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血液净化与二巯基丙磺酸钠治疗急性铊中毒临床分析
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摘要
目的:探讨急性铊中毒的临床特征、治疗方法及预后。方法:对我院2015年收治的2例急性铊中毒病例进行回顾性分析,观察其临床特征、血液净化与二巯丙磺钠的治疗效果及预后。结果:胃肠道症状、周围神经病及脱发是急性铊中毒的典型三联征;急性铊中毒经过及时血液净化等综合治疗,血铊、尿铊均明显下降,预后较好;二巯基丙磺酸钠驱铊治疗前后24h尿铊浓度无明显变化。结论:铊中毒是一种罕见疾病,提高临床医生对它的警惕性很重要。血液净化可有效清除毒物铊,二巯基丙磺酸钠无确切的驱铊作用。
Objective:To investigate the clinical manifestations,treatments and prognosis for acute thallium poisoning.Methods:A retrospective analysis was carried out on two patients hospitalized with acute thallium poisoning.We observed manifestations.treatments with blood purification and sodium dimercaptosulfonate(DMPS) treatment and prognosis.Results:The clinical presentations were the triad of gastroenteritis,polyneuropathy,and alopecia.The two patients treated with blood purification were significantly recoveried,with blood and urine thallium concentration gradually decreased.The urine thallium concentration in 24 hours were not increased after treated by DMPS.Conclusion:As a disease with low incidence,thallium poisoning should be considered by doctors.Blood purification therapies help in the clearance of thallium.DMPS migt not be effective.
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