电场诱导天然高分子核壳纳米纤维的制备、性能及应用
详细信息 查看官网全文
- 英文论文题名：Facile Fabrication of Core-Shell Polyelectrolyte Complexes Nanofibers Based on Electric Field Induced Phase Separation: Preparation, Simulation, and Applications
- 论文作者：朱晓磊 ; 刘勇 ; 聂俊 ; 马贵平
- 英文论文作者：Xiaolei Zhu ; Yong Liu ; Jun Nie ; Guiping Ma ; College of Materials Science and Engineering ; Beijing University of Chemical Technology
- 年：2016
- 作者机构：北京化工大学材料科学与工程学院;
- 论文关键词：电场诱导 ; 天然高分子 ; 核壳结构 ; 纳米纤维
- 会议召开时间：2016-11-18
- 会议录名称：中国第四届静电纺丝大会（CICE 2016）摘要集
- 语种：中文
- 分类号：TQ340.64
- 学会代码：ZGNM
- 会议名称：中国第四届静电纺丝大会(CICE 2016)
- 会议地点：中国北京
- 主办单位：中国复合材料学会超细纤维材料分会（筹）
- 学会名称：中关村科创纳米技术创新研究会
- 页数：1
- 文件大小：867k
- 原文格式：D
- 会议级别：全国
摘要
本研究中通过纺丝过程中电场引起相分离制备核壳结构HA/CS纳米纤维,壳聚糖和透明质酸分别在在电场诱导作用下形成纤维壳层和核层。通过SEM和TEM可以观察纤维的表面形貌和核壳结构;利用FTIR、XRD、DSC和XPS表征进一步证明壳层物质为CS,同时采用XRD、DSC和TGA等手段表征核壳结构纳米纤维膜的结晶性能和热力学性质;还采用DPD对此体系进行模拟并验证了和实际结果一致性;最后药物释放结果表明HA/CS核壳纳米纤维有一定的控释和缓释作用,细胞粘附和毒性的实验结果表明该材料在组织工程支架或医用敷料等领域有潜在的应用。
In this study, the core-shell structure HA / CS nanofibers are fabricated via electric field causes phase separation during the electrospinning, chitosan and hyaluronic acid form fiber core and shell layer under the electric field induced, respectively. The morphology and core-shell structure of the fiber can be characterized by SEM and TEM. The shell material is further proofed to be CS by FTIR, XRD, DSC and XPS, while using XRD, DSC and TGA can characterize the crystalline and thermodynamic properties of the core-shell structure nanofiber membrane. DPD is used to simulate the system and verify that it is consistent with the actual results. Finally, drug release results show that HA/CS core-shell nanofibers play a role in controlled release and sustained release, cell adhesion and toxicity experimental results show that the material have potential applications in tissue engineering scaffold or medical dressings and other fields.
In this study, the core-shell structure HA / CS nanofibers are fabricated via electric field causes phase separation during the electrospinning, chitosan and hyaluronic acid form fiber core and shell layer under the electric field induced, respectively. The morphology and core-shell structure of the fiber can be characterized by SEM and TEM. The shell material is further proofed to be CS by FTIR, XRD, DSC and XPS, while using XRD, DSC and TGA can characterize the crystalline and thermodynamic properties of the core-shell structure nanofiber membrane. DPD is used to simulate the system and verify that it is consistent with the actual results. Finally, drug release results show that HA/CS core-shell nanofibers play a role in controlled release and sustained release, cell adhesion and toxicity experimental results show that the material have potential applications in tissue engineering scaffold or medical dressings and other fields.
引文
[1]Abrigo M.,Mc Arthur S.L.,Kingshott P.,Macromolecular Bioscience.2014,14:772-792.