奶牛乳腺炎无乳链球菌菌体蛋白抗原研究进展
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- 英文论文题名：Bacterial protein antigen of Streptococcus agalactiae mastitis Research Progress
- 论文作者：于辰龙 ; 锡林高娃 ; 吴金花 ; 白文丽 ; 布日额
- 英文论文作者：YU Chen-long ; XI Lin-gao-wa ; WU Jin-hua ; BAI Wen-li ; BU Ri-e ; Inner Mongolia Autonomous Region Engineering Technology Research Center of Prevention ; Control the Pathogenic Bacteria in Milk ; Inner Mongolia University for Nationalities ; Research Institute of Pathogenic in Milk ; College of Life Science ; Inner Mongolia University for Nationalities
- 年：2016
- 作者机构：内蒙古自治区乳源性致病菌防控工程技术研究中心;内蒙古民族大学生命科学学院;内蒙古民族大学乳源性致病菌研究所;
- 论文关键词：牛乳腺炎 ; 无乳链球菌 ; 菌体蛋白 ; 抗原性 ; 免疫
- 英文论文关键词：Bovine mastitis ; Streptococcus agalactiae ; Bacteria protein ; Antigenicity ; Immunity
- 会议召开时间：2016-07-20
- 会议录名称：中国畜牧兽医学会兽医公共卫生学分会第五次学术研讨会论文集
- 语种：中文
- 分类号：S858.23
- 学会代码：SYGW
- 会议名称：中国畜牧兽医学会兽医公共卫生学分会第五次学术研讨会
- 会议地点：中国内蒙古通辽
- 主办单位：中国畜牧兽医学会兽医公共卫生学分会
- 学会名称：中国畜牧兽医学会兽医公共卫生学分会
- 页数：5
- 文件大小：517k
- 原文格式：D
- 会议级别：全国
摘要
奶牛乳腺炎是影响奶牛产奶的重要疾病之一,其病因复杂,但主要以无乳链球菌等致病菌感染所致。无乳链球菌不仅引起奶牛乳腺炎,同时也是重要的人畜共患性致病菌,因此具有重要的公共卫生意义。对于奶牛乳腺炎的防治技术研究一直未能够获得有效突破,常规疫苗经临床使用效果不佳,因此探索其新型有效抗原靶位抗原成为目前研究的"热点"。根据国内外研究报道,无乳链球菌具有多种重要的菌体蛋白,表现良好的抗原性,可作为研究新型疫苗的候选抗原蛋白。本文重点概述其5种菌体蛋白,即菌毛岛屿PI、表面免疫相关蛋白sip、磷酸甘油激酶Pgk、纤维蛋白原结合蛋白Fbs A/B、黏附蛋白Bi BA的研究进展,为相关研究人员提供具有价值的研究信息。
garget is one of the major diseases affecting milk production,which caused complex,but mainly due to pathogens infection such as Streptococcus agalactiae.Streptococcus agalactiae not only causes garget,but also is an important zoonotic pathogens,and therefore has important public health implications.For the study of garget prevention and control technology have not been able to get broken,conventional vaccines have poor clinical results,so the exploration of its new effective target antigens become "hot spots" of present study.According to domestic research reports,Streptococcus agalactiae with many important bacterial proteins,has good antigenic,which can be used as a candidate antigen protein of studying new generation vaccine.This article will focuse on outlining the research progress in its five kinds of bacterial proteins.They are pili islands PI,the surface of immune-related proteins sip,phosphoglycerokinase Pgk,fibrinogen binding protein Fbs A/B,Research Bi BAadhesion protein.l hope it can provid valuable research information for the relevant researchers.
garget is one of the major diseases affecting milk production,which caused complex,but mainly due to pathogens infection such as Streptococcus agalactiae.Streptococcus agalactiae not only causes garget,but also is an important zoonotic pathogens,and therefore has important public health implications.For the study of garget prevention and control technology have not been able to get broken,conventional vaccines have poor clinical results,so the exploration of its new effective target antigens become "hot spots" of present study.According to domestic research reports,Streptococcus agalactiae with many important bacterial proteins,has good antigenic,which can be used as a candidate antigen protein of studying new generation vaccine.This article will focuse on outlining the research progress in its five kinds of bacterial proteins.They are pili islands PI,the surface of immune-related proteins sip,phosphoglycerokinase Pgk,fibrinogen binding protein Fbs A/B,Research Bi BAadhesion protein.l hope it can provid valuable research information for the relevant researchers.
引文
[1]布日额,刘娣,华玉平,等.通辽地区奶牛乳房炎无乳链球菌的分离与鉴定[J].黑龙江畜牧兽医,2009,52(3):76-77.
[2]Lindahl G,Stalhammar-Carlemalm,MAreschoug T.Surface Proteins of Streptococcus agalactiae and Related Proteins in Other Bacterial Pathogens[J].Clin Microbiol Rev,2005,18(1):102-127.
[3]Domenico Maione,et al;SCIENCE,2005,20.
[4]Peter Lauer,et al,SCIENCE,2005.
[5]Brodeur BR,Boger M,Charlebois I,et al.Idengtification of group B Streptococcal sip protein,which elicits cross-protectivemmunity[J].infection and immunity,2000,68(10):5610-5618.
[6]锡林高娃,吴金花,布日额,等.牛乳腺炎无乳链球菌菌毛岛屿辅助蛋白AP1基因的克隆及其表达产物的抗原性鉴定[J].中国病原生物学杂志,2013,8(6):481-488.
[7]郎景民,布日额,吴金花,等.牛源无乳链球菌sip蛋白抗原优势区的原核表达及其间接ELISA检测方法的建立[J].中国病原生物学杂志,2010,5(11):38-39.
[8]Martin D,Rioux S,Gagnon E,et a1.Protection from Group B Streptococcal infection in neonatal mice by maternal im-munization with recombinant Sip protein[J].Infection and Immunity,2002,70(9):4897-4901.
[9]Shannon D M,Stephen W,Katherine K,et al.Naturally occurring antibodies for the group B streptococcal surface immunogenic protein(Sip)in pregnant women and newborn babies[J].Vaccine,2006,24(47-48):6905-6912
[10]曾祖聪,曹建萌,卢迈新,等.罗非鱼无乳链球菌Lrr G-Sip融合基因原核表达载体的构建及表达[J].南方水产科学,2014,10(5):17-22.
[11]Hughes M J,Moore JC,Lane JD,et al.Identification of major out-er surface proteins of Streptococcus agalactiae[J].infect immun,2002,70(3):1254-9.
[12]布日额,任晓峰,吴金花,等.牛乳腺炎无乳链球菌表面蛋白pgk抗原优势区的原核表达及其间接ELISA检测方法的建立[J].中国预防兽医学报,2013,35(4):312-316.
[13]Ragunathan P,Ponnuraj K,Expression,purification and structural.analysis of a fibrinogen receptor Fbs A from streptococcus agalactiae[J].protein J,2011,30(3):159-166.
[14]张雪峰.D群链球菌表面蛋白Fbs A的提取及免疫原性初步探讨[D].北京:北京生物制品研究所,2008.
[15]Santi I,Scarselli M,Mariani M,et al,Bi Ba:a novel immu-nogenic bacterial adhesin contributing to group Bsteptococcus survival in human blood[J].Mo LMicrobiol.2007.63(3):754-767.
[16]梁阳秋.猪链球菌2型三种免疫原性蛋白基因片段的串联表达及其斑马鱼免疫保护试验[D].南京:南京农业大学,2011.
[17]迟佳琦.金黄色葡萄球菌TRAP与无乳链球菌SIP蛋白融合表达及免疫保护作用[D].大庆:黑龙江八一农垦大学,2012.
[18]王鹤.停乳链球菌Gap C蛋白与鼠伤寒沙门菌Fli C蛋白的融合表达及免疫原性研究[D].大庆:黑龙江八一农垦大学,2012.
[2]Lindahl G,Stalhammar-Carlemalm,MAreschoug T.Surface Proteins of Streptococcus agalactiae and Related Proteins in Other Bacterial Pathogens[J].Clin Microbiol Rev,2005,18(1):102-127.
[3]Domenico Maione,et al;SCIENCE,2005,20.
[4]Peter Lauer,et al,SCIENCE,2005.
[5]Brodeur BR,Boger M,Charlebois I,et al.Idengtification of group B Streptococcal sip protein,which elicits cross-protectivemmunity[J].infection and immunity,2000,68(10):5610-5618.
[6]锡林高娃,吴金花,布日额,等.牛乳腺炎无乳链球菌菌毛岛屿辅助蛋白AP1基因的克隆及其表达产物的抗原性鉴定[J].中国病原生物学杂志,2013,8(6):481-488.
[7]郎景民,布日额,吴金花,等.牛源无乳链球菌sip蛋白抗原优势区的原核表达及其间接ELISA检测方法的建立[J].中国病原生物学杂志,2010,5(11):38-39.
[8]Martin D,Rioux S,Gagnon E,et a1.Protection from Group B Streptococcal infection in neonatal mice by maternal im-munization with recombinant Sip protein[J].Infection and Immunity,2002,70(9):4897-4901.
[9]Shannon D M,Stephen W,Katherine K,et al.Naturally occurring antibodies for the group B streptococcal surface immunogenic protein(Sip)in pregnant women and newborn babies[J].Vaccine,2006,24(47-48):6905-6912
[10]曾祖聪,曹建萌,卢迈新,等.罗非鱼无乳链球菌Lrr G-Sip融合基因原核表达载体的构建及表达[J].南方水产科学,2014,10(5):17-22.
[11]Hughes M J,Moore JC,Lane JD,et al.Identification of major out-er surface proteins of Streptococcus agalactiae[J].infect immun,2002,70(3):1254-9.
[12]布日额,任晓峰,吴金花,等.牛乳腺炎无乳链球菌表面蛋白pgk抗原优势区的原核表达及其间接ELISA检测方法的建立[J].中国预防兽医学报,2013,35(4):312-316.
[13]Ragunathan P,Ponnuraj K,Expression,purification and structural.analysis of a fibrinogen receptor Fbs A from streptococcus agalactiae[J].protein J,2011,30(3):159-166.
[14]张雪峰.D群链球菌表面蛋白Fbs A的提取及免疫原性初步探讨[D].北京:北京生物制品研究所,2008.
[15]Santi I,Scarselli M,Mariani M,et al,Bi Ba:a novel immu-nogenic bacterial adhesin contributing to group Bsteptococcus survival in human blood[J].Mo LMicrobiol.2007.63(3):754-767.
[16]梁阳秋.猪链球菌2型三种免疫原性蛋白基因片段的串联表达及其斑马鱼免疫保护试验[D].南京:南京农业大学,2011.
[17]迟佳琦.金黄色葡萄球菌TRAP与无乳链球菌SIP蛋白融合表达及免疫保护作用[D].大庆:黑龙江八一农垦大学,2012.
[18]王鹤.停乳链球菌Gap C蛋白与鼠伤寒沙门菌Fli C蛋白的融合表达及免疫原性研究[D].大庆:黑龙江八一农垦大学,2012.
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