泛素-蛋白酶体系统与帕金森病
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摘要
帕金森病(PD)是常见的神经系统慢性退行性疾病,病变部位位于中脑黑质纹状体区。泛素-蛋白酶体系统(UPS)主要负责降解寿命较短的蛋白质,其功能减退是导致PD发病的重要机制之一。而如何安全增强UPS活性及确定泛素化部位的决定因素均有待于进一步研究。
引文
[1]中华医学会神经病学分会运动障碍及帕金森病学组,帕金森病的诊断[J].中华神经科学杂志.2006,39(6):408-409.
[2]Bergink S,Jentsch S.Principles of ubiquitin and SUMO modifications in DNA repair[J].Nature,2009,458,461-467.
[3]Amm I,Sommer T,Wolf DH.Protein quality control and elimination of protein waste:the role of the ubiquitin-proteasome system[J].Biochim Biophys Acta.2014,1843(1):182-196.
[4]Chen YJ,Wu H,Shen XZ.The ubiquitin-proteasome system and its potential application in hepatocellular carcinoma therapy[J].Cancer Letters.2016,379(2):245-252.
[5]Groll M,Potts BC.Proteasome structure,function,and lessons learned from beta-lactone inhibitors[J].Current Topics I Medicinal Chemistry.2011,11(23):2850-2878.
[6]Gallastegui N,Groll M.The 26S proteasome:assembly and function of a destructive machine[J].Trends in Biochemical Sciences.2010,35(11):634-642.
[7]Clague MJ,Coulson JM,Sylvie U.Cellular functions of the DUBs[J].Journal of Cell Science.2012,125(2):277-286.
[8]Wang X,Terpstra EJM.Ubiquitin receptors and protein quality control[J].Journal of Molecular and Cellular Cardiology.2013,55:73-84.
[9]L?w P.The role of ubiquitin-proteasome system in ageing[J].General and Comparative Endocrinology.2011,172(1):39-43.
[2]Bergink S,Jentsch S.Principles of ubiquitin and SUMO modifications in DNA repair[J].Nature,2009,458,461-467.
[3]Amm I,Sommer T,Wolf DH.Protein quality control and elimination of protein waste:the role of the ubiquitin-proteasome system[J].Biochim Biophys Acta.2014,1843(1):182-196.
[4]Chen YJ,Wu H,Shen XZ.The ubiquitin-proteasome system and its potential application in hepatocellular carcinoma therapy[J].Cancer Letters.2016,379(2):245-252.
[5]Groll M,Potts BC.Proteasome structure,function,and lessons learned from beta-lactone inhibitors[J].Current Topics I Medicinal Chemistry.2011,11(23):2850-2878.
[6]Gallastegui N,Groll M.The 26S proteasome:assembly and function of a destructive machine[J].Trends in Biochemical Sciences.2010,35(11):634-642.
[7]Clague MJ,Coulson JM,Sylvie U.Cellular functions of the DUBs[J].Journal of Cell Science.2012,125(2):277-286.
[8]Wang X,Terpstra EJM.Ubiquitin receptors and protein quality control[J].Journal of Molecular and Cellular Cardiology.2013,55:73-84.
[9]L?w P.The role of ubiquitin-proteasome system in ageing[J].General and Comparative Endocrinology.2011,172(1):39-43.