金黄色葡萄球菌溶血素研究进展
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- 英文论文题名：Progress in research on Staphylococcus aureus hemolysin
- 论文作者：白文丽 ; 锡林高娃 ; 吴金花 ; 布日额
- 英文论文作者：BAI Wen-li ; XI Lin-gao-wa ; WU Jin-hua ; BU Ri-e ; Inner Mongolia Autonomous Region Engineering Technology Research Center of Prevention ; Control the Pathogenic Bacteria in Milk ; Inner Mongolia University for Nationalities ; Research Institute of Pathogenic in Milk ; College of Life Science ; Inner Mongolia University for Nationalities
- 年：2016
- 作者机构：内蒙古自治区乳源性致病菌防控工程技术研究中心;内蒙古民族大学生命科学学院;内蒙古民族大学乳源性致病菌研究所;
- 论文关键词：金黄色葡萄球菌 ; 毒素 ; 溶血素 ; 展望
- 会议召开时间：2016-07-20
- 会议录名称：中国畜牧兽医学会兽医公共卫生学分会第五次学术研讨会论文集
- 语种：中文
- 分类号：S852.611
- 学会代码：SYGW
- 会议名称：中国畜牧兽医学会兽医公共卫生学分会第五次学术研讨会
- 会议地点：中国内蒙古通辽
- 主办单位：中国畜牧兽医学会兽医公共卫生学分会
- 学会名称：中国畜牧兽医学会兽医公共卫生学分会
- 页数：5
- 文件大小：528k
- 原文格式：D
- 会议级别：全国
摘要
自21世纪以来,金黄色葡萄球菌迅速成为国内外人畜受感染的重要致病菌,造成严重的感染与发病。随着人畜抗生素的滥用,多重耐药菌,甚至"超级细菌"产生的报道逐年增多,使得金黄色葡萄球菌成为重要的公共卫生安全问题而备受重视。因此,国内外学者为了能够有效预防金黄色葡萄球菌的危害,近年来针对金黄色葡萄球菌的致病因子进行了一系列的研究,尤其对其溶血素的研究报道较多,并获得了一些进展。本文主要对近年来国内外金黄色葡萄球菌溶血素研究状况做一综述和展望。
Since the 21 st century,Staphylococcus aureus is rapidly becoming an important bacteria which infected humans and animals over the world,causing serious infection and disease.With the overuse of antibiotics on livestock,reporting multi-drug resistant and even "super bacteria" increased year by year,so that Staphylococcus aureus has become an important public health and safety issue.Thus,scholars in order to prevent Staphylococcus aureus effectively,contrary to the virulence factor of staphylococcus aureus carried out a series of research in recent years,particularly research for hemolysin and get some progress.This paper focuses on the research situation for recent domestic Staphylococcus aureus hemolysin do a review and outlook.
Since the 21 st century,Staphylococcus aureus is rapidly becoming an important bacteria which infected humans and animals over the world,causing serious infection and disease.With the overuse of antibiotics on livestock,reporting multi-drug resistant and even "super bacteria" increased year by year,so that Staphylococcus aureus has become an important public health and safety issue.Thus,scholars in order to prevent Staphylococcus aureus effectively,contrary to the virulence factor of staphylococcus aureus carried out a series of research in recent years,particularly research for hemolysin and get some progress.This paper focuses on the research situation for recent domestic Staphylococcus aureus hemolysin do a review and outlook.
引文
[1]李冬野,崔玉东,侯喜林,等.金黄色葡萄球菌β﹣溶血素的原核表达及其溶血素活性检测[J].中国人兽共患病学报,2007,23(2):136-139.
[2]Vandenesch F,Lina G,Henry T.Staphylococcus aureus hemolysins,bi-component leukocidins,and cytolytic peptides:a redundant arsenal of membrane-damaging virulence factors[J].Front Cell Infect Microbiol,2012,2:12.
[3]Wardenburg J B,Patel R J,Schneewind O.Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia[J].Infect Immun,2007,75:1040-1044.
[4]Wardenburg JB,Schneewind O.Vaccine protection against Staphylococcus aureus pneumonia[J].JExp Med,2008,205:287-294.
[5]刘瑞田.金黄色葡萄球菌外毒素的研究进展[J].国外兽医学-畜禽疾病,1994,15(1)12-14.
[6]Galdiero S,Gouaus E.High resolution crystallographic studies of alpha-hemolysin-phospholipid complexes define heptamer-lipid head group interactions:implication for understanding proteinlipid interactions[J].Protein Sci.2004,13(6):1503-1511.
[7]Wadstrom,T,R.Molly.Some biological properties of purified staphylococcal hemolysins[J].Toxicon,1972,(10):511-519.
[8]Cheng GY,Dong AC,Otto M.Direct and synergistic hemolysis caused by Staphylococcus phenol-soluble modulins:implications for diagnosis and pathogenesis[J].Microbes Infect,2012,14(4):380-386.
[9]Kobayashi SD,Deleo FR.An update on community-associated MRSA virulence[J].Curr Opin Pharmacol,2009,9(5):545-551.
[10]Dumont AL,Nygard TK,Watkins RL,et al.Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis[J].Mol Microbiol,2011,79(3):814-825.
[11]Tristan A,Benito Y,Montserret R,et al.The signal peptide of Staphylococcus aureus panton valentine leukocidin Luk S component mediates increased adhesion to heparin sulfates[J].PLo S One.2009,4(4):5042.
[12]杨钦,王长法,杨宏军.牛乳中金黄色葡萄菌山东分离株β﹣溶血素的克隆、表达及溶血活性分析[J].中国农业科学,2009,42(1):324-330.
[13]Omoe K,Ishikawa M,Shimoda Y,et al.Detection of seg,seh,and sei genes in Staphylococcus aureus isolates and determination of the enterotoxin productivities of S.aureus isolates harboring seg,seh,or sei genes[J].J Clin Microbiol,2002,40(3):857-862.
[14]Jayasinghe L,Miles G,Bayley H.Role of the amino latch of staphylococcal alpha-hemolysin in pore formation:a cooperative interaction between the N terminus and position 217[J].Biol Chem,2006,281(4):2195-2204.
[15]De Leo Fottom.An antidote for Staphylococcus aureus pneumonia[J].JEM 2008,205(2):271-274.
[2]Vandenesch F,Lina G,Henry T.Staphylococcus aureus hemolysins,bi-component leukocidins,and cytolytic peptides:a redundant arsenal of membrane-damaging virulence factors[J].Front Cell Infect Microbiol,2012,2:12.
[3]Wardenburg J B,Patel R J,Schneewind O.Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia[J].Infect Immun,2007,75:1040-1044.
[4]Wardenburg JB,Schneewind O.Vaccine protection against Staphylococcus aureus pneumonia[J].JExp Med,2008,205:287-294.
[5]刘瑞田.金黄色葡萄球菌外毒素的研究进展[J].国外兽医学-畜禽疾病,1994,15(1)12-14.
[6]Galdiero S,Gouaus E.High resolution crystallographic studies of alpha-hemolysin-phospholipid complexes define heptamer-lipid head group interactions:implication for understanding proteinlipid interactions[J].Protein Sci.2004,13(6):1503-1511.
[7]Wadstrom,T,R.Molly.Some biological properties of purified staphylococcal hemolysins[J].Toxicon,1972,(10):511-519.
[8]Cheng GY,Dong AC,Otto M.Direct and synergistic hemolysis caused by Staphylococcus phenol-soluble modulins:implications for diagnosis and pathogenesis[J].Microbes Infect,2012,14(4):380-386.
[9]Kobayashi SD,Deleo FR.An update on community-associated MRSA virulence[J].Curr Opin Pharmacol,2009,9(5):545-551.
[10]Dumont AL,Nygard TK,Watkins RL,et al.Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis[J].Mol Microbiol,2011,79(3):814-825.
[11]Tristan A,Benito Y,Montserret R,et al.The signal peptide of Staphylococcus aureus panton valentine leukocidin Luk S component mediates increased adhesion to heparin sulfates[J].PLo S One.2009,4(4):5042.
[12]杨钦,王长法,杨宏军.牛乳中金黄色葡萄菌山东分离株β﹣溶血素的克隆、表达及溶血活性分析[J].中国农业科学,2009,42(1):324-330.
[13]Omoe K,Ishikawa M,Shimoda Y,et al.Detection of seg,seh,and sei genes in Staphylococcus aureus isolates and determination of the enterotoxin productivities of S.aureus isolates harboring seg,seh,or sei genes[J].J Clin Microbiol,2002,40(3):857-862.
[14]Jayasinghe L,Miles G,Bayley H.Role of the amino latch of staphylococcal alpha-hemolysin in pore formation:a cooperative interaction between the N terminus and position 217[J].Biol Chem,2006,281(4):2195-2204.
[15]De Leo Fottom.An antidote for Staphylococcus aureus pneumonia[J].JEM 2008,205(2):271-274.