刺激响应介孔氧化硅纳米载药系统的构筑及控制释放性能

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• 英文论文题名：Construction and Controlled Release of Stimuli-Responsive Mesoporous Silica Drug Delivery Systems
• 论文作者：吴姗姗 ; 周升旺 ; 黄煊 ; 杜学忠
• 英文论文作者：Shanshan Wu ; Shengwang Zhou ; Xuan Huang ; Xuezhong Du ; School of Chemistry and Chemical Engineering ; Nanjing University
• 年：2016
• 作者机构：南京大学化学化工学院;
• 论文关键词：纳米载药系统 ; 纳米阀 ; 纳米门 ; 刺激响应 ; 控制释放
• 会议召开时间：2016-07-01
• 会议录名称：中国化学会第30届学术年会摘要集-第二十四分会：超分子组装与软物质材料
• 语种：中文
• 分类号：TQ460.1;TB383.1
• 学会代码：ZGHY
• 会议名称：中国化学会第30届学术年会-第二十四分会 ; 超分子组装与软物质材料
• 会议地点：中国辽宁大连
• 主办单位：中国化学会
• 学会名称：中国化学会
• 页数：1
• 文件大小：143k
• 原文格式：D
• 会议级别：全国

摘要

刺激响应介孔氧化硅纳米载药系统的研究引起人们的极大兴趣,能够有效提高药物的治疗效果,降低药物的毒副作用。本文主要介绍我们在阀控和门控的介孔氧化硅纳米载药系统的研究工作。以生物相容性的介孔氧化硅纳米粒子(MSN)作为药物载体,将活性基团为端基的硅烷自组装修饰在MSN表面并进一步功能化修饰,通过多重弱键相互作用、动态共价键和甚至强共价键,将大环主体化合物、蛋白、DNA和量子点等结合到MSN表面,将药物封装在MSN孔道内,构成纳米阀和纳米门,构筑阀控和门控的MSN纳米载药系统,在pH、氧化还原、竞争结合、生物酶和近红外光等条件刺激下,多重弱键相互作用消除、动态共价键断裂以及纳米门控元件降解等,实现药物控制释放~([1-7])。构筑的刺激响应MSN纳米载药系统在肿瘤等疾病靶向药物治疗方面具有应用前景。
There has been an ever increasing interest in developing stimuli-responsive mesoporous silica drug delivery systems to improve therapeutic efficacy and minimize the adverse effects of drugs. This paper reports our research works on valved and gated mesoporous silica drug delivery systems. Biocompatible mesoporous silica nanoparticles(MSNs), as drug carriers, were modified with active group-terminated silanes via self-assembly followed by diverse functionalization, a variety of macrocyclic hosts, proteins, DNA, and quantum dots were bound to the MSN surfaces to develop nanovalves and nanogates for the encapsulation of drugs within MSN pores, thus smart valved and gated MSN drug delivery systems were constructed. Under the stimuli of pH, redox, competitive binding, enzymes, and near infrared lights, controlled release of the encapsulated drugs was realized. The constructed stimuli-responsive MSN drug delivery systems have promising applications in targeted tumor therapy.

引文

[1]Wu,S.;Huang,X.;Du,X.Angew.Chem.Int.Ed.2013,52:5580.
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    [6]Huang,X.;Du,X.ACS Appl.Mater.Interfaces 2014,6:20430.
    [7]Wu,S.;Huang,X.;Du,X.J.Mater.Chem.B 2015,3:1426.