微生物转化生产β-苯乙醇的研究进展
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- 英文论文题名：Production ofβ-Phenylethanol by Microbial Biotransformation
- 论文作者：王梦泽 ; 王敬文 ; 管世敏 ; 张硕 ; 蔡宝国 ; 荣绍丰 ; 李茜茜
- 英文论文作者：Wang Mengze ; Wang Jingwen ; Guan Shimin ; Zhang Shuo ; Cai Baoguo ; Rong Shaofeng ; Li Qianqian ; School of Perfume and Aroma Technology ; Shanghai Institute of Technology
- 年：2016
- 作者机构：上海应用技术大学香料香精技术与工程学院;
- 论文关键词：β-苯乙醇 ; 艾式途径 ; 反巴士德效应 ; 原位分离技术 ; 香气品质
- 英文论文关键词：β-phenylethanol ; Ehrlich pathway ; Crabtree effect ; In situ separation technology ; Aroma quality
- 会议召开时间：2016-06-15
- 会议录名称：第十一届中国香料香精学术研讨会论文集
- 英文会议录名称：The Proceedings of the 11th Seminar on Fragrance and Flavor China
- 语种：中文
- 分类号：TQ655;TQ929
- 学会代码：ZGXE
- 会议名称：第十一届中国香料香精学术研讨会
- 会议地点：中国上海
- 主办单位：中国香料香精化妆品工业协会
- 学会名称：中国香料香精化妆品工业协会
- 页数：8
- 文件大小：390k
- 原文格式：O
- 会议级别：全国
摘要
β-苯乙醇是一种具有玫瑰风味的芳香醇,目前在食品、化妆品等方面有广泛应用。随着社会经济的发展,生物转化法生产天然β-苯乙醇备受关注。本文从天然β-苯乙醇主要的生物合成途径、发酵过程中副产物乙醇导致的Crab仕ee效应解除、原位分离技术在β-苯乙醇发酵体系中的应用、β-苯乙醇香气品质的分析与调控等四个方面综述了微生物发酵生产天然β-苯乙醇的最新进展。并简要介绍了本课题组对生物转化β-苯乙醇的研究情况。
P-Phenylethanol is an important flavor and fragrance compound with a rose like smell.It is widely used in many industries,such as food industry and cosmetic industry.With the development of social economy,the production of natural P-phenylethanolby microbial biosynthesis has attracted much attention.This review described the mainpathways in the production of P-phenylethanolby yeasts,the solution of Crabtree effectin the fermentationprocess,the separation ofp-phenylethanol using an in situ separation technology,and the aroma quality analysis of P-phenylethanol.Moreover,it also briefly introduced the advances in biotechnological production of 2-phenylethanolin our research group.
P-Phenylethanol is an important flavor and fragrance compound with a rose like smell.It is widely used in many industries,such as food industry and cosmetic industry.With the development of social economy,the production of natural P-phenylethanolby microbial biosynthesis has attracted much attention.This review described the mainpathways in the production of P-phenylethanolby yeasts,the solution of Crabtree effectin the fermentationprocess,the separation ofp-phenylethanol using an in situ separation technology,and the aroma quality analysis of P-phenylethanol.Moreover,it also briefly introduced the advances in biotechnological production of 2-phenylethanolin our research group.
引文
[1]杨晓,陈芳,李景明.植物中2-苯乙醇的合成研究进展[J].园艺学报,2010,37:1690-1694.
[2]Fabre CE,BlancPJ,Goma G.Production of2-phenylethyl alcohol by Kluyveromycesmarxianus[J].BiotechnolProg,1998,14(2):270-274.
[3]Hua D,Lin S,Li Y.Enhanced 2-phenylethanol production from L-phenylalanine via in situ product adsorption[J].BiocatalBiotransfor,2010,28:259-266.
[4]李刚,朱文斌,牛飞等.肉苁蓉苯乙醇苷对大鼠精子体外氧化损伤的保护作用研究[J].时珍国医国药,2010,21(9):2205-2207.
[5]Etschmann MMW,Bluemke W,Sell D,Schrader J.Biotechnological production of 2-Phenylethanol[J].ApplMicrobiolBiotechnol,2002,59:1-8.
[6]HuaD,XuP.Recent advances in biotechnological production of 2-phenylethanol[J].BiotechnolAdv,2011,29(6):654-660.
[7]梅建凤.利用酵母细胞生物转化法合成天然2-苯乙醇的研究[D].浙江大学,2009.
[8]Ehrlich F.(U|¨)berdieBedingungen der Fusel(o|¨)lbildung(u|¨)nduberihrenZusammenhangmitdemE iweiβaufbau der Hefe[J].BerDtschChemGes,1907,40:1027-1047.
[9]AtsumiS,Hanai T LiaoJC.Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuelsU].Nature,2008,451:86-89.
[10]Chen B,Yang SK.Studies on bioconversion of phenylpyruvate to L-phenylalanine by Pseudomonas sp.E4-106[J].Chin J Appl Environ Biol,1998,4(1):60-64.
[11]LargePJ.Degradation of organic nitrogen compounds by yeasts.Yeast,1986,2(1):1-34.
[12]EtschmannMM,Bluemke W,Sell D,Schrader J.Biotechnological production of 2-phenylethanol[J].ApplMicrobiolBiotechnol,2002,59(1):1-8.
[13]Seward R,Willetts JC,Dinsdale MG,Lloyd D.The effects of ethanol,hexanlol,and 2-phenylethanol on cider yeast growth,viability,and energy status;synergistic inhibition[J].J Inst Brew,1996,102:439-443.
[14]EtschmannMM,SchraderJ.An aqueous-organic two-phase bioprocess for efficient production of the natural aroma chemicals 2-phenylethanol and2-phenylethykcetate with yeast[J]ApplMcrobiolBiotechnol,2006,71(4):440-443.
[15]Wang H,Dong QF,Guan A,Meng C,Shi XA,Guo YG.Synergistic inhibition effect of 2-phenylethanol and ethanol on bioproduction of natural2-phenylethanol by Saccharomyces cerevisiae and process enhancement[J].J BiosciBioeng,2011,3:1-6.
[16]Rong S,Ding B,Zhang X,Zheng X,Wang Y.Enhanced biotransformation of 2-phenylethanol with ethanol oxidation in a solid-liquid two-phase system by active dry yeast[J].CurrMicrobiol,2011,63(5):503-509.
[17]Leao C,van Uden N.Effects of ethanol and other alkanols on passive proton influx in theyeast Saccharomyces cerevisiae[J].BiochemBiophys,1984,774:43-48.
[18]Serp D,von Stockar U,Marison IW.Enhancement of 2-phenylethanol productivity bySaccharomyces cerevishe in two-phase fed-batch fermentation using solvent immobilization[J].BiotechnolBioeng,2003,82:103-110.
[19]Etschmann MMW,Sell D,Schrader J.Screening of yeasts for the production of the aromacompound2-phenylethanol in a molasses-based medium[J].BiotechnolLett,2003,25:531-536.
[20]王成涛,孙宝国,曹雁平等.酵母茵转化生产天然香料2-苯乙醇的研究[J].现代化工,2008,28(8):38-42.
[21]梅建凤,陈虹,王鸿.水/有机溶剂两相体系中生物转化合成2-苯乙醇[J].化学反应工程与工艺,2009,25(1):69-73.
[22]梅建凤,易喻等.溶剂萃取法分离生物转化法合成的2-苯乙醇[J].浙江工业大学学报,2011,39(6):635-638.
[23]Bruce LJ,Daugulis AJ.Solvent selection strategies for extractive biocatalysis[J].Biotechnol Progr,1991,7:116-124.
[24]Gao F,Daugulis AJ.Bioproduction of the aroma compound 2-phenylethanol in a solidliquidtwo-phase partitioning bioreactor system by Kluyveromycesmarxianus[J].BiotechnolBioeng,2009,104:332-339.
[25]Guan A,Wang H,Meng C,Shi XA,Guo YH.Biosynthesis of 2-phenylethanol by Saccharomyces cerevisiae sp.strain with ISPR technology[J].Chinese J Process Eng,2009,9:128-132.
[26]Mei JF,Min H,Lv Z.Enhanced biotransformation of L-phenylalanine to 2-phenylethanol using an in situ product adsorption technique[J].Process Biochem,2009,44:886-890.
[27]荣绍丰,付艳丽,王涛,何新舟.大孔吸附树脂对发酵液中2-苯乙醇的吸附研究[J].食品与生物技术学报,2010,29(5):693-697.
[28]Hang Wang,Qingfeng Dong.A continuous and adsorptive bioprocess for efficient production of the natural aroma chemical 2-phenylethanol with yeast.Enzyme and Microbial Technology[J].Enzyme and Microbial Technology,2011,48:404-407.
[29]Tashiro Y,Takeda K,Kobayashi G,Sonomoto K,Ishizaki A,Yoshino S.Highbutanol production by Clostridium saccharoperbutylacetonicumN1-4 in fed-batch culture with pH-stat continuous butyric acid and glucose feeding method[J].J BiosciBioeng,2004,98:263-268.
[30]丁保妹,付艳丽,张晓丽,荣绍丰.发酵法合成天然2-苯乙醇的香气品质分析[J].食品与发酵工业,2011,11:198-202.
[31]TianX,YeR,WangJ,ChenY,CaiB,GuanS,RongS,LiQ.Effects of aroma quality on the biotransformation of natural 2-phenylethanol produced using ascorbic acid[J].Electron J Biotechnol,2015,23(4):286-290.
[2]Fabre CE,BlancPJ,Goma G.Production of2-phenylethyl alcohol by Kluyveromycesmarxianus[J].BiotechnolProg,1998,14(2):270-274.
[3]Hua D,Lin S,Li Y.Enhanced 2-phenylethanol production from L-phenylalanine via in situ product adsorption[J].BiocatalBiotransfor,2010,28:259-266.
[4]李刚,朱文斌,牛飞等.肉苁蓉苯乙醇苷对大鼠精子体外氧化损伤的保护作用研究[J].时珍国医国药,2010,21(9):2205-2207.
[5]Etschmann MMW,Bluemke W,Sell D,Schrader J.Biotechnological production of 2-Phenylethanol[J].ApplMicrobiolBiotechnol,2002,59:1-8.
[6]HuaD,XuP.Recent advances in biotechnological production of 2-phenylethanol[J].BiotechnolAdv,2011,29(6):654-660.
[7]梅建凤.利用酵母细胞生物转化法合成天然2-苯乙醇的研究[D].浙江大学,2009.
[8]Ehrlich F.(U|¨)berdieBedingungen der Fusel(o|¨)lbildung(u|¨)nduberihrenZusammenhangmitdemE iweiβaufbau der Hefe[J].BerDtschChemGes,1907,40:1027-1047.
[9]AtsumiS,Hanai T LiaoJC.Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuelsU].Nature,2008,451:86-89.
[10]Chen B,Yang SK.Studies on bioconversion of phenylpyruvate to L-phenylalanine by Pseudomonas sp.E4-106[J].Chin J Appl Environ Biol,1998,4(1):60-64.
[11]LargePJ.Degradation of organic nitrogen compounds by yeasts.Yeast,1986,2(1):1-34.
[12]EtschmannMM,Bluemke W,Sell D,Schrader J.Biotechnological production of 2-phenylethanol[J].ApplMicrobiolBiotechnol,2002,59(1):1-8.
[13]Seward R,Willetts JC,Dinsdale MG,Lloyd D.The effects of ethanol,hexanlol,and 2-phenylethanol on cider yeast growth,viability,and energy status;synergistic inhibition[J].J Inst Brew,1996,102:439-443.
[14]EtschmannMM,SchraderJ.An aqueous-organic two-phase bioprocess for efficient production of the natural aroma chemicals 2-phenylethanol and2-phenylethykcetate with yeast[J]ApplMcrobiolBiotechnol,2006,71(4):440-443.
[15]Wang H,Dong QF,Guan A,Meng C,Shi XA,Guo YG.Synergistic inhibition effect of 2-phenylethanol and ethanol on bioproduction of natural2-phenylethanol by Saccharomyces cerevisiae and process enhancement[J].J BiosciBioeng,2011,3:1-6.
[16]Rong S,Ding B,Zhang X,Zheng X,Wang Y.Enhanced biotransformation of 2-phenylethanol with ethanol oxidation in a solid-liquid two-phase system by active dry yeast[J].CurrMicrobiol,2011,63(5):503-509.
[17]Leao C,van Uden N.Effects of ethanol and other alkanols on passive proton influx in theyeast Saccharomyces cerevisiae[J].BiochemBiophys,1984,774:43-48.
[18]Serp D,von Stockar U,Marison IW.Enhancement of 2-phenylethanol productivity bySaccharomyces cerevishe in two-phase fed-batch fermentation using solvent immobilization[J].BiotechnolBioeng,2003,82:103-110.
[19]Etschmann MMW,Sell D,Schrader J.Screening of yeasts for the production of the aromacompound2-phenylethanol in a molasses-based medium[J].BiotechnolLett,2003,25:531-536.
[20]王成涛,孙宝国,曹雁平等.酵母茵转化生产天然香料2-苯乙醇的研究[J].现代化工,2008,28(8):38-42.
[21]梅建凤,陈虹,王鸿.水/有机溶剂两相体系中生物转化合成2-苯乙醇[J].化学反应工程与工艺,2009,25(1):69-73.
[22]梅建凤,易喻等.溶剂萃取法分离生物转化法合成的2-苯乙醇[J].浙江工业大学学报,2011,39(6):635-638.
[23]Bruce LJ,Daugulis AJ.Solvent selection strategies for extractive biocatalysis[J].Biotechnol Progr,1991,7:116-124.
[24]Gao F,Daugulis AJ.Bioproduction of the aroma compound 2-phenylethanol in a solidliquidtwo-phase partitioning bioreactor system by Kluyveromycesmarxianus[J].BiotechnolBioeng,2009,104:332-339.
[25]Guan A,Wang H,Meng C,Shi XA,Guo YH.Biosynthesis of 2-phenylethanol by Saccharomyces cerevisiae sp.strain with ISPR technology[J].Chinese J Process Eng,2009,9:128-132.
[26]Mei JF,Min H,Lv Z.Enhanced biotransformation of L-phenylalanine to 2-phenylethanol using an in situ product adsorption technique[J].Process Biochem,2009,44:886-890.
[27]荣绍丰,付艳丽,王涛,何新舟.大孔吸附树脂对发酵液中2-苯乙醇的吸附研究[J].食品与生物技术学报,2010,29(5):693-697.
[28]Hang Wang,Qingfeng Dong.A continuous and adsorptive bioprocess for efficient production of the natural aroma chemical 2-phenylethanol with yeast.Enzyme and Microbial Technology[J].Enzyme and Microbial Technology,2011,48:404-407.
[29]Tashiro Y,Takeda K,Kobayashi G,Sonomoto K,Ishizaki A,Yoshino S.Highbutanol production by Clostridium saccharoperbutylacetonicumN1-4 in fed-batch culture with pH-stat continuous butyric acid and glucose feeding method[J].J BiosciBioeng,2004,98:263-268.
[30]丁保妹,付艳丽,张晓丽,荣绍丰.发酵法合成天然2-苯乙醇的香气品质分析[J].食品与发酵工业,2011,11:198-202.
[31]TianX,YeR,WangJ,ChenY,CaiB,GuanS,RongS,LiQ.Effects of aroma quality on the biotransformation of natural 2-phenylethanol produced using ascorbic acid[J].Electron J Biotechnol,2015,23(4):286-290.
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