.2009,74,374-380.
[4]李泽鸿,武丽敏,姚玉霞,王全凯.梅花鹿鹿茸不同产品中氨基酸含量的比较[J].氨基酸和生物资源,2007,29(3):16-18.
[5]刘琳玲,丛波,姜洪梅,杨福合.鹿茸多肽功能的研究进展[J].特产研究,2009,(2):67-70.
[6]Yan,MM;Qu,X B;Wang,X;Liu,N;Liu,ZQ;Zhao,DQ;Liu,SY.Purification,sequencing and biological activity of polypeptide from velvet antler[J].chemical journal of chinese universities-chinese.2007,28(10):1 893-1 896.
[7]Guan,SW;Duan,LX;Li,YY;Wang,BX;Zhou,QL.A novel polypeptide from Cervus nippon Temminck proliferation of epidermal cells and NIH3T3 cell line[J].acta biochimica polonica,2006,53(2):395-397.
[8]晋大鹏,胡志帅,陈书明.鹿茸的化学成分及其生物活性研究进展[J].山西中医学院学报,2009,10(2):67-73.
[9]桂丽萍,郭萍,郭远强.鹿茸化学成分和药理活性研究进展[J].药物评价研究,2010,33(3):237-240.
[10]Jeon,BT;Cheong,SH;Kim,DH;Park,JH;Park,PJ;Sung,SH;Thomas,DG;Kim,KH;Moon,SH.Effect of Antler Development Stage on the Chemical Composition of Velvet Antler in Elk(Cervus elaphus canadensis)[J].asian-australasian journal of animal sciences,2011,24(9):1 303-1 313.
[11]Kim K H,Kim K S,Choi B J,et al.Anti-bone resorption activity of deer antler aqua-acupunture,the pilose antler of Cervus Korean TEMMINCK vat.mantchuricus Swinhoe(Nokyong)in adjuvant-induced arthritic rats[J].Journal of Ethnopharmacology,2005,96(3):497-506.
[12]都宏霞,邱芳萍,解耸林.鹿茸多糖提取工艺的优化[J].现代食品科技,2006,22(4):130-132.
[13]徐桂英,徐元礼,刘玉华,等.梅花鹿鹿茸多糖优选提取工艺条件的研究[J].河南畜牧兽医,2007,28(2):9-10.
[14]熊和丽,杨鸣琦,杨萍,等.梅花鹿鹿茸蛋白聚糖的提取与分离[J].西北农业学报,2007,16(4):80-82.
[15]郑磊,金秀明,赵玉红.超声波辅助盐法提取鹿茸糖胺聚糖的工艺优化[J].食品科学,2010,31(16):61-66.
[16]赵玉红,郑磊,毛凤彪,等.利用Box-Behnken设计优化鹿茸糖胺聚糖的提取工艺[J].东北林业大学学报,2010,38(5):93-96.
[17]吉静娴,钱景,黄凤杰,吴梧桐,高向东.鹿茸的活性物质及药理作用的研究进展[J].中国生化药物杂志,2009,30(2):141-143.
[18]齐艳萍.鹿茸的化学成分及对肝损伤的修复作用[J].甘肃中医,2010,23(1).
[19]Zhou R,Li SF.Supercritical carbon dioxide and co-solvent extractions of estradiol and progesterone from antler velvet[J].Journal of Food Composition and Analysis,2009,22,72-78.
[20]杨若明,张经华,顾平圻,曹红,张林源,包塔娜,赵珊,项新华.高效液相色谱法分析麋鹿茸中的性激素[J].分析化学,2001,29(5):618.
[21]周冉,李淑芬.RP-HPLC同时快速测定鹿茸中尿嘧啶、次黄嘌呤、尿苷含量[J].药物分析杂志,2009,29(4):575-578.
[22]薄士儒,李庆杰,王春雨,等.鹿茸化学成分与药理作用研究进展[J].经济动物学报,10,14(4):243-248.
[23]吴瑕,常洋,何剑斌.鹿茸药理作用的研究进展[J].畜产品研究,2008,236:56-57.
[24]Landete-Castillejos T,Garcia A,Gallego L.Body weight,early growth and antler size influence antler bonemineral composition of Iberian Red Deer(Cervus elaphus hispanicus)[J].Bone,2007,40,230-235.
[25]Estevez,JA;Landete-Castillejos,T;Martinez,A;Garcia,AJ;Ceacero,F;Gaspar-Lopez,E;Calatayud,A;Gallego,L.Antlermineral composition of Iberian red deer Cervus elaphus hispanicus is related tomineral profile of diet[J],acta theriologica 2009,54(3):235-242.
[26]严铭铭,曲晓波,钟英杰,等.梅花鹿鹿茸中促进海马神经细胞增殖蛋白的分离纯化[J].中草药,2007,38(8):1 163-1 167.
[27]潘风光,孙威,周玉,等.梅花鹿鹿茸活性多肽的提取及免疫功效的初步研究[J].中国生物制品学杂志,2007,20(9):669-673.
[28]Lang Q Y,Wai,C M.Supercritical fluid extraction in herbal and natural product studies-a practical review[J].Talanta,2001,53(4-5):771-782.
[29]徐志红,李淑芬,王金宇,等.超临界CO2萃取鹿茸中的性激素研究[J].中国中药杂志,2007,32(19):2 000-2 003.
[30]Zhou R,Li S F,Zhang D C.Combination of Supercritical Fluid Extraction with Ultrasonic Extraction for Obtaining Sex Hormones and IGF-1 from Antler Velvet,separation science and engineering[J].Chinese Journal of Chemical Engineering,2009,17(3):370-380.
[2]WenH,JeonB,Moon SH,Song YH,Kang S,Yang HJ,Song YM,and Park S.Differentiation of Antlers from Deer on Different Feeds using an NMR-based Metabolomics Approach[J].Archives Pharmacal Research,2010,33(8):1 227-1 234.
[3]Jeon B,Kim S,Lee S,Park P,Sung S,Kim J,Moon S.Effect of antler growth period on the chemical composition of velvet antler in sika deer(Cervus nippon)[J].Mammalian biology.2009,74,374-380.
[4]李泽鸿,武丽敏,姚玉霞,王全凯.梅花鹿鹿茸不同产品中氨基酸含量的比较[J].氨基酸和生物资源,2007,29(3):16-18.
[5]刘琳玲,丛波,姜洪梅,杨福合.鹿茸多肽功能的研究进展[J].特产研究,2009,(2):67-70.
[6]Yan,MM;Qu,X B;Wang,X;Liu,N;Liu,ZQ;Zhao,DQ;Liu,SY.Purification,sequencing and biological activity of polypeptide from velvet antler[J].chemical journal of chinese universities-chinese.2007,28(10):1 893-1 896.
[7]Guan,SW;Duan,LX;Li,YY;Wang,BX;Zhou,QL.A novel polypeptide from Cervus nippon Temminck proliferation of epidermal cells and NIH3T3 cell line[J].acta biochimica polonica,2006,53(2):395-397.
[8]晋大鹏,胡志帅,陈书明.鹿茸的化学成分及其生物活性研究进展[J].山西中医学院学报,2009,10(2):67-73.
[9]桂丽萍,郭萍,郭远强.鹿茸化学成分和药理活性研究进展[J].药物评价研究,2010,33(3):237-240.
[10]Jeon,BT;Cheong,SH;Kim,DH;Park,JH;Park,PJ;Sung,SH;Thomas,DG;Kim,KH;Moon,SH.Effect of Antler Development Stage on the Chemical Composition of Velvet Antler in Elk(Cervus elaphus canadensis)[J].asian-australasian journal of animal sciences,2011,24(9):1 303-1 313.
[11]Kim K H,Kim K S,Choi B J,et al.Anti-bone resorption activity of deer antler aqua-acupunture,the pilose antler of Cervus Korean TEMMINCK vat.mantchuricus Swinhoe(Nokyong)in adjuvant-induced arthritic rats[J].Journal of Ethnopharmacology,2005,96(3):497-506.
[12]都宏霞,邱芳萍,解耸林.鹿茸多糖提取工艺的优化[J].现代食品科技,2006,22(4):130-132.
[13]徐桂英,徐元礼,刘玉华,等.梅花鹿鹿茸多糖优选提取工艺条件的研究[J].河南畜牧兽医,2007,28(2):9-10.
[14]熊和丽,杨鸣琦,杨萍,等.梅花鹿鹿茸蛋白聚糖的提取与分离[J].西北农业学报,2007,16(4):80-82.
[15]郑磊,金秀明,赵玉红.超声波辅助盐法提取鹿茸糖胺聚糖的工艺优化[J].食品科学,2010,31(16):61-66.
[16]赵玉红,郑磊,毛凤彪,等.利用Box-Behnken设计优化鹿茸糖胺聚糖的提取工艺[J].东北林业大学学报,2010,38(5):93-96.
[17]吉静娴,钱景,黄凤杰,吴梧桐,高向东.鹿茸的活性物质及药理作用的研究进展[J].中国生化药物杂志,2009,30(2):141-143.
[18]齐艳萍.鹿茸的化学成分及对肝损伤的修复作用[J].甘肃中医,2010,23(1).
[19]Zhou R,Li SF.Supercritical carbon dioxide and co-solvent extractions of estradiol and progesterone from antler velvet[J].Journal of Food Composition and Analysis,2009,22,72-78.
[20]杨若明,张经华,顾平圻,曹红,张林源,包塔娜,赵珊,项新华.高效液相色谱法分析麋鹿茸中的性激素[J].分析化学,2001,29(5):618.
[21]周冉,李淑芬.RP-HPLC同时快速测定鹿茸中尿嘧啶、次黄嘌呤、尿苷含量[J].药物分析杂志,2009,29(4):575-578.
[22]薄士儒,李庆杰,王春雨,等.鹿茸化学成分与药理作用研究进展[J].经济动物学报,10,14(4):243-248.
[23]吴瑕,常洋,何剑斌.鹿茸药理作用的研究进展[J].畜产品研究,2008,236:56-57.
[24]Landete-Castillejos T,Garcia A,Gallego L.Body weight,early growth and antler size influence antler bonemineral composition of Iberian Red Deer(Cervus elaphus hispanicus)[J].Bone,2007,40,230-235.
[25]Estevez,JA;Landete-Castillejos,T;Martinez,A;Garcia,AJ;Ceacero,F;Gaspar-Lopez,E;Calatayud,A;Gallego,L.Antlermineral composition of Iberian red deer Cervus elaphus hispanicus is related tomineral profile of diet[J],acta theriologica 2009,54(3):235-242.
[26]严铭铭,曲晓波,钟英杰,等.梅花鹿鹿茸中促进海马神经细胞增殖蛋白的分离纯化[J].中草药,2007,38(8):1 163-1 167.
[27]潘风光,孙威,周玉,等.梅花鹿鹿茸活性多肽的提取及免疫功效的初步研究[J].中国生物制品学杂志,2007,20(9):669-673.
[28]Lang Q Y,Wai,C M.Supercritical fluid extraction in herbal and natural product studies-a practical review[J].Talanta,2001,53(4-5):771-782.
[29]徐志红,李淑芬,王金宇,等.超临界CO2萃取鹿茸中的性激素研究[J].中国中药杂志,2007,32(19):2 000-2 003.
[30]Zhou R,Li S F,Zhang D C.Combination of Supercritical Fluid Extraction with Ultrasonic Extraction for Obtaining Sex Hormones and IGF-1 from Antler Velvet,separation science and engineering[J].Chinese Journal of Chemical Engineering,2009,17(3):370-380.