氨基酸/无机纳米晶配位界面效应
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- 英文论文题名：Interfacial Coordination between Biomolecule and Inorganic Nanocrystals
- 论文作者：周云龙
- 英文论文作者：Yunlong Zhou ; Wenzhou Institute of Biomaterials and Engineering ; CNITECH ; CAS
- 年：2016
- 作者机构：温州生物材料与工程研究所(中科院温州生材所筹);
- 论文关键词：无机纳米晶 ; 氨基酸 ; 界面 ; 超结构 ; 凝胶
- 会议召开时间：2016-07-03
- 会议录名称：中国化学会第30届学术年会摘要集-论坛二：新型前沿交叉化学论坛
- 语种：中文
- 分类号：TB383.1;O641.4
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-论坛二 ; 新型前沿交叉化学论坛
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：3
- 文件大小：254k
- 原文格式：D
- 会议级别：全国
摘要
功能化蛋白通过界面氨基酸之间的相互作用调控蛋白结构及功能。与之相似,无机胶装纳米晶的界面结构也对纳米晶组装体之间各种弱相互作用调控发挥着重要作用。我们最近的一些工作发现胶体纳米晶的稳定剂分子如氨基酸、多肽小分子同无机晶核的配位结构可以调控纳米晶的介观特性。这包括:(1)半胱氨酸分子为稳定剂时,纳米晶可以在氨基酸分子之间的相互作用及手性特性诱导下生成手性可控的二元手性超结构;(2)谷胱甘肽分子通过同不同尺寸纳米晶的动态三点配位构型-单点配位变化,可调控纳米晶的能量耗散,并生成宏观粘弹性可调的纳米晶水凝胶。这些研究结果为从分子尺度上可控调节胶体纳米晶组装体的结构及功能提供了重要依据。
The functions and structures of proteins can be adjusted by the interaction of amino acid units. Similarly, the interfacial structures of colloidal inorganic nanocrystals play a key role in the coordination and non-coordination forces. In our recent work, we found that the properties of colloidal nanocrystals at nanoscale/ microscale can be controlled via the coordination and non-coordination between amino acids/peptides and inorganic "core". we firstly fund the chirality of cysteine could guide inorganic nanocrystals self-assembly into chiral nanocrystal supernanostructures via the coordination of overall fine balanced interparticle forces between cysteine and nanocrystals "core". Furtherly, we revealed that glutathione stabilized inorganic nanocrystals present macro-viscoelasticity, which is simultaneous increase of stiffness and energy dissipation. This paradoxical mechanical behavior is related to the specific triple/single bond configuration between nanocrystal and glutathione. Our results pave the road for the controllable adjustment of new multifunctional nanocrystal assemblies from the bottom-up at molecule scale.
The functions and structures of proteins can be adjusted by the interaction of amino acid units. Similarly, the interfacial structures of colloidal inorganic nanocrystals play a key role in the coordination and non-coordination forces. In our recent work, we found that the properties of colloidal nanocrystals at nanoscale/ microscale can be controlled via the coordination and non-coordination between amino acids/peptides and inorganic "core". we firstly fund the chirality of cysteine could guide inorganic nanocrystals self-assembly into chiral nanocrystal supernanostructures via the coordination of overall fine balanced interparticle forces between cysteine and nanocrystals "core". Furtherly, we revealed that glutathione stabilized inorganic nanocrystals present macro-viscoelasticity, which is simultaneous increase of stiffness and energy dissipation. This paradoxical mechanical behavior is related to the specific triple/single bond configuration between nanocrystal and glutathione. Our results pave the road for the controllable adjustment of new multifunctional nanocrystal assemblies from the bottom-up at molecule scale.
引文
[1]Zhou,Y.L.et al.Biomimetic Hierarchical Assembly of Helical Supraparticles from Chiral Nanoparticles.ACSNano 2016,10,3248-3256.
[2]Zhou,Y.L.et al.Molecular Contacts and Macroscale Mechanics in Nanoparticulate Hydrogels:Simultaneous Increase of Stiffness and Energy Dissipation.Resubmitted to Nature Chemistry.
[1]Y.L.Zhou et al.Enantioselectivity of Biomimetic Rod-Like Supraparticles:Self-Assembled from Chiral Nanoparticles.Unpublished
[2]Y.L.Zhou et al.Anomalies of Mechanical Properties in Nanoparticle Hydrogels.Unpublished
[2]Zhou,Y.L.et al.Molecular Contacts and Macroscale Mechanics in Nanoparticulate Hydrogels:Simultaneous Increase of Stiffness and Energy Dissipation.Resubmitted to Nature Chemistry.
[1]Y.L.Zhou et al.Enantioselectivity of Biomimetic Rod-Like Supraparticles:Self-Assembled from Chiral Nanoparticles.Unpublished
[2]Y.L.Zhou et al.Anomalies of Mechanical Properties in Nanoparticle Hydrogels.Unpublished