针刺对原发性失眠症患者过度觉醒干预作用及其相关神经电生理学机制研究

详细信息    查看官网全文

• 英文论文题名：Research on Hyperarousal and Its Associated Nerve Electrophysiology Mechanism in Patients of Primary Insomnia Intervened With Acupuncture
• 论文作者：刘义 ; 毛洪京 ; 莫亚莉 ; 刘文娟 ; 尹岩 ; 徐莲莲 ; 余正和
• 英文论文作者：LIU Yi ; MAO Hongjing ; MO Yali ; LIU Wenjuan ; YIN Yan ; XU Lianlian ; YU Zhenghe ; Hangzhou Seventh People's Hospital
• 年：2016
• 作者机构：杭州市第七人民医院心理科;
• 论文关键词：针刺 ; 原发性失眠症 ; 过度觉醒 ; 神经电生理学
• 英文论文关键词：acupuncture ; primary insomnia ; hyperarousal ; nerve electrophysiology
• 会议召开时间：2016-05-27
• 会议录名称：中国睡眠研究会第九届学术年会汇编
• 语种：中文
• 分类号：R246.6
• 学会代码：OGSF
• 会议名称：中国睡眠研究会第九届学术年会
• 会议地点：中国上海
• 主办单位：中国睡眠研究会
• 学会名称：中国睡眠研究会
• 页数：2
• 文件大小：93k
• 原文格式：O
• 会议级别：全国

摘要

目的:比较针刺与唑吡坦干预原发性失眠症患者觉醒状态的差异,并探讨其相关神经电生理学机制。方法:将61例原发性失眠症患者随机分为药物组(30例)和针刺组(31例),连续治疗4周。比较两组治疗前后匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)评分、多导睡眠监测仪(polysomnography,PSG)监测睡眠结构相关指标及多次睡眠潜伏时间试验(multiple sleep latencytest,MSLT)的平均睡眠潜伏时间(mean sleep latency,MSL)变化。结果:两组治疗后PSQI评分较本组治疗前明显降低(均P<0.01)。针刺组治疗后PSQI评分较药物组降低(P<0.05)。两组治疗后较本组治疗前睡眠潜伏期(sleep onset latency,SOL)缩短、觉醒次数(number of awake1nings,NWAK)、入睡后清醒时间(wake after sleep onset,WASO)减少,总睡眠时间(total sleep time,TST)增多、睡眠效率(sleep efficiency,SE)明显增高(均P<0.01),药物组治疗后非快速眼动3期(non-rapid eye movement period 3,N3)较本组治疗前增多,N1、N2和快速眼动睡眠期(rapid eye movement period,REM)比例较本组治疗前比较无统计学意义(均P>0.05),而针刺组治疗后较本组治疗前N1、N2比例减少,N3、REM比例增多(均P<0.01)。两组治疗后SOL、NWAK、WASO、TST、SE比较差异无统计学意义(均P>0.05),针刺组治疗后较药物组N1、N2比例减少,N3、REM比例增多(均P<0.01)。两组治疗后MSLT的MSL较治疗前明显缩短(均P<0.01)。针刺组治疗后MSLT的MSL较药物组缩短(P<0.05)。结论:针刺较唑吡坦能够更有效地改善原发性失眠症患者的睡眠质量,并更有利于调节其过度觉醒状态。
Objective.To compare the difference in arousal state between the treatment of acupuncture and Zolpidem and explore its associated nerve electrophysiology mechanism in patients of primary insomnia.Methods:61 cases of primary insomnia were randomized into drug group(30 cases) and acupuncture group(31 cases),continuously for 4 weeks.Compare with the difference in Pittsburgh Sleep Quality Index(PSQI) scores,indicators related sleep structure by polysomnography(PSG),mean sleep latency(MSL) by multiple sleep latency test(MSLT) between two groups before and after treatment.Results:PSQI scores after treatment were obviously decreased compared with that before treatment in each groups(all P<0.01).PSQI scores in acupuncture group after treatment were decreased compared with drug group(P<0.05).Sleep onset latency(SOL),number of awakenings(NWAK),wake after sleep onset(WASO),total sleep time(TST),sleep efficiency(SE) after treatment were obviously increased compared with that before treatment in each groups(all P<0.01),percentage of non-rapid eye movement period 3(N3)after treatment were increased compared with that before treatment in drug group(P<0.05),Nl>N2 and rapid eye movement period(REM) after treatment were not statistically significant compared with that before treatment in drug group(all P>0.05),but percentage of Nl,N2 after treatment were decreased,N3,REM were increased compared with that before treatment in acupuncture group(all P<0.01).SOL,NWAK,WASO,TST,SE after treatment were not statistically significant in each groups(all P>0.05),percentage of Nl,N2 in acupuncture group after treatment were decreased,N3,REM were increased compared with drug group(all P<0.01).Mean sleep latency(MSL)of multiple sleep latency test(MSLT) after treatment were obviously decreased compare with that before treatment in each groups(all P<0.01).After treatment MSL of MSLT in acupuncture group were decreased compare with drug group(P<0.05).Conclusion:Acupuncture could more effectively improve sleep quality and more beneficially regulate hyperarousal state compared with Zolpidem in primary insomnia patients.

引文