超小无机纳米分子影像探针
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- 英文论文题名：Ultrasmall inorganic molecular imaging probes
- 论文作者：李桢
- 英文论文作者：Zhen Li ; Center for Molecular Imaging and Nuclear Medicine ; School of Radiation Medicine and Protection ; Soochow University
- 年：2016
- 作者机构：苏州大学放射医学与防护学院;
- 论文关键词：超小无机纳米颗粒 ; 尺寸效应 ; 分子影像 ; 肿瘤
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TQ421.7
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：135k
- 原文格式：D
- 会议级别：全国
摘要
当材料尺寸减小至纳米或亚纳米尺度时,它们就会表现出与体相材料迥异的物理化学性质。~([1])例如当磁性氧化铁纳米颗粒的尺寸减小至临界尺寸时(如Fe_3O_4的临界转变尺寸约为20nm),它们由铁磁性转变为超顺磁性。这些超顺磁性纳米颗粒可以用作核磁共振成像的负增强造影剂。进一步减小超顺磁性纳米颗粒尺寸,它们由超顺磁性转变为顺磁性。这些顺磁性超小纳米颗粒可以同时用作核磁共振成像的正增强和负增强造双重。因此,通过调控纳米颗粒的尺寸可以有效调控其性质,实现它们在不同领域的应用。这里将介绍我们在超小磁性纳米颗粒、~([2-4])荧光金属纳米簇、~([5])超小金属氧化物纳米颗粒、~([6])超小黒磷量子点~([7])方面的研究工作,探讨它们在分子影像,肿瘤诊断与治疗方面的潜在应用。
When the size of inorganic particles is reduced to nano scale or sub-nanometer scale, they exhibit novel properties in comparison with their bulk analogues. One example is magnetic iron oxide nanoparticles(MIONs), which show superparamagnetism when their size is below the critical size(e.g. 20 nm for Fe_3O_4 particles) where they turn from ferromagnetic into superparamagnetic. These superparamagnetic MIONs have been extensively used as negative contrast agents for magnetic resonance imaging(MRI). Further decrease of their size leads to the change of their magnetic property from superparamagnetic into paramagnetic, which enable them to simultaneously serve as dual contrast agent for T1-and T2-weighted MRI. Here I will introduce our research work on ultrasmall MIONs for MRI, ultrasmall metallic nanoclusters for fluorescence imaging, ultrasmall metal oxide nanoparticles for cancer imaging and therapy, and ultrasmall black phosphorous quantum dots for photothermal therapy.
When the size of inorganic particles is reduced to nano scale or sub-nanometer scale, they exhibit novel properties in comparison with their bulk analogues. One example is magnetic iron oxide nanoparticles(MIONs), which show superparamagnetism when their size is below the critical size(e.g. 20 nm for Fe_3O_4 particles) where they turn from ferromagnetic into superparamagnetic. These superparamagnetic MIONs have been extensively used as negative contrast agents for magnetic resonance imaging(MRI). Further decrease of their size leads to the change of their magnetic property from superparamagnetic into paramagnetic, which enable them to simultaneously serve as dual contrast agent for T1-and T2-weighted MRI. Here I will introduce our research work on ultrasmall MIONs for MRI, ultrasmall metallic nanoclusters for fluorescence imaging, ultrasmall metal oxide nanoparticles for cancer imaging and therapy, and ultrasmall black phosphorous quantum dots for photothermal therapy.
引文
[1]Z.Li,Q.Sun,Y.Zhu,B.Tan,Z.P.Xu,S.X.Dou,J.Mater.Chem.B 2014,2,2793-2818.
[2]Z.Li,P.W.Yi,Q.Sun,H.Lei,H.L.Zhao,Z.H.Zhu,S.C.Smith,M.B.Lan,G.Q.Lu,Adv.Funct.Mater.2012,22,2387-2393.
[3]Z.Li,S.X.Wang,Q.Sun,H.L.Zhao,H.Lei,M.B.Lan,Z.X.Cheng,X.L.Wang,S.X.Dou,G.Q.Lu,Adv.Healthcare Mater.2013,2,958-964.
[4]Z.Li,B.Tan,M.Allix,A.I.Cooper,M.J.Rosseinsky,Small 2008,4,231-239.
[5]H.Zhang,X.Huang,L.Li,G.Zhang,I.Hussain,Z.Li,B.Tan,Chem.Commun.2012,48,567-569.
[6]L.Wen,L.Chen,S.Zheng,J.Zeng,G.Duan,Y.Wang,G.Wang,Z.Chai,Z.Li,M.Gao,Adv.Mater.2016,201506428R1.
[7]C.Sun,L.Wen,J.Zeng,Y.Wang,Q.Sun,L.Deng,C.Zhao,Z.Li,Biomaterials 2016,91,81-89.
[2]Z.Li,P.W.Yi,Q.Sun,H.Lei,H.L.Zhao,Z.H.Zhu,S.C.Smith,M.B.Lan,G.Q.Lu,Adv.Funct.Mater.2012,22,2387-2393.
[3]Z.Li,S.X.Wang,Q.Sun,H.L.Zhao,H.Lei,M.B.Lan,Z.X.Cheng,X.L.Wang,S.X.Dou,G.Q.Lu,Adv.Healthcare Mater.2013,2,958-964.
[4]Z.Li,B.Tan,M.Allix,A.I.Cooper,M.J.Rosseinsky,Small 2008,4,231-239.
[5]H.Zhang,X.Huang,L.Li,G.Zhang,I.Hussain,Z.Li,B.Tan,Chem.Commun.2012,48,567-569.
[6]L.Wen,L.Chen,S.Zheng,J.Zeng,G.Duan,Y.Wang,G.Wang,Z.Chai,Z.Li,M.Gao,Adv.Mater.2016,201506428R1.
[7]C.Sun,L.Wen,J.Zeng,Y.Wang,Q.Sun,L.Deng,C.Zhao,Z.Li,Biomaterials 2016,91,81-89.