胞外诱捕网(Extracellular Traps,ETs):先天性免疫细胞第三种杀伤机制
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- 英文论文题名：Research progress on Extracellular traps:Third kinds of defence mechanisms of innate immune cells
- 论文作者：廖成水 ; 程相朝
- 英文论文作者：LIAO Cheng-shui ; CHENG Xiang-chao ; Animal Disease and Public Security Academician Workstation of Henan Province/The Key Lab of Animal Disease and Public Health ; Henan University of Science and Technology
- 年：2016
- 作者机构：河南省动物疫病与公共安全院士工作站/河南科技大学动物疫病与公共卫生重点实验室;
- 论文关键词：固有免疫细胞 ; 胞外诱捕网 ; 外捕作用 ; 杀菌活性
- 英文论文关键词：Innate immune cells ; extracellular traps ; ETosis ; bactericidal activity
- 会议召开时间：2016-11-04
- 会议录名称：中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会论文集
- 语种：中文
- 分类号：S852.4
- 学会代码：ZGXJ
- 会议名称：中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会
- 会议地点：中国山东青岛
- 主办单位：中国畜牧兽医学会动物微生态学分会
- 学会名称：中国畜牧兽医学会
- 页数：5
- 文件大小：491k
- 原文格式：O
- 会议级别：全国
摘要
胞外诱捕网(extracellular traps,ETs)的释放是近来新发现的一种由DNA和颗粒蛋白组成的先天免疫防御机制。作为继吞噬作用、自噬之后的第三种杀伤机制,大量的研究已经证实ETs在体内外可捕获和杀伤绝大多数的细菌、病毒、真菌和寄生虫,本文对ETs的概念、形成的分子机制以及ETs在宿主防御中的作用进行了简要的介绍,这将对固有免疫细胞防御策略的新认识具有重要的意义。
Extracellular traps(ETs),composed of DNA and granular proteins,is a new innate immune phagocytosis-independent extracellular defence mechanism which was discovered in recent years.As the third killing mechanisms of innate immune cells after phagocytosis and autophagocytosis,ETs can ensnare varied kinds of invading microbes inducing bacteria,virus,fungi,and protozoa to prevent local diffusion and kill them in vitro,and also in vivo.In this review,we will briefly describe the recent progress of the concept and molecular mechanism of ETs,and its role in host defense.This review have substantial significance on the new understanding of defense strategy in innate immune cells.
Extracellular traps(ETs),composed of DNA and granular proteins,is a new innate immune phagocytosis-independent extracellular defence mechanism which was discovered in recent years.As the third killing mechanisms of innate immune cells after phagocytosis and autophagocytosis,ETs can ensnare varied kinds of invading microbes inducing bacteria,virus,fungi,and protozoa to prevent local diffusion and kill them in vitro,and also in vivo.In this review,we will briefly describe the recent progress of the concept and molecular mechanism of ETs,and its role in host defense.This review have substantial significance on the new understanding of defense strategy in innate immune cells.
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